ERBIN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERBIN_HUMAN
• UniProt AC: Q96RT1
• Protein Name: Erbin {ECO:0000303|PubMed:10878805}
• Gene Name: ERBIN {ECO:0000303|PubMed:10878805}
• Organism: Homo sapiens (Human).
• Sequence Length: 1412
• Subcellular Localization: Cell junction, hemidesmosome . Nucleus membrane. Basolateral cell membrane . Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concen
• Protein Description: Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. [PubMed: 16203728 Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion]
• Protein Sequence: MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKFKAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEIMERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHDSDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVKITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRGPTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQSYAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSVSSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNASRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKKHPQTSSSGDPCQDGIFISGQQNYSSATLSHKDVPPDSLMKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	S-palmitoylation	LFVRLVPCRCLRGEE HEEEEEECHHHCCCC		29575903
16	S-palmitoylation	VRLVPCRCLRGEEET EEEEECHHHCCCCEE		29575903
30	Phosphorylation	TVTTLDYSHCSLEQV EEEEEECCCCCHHHC		23312004
33	Phosphorylation	TLDYSHCSLEQVPKE EEECCCCCHHHCCHH		23312004
46	Ubiquitination	KEIFTFEKTLEELYL HHHCCHHHHHHHHHC		33845483
52	Phosphorylation	EKTLEELYLDANQIE HHHHHHHHCCHHHHH		20007894
63	Ubiquitination	NQIEELPKQLFNCQS HHHHHHHHHHHCCCC		29967540
70	Phosphorylation	KQLFNCQSLHKLSLP HHHHCCCCCHHCCCC		29449344
73	Ubiquitination	FNCQSLHKLSLPDND HCCCCCHHCCCCCCC		29967540
101	Ubiquitination	LRELDVSKNGIQEFP CHHCCCCCCCHHHCH		33845483
118	Phosphorylation	IKNCKVLTIVEASVN HCCCEEEEEEEEECC		26074081
123	Phosphorylation	VLTIVEASVNPISKL EEEEEEEECCCHHHC		26074081
128	Phosphorylation	EASVNPISKLPDGFS EEECCCHHHCCCHHH		26074081
162	Ubiquitination	ANFGRLTKLQILELR CCCCCCCHHHHHHHH		23000965
178	Ubiquitination	NQLKMLPKTMNRLTQ HHHHCCHHHHHHHHH		29967540
220	Phosphorylation	WMDANRLTFIPGFIG HCCHHHHCCCCCHHH		-
230	Ubiquitination	PGFIGSLKQLTYLDV CCHHHHHHHCEEEEC		-
238	Phosphorylation	QLTYLDVSKNNIEMV HCEEEECCCCCHHHH		-
369	Ubiquitination	EEMGDMQKLKVINLS HHHCCCCEEEEEECC		29967540
