dbPTM

GTSE1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GTSE1_HUMAN
UniProt AC	Q9NYZ3
Protein Name	G2 and S phase-expressed protein 1
Gene Name	GTSE1
Organism	Homo sapiens (Human).
Sequence Length	720
Subcellular Localization	Cytoplasm, cytoskeleton. Associated with microtubules.
Protein Description	May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression..
Protein Sequence	MDDPKKEDILLLADEKFDFDLSLSSSSANEDDEVFFGPFGHKERCIAASLELNNPVPEQPPLPTSESPFAWSPLAGEKFVEVYKEAHLLALHIESSSRNQAAQAAKPEDPRSQGVERFIQESKLKINLFEKEKEMKKSPTSLKRETYYLSDSPLLGPPVGEPRLLASSPALPSSGAQARLTRAPGPPHSAHALPRESCTAHAASQAATQRKPGTKLLLPRAASVRGRSIPGAAEKPKKEIPASPSRTKIPAEKESHRDVLPDKPAPGAVNVPAAGSHLGQGKRAIPVPNKLGLKKTLLKAPGSTSNLARKSSSGPVWSGASSACTSPAVGKAKSSEFASIPANSSRPLSNISKSGRMGPAMLRPALPAGPVGASSWQAKRVDVSELAAEQLTAPPSASPTQPQTPEGGGQWLNSSCAWSESSQLNKTRSIRRRDSCLNSKTKVMPTPTNQFKIPKFSIGDSPDSSTPKLSRAQRPQSCTSVGRVTVHSTPVRRSSGPAPQSLLSAWRVSALPTPASRRCSGLPPMTPKTMPRAVGSPLCVPARRRSSEPRKNSAMRTEPTRESNRKTDSRLVDVSPDRGSPPSRVPQALNFSPEESDSTFSKSTATEVAREEAKPGGDAAPSEALLVDIKLEPLAVTPDAASQPLIDLPLIDFCDTPEAHVAVGSESRPLIDLMTNTPDMNKNVAKPSPVVGQLIDLSSPLIQLSPEADKENVDSPLLKF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Sumoylation	--MDDPKKEDILLLA --CCCCCHHCEEEEC	67.04	-
25	Ubiquitination	DFDLSLSSSSANEDD CCEEECCCCCCCCCC	33.34	29967540
64	Phosphorylation	PEQPPLPTSESPFAW CCCCCCCCCCCCCCC	53.46	28102081
65	Phosphorylation	EQPPLPTSESPFAWS CCCCCCCCCCCCCCC	33.85	28102081
67	Phosphorylation	PPLPTSESPFAWSPL CCCCCCCCCCCCCCC	25.70	22199227
72	Phosphorylation	SESPFAWSPLAGEKF CCCCCCCCCCCCCHH	13.45	22199227
83	Phosphorylation	GEKFVEVYKEAHLLA CCHHHHHHHHHHHHH	6.93	-
86	Phosphorylation	FVEVYKEAHLLALHI HHHHHHHHHHHHHHC	8.42	20068231
91	Phosphorylation	KEAHLLALHIESSSR HHHHHHHHHCCCCCH	4.16	20068231
95	Phosphorylation	LLALHIESSSRNQAA HHHHHCCCCCHHHHH	32.77	21712546
96	Phosphorylation	LALHIESSSRNQAAQ HHHHCCCCCHHHHHH	22.11	28555341
106	Ubiquitination	NQAAQAAKPEDPRSQ HHHHHHCCCCCHHHH	52.54	-
112	Phosphorylation	AKPEDPRSQGVERFI CCCCCHHHHHHHHHH	36.35	28555341
114	Phosphorylation	PEDPRSQGVERFIQE CCCHHHHHHHHHHHH	25.21	-
123	Sumoylation	ERFIQESKLKINLFE HHHHHHHHHCEECHH	53.71	-
123	Acetylation	ERFIQESKLKINLFE HHHHHHHHHCEECHH	53.71	25953088
123	Ubiquitination	ERFIQESKLKINLFE HHHHHHHHHCEECHH	53.71	-
125	Ubiquitination	FIQESKLKINLFEKE HHHHHHHCEECHHHH	33.03	24816145
133	Ubiquitination	INLFEKEKEMKKSPT EECHHHHHHHHCCCC	74.34	-
