dbPTM

XRCC5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	XRCC5_HUMAN
UniProt AC	P13010
Protein Name	X-ray repair cross-complementing protein 5
Gene Name	XRCC5
Organism	Homo sapiens (Human).
Sequence Length	732
Subcellular Localization	Nucleus . Nucleus, nucleolus . Chromosome .
Protein Description	Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. [PubMed: 12145306]
Protein Sequence	MVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNYECLVYVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIKTLFPLIEAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNPAENFRVLVKQKKASFEEASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLKALQEKVEIKQLNHFWEIVVQDGITLITKEEASGSSVTAEEAKKFLAPKDKPSGDTAAVFEEGGDVDDLLDMI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Methylation	-MVRSGNKAAVVLCM -CCCCCCCEEEEEEE	41.05	23748837
35	Ubiquitination	ESPFEQAKKVITMFV CCHHHHHHHHHHHHH	47.47	23000965
36	Ubiquitination	SPFEQAKKVITMFVQ CHHHHHHHHHHHHHH	41.72	23000965
39	Phosphorylation	EQAKKVITMFVQRQV HHHHHHHHHHHHHHH	13.93	20068231
40	Sulfoxidation	QAKKVITMFVQRQVF HHHHHHHHHHHHHHH	1.81	21406390
51	Sumoylation	RQVFAENKDEIALVL HHHHHCCCCEEEEEE	48.52	-
84	Sulfoxidation	ITVHRHLMLPDFDLL EEEEEECCCCCCCHH	4.11	28183972
102	Phosphorylation	ESKIQPGSQQADFLD HHHCCCCCHHHHHHH	26.29	25159151
125	Ubiquitination	IQHETIGKKFEKRHI HCCHHCCHHHHHHHH	50.90	21906983
126	Ubiquitination	QHETIGKKFEKRHIE CCHHCCHHHHHHHHH	54.25	22817900
129	Ubiquitination	TIGKKFEKRHIEIFT HCCHHHHHHHHHHHH	53.03	22817900
136	Phosphorylation	KRHIEIFTDLSSRFS HHHHHHHHCHHHHCC	41.51	23403867
140	Phosphorylation	EIFTDLSSRFSKSQL HHHHCHHHHCCHHHH	44.64	23403867
141	Methylation	IFTDLSSRFSKSQLD HHHCHHHHCCHHHHH	36.16	115481507
143	Phosphorylation	TDLSSRFSKSQLDII HCHHHHCCHHHHHHH	30.22	28152594
144	Acetylation	DLSSRFSKSQLDIII CHHHHCCHHHHHHHH	39.24	19608861
144	Ubiquitination	DLSSRFSKSQLDIII CHHHHCCHHHHHHHH	39.24	23000965
145	Phosphorylation	LSSRFSKSQLDIIIH HHHHCCHHHHHHHHH	34.47	22617229
153	Phosphorylation	QLDIIIHSLKKCDIS HHHHHHHHHCCCCEE	31.32	28102081
155	2-Hydroxyisobutyrylation	DIIIHSLKKCDISLQ HHHHHHHCCCCEEEE	55.13	-
155	Acetylation	DIIIHSLKKCDISLQ HHHHHHHCCCCEEEE	55.13	25825284
155	Succinylation	DIIIHSLKKCDISLQ HHHHHHHCCCCEEEE	55.13	23954790
155	Ubiquitination	DIIIHSLKKCDISLQ HHHHHHHCCCCEEEE	55.13	22817900
156	Acetylation	IIIHSLKKCDISLQF HHHHHHCCCCEEEEE	42.29	26051181
156	Ubiquitination	IIIHSLKKCDISLQF HHHHHHCCCCEEEEE	42.29	21906983
171	Ubiquitination	FLPFSLGKEDGSGDR EEEECCCCCCCCCCC	58.90	-