371	Ubiquitination	MGDMQKLKVINLSDN HCCCCEEEEEECCCC		33845483
381	Ubiquitination	NLSDNRLKNLPFSFT ECCCCCHHCCCCCHH		27667366
386	Phosphorylation	RLKNLPFSFTKLQQL CHHCCCCCHHHHHHH		24719451
399	Phosphorylation	QLTAMWLSDNQSKPL HHHHHHCCCCCCCCC		20860994
403	Phosphorylation	MWLSDNQSKPLIPLQ HHCCCCCCCCCCCCC		20860994
404	Ubiquitination	WLSDNQSKPLIPLQK HCCCCCCCCCCCCCC		-
411	Ubiquitination	KPLIPLQKETDSETQ CCCCCCCCCCCCHHH		33845483
419	Ubiquitination	ETDSETQKMVLTNYM CCCCHHHHHHHHHCC		29967540
433	Phosphorylation	MFPQQPRTEDVMFIS CCCCCCCCCCCEEEC		23663014
440	Phosphorylation	TEDVMFISDNESFNP CCCCEEECCCCCCCH		30266825
444	Phosphorylation	MFISDNESFNPSLWE EEECCCCCCCHHHHH		30266825
448	Phosphorylation	DNESFNPSLWEEQRK CCCCCCHHHHHHHHH		30266825
468	Acetylation	AFECDEDKDEREAPP EEECCCCCCCCCCCC		26051181
483	Phosphorylation	REGNLKRYPTPYPDE CCCCCCCCCCCCCHH		23927012
485	Phosphorylation	GNLKRYPTPYPDELK CCCCCCCCCCCHHHH		30266825
487	Phosphorylation	LKRYPTPYPDELKNM CCCCCCCCCHHHHHH		30266825
492	Ubiquitination	TPYPDELKNMVKTVQ CCCCHHHHHHHHHHH		22817900
492 (in isoform 1)	Ubiquitination	-		21906983
492 (in isoform 2)	Ubiquitination	-		21906983
492 (in isoform 3)	Ubiquitination	-		21906983
492 (in isoform 4)	Ubiquitination	-		21906983
492 (in isoform 5)	Ubiquitination	-		21906983
492 (in isoform 6)	Ubiquitination	-		21906983
492 (in isoform 7)	Ubiquitination	-		21906983
496	Ubiquitination	DELKNMVKTVQTIVH HHHHHHHHHHHHHHH		22817900
497	Phosphorylation	ELKNMVKTVQTIVHR HHHHHHHHHHHHHHH		21964256
500	Phosphorylation	NMVKTVQTIVHRLKD HHHHHHHHHHHHHCC		27535140
506	Sumoylation	QTIVHRLKDEETNED HHHHHHHCCCCCCCC		-
506	Sumoylation	QTIVHRLKDEETNED HHHHHHHCCCCCCCC		-
506	Ubiquitination	QTIVHRLKDEETNED HHHHHHHCCCCCCCC		33845483
519	Ubiquitination	EDSGRDLKPHEDQQD CCCCCCCCCCCCHHH		21963094
529	Ubiquitination	EDQQDINKDVGVKTS CCHHHHCCCCCCCCC		29967540
538	Phosphorylation	VGVKTSESTTTVKSK CCCCCCCCCCEECCC		-
552	Phosphorylation	KVDEREKYMIGNSVQ CCCHHHHHHCCCCEE		29978859
557	Phosphorylation	EKYMIGNSVQKISEP HHHHCCCCEEECCCC		29978859
562	Phosphorylation	GNSVQKISEPEAEIS CCCEEECCCCCCCCC		21815630
569	Phosphorylation	SEPEAEISPGSLPVT CCCCCCCCCCCCCCC		30266825
572	Phosphorylation	EAEISPGSLPVTANM CCCCCCCCCCCCCCC		30266825
576	Phosphorylation	SPGSLPVTANMKASE CCCCCCCCCCCCHHH		30266825
598	Phosphorylation	HDDVFEESEELSSDE CHHHHHHHHHCCCHH		26503892
602	Phosphorylation	FEESEELSSDEEMKM HHHHHHCCCHHHHHH		23927012
