dbPTM

MTUS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MTUS1_HUMAN
UniProt AC	Q9ULD2
Protein Name	Microtubule-associated tumor suppressor 1
Gene Name	MTUS1
Organism	Homo sapiens (Human).
Sequence Length	1270
Subcellular Localization	Mitochondrion . Golgi apparatus. Cell membrane. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin-II.. Isoform 1: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.
Protein Description	Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth..
Protein Sequence	MTDDNSDDKIEDELQTFFTSDKDGNTHAYNPKSPPTQNSSASSVNWNSANPDDMVVDYETDPAVVTGENISLSLQGVEVFGHEKSSSDFISKQVLDMHKDSICQCPALVGTEKPKYLQHSCHSLEAVEGQSVEPSLPFVWKPNDNLNCAGYCDALELNQTFDMTVDKVNCTFISHHAIGKSQSFHTAGSLPPTGRRSGSTSSLSYSTWTSSHSDKTHARETTYDRESFENPQVTPSEAQDMTYTAFSDVVMQSEVFVSDIGNQCACSSGKVTSEYTDGSQQRLVGEKETQALTPVSDGMEVPNDSALQEFFCLSHDESNSEPHSQSSYRHKEMGQNLRETVSYCLIDDECPLMVPAFDKSEAQVLNPEHKVTETEDTQMVSKGKDLGTQNHTSELILSSPPGQKVGSSFGLTWDANDMVISTDKTMCMSTPVLEPTKVTFSVSPIEATEKCKKVEKGNRGLKNIPDSKEAPVNLCKPSLGKSTIKTNTPIGCKVRKTEIISYPRPNFKNVKAKVMSRAVLQPKDAALSKVTPRPQQTSASSPSSVNSRQQTVLSRTPRSDLNADKKAEILINKTHKQQFNKLITSQAVHVTTHSKNASHRVPRTTSAVKSNQEDVDKASSSNSACETGSVSALFQKIKGILPVKMESAECLEMTYVPNIDRISPEKKGEKENGTSMEKQELKQEIMNETFEYGSLFLGSASKTTTTSGRNISKPDSCGLRQIAAPKAKVGPPVSCLRRNSDNRNPSADRAVSPQRIRRVSSSGKPTSLKTAQSSWVNLPRPLPKSKASLKSPALRRTGSTPSIASTHSELSTYSNNSGNAAVIKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLMKTPPKGPSRKNLFTALNAVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQSPRNSGSFPSPSISPR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTDDNSDDK ------CCCCCCCHH	64.46	27732954
4 (in isoform 3)	Phosphorylation	-	65.06	-
6	Phosphorylation	--MTDDNSDDKIEDE --CCCCCCCHHHHHH	54.93	20873877
8 (in isoform 3)	Phosphorylation	-	54.36	-
11 (in isoform 3)	Phosphorylation	-	51.69	-
13 (in isoform 6)	Phosphorylation	-	29.95	-
16	Phosphorylation	KIEDELQTFFTSDKD HHHHHHHHHEECCCC	33.08	20873877
24 (in isoform 6)	Phosphorylation	-	46.83	-
40	Phosphorylation	SPPTQNSSASSVNWN CCCCCCCCCCCCCCC	39.45	30576142
46	Ubiquitination	SSASSVNWNSANPDD CCCCCCCCCCCCCCC	9.67	33845483
54	Ubiquitination	NSANPDDMVVDYETD CCCCCCCEEEEEECC	4.05	33845483
56	Ubiquitination	ANPDDMVVDYETDPA CCCCCEEEEEECCCE	5.35	33845483
60	Phosphorylation	DMVVDYETDPAVVTG CEEEEEECCCEEEEC	40.84	30576142
67	Ubiquitination	TDPAVVTGENISLSL CCCEEEECCCEEEEE	17.84	33845483
75	Ubiquitination	ENISLSLQGVEVFGH CCEEEEEECEEEECC	50.97	33845483
77	Ubiquitination	ISLSLQGVEVFGHEK EEEEEECEEEECCCC	3.51	33845483
85	Phosphorylation	EVFGHEKSSSDFISK EEECCCCCHHHHHHH	31.90	27251275
87	Phosphorylation	FGHEKSSSDFISKQV ECCCCCHHHHHHHHH	43.56	30576142