175	Phosphorylation	SLGKEDGSGDRGDGP CCCCCCCCCCCCCCC	50.25	20873877
191	Phosphorylation	RLGGHGPSFPLKGIT CCCCCCCCCCCCCCC	44.05	23403867
195	Sumoylation	HGPSFPLKGITEQQK CCCCCCCCCCCHHHH	48.80	-
195	Acetylation	HGPSFPLKGITEQQK CCCCCCCCCCCHHHH	48.80	19608861
195	Neddylation	HGPSFPLKGITEQQK CCCCCCCCCCCHHHH	48.80	32015554
195	Sumoylation	HGPSFPLKGITEQQK CCCCCCCCCCCHHHH	48.80	28112733
195	Ubiquitination	HGPSFPLKGITEQQK CCCCCCCCCCCHHHH	48.80	23000965
198	Phosphorylation	SFPLKGITEQQKEGL CCCCCCCCHHHHHHH	36.09	20860994
202	2-Hydroxyisobutyrylation	KGITEQQKEGLEIVK CCCCHHHHHHHHHEE	54.14	-
202	Acetylation	KGITEQQKEGLEIVK CCCCHHHHHHHHHEE	54.14	26051181
202	Ubiquitination	KGITEQQKEGLEIVK CCCCHHHHHHHHHEE	54.14	22817900
225	Phosphorylation	EDGLDEIYSFSESLR CCCHHHHHHHCHHHH	11.13	-
233	Acetylation	SFSESLRKLCVFKKI HHCHHHHHHHHHHCC	52.08	27178108
233	Ubiquitination	SFSESLRKLCVFKKI HHCHHHHHHHHHHCC	52.08	21906983
235	S-nitrosocysteine	SESLRKLCVFKKIER CHHHHHHHHHHCCHH	3.66	-
235	S-nitrosylation	SESLRKLCVFKKIER CHHHHHHHHHHCCHH	3.66	19483679
238	Acetylation	LRKLCVFKKIERHSI HHHHHHHHCCHHCCC	32.23	25953088
238	Ubiquitination	LRKLCVFKKIERHSI HHHHHHHHCCHHCCC	32.23	22817900
239	Ubiquitination	RKLCVFKKIERHSIH HHHHHHHCCHHCCCC	38.03	-
244	Phosphorylation	FKKIERHSIHWPCRL HHCCHHCCCCCCEEE	23.52	30108239
249	S-nitrosocysteine	RHSIHWPCRLTIGSN HCCCCCCEEEEECCC	4.74	-
249	S-nitrosylation	RHSIHWPCRLTIGSN HCCCCCCEEEEECCC	4.74	22178444
252	Phosphorylation	IHWPCRLTIGSNLSI CCCCEEEEECCCHHH	12.16	23403867
255	Phosphorylation	PCRLTIGSNLSIRIA CEEEEECCCHHHHHH	30.65	30266825
258	Phosphorylation	LTIGSNLSIRIAAYK EEECCCHHHHHHHHH	17.67	30266825
265	Acetylation	SIRIAAYKSILQERV HHHHHHHHHHHHHHH	26.71	19608861
265	Malonylation	SIRIAAYKSILQERV HHHHHHHHHHHHHHH	26.71	26320211
265	Ubiquitination	SIRIAAYKSILQERV HHHHHHHHHHHHHHH	26.71	23000965
266	Phosphorylation	IRIAAYKSILQERVK HHHHHHHHHHHHHHH	18.82	26546556
273	Ubiquitination	SILQERVKKTWTVVD HHHHHHHHHCEEEEE	51.19	23000965
274	Ubiquitination	ILQERVKKTWTVVDA HHHHHHHHCEEEEEC	46.57	23000965
275	Phosphorylation	LQERVKKTWTVVDAK HHHHHHHCEEEEECH	22.20	23312004
277	Phosphorylation	ERVKKTWTVVDAKTL HHHHHCEEEEECHHC	18.84	23312004
282	Acetylation	TWTVVDAKTLKKEDI CEEEEECHHCCHHHC	50.34	23236377
282	Ubiquitination	TWTVVDAKTLKKEDI CEEEEECHHCCHHHC	50.34	27667366
285	Acetylation	VVDAKTLKKEDIQKE EEECHHCCHHHCCCC	60.39	25953088
285	Sumoylation	VVDAKTLKKEDIQKE EEECHHCCHHHCCCC	60.39	-
285	Ubiquitination	VVDAKTLKKEDIQKE EEECHHCCHHHCCCC	60.39	32015554