603	Phosphorylation	EESEELSSDEEMKMA HHHHHCCCHHHHHHH		23927012
619	Phosphorylation	MRPPLIETSINQPKV HCCCCEECCCCCCEE		22199227
620	Phosphorylation	RPPLIETSINQPKVV CCCCEECCCCCCEEE		25159151
630	Phosphorylation	QPKVVALSNNKKDDT CCEEEEECCCCCCCC		25159151
637	Phosphorylation	SNNKKDDTKETDSLS CCCCCCCCCCCCCCC		23663014
640	Phosphorylation	KKDDTKETDSLSDEV CCCCCCCCCCCCHHH		25849741
642	Phosphorylation	DDTKETDSLSDEVTH CCCCCCCCCCHHHHC		30266825
644	Phosphorylation	TKETDSLSDEVTHNS CCCCCCCCHHHHCCC		23663014
648	Phosphorylation	DSLSDEVTHNSNQNN CCCCHHHHCCCCCCC		23663014
651	Phosphorylation	SDEVTHNSNQNNSNC CHHHHCCCCCCCCCC		25850435
656	Phosphorylation	HNSNQNNSNCSSPSR CCCCCCCCCCCCCCC		23663014
659	Phosphorylation	NQNNSNCSSPSRMSD CCCCCCCCCCCCCCC		23663014
660	Phosphorylation	QNNSNCSSPSRMSDS CCCCCCCCCCCCCCC		23663014
662	Phosphorylation	NSNCSSPSRMSDSVS CCCCCCCCCCCCCEE		23663014
665	Phosphorylation	CSSPSRMSDSVSLNT CCCCCCCCCCEECCC		28348404
667	Phosphorylation	SPSRMSDSVSLNTDS CCCCCCCCEECCCCC		25627689
669	Phosphorylation	SRMSDSVSLNTDSSQ CCCCCCEECCCCCCC		28348404
672	Phosphorylation	SDSVSLNTDSSQDTS CCCEECCCCCCCCCC		28348404
674	Phosphorylation	SVSLNTDSSQDTSLC CEECCCCCCCCCCCC		28348404
675	Phosphorylation	VSLNTDSSQDTSLCS EECCCCCCCCCCCCC		28348404
679	Phosphorylation	TDSSQDTSLCSPVKQ CCCCCCCCCCCCCEE		26074081
682	Phosphorylation	SQDTSLCSPVKQTHI CCCCCCCCCCEEECC		26074081
687	Phosphorylation	LCSPVKQTHIDINSK CCCCCEEECCCCCHH		20068231
690	Ubiquitination	PVKQTHIDINSKIRQ CCEEECCCCCHHHHH		32015554
693	Phosphorylation	QTHIDINSKIRQEDE EECCCCCHHHHHCCC		20068231
694	Ubiquitination	THIDINSKIRQEDEN ECCCCCHHHHHCCCC		22817900
694 (in isoform 1)	Ubiquitination	-		21906983
694 (in isoform 2)	Ubiquitination	-		21906983
694 (in isoform 3)	Ubiquitination	-		21906983
694 (in isoform 4)	Ubiquitination	-		21906983
694 (in isoform 5)	Ubiquitination	-		21906983
694 (in isoform 6)	Ubiquitination	-		21906983
694 (in isoform 7)	Ubiquitination	-		21906983
704	Phosphorylation	QEDENFNSLLQNGDI HCCCCHHHHHHCCCC		25849741
714	Phosphorylation	QNGDILNSSTEEKFK HCCCCCCCCHHHHHH		30266825
715	Phosphorylation	NGDILNSSTEEKFKA CCCCCCCCHHHHHHH		30266825
715	Ubiquitination	NGDILNSSTEEKFKA CCCCCCCCHHHHHHH		29967540
716	Phosphorylation	GDILNSSTEEKFKAH CCCCCCCHHHHHHHC		30266825
719	Ubiquitination	LNSSTEEKFKAHDKK CCCCHHHHHHHCCCC		29967540
722	Ubiquitination	STEEKFKAHDKKDFN CHHHHHHHCCCCCCC		29967540