138	Phosphorylation	KEKEMKKSPTSLKRE HHHHHHCCCCCCCCC	28.08	26055452
140	Phosphorylation	KEMKKSPTSLKRETY HHHHCCCCCCCCCEE	54.50	20068231
141	Phosphorylation	EMKKSPTSLKRETYY HHHCCCCCCCCCEEE	34.97	20068231
142	Sumoylation	MKKSPTSLKRETYYL HHCCCCCCCCCEEEC	7.16	-
142	Ubiquitination	MKKSPTSLKRETYYL HHCCCCCCCCCEEEC	7.16	29967540
143	Sumoylation	KKSPTSLKRETYYLS HCCCCCCCCCEEECC	48.21	-
144	Ubiquitination	KSPTSLKRETYYLSD CCCCCCCCCEEECCC	46.94	33845483
146	Phosphorylation	PTSLKRETYYLSDSP CCCCCCCEEECCCCC	22.84	26055452
147	Phosphorylation	TSLKRETYYLSDSPL CCCCCCEEECCCCCC	9.54	21712546
148	Phosphorylation	SLKRETYYLSDSPLL CCCCCEEECCCCCCC	13.72	16964243
150	Phosphorylation	KRETYYLSDSPLLGP CCCEEECCCCCCCCC	21.66	25159151
150	Ubiquitination	KRETYYLSDSPLLGP CCCEEECCCCCCCCC	21.66	29967540
152	Phosphorylation	ETYYLSDSPLLGPPV CEEECCCCCCCCCCC	17.67	25159151
157	Phosphorylation	SDSPLLGPPVGEPRL CCCCCCCCCCCCCEE	22.00	20068231
159	Phosphorylation	SPLLGPPVGEPRLLA CCCCCCCCCCCEEEE	17.84	20068231
160	Phosphorylation	PLLGPPVGEPRLLAS CCCCCCCCCCEEEEC	44.99	20068231
162	Sumoylation	LGPPVGEPRLLASSP CCCCCCCCEEEECCC	26.70	-
165	Phosphorylation	PVGEPRLLASSPALP CCCCCEEEECCCCCC	4.60	20068231
167	Phosphorylation	GEPRLLASSPALPSS CCCEEEECCCCCCCC	36.50	29255136
168	Phosphorylation	EPRLLASSPALPSSG CCEEEECCCCCCCCC	14.48	29255136
169	Phosphorylation	PRLLASSPALPSSGA CEEEECCCCCCCCCH	35.01	-
171	Phosphorylation	LLASSPALPSSGAQA EEECCCCCCCCCHHC	4.86	20068231
173	Phosphorylation	ASSPALPSSGAQARL ECCCCCCCCCHHCHH	42.10	25159151
174	Phosphorylation	SSPALPSSGAQARLT CCCCCCCCCHHCHHH	35.89	25159151
181	Phosphorylation	SGAQARLTRAPGPPH CCHHCHHHCCCCCCC	21.16	22210691
182	Methylation	GAQARLTRAPGPPHS CHHCHHHCCCCCCCC	43.29	-
186	Phosphorylation	RLTRAPGPPHSAHAL HHHCCCCCCCCCCCC	23.52	19691289
187	Phosphorylation	LTRAPGPPHSAHALP HHCCCCCCCCCCCCC	39.72	18691976
189	Phosphorylation	RAPGPPHSAHALPRE CCCCCCCCCCCCCHH	27.76	25159151
192	Phosphorylation	GPPHSAHALPRESCT CCCCCCCCCCHHHHH	20.98	20068231
193	Phosphorylation	PPHSAHALPRESCTA CCCCCCCCCHHHHHH	2.70	20068231
197	Phosphorylation	AHALPRESCTAHAAS CCCCCHHHHHHHHHH	20.32	28555341
199	Phosphorylation	ALPRESCTAHAASQA CCCHHHHHHHHHHHH	30.66	28555341
201	Methylation	PRESCTAHAASQAAT CHHHHHHHHHHHHHH	12.04	-
208	Phosphorylation	HAASQAATQRKPGTK HHHHHHHHCCCCCCE	31.74	24719451
215	Acetylation	TQRKPGTKLLLPRAA HCCCCCCEEEECCCH	42.95	25953088