100	Ubiquitination	QVLDMHKDSICQCPA HHHHHCCCCCCCCCC	28.67	29967540
121	Ubiquitination	PKYLQHSCHSLEAVE CCHHHHHCCCCEECC	2.07	29967540
123	Phosphorylation	YLQHSCHSLEAVEGQ HHHHHCCCCEECCCC	32.03	24275569
148	Ubiquitination	KPNDNLNCAGYCDAL CCCCCCCCCCCCCHH	3.33	33845483
154	Ubiquitination	NCAGYCDALELNQTF CCCCCCCHHHCCCEE	10.20	29967540
156	Ubiquitination	AGYCDALELNQTFDM CCCCCHHHCCCEECE	47.60	33845483
158	Ubiquitination	YCDALELNQTFDMTV CCCHHHCCCEECEEE	29.48	33845483
163	Ubiquitination	ELNQTFDMTVDKVNC HCCCEECEEECEECE	3.25	29967540
171	Phosphorylation	TVDKVNCTFISHHAI EECEECEEEEECCCC	20.85	25159151
174	Phosphorylation	KVNCTFISHHAIGKS EECEEEEECCCCCCC	12.67	23312004
180	Methylation	ISHHAIGKSQSFHTA EECCCCCCCCCCCCC	38.93	115973387
181	Phosphorylation	SHHAIGKSQSFHTAG ECCCCCCCCCCCCCC	26.33	24275569
183	Phosphorylation	HAIGKSQSFHTAGSL CCCCCCCCCCCCCCC	26.53	30206219
186	Phosphorylation	GKSQSFHTAGSLPPT CCCCCCCCCCCCCCC	30.61	30206219
189	Phosphorylation	QSFHTAGSLPPTGRR CCCCCCCCCCCCCCC	34.93	27732954
197	Phosphorylation	LPPTGRRSGSTSSLS CCCCCCCCCCCCCEE	35.42	21955146
199	Phosphorylation	PTGRRSGSTSSLSYS CCCCCCCCCCCEEEE	26.77	25159151
200	Phosphorylation	TGRRSGSTSSLSYST CCCCCCCCCCEEEEE	26.34	28152594
201	Phosphorylation	GRRSGSTSSLSYSTW CCCCCCCCCEEEEEC	30.86	28152594
202	Phosphorylation	RRSGSTSSLSYSTWT CCCCCCCCEEEEECC	22.79	28152594
202	Ubiquitination	RRSGSTSSLSYSTWT CCCCCCCCEEEEECC	22.79	29967540
204	Phosphorylation	SGSTSSLSYSTWTSS CCCCCCEEEEECCCC	20.98	28152594
205	Phosphorylation	GSTSSLSYSTWTSSH CCCCCEEEEECCCCC	18.53	27251275
206	Phosphorylation	STSSLSYSTWTSSHS CCCCEEEEECCCCCC	17.69	27251275
207	Phosphorylation	TSSLSYSTWTSSHSD CCCEEEEECCCCCCC	25.24	27251275
209	Phosphorylation	SLSYSTWTSSHSDKT CEEEEECCCCCCCCC	22.05	23186163
227	Ubiquitination	ETTYDRESFENPQVT CCCCCHHHCCCCCCC	38.46	29967540
236	Ubiquitination	ENPQVTPSEAQDMTY CCCCCCHHHHCCCCE	35.88	29967540
248	Ubiquitination	MTYTAFSDVVMQSEV CCEECCHHHHCCCEE	30.49	29967540
249	Ubiquitination	TYTAFSDVVMQSEVF CEECCHHHHCCCEEE	3.60	33845483
257	Ubiquitination	VMQSEVFVSDIGNQC HCCCEEEEEECCCCE	6.41	29967540
261	Ubiquitination	EVFVSDIGNQCACSS EEEEEECCCCEEECC	24.13	24816145
276	Phosphorylation	GKVTSEYTDGSQQRL CCEEEEECCCCCEEE	29.81	27732954
279	Phosphorylation	TSEYTDGSQQRLVGE EEEECCCCCEEEECC	26.42	25159151
322	Ubiquitination	HDESNSEPHSQSSYR CCCCCCCCCCCHHHH	32.05	33845483
329	Ubiquitination	PHSQSSYRHKEMGQN CCCCHHHHHHHHHCH	36.03	29967540
334	Ubiquitination	SYRHKEMGQNLRETV HHHHHHHHCHHHHHH	17.83	24816145
338	Ubiquitination	KEMGQNLRETVSYCL HHHHCHHHHHHHEEE	45.12	29967540
340	Phosphorylation	MGQNLRETVSYCLID HHCHHHHHHHEEEEC	14.33	28348404