726	Ubiquitination	KFKAHDKKDFNLPEY HHHHCCCCCCCCCCC		29967540
733	Phosphorylation	KDFNLPEYDLNVEER CCCCCCCCCCCHHHH		20007894
765	Ubiquitination	HKLDHINMNLNKLIT CCCHHHCCCHHHHHC		29967540
769	Ubiquitination	HINMNLNKLITNDTF HHCCCHHHHHCCCCC		29967540
772	Phosphorylation	MNLNKLITNDTFQPE CCHHHHHCCCCCCHH		28634298
775	Phosphorylation	NKLITNDTFQPEIME HHHHCCCCCCHHHHH		28634298
781	Sulfoxidation	DTFQPEIMERSKTQD CCCCHHHHHHCCCCC		21406390
784	Phosphorylation	QPEIMERSKTQDIVL CHHHHHHCCCCCEEE		23312004
786	Phosphorylation	EIMERSKTQDIVLGT HHHHHCCCCCEEEEC		27251275
793	Phosphorylation	TQDIVLGTSFLSINS CCCEEEECCEEECCC		22199227
794	Phosphorylation	QDIVLGTSFLSINSK CCEEEECCEEECCCH		22199227
797	Phosphorylation	VLGTSFLSINSKEET EEECCEEECCCHHHH		22199227
800	Phosphorylation	TSFLSINSKEETEHL CCEEECCCHHHHHHH		22617229
812	Acetylation	EHLENGNKYPNLESV HHHHCCCCCCCHHHH		26051181
813	Phosphorylation	HLENGNKYPNLESVN HHHCCCCCCCHHHHH		-
818	Phosphorylation	NKYPNLESVNKVNGH CCCCCHHHHHCCCCC		23532336
826	Phosphorylation	VNKVNGHSEETSQSP HHCCCCCCCCCCCCC		23663014
829	Phosphorylation	VNGHSEETSQSPNRT CCCCCCCCCCCCCCC		23663014
830	Phosphorylation	NGHSEETSQSPNRTE CCCCCCCCCCCCCCC		23663014
832	Phosphorylation	HSEETSQSPNRTEPH CCCCCCCCCCCCCCC		23663014
836	Phosphorylation	TSQSPNRTEPHDSDC CCCCCCCCCCCCCCC		23663014
840	Phosphorylation	PNRTEPHDSDCSVDL CCCCCCCCCCCCEEE		33259812
841	Phosphorylation	NRTEPHDSDCSVDLG CCCCCCCCCCCEEEC		30266825
844	Phosphorylation	EPHDSDCSVDLGISK CCCCCCCCEEECCCC		30266825
850	Phosphorylation	CSVDLGISKSTEDLS CCEEECCCCCCCCCC		30278072
852	Phosphorylation	VDLGISKSTEDLSPQ EEECCCCCCCCCCCC		29255136
853	Phosphorylation	DLGISKSTEDLSPQK EECCCCCCCCCCCCC		30266825
856	Ubiquitination	ISKSTEDLSPQKSGP CCCCCCCCCCCCCCC		29967540
857	Phosphorylation	SKSTEDLSPQKSGPV CCCCCCCCCCCCCCC		29255136
860	Ubiquitination	TEDLSPQKSGPVGSV CCCCCCCCCCCCCCE		29967540
861	Phosphorylation	EDLSPQKSGPVGSVV CCCCCCCCCCCCCEE		24732914
866	Phosphorylation	QKSGPVGSVVKSHSI CCCCCCCCEEEECCC		25159151
868	Phosphorylation	SGPVGSVVKSHSITN CCCCCCEEEECCCCC		32142685
870	Phosphorylation	PVGSVVKSHSITNME CCCCEEEECCCCCCE		30266825
872	Phosphorylation	GSVVKSHSITNMEIG CCEEEECCCCCCEEC		23927012
874	Phosphorylation	VVKSHSITNMEIGGL EEEECCCCCCEECCE		30266825
884	Phosphorylation	EIGGLKIYDILSDNG EECCEEEEEHHHCCC		27273156
888	Phosphorylation	LKIYDILSDNGPQQP EEEEEHHHCCCCCCC		26356563
897	Phosphorylation	NGPQQPSTTVKITSA CCCCCCCCEEEEEEC		26267517