215	Methylation	TQRKPGTKLLLPRAA HCCCCCCEEEECCCH	42.95	-
223	Phosphorylation	LLLPRAASVRGRSIP EEECCCHHCCCCCCC	16.03	23882029
228	Phosphorylation	AASVRGRSIPGAAEK CHHCCCCCCCCCCCC	35.64	25394399
234	Methylation	RSIPGAAEKPKKEIP CCCCCCCCCCCCCCC	70.16	-
235	Acetylation	SIPGAAEKPKKEIPA CCCCCCCCCCCCCCC	58.36	25953088
242	Phosphorylation	KPKKEIPASPSRTKI CCCCCCCCCCCCCCC	39.47	-
243	Phosphorylation	PKKEIPASPSRTKIP CCCCCCCCCCCCCCC	20.32	23401153
245	Phosphorylation	KEIPASPSRTKIPAE CCCCCCCCCCCCCCC	50.52	30266825
247	Phosphorylation	IPASPSRTKIPAEKE CCCCCCCCCCCCCHH	37.35	22199227
262	Phosphorylation	SHRDVLPDKPAPGAV HCCCCCCCCCCCCCC	66.46	19691289
264	Phosphorylation	RDVLPDKPAPGAVNV CCCCCCCCCCCCCCC	51.58	20068230
276	Phosphorylation	VNVPAAGSHLGQGKR CCCCCCCCCCCCCCC	15.71	25159151
290	Acetylation	RAIPVPNKLGLKKTL CCCCCCCCCCCCHHH	37.55	25953088
295	Phosphorylation	PNKLGLKKTLLKAPG CCCCCCCHHHHCCCC	49.82	-
303	Phosphorylation	TLLKAPGSTSNLARK HHHCCCCCCHHHCHH	27.83	25159151
304	Phosphorylation	LLKAPGSTSNLARKS HHCCCCCCHHHCHHC	27.78	19691289
305	Phosphorylation	LKAPGSTSNLARKSS HCCCCCCHHHCHHCC	31.38	29496963
310	Methylation	STSNLARKSSSGPVW CCHHHCHHCCCCCCC	49.43	-
311	Phosphorylation	TSNLARKSSSGPVWS CHHHCHHCCCCCCCC	24.96	29978859
312	Phosphorylation	SNLARKSSSGPVWSG HHHCHHCCCCCCCCC	42.20	23882029
313	Phosphorylation	NLARKSSSGPVWSGA HHCHHCCCCCCCCCC	54.96	29978859
318	Phosphorylation	SSSGPVWSGASSACT CCCCCCCCCCCCCCC	25.39	29978859
318	Ubiquitination	SSSGPVWSGASSACT CCCCCCCCCCCCCCC	25.39	29967540
321	Phosphorylation	GPVWSGASSACTSPA CCCCCCCCCCCCCCC	23.22	29978859
321	Ubiquitination	GPVWSGASSACTSPA CCCCCCCCCCCCCCC	23.22	21890473
322	Phosphorylation	PVWSGASSACTSPAV CCCCCCCCCCCCCCC	27.16	23882029
323	Phosphorylation	VWSGASSACTSPAVG CCCCCCCCCCCCCCC	9.71	-
325	Phosphorylation	SGASSACTSPAVGKA CCCCCCCCCCCCCCC	37.15	28450419
326	Phosphorylation	GASSACTSPAVGKAK CCCCCCCCCCCCCCC	15.67	23882029
329	Methylation	SACTSPAVGKAKSSE CCCCCCCCCCCCCCC	10.30	-
331	Acetylation	CTSPAVGKAKSSEFA CCCCCCCCCCCCCCC	46.15	25953088
331	Methylation	CTSPAVGKAKSSEFA CCCCCCCCCCCCCCC	46.15	-
331	Phosphorylation	CTSPAVGKAKSSEFA CCCCCCCCCCCCCCC	46.15	27251275
332	Phosphorylation	TSPAVGKAKSSEFAS CCCCCCCCCCCCCCC	15.84	24719451
334	Phosphorylation	PAVGKAKSSEFASIP CCCCCCCCCCCCCCC	39.70	20068231
335	Phosphorylation	AVGKAKSSEFASIPA CCCCCCCCCCCCCCC	35.71	28555341