342	Phosphorylation	QNLRETVSYCLIDDE CHHHHHHHEEEECCC	19.97	28348404
343	Ubiquitination	NLRETVSYCLIDDEC HHHHHHHEEEECCCC	6.22	33845483
355	Ubiquitination	DECPLMVPAFDKSEA CCCCCEEECCCHHHC	17.16	24816145
360	Phosphorylation	MVPAFDKSEAQVLNP EEECCCHHHCHHCCC	39.75	25159151
372	Phosphorylation	LNPEHKVTETEDTQM CCCCCCCCCCCCCCC	41.83	26074081
374	Phosphorylation	PEHKVTETEDTQMVS CCCCCCCCCCCCCHH	29.78	26074081
377	Phosphorylation	KVTETEDTQMVSKGK CCCCCCCCCCHHCCC	16.60	26074081
379	Sulfoxidation	TETEDTQMVSKGKDL CCCCCCCCHHCCCCC	3.89	21406390
381	Phosphorylation	TEDTQMVSKGKDLGT CCCCCCHHCCCCCCC	30.28	23403867
392	Phosphorylation	DLGTQNHTSELILSS CCCCCCCCEEEEECC	31.29	30266825
393	Phosphorylation	LGTQNHTSELILSSP CCCCCCCEEEEECCC	23.90	30266825
398	Phosphorylation	HTSELILSSPPGQKV CCEEEEECCCCCCCC	33.53	30266825
399	Phosphorylation	TSELILSSPPGQKVG CEEEEECCCCCCCCC	31.50	30266825
408	Phosphorylation	PGQKVGSSFGLTWDA CCCCCCCCCCCEECC	19.87	-
412	Phosphorylation	VGSSFGLTWDANDMV CCCCCCCEECCCCCE	22.98	-
424	Ubiquitination	DMVISTDKTMCMSTP CCEEECCCCEECCCC	37.94	33845483
429	Phosphorylation	TDKTMCMSTPVLEPT CCCCEECCCCCCCCC	25.32	28348404
430	Phosphorylation	DKTMCMSTPVLEPTK CCCEECCCCCCCCCE	7.19	25159151
436	Ubiquitination	STPVLEPTKVTFSVS CCCCCCCCEEEEEEC	28.86	24816145
441	Phosphorylation	EPTKVTFSVSPIEAT CCCEEEEEECCCHHH	16.60	30266825
443	Phosphorylation	TKVTFSVSPIEATEK CEEEEEECCCHHHHH	20.97	30266825
448	Phosphorylation	SVSPIEATEKCKKVE EECCCHHHHHHCCHH	24.16	30266825
450	Ubiquitination	SPIEATEKCKKVEKG CCCHHHHHHCCHHCC	47.18	33845483
462	Ubiquitination	EKGNRGLKNIPDSKE HCCCCCCCCCCCCCC	56.51	29967540
476	Ubiquitination	EAPVNLCKPSLGKST CCCCCCCCCCCCCCC	40.59	33845483
478	Phosphorylation	PVNLCKPSLGKSTIK CCCCCCCCCCCCCCC	34.94	20068231
482	Phosphorylation	CKPSLGKSTIKTNTP CCCCCCCCCCCCCCC	33.30	20068231
483	Phosphorylation	KPSLGKSTIKTNTPI CCCCCCCCCCCCCCC	29.94	20068231
486	Phosphorylation	LGKSTIKTNTPIGCK CCCCCCCCCCCCCCE	40.24	23312004
488	Phosphorylation	KSTIKTNTPIGCKVR CCCCCCCCCCCCEEE	22.86	23312004
502	Phosphorylation	RKTEIISYPRPNFKN EECEEEEECCCCCCC	7.89	28555341
528	Phosphorylation	QPKDAALSKVTPRPQ CCCHHHHCCCCCCCC	21.98	19413330
529	Ubiquitination	PKDAALSKVTPRPQQ CCHHHHCCCCCCCCC	51.48	33845483
531	Phosphorylation	DAALSKVTPRPQQTS HHHHCCCCCCCCCCC	19.81	29396449
537	Phosphorylation	VTPRPQQTSASSPSS CCCCCCCCCCCCCCC	22.48	29396449
538	Phosphorylation	TPRPQQTSASSPSSV CCCCCCCCCCCCCCC	23.09	25159151
540	Phosphorylation	RPQQTSASSPSSVNS CCCCCCCCCCCCCCH	42.42	30576142
541	Phosphorylation	PQQTSASSPSSVNSR CCCCCCCCCCCCCHH	28.63	25159151
543	Phosphorylation	QTSASSPSSVNSRQQ CCCCCCCCCCCHHHH	49.19	29396449
