AGTR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AGTR2_HUMAN
• UniProt AC: P50052
• Protein Name: Type-2 angiotensin II receptor
• Gene Name: AGTR2
• Organism: Homo sapiens (Human).
• Sequence Length: 363
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation..
• Protein Sequence: MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	N-linked_Glycosylation	----MKGNSTLATTS ----CCCCCCCCCCC	26.71	UniProtKB CARBOHYD
13	N-linked_Glycosylation	TLATTSKNITSGLHF CCCCCCCCCCCCEEE	42.40	UniProtKB CARBOHYD
24	N-linked_Glycosylation	GLHFGLVNISGNNES CEEEEEEEECCCCCC	27.96	UniProtKB CARBOHYD
29	N-linked_Glycosylation	LVNISGNNESTLNCS EEEECCCCCCCCCCC	48.39	UniProtKB CARBOHYD
34	N-linked_Glycosylation	GNNESTLNCSQKPSD CCCCCCCCCCCCCCH	24.39	UniProtKB CARBOHYD
105	Phosphorylation	PLWATYYSYRYDWLF HHHHHHHHHCHHHHH	7.85	24719451
143	Phosphorylation	TCMSVDRYQSVIYPF HHCCCCHHHHHHHHH	10.73	27732954
145	Phosphorylation	MSVDRYQSVIYPFLS CCCCHHHHHHHHHHH	11.10	27732954
148	Phosphorylation	DRYQSVIYPFLSQRR CHHHHHHHHHHHCCC	5.93	27732954
152	Phosphorylation	SVIYPFLSQRRNPWQ HHHHHHHHCCCCCCC	23.24	27732954
203	Acetylation	IMAFPPEKYAQWSAG EECCCHHHHHHHHHH	52.22	7363905
331	Phosphorylation	RFQQKLRSVFRVPIT HHHHHHHHHHCCCCH	35.72	-
346	Phosphorylation	WLQGKRESMSCRKSS HHCCCHHHHCCCCCH	21.74	30576142
354	Phosphorylation	MSCRKSSSLREMETF HCCCCCHHHHHHHHH	38.24	30576142
360	Phosphorylation	SSLREMETFVS---- HHHHHHHHHCC----	28.20	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AGTR2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AGTR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AGTR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTUS1_HUMAN	MTUS1	physical	15123706
ATRAP_HUMAN	AGTRAP	physical	11733189
TIMP3_HUMAN	TIMP3	physical	18344519

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.