339	Phosphorylation	AKSSEFASIPANSSR CCCCCCCCCCCCCCC	34.13	20068231
340	Phosphorylation	KSSEFASIPANSSRP CCCCCCCCCCCCCCC	3.15	27251275
344	Phosphorylation	FASIPANSSRPLSNI CCCCCCCCCCCCCCC	29.81	20068231
345	Phosphorylation	ASIPANSSRPLSNIS CCCCCCCCCCCCCCC	37.41	20068231
349	Phosphorylation	ANSSRPLSNISKSGR CCCCCCCCCCCCCCC	34.50	30576142
350	Methylation	NSSRPLSNISKSGRM CCCCCCCCCCCCCCC	50.68	-
352	Phosphorylation	SRPLSNISKSGRMGP CCCCCCCCCCCCCCC	25.64	29496963
352	Ubiquitination	SRPLSNISKSGRMGP CCCCCCCCCCCCCCC	25.64	29967540
353	Phosphorylation	RPLSNISKSGRMGPA CCCCCCCCCCCCCCC	53.80	-
354	Phosphorylation	PLSNISKSGRMGPAM CCCCCCCCCCCCCCC	25.49	21712546
364	Phosphorylation	MGPAMLRPALPAGPV CCCCCCCCCCCCCCC	33.90	-
368	Phosphorylation	MLRPALPAGPVGASS CCCCCCCCCCCCCCC	35.45	18669648
372	Ubiquitination	ALPAGPVGASSWQAK CCCCCCCCCCCCCCE	23.91	29967540
396	Phosphorylation	EQLTAPPSASPTQPQ HHCCCCCCCCCCCCC	40.08	26074081
398	Phosphorylation	LTAPPSASPTQPQTP CCCCCCCCCCCCCCC	32.58	26074081
398	Ubiquitination	LTAPPSASPTQPQTP CCCCCCCCCCCCCCC	32.58	29967540
400	Phosphorylation	APPSASPTQPQTPEG CCCCCCCCCCCCCCC	50.84	26074081
427	Phosphorylation	ESSQLNKTRSIRRRD CCHHHCCCHHHHHHH	28.68	23882029
429	Phosphorylation	SQLNKTRSIRRRDSC HHHCCCHHHHHHHHH	26.19	23882029
435	Phosphorylation	RSIRRRDSCLNSKTK HHHHHHHHHHCCCCC	20.77	27273156
439	Phosphorylation	RRDSCLNSKTKVMPT HHHHHHCCCCCCCCC	28.84	29496963
441	Phosphorylation	DSCLNSKTKVMPTPT HHHHCCCCCCCCCCC	28.79	30622161
446	Phosphorylation	SKTKVMPTPTNQFKI CCCCCCCCCCCCCCC	25.34	25159151
448	Phosphorylation	TKVMPTPTNQFKIPK CCCCCCCCCCCCCCC	44.10	26074081
454	Phosphorylation	PTNQFKIPKFSIGDS CCCCCCCCCCCCCCC	32.03	20068231
455	Ubiquitination	TNQFKIPKFSIGDSP CCCCCCCCCCCCCCC	56.04	21890473
457	Phosphorylation	QFKIPKFSIGDSPDS CCCCCCCCCCCCCCC	31.61	22617229
458	Phosphorylation	FKIPKFSIGDSPDSS CCCCCCCCCCCCCCC	8.82	20068231
461	Phosphorylation	PKFSIGDSPDSSTPK CCCCCCCCCCCCCCC	25.95	23401153
464	Phosphorylation	SIGDSPDSSTPKLSR CCCCCCCCCCCCCCH	39.22	29255136
465	Phosphorylation	IGDSPDSSTPKLSRA CCCCCCCCCCCCCHH	56.99	29255136
466	Phosphorylation	GDSPDSSTPKLSRAQ CCCCCCCCCCCCHHC	28.52	29255136
470	Phosphorylation	DSSTPKLSRAQRPQS CCCCCCCCHHCCCCC	31.53	27174698
471	Ubiquitination	SSTPKLSRAQRPQSC CCCCCCCHHCCCCCC	45.21	29967540
474	Ubiquitination	PKLSRAQRPQSCTSV CCCCHHCCCCCCCCC	30.18	21890473