544	Phosphorylation	TSASSPSSVNSRQQT CCCCCCCCCCHHHHH	28.80	25159151
547	Phosphorylation	SSPSSVNSRQQTVLS CCCCCCCHHHHHHHC	29.34	27251275
551	Phosphorylation	SVNSRQQTVLSRTPR CCCHHHHHHHCCCCC	18.31	25627689
554	Phosphorylation	SRQQTVLSRTPRSDL HHHHHHHCCCCCHHC	29.76	25627689
556	Phosphorylation	QQTVLSRTPRSDLNA HHHHHCCCCCHHCCC	21.48	25159151
566	Ubiquitination	SDLNADKKAEILINK HHCCCCHHHHHHCCC	52.37	33845483
584	Phosphorylation	QQFNKLITSQAVHVT HHHHHHHHCCEEEEE	25.81	-
585	Phosphorylation	QFNKLITSQAVHVTT HHHHHHHCCEEEEEE	14.78	28555341
591	Phosphorylation	TSQAVHVTTHSKNAS HCCEEEEEECCCCCC	12.15	28555341
609	Ubiquitination	PRTTSAVKSNQEDVD CCCCHHHHCCHHHHH	43.32	33845483
619	Phosphorylation	QEDVDKASSSNSACE HHHHHHHHCCCCHHH	39.79	28985074
623	Phosphorylation	DKASSSNSACETGSV HHHHCCCCHHHHCCH	35.92	27050516
629	Phosphorylation	NSACETGSVSALFQK CCHHHHCCHHHHHHH	21.96	27251275
638	Ubiquitination	SALFQKIKGILPVKM HHHHHHHHCCCCCCC	47.11	33845483
647	Phosphorylation	ILPVKMESAECLEMT CCCCCCCCHHHEEEE	26.35	27251275
654	Phosphorylation	SAECLEMTYVPNIDR CHHHEEEEECCCCCC	16.40	30266825
655	Phosphorylation	AECLEMTYVPNIDRI HHHEEEEECCCCCCC	16.76	30266825
663	Phosphorylation	VPNIDRISPEKKGEK CCCCCCCCCCCCCCC	28.09	30266825
674	Phosphorylation	KGEKENGTSMEKQEL CCCCCCCCCCCHHHH	36.16	28985074
694	Phosphorylation	NETFEYGSLFLGSAS HHHHHCCCEECCCCC	18.29	-
703	Phosphorylation	FLGSASKTTTTSGRN ECCCCCCCCCCCCCC	27.21	29759185
704	Phosphorylation	LGSASKTTTTSGRNI CCCCCCCCCCCCCCC	31.64	29759185
705	Phosphorylation	GSASKTTTTSGRNIS CCCCCCCCCCCCCCC	24.97	29759185
706	Phosphorylation	SASKTTTTSGRNISK CCCCCCCCCCCCCCC	27.39	29759185
707	Phosphorylation	ASKTTTTSGRNISKP CCCCCCCCCCCCCCC	33.39	-
712	Phosphorylation	TTSGRNISKPDSCGL CCCCCCCCCCCCCCC	41.50	-
713	Ubiquitination	TSGRNISKPDSCGLR CCCCCCCCCCCCCCC	49.39	33845483
716	Phosphorylation	RNISKPDSCGLRQIA CCCCCCCCCCCCHHC	20.72	25159151
734	Phosphorylation	AKVGPPVSCLRRNSD CCCCCCHHHHCCCCC	17.13	28555341
740	Phosphorylation	VSCLRRNSDNRNPSA HHHHCCCCCCCCCCC	34.16	33259812
746	Phosphorylation	NSDNRNPSADRAVSP CCCCCCCCCCCCCCH	46.48	27282143
752	Phosphorylation	PSADRAVSPQRIRRV CCCCCCCCHHHHHHC	17.84	27273156
760	Phosphorylation	PQRIRRVSSSGKPTS HHHHHHCCCCCCCCC	19.58	27273156
760 (in isoform 2)	Phosphorylation	-	19.58	21955146
761	Phosphorylation	QRIRRVSSSGKPTSL HHHHHCCCCCCCCCC	40.01	27273156
761 (in isoform 2)	Phosphorylation	-	40.01	25849741
762	Phosphorylation	RIRRVSSSGKPTSLK HHHHCCCCCCCCCCC	43.24	28555341
762 (in isoform 2)	Phosphorylation	-	43.24	27732954
766	Phosphorylation	VSSSGKPTSLKTAQS CCCCCCCCCCCCCHH	50.61	23312004