286	Ubiquitination	VDAKTLKKEDIQKET EECHHCCHHHCCCCE	64.83	22817900
291	Ubiquitination	LKKEDIQKETVYCLN CCHHHCCCCEEEECC	56.54	33845483
295	Nitration	DIQKETVYCLNDDDE HCCCCEEEECCCCCC	9.91	-
295	Phosphorylation	DIQKETVYCLNDDDE HCCCCEEEECCCCCC	9.91	27642862
296	S-nitrosocysteine	IQKETVYCLNDDDET CCCCEEEECCCCCCC	2.19	-
296	S-nitrosylation	IQKETVYCLNDDDET CCCCEEEECCCCCCC	2.19	19483679
307	Sumoylation	DDETEVLKEDIIQGF CCCCHHHHHHHHHCC	59.52	-
307	Ubiquitination	DDETEVLKEDIIQGF CCCCHHHHHHHHHCC	59.52	21906983
316	Phosphorylation	DIIQGFRYGSDIVPF HHHHCCCCCCCCCCH	20.79	28152594
318	Phosphorylation	IQGFRYGSDIVPFSK HHCCCCCCCCCCHHH	18.41	25159151
324	Phosphorylation	GSDIVPFSKVDEEQM CCCCCCHHHCCHHHH	26.21	20873877
325	Sumoylation	SDIVPFSKVDEEQMK CCCCCHHHCCHHHHH	54.83	-
325	Acetylation	SDIVPFSKVDEEQMK CCCCCHHHCCHHHHH	54.83	26051181
325	Neddylation	SDIVPFSKVDEEQMK CCCCCHHHCCHHHHH	54.83	32015554
325	Sumoylation	SDIVPFSKVDEEQMK CCCCCHHHCCHHHHH	54.83	-
325	Ubiquitination	SDIVPFSKVDEEQMK CCCCCHHHCCHHHHH	54.83	23000965
332	Sumoylation	KVDEEQMKYKSEGKC HCCHHHHHHCCCCCE	49.58	-
332	Acetylation	KVDEEQMKYKSEGKC HCCHHHHHHCCCCCE	49.58	19608861
332	Methylation	KVDEEQMKYKSEGKC HCCHHHHHHCCCCCE	49.58	7713937
332	Sumoylation	KVDEEQMKYKSEGKC HCCHHHHHHCCCCCE	49.58	19608861
332	Ubiquitination	KVDEEQMKYKSEGKC HCCHHHHHHCCCCCE	49.58	23000965
333	Phosphorylation	VDEEQMKYKSEGKCF CCHHHHHHCCCCCEE	17.88	28176443
334	Methylation	DEEQMKYKSEGKCFS CHHHHHHCCCCCEEE	36.19	24797987
334	Ubiquitination	DEEQMKYKSEGKCFS CHHHHHHCCCCCEEE	36.19	23000965
335	Phosphorylation	EEQMKYKSEGKCFSV HHHHHHCCCCCEEEE	48.79	29214152
338	Sumoylation	MKYKSEGKCFSVLGF HHHCCCCCEEEEEHH	28.23	-
338	2-Hydroxyisobutyrylation	MKYKSEGKCFSVLGF HHHCCCCCEEEEEHH	28.23	-
338	Acetylation	MKYKSEGKCFSVLGF HHHCCCCCEEEEEHH	28.23	23954790
338	Malonylation	MKYKSEGKCFSVLGF HHHCCCCCEEEEEHH	28.23	26320211
338	Sumoylation	MKYKSEGKCFSVLGF HHHCCCCCEEEEEHH	28.23	19608861
338	Ubiquitination	MKYKSEGKCFSVLGF HHHCCCCCEEEEEHH	28.23	23000965
339	S-nitrosocysteine	KYKSEGKCFSVLGFC HHCCCCCEEEEEHHH	4.52	-
339	S-nitrosylation	KYKSEGKCFSVLGFC HHCCCCCEEEEEHHH	4.52	19483679
341	Phosphorylation	KSEGKCFSVLGFCKS CCCCCEEEEEHHHCC	26.38	21712546
346	S-nitrosocysteine	CFSVLGFCKSSQVQR EEEEEHHHCCHHHHH	3.87	-
346	S-nitrosylation	CFSVLGFCKSSQVQR EEEEEHHHCCHHHHH	3.87	19483679
347	Acetylation	FSVLGFCKSSQVQRR EEEEHHHCCHHHHHH	51.37	25953088
347	Ubiquitination	FSVLGFCKSSQVQRR EEEEHHHCCHHHHHH	51.37	21906983
348	Phosphorylation	SVLGFCKSSQVQRRF EEEHHHCCHHHHHHH	27.47	23882029