476	Phosphorylation	LSRAQRPQSCTSVGR CCHHCCCCCCCCCCE	54.01	27251275
477	Phosphorylation	SRAQRPQSCTSVGRV CHHCCCCCCCCCCEE	23.26	25159151
479	Phosphorylation	AQRPQSCTSVGRVTV HCCCCCCCCCCEEEE	31.52	21712546
480	Phosphorylation	QRPQSCTSVGRVTVH CCCCCCCCCCEEEEE	27.23	25159151
483	Phosphorylation	QSCTSVGRVTVHSTP CCCCCCCEEEEECCC	20.83	-
485	Phosphorylation	CTSVGRVTVHSTPVR CCCCCEEEEECCCCC	15.90	25159151
488	Phosphorylation	VGRVTVHSTPVRRSS CCEEEEECCCCCCCC	30.03	25159151
489	Phosphorylation	GRVTVHSTPVRRSSG CEEEEECCCCCCCCC	15.78	25159151
492	Methylation	TVHSTPVRRSSGPAP EEECCCCCCCCCCCC	33.69	-
494	Phosphorylation	HSTPVRRSSGPAPQS ECCCCCCCCCCCCHH	29.14	19691289
495	Phosphorylation	STPVRRSSGPAPQSL CCCCCCCCCCCCHHH	47.16	18669648
496	Phosphorylation	TPVRRSSGPAPQSLL CCCCCCCCCCCHHHH	24.52	24719451
498	Phosphorylation	VRRSSGPAPQSLLSA CCCCCCCCCHHHHHH	20.49	18669648
499	Phosphorylation	RRSSGPAPQSLLSAW CCCCCCCCHHHHHHH	27.68	18669648
501	Phosphorylation	SSGPAPQSLLSAWRV CCCCCCHHHHHHHHH	30.16	18669648
504	Phosphorylation	PAPQSLLSAWRVSAL CCCHHHHHHHHHCCC	30.95	18669648
507	Phosphorylation	QSLLSAWRVSALPTP HHHHHHHHHCCCCCC	16.54	20068231
508	Phosphorylation	SLLSAWRVSALPTPA HHHHHHHHCCCCCCH	2.47	24719451
509	Phosphorylation	LLSAWRVSALPTPAS HHHHHHHCCCCCCHH	18.60	28348404
511	Methylation	SAWRVSALPTPASRR HHHHHCCCCCCHHHC	3.65	-
513	Phosphorylation	WRVSALPTPASRRCS HHHCCCCCCHHHCCC	32.13	25159151
514	Phosphorylation	RVSALPTPASRRCSG HHCCCCCCHHHCCCC	26.71	16964243
516	Phosphorylation	SALPTPASRRCSGLP CCCCCCHHHCCCCCC	22.82	25159151
520	Phosphorylation	TPASRRCSGLPPMTP CCHHHCCCCCCCCCC	41.37	25159151
523	Phosphorylation	SRRCSGLPPMTPKTM HHCCCCCCCCCCCCC	21.82	27251275
526	Phosphorylation	CSGLPPMTPKTMPRA CCCCCCCCCCCCCCC	27.66	25159151
528	Phosphorylation	GLPPMTPKTMPRAVG CCCCCCCCCCCCCCC	48.57	24719451
529	Phosphorylation	LPPMTPKTMPRAVGS CCCCCCCCCCCCCCC	33.34	22199227
532	Phosphorylation	MTPKTMPRAVGSPLC CCCCCCCCCCCCCCC	30.96	24719451
535	Phosphorylation	KTMPRAVGSPLCVPA CCCCCCCCCCCCCCC	23.66	20068231
536	Phosphorylation	TMPRAVGSPLCVPAR CCCCCCCCCCCCCCC	14.22	22167270
539	Phosphorylation	RAVGSPLCVPARRRS CCCCCCCCCCCCCCC	3.80	24719451
545	Phosphorylation	LCVPARRRSSEPRKN CCCCCCCCCCCCCCC	38.69	24719451
548	Phosphorylation	PARRRSSEPRKNSAM CCCCCCCCCCCCCCC	50.82	20068230
555	Phosphorylation	EPRKNSAMRTEPTRE CCCCCCCCCCCCCHH	5.67	19691289
567	Phosphorylation	TRESNRKTDSRLVDV CHHHCCCCCCCCEEC	35.65	21712546