898	Phosphorylation	GPQQPSTTVKITSAV CCCCCCCEEEEEECC		26267517
904	Ubiquitination	TTVKITSAVDGKNIV CEEEEEECCCCCCEE		29967540
908	Ubiquitination	ITSAVDGKNIVRSKS EEECCCCCCEEEECC		29967540
913	Phosphorylation	DGKNIVRSKSATLLY CCCCEEEECCEEEEE		23401153
914	Ubiquitination	GKNIVRSKSATLLYD CCCEEEECCEEEEEC		-
915	Phosphorylation	KNIVRSKSATLLYDQ CCEEEECCEEEEECC		21945579
917	Phosphorylation	IVRSKSATLLYDQPL EEEECCEEEEECCCE		21945579
920	Phosphorylation	SKSATLLYDQPLQVF ECCEEEEECCCEEEE		21945579
928	Phosphorylation	DQPLQVFTGSSSSSD CCCEEEEECCCCHHH		21945579
930	Phosphorylation	PLQVFTGSSSSSDLI CEEEEECCCCHHHHC		21945579
931	Phosphorylation	LQVFTGSSSSSDLIS EEEEECCCCHHHHCC		21945579
932	Phosphorylation	QVFTGSSSSSDLISG EEEECCCCHHHHCCC		21945579
933	Phosphorylation	VFTGSSSSSDLISGT EEECCCCHHHHCCCC		21945579
934	Phosphorylation	FTGSSSSSDLISGTK EECCCCHHHHCCCCE		21945579
938	Phosphorylation	SSSSDLISGTKAIFK CCHHHHCCCCEEEEE		21945579
940	Phosphorylation	SSDLISGTKAIFKFD HHHHCCCCEEEEEEC		21945579
941	Ubiquitination	SDLISGTKAIFKFDS HHHCCCCEEEEEECC		29967540
945	Ubiquitination	SGTKAIFKFDSNHNP CCCEEEEEECCCCCC		29967540
948	Phosphorylation	KAIFKFDSNHNPEEP EEEEEECCCCCCCCC		21945579
962	Phosphorylation	PNIIRGPTSGPQSAP CCCCCCCCCCCCCCC		21945579
963	Phosphorylation	NIIRGPTSGPQSAPQ CCCCCCCCCCCCCCC		21945579
967	Phosphorylation	GPTSGPQSAPQIYGP CCCCCCCCCCCCCCC		21945579
972	Phosphorylation	PQSAPQIYGPPQYNI CCCCCCCCCCCCCCE		21945579
977	Phosphorylation	QIYGPPQYNIQYSSS CCCCCCCCCEEECCC		21945579
981	Phosphorylation	PPQYNIQYSSSAAVK CCCCCEEECCCHHHH		21945579
982	Phosphorylation	PQYNIQYSSSAAVKD CCCCEEECCCHHHHH		21945579
983	Phosphorylation	QYNIQYSSSAAVKDT CCCEEECCCHHHHHH		21945579
984	Phosphorylation	YNIQYSSSAAVKDTL CCEEECCCHHHHHHH		21945579
994	Phosphorylation	VKDTLWHSKQNPQID HHHHHHCCCCCCCCC		-
1013	O-linked_Glycosylation	PPQLLPRSESTENQS CCHHCCCCCCCCCHH		30379171
1013	Phosphorylation	PPQLLPRSESTENQS CCHHCCCCCCCCCHH		29396449
1015	Phosphorylation	QLLPRSESTENQSYA HHCCCCCCCCCHHHH		25262027
1016	Phosphorylation	LLPRSESTENQSYAK HCCCCCCCCCHHHHH		29396449
1019	Ubiquitination	RSESTENQSYAKHSA CCCCCCCHHHHHHHC		21963094
1020	Phosphorylation	SESTENQSYAKHSAN CCCCCCHHHHHHHCC		29396449
1021	Phosphorylation	ESTENQSYAKHSANM CCCCCHHHHHHHCCC		22817900
1023	Ubiquitination	TENQSYAKHSANMNF CCCHHHHHHHCCCCC		21963094
1040	Phosphorylation	HNNVRANTAYHLHQR CCCHHCHHHHHHHHH		-