767	Phosphorylation	SSSGKPTSLKTAQSS CCCCCCCCCCCCHHH	36.07	23312004
773	Phosphorylation	TSLKTAQSSWVNLPR CCCCCCHHHCCCCCC	24.57	27251275
774	Phosphorylation	SLKTAQSSWVNLPRP CCCCCHHHCCCCCCC	23.98	27251275
786	Methylation	PRPLPKSKASLKSPA CCCCCCCHHHCCCHH	48.39	115973391
788	Phosphorylation	PLPKSKASLKSPALR CCCCCHHHCCCHHHH	39.81	23312004
790	Methylation	PKSKASLKSPALRRT CCCHHHCCCHHHHHC	52.47	115973395
791	Phosphorylation	KSKASLKSPALRRTG CCHHHCCCHHHHHCC	22.24	28188228
797	Phosphorylation	KSPALRRTGSTPSIA CCHHHHHCCCCCCHH	29.11	24275569
799	Phosphorylation	PALRRTGSTPSIAST HHHHHCCCCCCHHHC	36.21	25849741
800	Phosphorylation	ALRRTGSTPSIASTH HHHHCCCCCCHHHCH	23.54	24275569
802	Phosphorylation	RRTGSTPSIASTHSE HHCCCCCCHHHCHHH	30.76	28857561
805	Phosphorylation	GSTPSIASTHSELST CCCCCHHHCHHHHHC	25.61	27732954
806	Phosphorylation	STPSIASTHSELSTY CCCCHHHCHHHHHCC	22.02	27732954
808	Phosphorylation	PSIASTHSELSTYSN CCHHHCHHHHHCCCC	40.08	30206219
811	Phosphorylation	ASTHSELSTYSNNSG HHCHHHHHCCCCCCC	22.65	30206219
812	Phosphorylation	STHSELSTYSNNSGN HCHHHHHCCCCCCCC	43.52	30206219
813	Phosphorylation	THSELSTYSNNSGNA CHHHHHCCCCCCCCE	13.16	23312004
814	Phosphorylation	HSELSTYSNNSGNAA HHHHHCCCCCCCCEE	29.62	23312004
817	Phosphorylation	LSTYSNNSGNAAVIK HHCCCCCCCCEEEEE	37.36	23312004
825	Phosphorylation	GNAAVIKYEEKPPKP CCEEEEEEECCCCCC	20.42	20860994
847	Ubiquitination	GSFYLKPLVSRAHVH CCEECHHCEECEEEE	5.37	33845483
855	Ubiquitination	VSRAHVHLMKTPPKG EECEEEEEECCCCCC	3.51	33845483
857	Ubiquitination	RAHVHLMKTPPKGPS CEEEEEECCCCCCCC	65.33	33845483
858	Phosphorylation	AHVHLMKTPPKGPSR EEEEEECCCCCCCCH	30.75	28152594
864	Phosphorylation	KTPPKGPSRKNLFTA CCCCCCCCHHHHHHH	65.63	28152594
878	Phosphorylation	ALNAVEKSRQKNPRS HHHHHHHHHCCCCCC	26.83	21712546
901	Ubiquitination	PDALPPEKTLELTQY CCCCCCHHHEEEEEE	65.27	33845483
906	Phosphorylation	PEKTLELTQYKTKCE CHHHEEEEEECCCCC	22.07	28555341
909	Ubiquitination	TLELTQYKTKCENQS HEEEEEECCCCCCCC	31.52	33845483
911	Ubiquitination	ELTQYKTKCENQSGF EEEEECCCCCCCCCC	35.09	33845483
916	Phosphorylation	KTKCENQSGFILQLK CCCCCCCCCCHHHHH	47.45	24719451
931	Phosphorylation	QLLACGNTKFEALTV HHHHCCCCHHHHHHH	23.53	29083192
955	Ubiquitination	EEALKQHKTLSQELV HHHHHHCCCHHHHHH	48.98	29967540
958	Phosphorylation	LKQHKTLSQELVNLR HHHCCCHHHHHHHHH	27.17	25849741
989	Phosphorylation	RNELQTVYEAFVQQH HHHHHHHHHHHHHHH	12.62	27642862
1028	Ubiquitination	TYIEEAEKYKMQLQE HHHHHHHHHHHHHHH	58.16	29967540
1037	Ubiquitination	KMQLQEQFDNLNAAH HHHHHHHHHCCHHHH	7.09	29967540
1047	Phosphorylation	LNAAHETSKLEIEAS CHHHHHHCCCEEECC	32.05	28555341
1054	Phosphorylation	SKLEIEASHSEKLEL CCCEEECCHHHHHHH	18.11	25690035