569	Phosphorylation	ESNRKTDSRLVDVSP HHCCCCCCCCEECCC	32.52	27134283
575	Phosphorylation	DSRLVDVSPDRGSPP CCCCEECCCCCCCCC	19.33	19664994
580	Phosphorylation	DVSPDRGSPPSRVPQ ECCCCCCCCCCCCCC	34.23	29255136
583	Phosphorylation	PDRGSPPSRVPQALN CCCCCCCCCCCCHHC	49.66	29255136
592	Phosphorylation	VPQALNFSPEESDST CCCHHCCCHHHCCCC	30.26	23927012
594	Phosphorylation	QALNFSPEESDSTFS CHHCCCHHHCCCCCC	69.78	19664994
596	Phosphorylation	LNFSPEESDSTFSKS HCCCHHHCCCCCCHH	34.89	30266825
598	Phosphorylation	FSPEESDSTFSKSTA CCHHHCCCCCCHHHH	40.40	30266825
599	Phosphorylation	SPEESDSTFSKSTAT CHHHCCCCCCHHHHH	36.60	30266825
601	Phosphorylation	EESDSTFSKSTATEV HHCCCCCCHHHHHHH	26.28	23927012
602	Phosphorylation	ESDSTFSKSTATEVA HCCCCCCHHHHHHHH	47.86	33259812
603	Phosphorylation	SDSTFSKSTATEVAR CCCCCCHHHHHHHHH	23.29	25627689
606	Phosphorylation	TFSKSTATEVAREEA CCCHHHHHHHHHHHC	30.95	28555341
611	Phosphorylation	TATEVAREEAKPGGD HHHHHHHHHCCCCCC	53.20	19691289
615	Phosphorylation	VAREEAKPGGDAAPS HHHHHCCCCCCCCCC	60.07	-
637	Phosphorylation	KLEPLAVTPDAASQP EEEECEECCCHHCCC	15.16	26074081
642	Phosphorylation	AVTPDAASQPLIDLP EECCCHHCCCCCCCC	33.77	26074081
656	Phosphorylation	PLIDFCDTPEAHVAV CEEECCCCCCHHEEC	24.98	25159151
675	Phosphorylation	RPLIDLMTNTPDMNK CCCCHHHCCCCCCCC	43.15	25850435
677	Phosphorylation	LIDLMTNTPDMNKNV CCHHHCCCCCCCCCC	16.11	25850435
688	Phosphorylation	NKNVAKPSPVVGQLI CCCCCCCCCCHHHHH	29.62	25159151
694	Phosphorylation	PSPVVGQLIDLSSPL CCCCHHHHHCCCCCC	2.43	-
696	Phosphorylation	PVVGQLIDLSSPLIQ CCHHHHHCCCCCCEE	49.44	20068231
698	Phosphorylation	VGQLIDLSSPLIQLS HHHHHCCCCCCEECC	26.60	29255136
699	Phosphorylation	GQLIDLSSPLIQLSP HHHHCCCCCCEECCC	30.90	29255136
705	Phosphorylation	SSPLIQLSPEADKEN CCCCEECCCCHHHCC	12.34	29255136
707	Phosphorylation	PLIQLSPEADKENVD CCEECCCCHHHCCCC	67.15	20068231
715	Phosphorylation	ADKENVDSPLLKF-- HHHCCCCCCCCCC--	17.11	29255136
717	Phosphorylation	KENVDSPLLKF---- HCCCCCCCCCC----	10.59	20068231
718	Phosphorylation	ENVDSPLLKF----- CCCCCCCCCC-----	6.39	20068231
724	Phosphorylation	LLKF----------- CCCC-----------		20068231
734	Phosphorylation	--------------------- ---------------------		19413330

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
223	S	Phosphorylation	Kinase	PLK1	P53350	PSP