1042	Phosphorylation	NVRANTAYHLHQRLG CHHCHHHHHHHHHHC		28796482
1060	Phosphorylation	HGEMWAISPNDRLIP CCCCEEECCCCCCCC		21712546
1070	Phosphorylation	DRLIPAVTRSTIQRQ CCCCCHHCHHHHHCC		22199227
1073	Phosphorylation	IPAVTRSTIQRQSSV CCHHCHHHHHCCCCC		-
1075	Phosphorylation	AVTRSTIQRQSSVSS HHCHHHHHCCCCCCC		32645325
1078	Phosphorylation	RSTIQRQSSVSSTAS HHHHHCCCCCCCCCE		30266825
1079	Phosphorylation	STIQRQSSVSSTASV HHHHCCCCCCCCCEE		30266825
1081	Phosphorylation	IQRQSSVSSTASVNL HHCCCCCCCCCEEEC		30266825
1082	Phosphorylation	QRQSSVSSTASVNLG HCCCCCCCCCEEECC		30266825
1083	Phosphorylation	RQSSVSSTASVNLGD CCCCCCCCCEEECCC		30266825
1085	Phosphorylation	SSVSSTASVNLGDPG CCCCCCCEEECCCCC		26055452
1093	Phosphorylation	VNLGDPGSTRRAQIP EECCCCCCCCCCCCC		21712546
1094	Phosphorylation	NLGDPGSTRRAQIPE ECCCCCCCCCCCCCC		24043423
1104	Phosphorylation	AQIPEGDYLSYREFH CCCCCCCCCCHHHHH		21945579
1106	Phosphorylation	IPEGDYLSYREFHSA CCCCCCCCHHHHHCC		21945579
1107	Phosphorylation	PEGDYLSYREFHSAG CCCCCCCHHHHHCCC		21945579
1112	Phosphorylation	LSYREFHSAGRTPPM CCHHHHHCCCCCCCC		21945579
1116	Phosphorylation	EFHSAGRTPPMMPGS HHHCCCCCCCCCCCC		27422710
1123	Phosphorylation	TPPMMPGSQRPLSAR CCCCCCCCCCCCCCC		26074081
1128	Phosphorylation	PGSQRPLSARTYSID CCCCCCCCCCEEECC		26074081
1131	Phosphorylation	QRPLSARTYSIDGPN CCCCCCCEEECCCCC		26074081
1132	Phosphorylation	RPLSARTYSIDGPNA CCCCCCEEECCCCCC		16094384
1133	Phosphorylation	PLSARTYSIDGPNAS CCCCCEEECCCCCCC		22617229
1140	Phosphorylation	SIDGPNASRPQSARP ECCCCCCCCCCCCCC		27422710
1144	Phosphorylation	PNASRPQSARPSINE CCCCCCCCCCCCHHH		27422710
1148	Phosphorylation	RPQSARPSINEIPER CCCCCCCCHHHCCCC		26074081
1156	Phosphorylation	INEIPERTMSVSDFN HHHCCCCCCCHHHCC		21945579
1158	Phosphorylation	EIPERTMSVSDFNYS HCCCCCCCHHHCCCC		21945579
1160	Phosphorylation	PERTMSVSDFNYSRT CCCCCCHHHCCCCCC		21945579
1164	Phosphorylation	MSVSDFNYSRTSPSK CCHHHCCCCCCCCCC		21945579
1165	Phosphorylation	SVSDFNYSRTSPSKR CHHHCCCCCCCCCCC		21945579
1167	Phosphorylation	SDFNYSRTSPSKRPN HHCCCCCCCCCCCCC		27251789
1168	Phosphorylation	DFNYSRTSPSKRPNA HCCCCCCCCCCCCCC		26657352
1170	Phosphorylation	NYSRTSPSKRPNARV CCCCCCCCCCCCCCC		30576142
1179	Phosphorylation	RPNARVGSEHSLLDP CCCCCCCCCCCCCCC		30266825
1182	Phosphorylation	ARVGSEHSLLDPPGK CCCCCCCCCCCCCCC		30266825
1212 (in isoform 8)	Phosphorylation	-		29978859
1215 (in isoform 8)	Phosphorylation	-		29978859
