ORC4_HUMAN - dbPTM
ORC4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ORC4_HUMAN
UniProt AC O43929
Protein Name Origin recognition complex subunit 4
Gene Name ORC4
Organism Homo sapiens (Human).
Sequence Length 436
Subcellular Localization Nucleus.
Protein Description Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3..
Protein Sequence MSSRKSKSNSLIHTECLSQVQRILRERFCRQSPHSNLFGVQVQYKHLSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALKKGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRFSHRQIHLMNSFGFPQYVKIFKEQLSLPAEFPDKVFAEKWNENVQYLSEDRSVQEVLQKHFNISKNLRSLHMLLMLALNRVTASHPFMTAVDLMEASQLCSMDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFVQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMERTSGNSQREYQLMKLLLDNTQIMNALQKYPNCPTDVRQWATSSLSWL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MSSRKSKSNSLIH
--CCCCCCCCCCCHH		39.9629496963
7Methylation-MSSRKSKSNSLIHT
-CCCCCCCCCCCHHH		57.6124129315
8PhosphorylationMSSRKSKSNSLIHTE
CCCCCCCCCCCHHHH		38.4520068231
10PhosphorylationSRKSKSNSLIHTECL
CCCCCCCCCHHHHHH		35.4720068231
14PhosphorylationKSNSLIHTECLSQVQ
CCCCCHHHHHHHHHH		22.7720068231
18PhosphorylationLIHTECLSQVQRILR
CHHHHHHHHHHHHHH		39.7120068231
32PhosphorylationRERFCRQSPHSNLFG
HHHHHHCCCCCCCCC		12.7720068231
35PhosphorylationFCRQSPHSNLFGVQV
HHHCCCCCCCCCHHH		38.3220068231
48PhosphorylationQVQYKHLSELLKRTA
HHHHHHHHHHHHHHH		26.39-
52UbiquitinationKHLSELLKRTALHGE
HHHHHHHHHHHHCCC		61.40-
54PhosphorylationLSELLKRTALHGESN
HHHHHHHHHHCCCCC		31.80-
112UbiquitinationINDKIALKEITRQLN
CCHHHHHHHHHHHCC		37.74-
204UbiquitinationDILELLEKRVKSRFS
HHHHHHHHHHHHCCC		63.5621890473
204UbiquitinationDILELLEKRVKSRFS
HHHHHHHHHHHHCCC		63.5621890473
204UbiquitinationDILELLEKRVKSRFS
HHHHHHHHHHHHCCC		63.5621906983
231AcetylationPQYVKIFKEQLSLPA
HHHHHHHHHHHCCCC		48.2826051181
231UbiquitinationPQYVKIFKEQLSLPA
HHHHHHHHHHHCCCC		48.2821906983
235PhosphorylationKIFKEQLSLPAEFPD
HHHHHHHCCCCCCCC		31.81-
243UbiquitinationLPAEFPDKVFAEKWN
CCCCCCCHHHHHHHH		39.2221890473
243UbiquitinationLPAEFPDKVFAEKWN
CCCCCCCHHHHHHHH		39.2221890473
243UbiquitinationLPAEFPDKVFAEKWN
CCCCCCCHHHHHHHH		39.2221890473
248UbiquitinationPDKVFAEKWNENVQY
CCHHHHHHHHHHCHH		52.4721906983
260MethylationVQYLSEDRSVQEVLQ
CHHHCCCCCHHHHHH		34.38115486041
268UbiquitinationSVQEVLQKHFNISKN
CHHHHHHHHCCCCHH		46.10-
274UbiquitinationQKHFNISKNLRSLHM
HHHCCCCHHHHHHHH		57.09-
278PhosphorylationNISKNLRSLHMLLML
CCCHHHHHHHHHHHH		26.2820068231
360UbiquitinationFQKFVQRKAHSVYNF
HHHHHHHHCHHCCCC		33.10-
369UbiquitinationHSVYNFEKPVVMKAF
HHCCCCCCHHHHHHH		38.69-
386UbiquitinationLQQLELIKPMERTSG
HHHHHHHCCCCCCCC		51.4321906983
399PhosphorylationSGNSQREYQLMKLLL
CCCCHHHHHHHHHHH		14.7729496907
417AcetylationQIMNALQKYPNCPTD
HHHHHHHHCCCCCCC		64.6226051181
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ORC4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ORC4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ORC4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MCM2_HUMANMCM2physical
12614612
ORC1_HUMANORC1physical
12614612
ORC2_HUMANORC2physical
12614612
ORC5_HUMANORC5physical
12614612
ORC6_HUMANORC6physical
12614612
MCM3_HUMANMCM3physical
12614612
MCM4_HUMANMCM4physical
12614612
MCM6_HUMANMCM6physical
12614612
ORC5_HUMANORC5physical
11395502
ORC2_HUMANORC2physical
9353276
ORC3_HUMANORC3physical
10402192
CCL2_HUMANCCL2physical
21383955
XRCC5_HUMANXRCC5physical
15910003
XRCC6_HUMANXRCC6physical
15910003
ORC3_HUMANORC3physical
15910003
ORC2_HUMANORC2physical
15910003
ORC6_HUMANORC6physical
15910003
A4_HUMANAPPphysical
21832049
ORC6_HUMANORC6physical
15232106
MCM10_HUMANMCM10physical
15232106
ORC5_HUMANORC5physical
15232106
ORC2_HUMANORC2physical
15232106
ITF2_HUMANTCF4physical
25416956
RIR2B_HUMANRRM2Bphysical
25416956
LACC1_HUMANLACC1physical
26186194
LACC1_HUMANLACC1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613800Meier-Gorlin syndrome 2 (MGORS2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ORC4_HUMAN

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Related Literatures of Post-Translational Modification

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