435	S	Phosphorylation	Kinase	PLK1	P53350	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GTSE1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GTSE1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AP2A1_HUMAN	AP2A1	physical	26496610
AP2A2_HUMAN	AP2A2	physical	26496610
AP1B1_HUMAN	AP1B1	physical	26496610
AP2B1_HUMAN	AP2B1	physical	26496610
AP1G1_HUMAN	AP1G1	physical	26496610
CALU_HUMAN	CALU	physical	26496610
CDC42_HUMAN	CDC42	physical	26496610
AP2M1_HUMAN	AP2M1	physical	26496610
AP1S1_HUMAN	AP1S1	physical	26496610
CLCA_HUMAN	CLTA	physical	26496610
CLCB_HUMAN	CLTB	physical	26496610
CLH1_HUMAN	CLTC	physical	26496610
KC1A_HUMAN	CSNK1A1	physical	26496610
KC1E_HUMAN	CSNK1E	physical	26496610
DAB2_HUMAN	DAB2	physical	26496610
EPS15_HUMAN	EPS15	physical	26496610
GAK_HUMAN	GAK	physical	26496610
GNAI3_HUMAN	GNAI3	physical	26496610
GOGA2_HUMAN	GOLGA2	physical	26496610
HIP1_HUMAN	HIP1	physical	26496610
MPRI_HUMAN	IGF2R	physical	26496610
NBR1_HUMAN	NBR1	physical	26496610
MYO6_HUMAN	MYO6	physical	26496610
NDUA9_HUMAN	NDUFA9	physical	26496610
OCRL_HUMAN	OCRL	physical	26496610
PER1_HUMAN	PER1	physical	26496610
P3C2A_HUMAN	PIK3C2A	physical	26496610
PKP2_HUMAN	PKP2	physical	26496610
RAB1A_HUMAN	RAB1A	physical	26496610
RCN1_HUMAN	RCN1	physical	26496610
SEC13_HUMAN	SEC13	physical	26496610
RAB7A_HUMAN	RAB7A	physical	26496610
CLH2_HUMAN	CLTCL1	physical	26496610
PICAL_HUMAN	PICALM	physical	26496610
PKP4_HUMAN	PKP4	physical	26496610
USO1_HUMAN	USO1	physical	26496610
NUMB_HUMAN	NUMB	physical	26496610
TNK1_HUMAN	TNK1	physical	26496610
SYNJ1_HUMAN	SYNJ1	physical	26496610
AP1M1_HUMAN	AP1M1	physical	26496610
HERC2_HUMAN	HERC2	physical	26496610
HIP1R_HUMAN	HIP1R	physical	26496610
NUMBL_HUMAN	NUMBL	physical	26496610
SC24C_HUMAN	SEC24C	physical	26496610
MARF1_HUMAN	KIAA0430	physical	26496610
EPN4_HUMAN	CLINT1	physical	26496610
SC16A_HUMAN	SEC16A	physical	26496610
MVP_HUMAN	MVP	physical	26496610
ACK1_HUMAN	TNK2	physical	26496610
DCAF7_HUMAN	DCAF7	physical	26496610
SC24B_HUMAN	SEC24B	physical	26496610
RBM14_HUMAN	RBM14	physical	26496610
SC23A_HUMAN	SEC23A	physical	26496610
VTI1B_HUMAN	VTI1B	physical	26496610
STABP_HUMAN	STAMBP	physical	26496610
SC24A_HUMAN	SEC24A	physical	26496610
SDCG3_HUMAN	SDCCAG3	physical	26496610
RBP1_HUMAN	RALBP1	physical	26496610
PKP3_HUMAN	PKP3	physical	26496610
SYNRG_HUMAN	SYNRG	physical	26496610
AAK1_HUMAN	AAK1	physical	26496610
BTBD3_HUMAN	BTBD3	physical	26496610