1223 (in isoform 8)	Phosphorylation	-		27251275
1224 (in isoform 8)	Phosphorylation	-		27251275
1226 (in isoform 8)	Phosphorylation	-		28348404
1227 (in isoform 8)	Phosphorylation	-		28348404
1235	Phosphorylation	FISGQQNYSSATLSH EEECCCCCCCCCCCC		22817900
1242 (in isoform 8)	Phosphorylation	-		22496350
1245	Phosphorylation	ATLSHKDVPPDSLMK CCCCCCCCCCHHHCC		24719451
1252	Phosphorylation	VPPDSLMKMPLSNGQ CCCHHHCCCCCCCCC		17389395
1253	Ubiquitination	PPDSLMKMPLSNGQM CCHHHCCCCCCCCCC		27667366
1256	Phosphorylation	SLMKMPLSNGQMGQP HHCCCCCCCCCCCCC		25599653
1257	Ubiquitination	LMKMPLSNGQMGQPL HCCCCCCCCCCCCCC		27667366
1264	Phosphorylation	NGQMGQPLRPQANYS CCCCCCCCCCCCCHH		24719451
1269	Phosphorylation	QPLRPQANYSQIHHP CCCCCCCCHHHCCCC		24719451
1269 (in isoform 6)	Phosphorylation	-		25849741
1270	Phosphorylation	PLRPQANYSQIHHPP CCCCCCCHHHCCCCC		27259358
1271	Phosphorylation	LRPQANYSQIHHPPQ CCCCCCHHHCCCCCC		16094384
1274	Ubiquitination	QANYSQIHHPPQASV CCCHHHCCCCCCHHH		29967540
1278	Ubiquitination	SQIHHPPQASVARHP HHCCCCCCHHHCCCC		29967540
1286	Phosphorylation	ASVARHPSREQLIDY HHHCCCCCHHHHHHH		26055452
1293	Phosphorylation	SREQLIDYLMLKVAH CHHHHHHHHHHHHHC		21945579
1294 (in isoform 6)	Phosphorylation	-		24532841
1304	Phosphorylation	KVAHQPPYTQPHCSP HHHCCCCCCCCCCCC		25159151
1305	Phosphorylation	VAHQPPYTQPHCSPR HHCCCCCCCCCCCCC		28796482
1310	Phosphorylation	PYTQPHCSPRQGHEL CCCCCCCCCCCCCHH		25159151
1319	Ubiquitination	RQGHELAKQEIRVRV CCCCHHHHHEEEEEE		29967540
1322	Ubiquitination	HELAKQEIRVRVEKD CHHHHHEEEEEEECC		27667366
1326	Ubiquitination	KQEIRVRVEKDPELG HHEEEEEEECCCCCC		27667366
1335	Phosphorylation	KDPELGFSISGGVGG CCCCCCCEECCCCCC		28122231
1337	Phosphorylation	PELGFSISGGVGGRG CCCCCEECCCCCCCC		28122231
1367	Ubiquitination	QPEGPASKLLQPGDK CCCCCHHHHCCCCCE		27667366
1370	Ubiquitination	GPASKLLQPGDKIIQ CCHHHHCCCCCEEEE		27667366
1374	Ubiquitination	KLLQPGDKIIQANGY HHCCCCCEEEEECCE		27667366
1381	Phosphorylation	KIIQANGYSFINIEH EEEEECCEEEEEECC		26356563
1382	Phosphorylation	IIQANGYSFINIEHG EEEECCEEEEEECCC		26356563
1393	Phosphorylation	IEHGQAVSLLKTFQN ECCCCHHHHHHHHCC		24719451
1411	Ubiquitination	LIIVREVSS------ EEEEEECCC------		27667366
1415	Ubiquitination	REVSS---------- EECCC----------		27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ERBIN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ERBIN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERBIN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ITB4_HUMAN	ITGB4	physical	11375975