1081	Acetylation	KKGHEIEKKSLEDLL HCCCCCCCCCHHHHH	54.01	7959879
1082	Ubiquitination	KGHEIEKKSLEDLLS CCCCCCCCCHHHHHH	47.70	29967540
1083	Phosphorylation	GHEIEKKSLEDLLSE CCCCCCCCHHHHHHH	48.32	27499020
1089	Phosphorylation	KSLEDLLSEKQESLE CCHHHHHHHHHHHHH	50.47	24719451
1091	Acetylation	LEDLLSEKQESLEKQ HHHHHHHHHHHHHHH	56.86	7959889
1091	Ubiquitination	LEDLLSEKQESLEKQ HHHHHHHHHHHHHHH	56.86	29967540
1123	Ubiquitination	EEQKRRAREKANLKN HHHHHHHHHHHCCCC	44.10	33845483
1135	Ubiquitination	LKNPQIMYLEQELES CCCHHHHHHHHHHHH	14.55	24816145
1177	Acetylation	NNTALVDKLKRFQQE CCHHHHHHHHHHHHH	48.72	23236377
1177	Ubiquitination	NNTALVDKLKRFQQE CCHHHHHHHHHHHHH	48.72	33845483
1189	Ubiquitination	QQENEELKARMDKHM HHHCHHHHHHHHHHH	36.91	24816145
1199	Phosphorylation	MDKHMAISRQLSTEQ HHHHHHHHHHCHHHH	12.39	-
1203	Phosphorylation	MAISRQLSTEQAVLQ HHHHHHCHHHHHHHH	22.89	30266825
1204	Phosphorylation	AISRQLSTEQAVLQE HHHHHCHHHHHHHHH	40.48	27273156
1212	Phosphorylation	EQAVLQESLEKESKV HHHHHHHHHHHHHHH	28.94	29507054
1224	Phosphorylation	SKVNKRLSMENEELL HHHHHHHHCCCHHHH	28.25	30266825
1241	Phosphorylation	LHNGDLCSPKRSPTS HHCCCCCCCCCCCCC	40.53	25159151
1245	Phosphorylation	DLCSPKRSPTSSAIP CCCCCCCCCCCCCCC	38.36	30266825
1247	Phosphorylation	CSPKRSPTSSAIPLQ CCCCCCCCCCCCCCC	36.24	30266825
1248	Phosphorylation	SPKRSPTSSAIPLQS CCCCCCCCCCCCCCC	22.58	22167270
1249	Phosphorylation	PKRSPTSSAIPLQSP CCCCCCCCCCCCCCC	32.47	30206219
1255	Phosphorylation	SSAIPLQSPRNSGSF CCCCCCCCCCCCCCC	33.25	30266825
1259	Phosphorylation	PLQSPRNSGSFPSPS CCCCCCCCCCCCCCC	36.77	22167270
1261	Phosphorylation	QSPRNSGSFPSPSIS CCCCCCCCCCCCCCC	33.53	22167270
1264	Phosphorylation	RNSGSFPSPSISPR- CCCCCCCCCCCCCC-	29.30	29255136
1266	Phosphorylation	SGSFPSPSISPR--- CCCCCCCCCCCC---	39.78	29255136
1268	Phosphorylation	SFPSPSISPR----- CCCCCCCCCC-----	20.96	29255136

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MTUS1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MTUS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MTUS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTN6_RAT	Ptpn6	physical	17068200
ORC4_HUMAN	ORC4	physical	21988832
CLU_HUMAN	CLUH	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
114550	Hepatocellular carcinoma (HCC)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MTUS1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1264 AND SER-1268, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1268, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-443, AND MASSSPECTROMETRY.	16565220 [Abstract]
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