EPN2_HUMAN	EPN2	physical	26496610
TNR6B_HUMAN	TNRC6B	physical	26496610
N4BP3_HUMAN	N4BP3	physical	26496610
DNMBP_HUMAN	DNMBP	physical	26496610
EDC4_HUMAN	EDC4	physical	26496610
NECP1_HUMAN	NECAP1	physical	26496610
SERA_HUMAN	PHGDH	physical	26496610
TNR6A_HUMAN	TNRC6A	physical	26496610
P2R3B_HUMAN	PPP2R3B	physical	26496610
EPN1_HUMAN	EPN1	physical	26496610
SNX9_HUMAN	SNX9	physical	26496610
LIMA1_HUMAN	LIMA1	physical	26496610
DJB11_HUMAN	DNAJB11	physical	26496610
BMP2K_HUMAN	BMP2K	physical	26496610
SCYL2_HUMAN	SCYL2	physical	26496610
ERBIN_HUMAN	ERBB2IP	physical	26496610
KDIS_HUMAN	KIDINS220	physical	26496610
STALP_HUMAN	STAMBPL1	physical	26496610
DEN1A_HUMAN	DENND1A	physical	26496610
ZN106_HUMAN	ZNF106	physical	26496610
SMAP2_HUMAN	SMAP2	physical	26496610
CRTC3_HUMAN	CRTC3	physical	26496610
WNK1_HUMAN	WNK1	physical	26496610
ACD11_HUMAN	ACAD11	physical	26496610
LZTS2_HUMAN	LZTS2	physical	26496610
MYPN_HUMAN	MYPN	physical	26496610
REPS1_HUMAN	REPS1	physical	26496610
STON2_HUMAN	STON2	physical	26496610
FCHO2_HUMAN	FCHO2	physical	26496610
SESQ2_HUMAN	FAM109B	physical	26496610
CRTC2_HUMAN	CRTC2	physical	26496610
FA83B_HUMAN	FAM83B	physical	26496610
FA83H_HUMAN	FAM83H	physical	26496610
WAC2A_HUMAN	FAM21A	physical	26496610
KAPCA_HUMAN	PRKACA	physical	26496610
GAST_HUMAN	GAST	physical	28514442
ACD11_HUMAN	ACAD11	physical	28514442
XAGE3_HUMAN	XAGE3	physical	28514442
DDB2_HUMAN	DDB2	physical	28514442
CARM1_HUMAN	CARM1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GTSE1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-592, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168; SER-326; SER-536AND SER-715, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152; SER-168; SER-477;THR-479; SER-480; SER-495; SER-501; SER-504; SER-509; THR-513;SER-516; SER-520; THR-526; SER-536; SER-575; SER-580 AND SER-592, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168 AND SER-592, ANDMASS SPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243 AND SER-303, ANDMASS SPECTROMETRY.	19007248 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168, AND MASSSPECTROMETRY.	17924679 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168; SER-494; SER-495;SER-501; SER-504; SER-536; SER-575; SER-580 AND SER-592, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-592, AND MASSSPECTROMETRY.	15302935 [Abstract]