DYST_HUMAN	DST	physical	11375975
KCNA4_HUMAN	KCNA4	physical	11278603
NMDE3_HUMAN	GRIN2C	physical	11278603
NMDE2_HUMAN	GRIN2B	physical	11278603
ERBB2_HUMAN	ERBB2	physical	11278603
ERBIN_HUMAN	ERBB2IP	physical	11278603
PICK1_HUMAN	PICK1	physical	11278603
ERBB2_HUMAN	ERBB2	physical	10878805
LRRC1_HUMAN	LRRC1	physical	11440998
PKP4_MOUSE	Pkp4	physical	12047349
PKP4_HUMAN	PKP4	physical	12047349
PKP4_HUMAN	PKP4	physical	11711544
RASH_HUMAN	HRAS	physical	12379659
CTND1_HUMAN	CTNND1	physical	11821434
ARVC_HUMAN	ARVCF	physical	11821434
PKP4_HUMAN	PKP4	physical	11821434
SMAD2_HUMAN	SMAD2	physical	17591701
SMAD3_HUMAN	SMAD3	physical	17591701
ACTN1_HUMAN	ACTN1	physical	15123239
ACTN2_HUMAN	ACTN2	physical	15123239
ABCA1_HUMAN	ABCA1	physical	15123239
ABR_HUMAN	ABR	physical	15123239
AGTR2_HUMAN	AGTR2	physical	15123239
APC_HUMAN	APC	physical	15123239
ARVC_HUMAN	ARVCF	physical	15123239
AT2B1_HUMAN	ATP2B1	physical	15123239
AT2B2_HUMAN	ATP2B2	physical	15123239
AT2B4_HUMAN	ATP2B4	physical	15123239
AVR2A_HUMAN	ACVR2A	physical	15123239
AVR2B_HUMAN	ACVR2B	physical	15123239
BAF_HUMAN	BANF1	physical	15123239
BCR_HUMAN	BCR	physical	15123239
CATG_HUMAN	CTSG	physical	15123239
KCNA4_HUMAN	KCNA4	physical	15123239
KCNA5_HUMAN	KCNA5	physical	15123239
SCN4A_HUMAN	SCN4A	physical	15123239
COPB_HUMAN	COPB1	physical	15123239
CRCM_HUMAN	MCC	physical	15123239
CSKP_HUMAN	CASK	physical	15123239
CTNB1_HUMAN	CTNNB1	physical	15123239
GCYA2_HUMAN	GUCY1A2	physical	15123239
EM55_HUMAN	MPP1	physical	15123239
FOXO3_HUMAN	FOXO3	physical	15123239
LAMB1_HUMAN	LAMB1	physical	15123239
MAP4_HUMAN	MAP4	physical	15123239
MEF2A_HUMAN	MEF2A	physical	15123239
MK12_HUMAN	MAPK12	physical	15123239
MPP2_HUMAN	MPP2	physical	15123239
MPP3_HUMAN	MPP3	physical	15123239
MRP4_HUMAN	ABCC4	physical	15123239
NMDE3_HUMAN	GRIN2C	physical	15123239
NR2E1_HUMAN	NR2E1	physical	15123239
S6A12_HUMAN	SLC6A12	physical	15123239
RBTN1_HUMAN	LMO1	physical	15123239
SC5A5_HUMAN	SLC5A5	physical	15123239
SC5A6_HUMAN	SLC5A6	physical	15123239
VIPR2_HUMAN	VIPR2	physical	15123239
ARHG7_HUMAN	ARHGEF7	physical	15123239
RBTN2_HUMAN	LMO2	physical	21988832
STAT3_HUMAN	STAT3	physical	21988832
CBL_HUMAN	CBL	physical	25521828
FBW1A_HUMAN	BTRC	physical	26056141

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.