357	Sulfoxidation	QVQRRFFMGNQVLKV HHHHHHHCCHHHEEE	4.53	21406390
363	Acetylation	FMGNQVLKVFAARDD HCCHHHEEEEECCCH	36.13	26051181
363	Ubiquitination	FMGNQVLKVFAARDD HCCHHHEEEEECCCH	36.13	23000965
378	Phosphorylation	EAAAVALSSLIHALD HHHHHHHHHHHHHHC	17.23	18452278
379	Phosphorylation	AAAVALSSLIHALDD HHHHHHHHHHHHHCC	31.99	18452278
389	Sulfoxidation	HALDDLDMVAIVRYA HHHCCCCHHHHHHHH	2.59	30846556
399	Acetylation	IVRYAYDKRANPQVG HHHHHHHCCCCCCCE	40.51	26051181
399	Ubiquitination	IVRYAYDKRANPQVG HHHHHHHCCCCCCCE	40.51	-
413	Ubiquitination	GVAFPHIKHNYECLV EEECCCCCCCEEEEE	23.82	16196087
416	Phosphorylation	FPHIKHNYECLVYVQ CCCCCCCEEEEEEEE	14.03	-
433	Phosphorylation	FMEDLRQYMFSSLKN CHHHHHHHHHHHHCC	8.16	23312004
436	Phosphorylation	DLRQYMFSSLKNSKK HHHHHHHHHHCCCCC	20.45	30108239
437	Phosphorylation	LRQYMFSSLKNSKKY HHHHHHHHHCCCCCC	31.90	30108239
439	Acetylation	QYMFSSLKNSKKYAP HHHHHHHCCCCCCCC	62.21	25953088
439	Ubiquitination	QYMFSSLKNSKKYAP HHHHHHHCCCCCCCC	62.21	21906983
442	Ubiquitination	FSSLKNSKKYAPTEA HHHHCCCCCCCCCHH	60.23	22817900
443	Sumoylation	SSLKNSKKYAPTEAQ HHHCCCCCCCCCHHH	46.60	-
443	Acetylation	SSLKNSKKYAPTEAQ HHHCCCCCCCCCHHH	46.60	7709569
443	Sumoylation	SSLKNSKKYAPTEAQ HHHCCCCCCCCCHHH	46.60	-
443	Ubiquitination	SSLKNSKKYAPTEAQ HHHCCCCCCCCCHHH	46.60	22817900
460	Phosphorylation	AVDALIDSMSLAKKD HHHHHHHHHHHCCCC	11.86	23532336
461	Sulfoxidation	VDALIDSMSLAKKDE HHHHHHHHHHCCCCC	3.18	28183972
462	Phosphorylation	DALIDSMSLAKKDEK HHHHHHHHHCCCCCC	29.18	23532336
465	2-Hydroxyisobutyrylation	IDSMSLAKKDEKTDT HHHHHHCCCCCCCCC	67.08	-
465	Ubiquitination	IDSMSLAKKDEKTDT HHHHHHCCCCCCCCC	67.08	21906983
466	2-Hydroxyisobutyrylation	DSMSLAKKDEKTDTL HHHHHCCCCCCCCCH	66.56	-
466	Acetylation	DSMSLAKKDEKTDTL HHHHHCCCCCCCCCH	66.56	25953088
466	Succinylation	DSMSLAKKDEKTDTL HHHHHCCCCCCCCCH	66.56	23954790
466	Ubiquitination	DSMSLAKKDEKTDTL HHHHHCCCCCCCCCH	66.56	22817900
469	2-Hydroxyisobutyrylation	SLAKKDEKTDTLEDL HHCCCCCCCCCHHHH	62.93	-
469	Acetylation	SLAKKDEKTDTLEDL HHCCCCCCCCCHHHH	62.93	25953088
469	Ubiquitination	SLAKKDEKTDTLEDL HHCCCCCCCCCHHHH	62.93	21906983
470	Phosphorylation	LAKKDEKTDTLEDLF HCCCCCCCCCHHHHC	31.97	29214152
472	Phosphorylation	KKDEKTDTLEDLFPT CCCCCCCCHHHHCCC	36.96	29214152
480	Phosphorylation	LEDLFPTTKIPNPRF HHHHCCCCCCCCHHH	27.49	24719451
481	Acetylation	EDLFPTTKIPNPRFQ HHHCCCCCCCCHHHH	59.66	25953088
481	Ubiquitination	EDLFPTTKIPNPRFQ HHHCCCCCCCCHHHH	59.66	23000965
493	S-nitrosocysteine	RFQRLFQCLLHRALH HHHHHHHHHHHHHHC	3.23	-
493	S-nitrosylation	RFQRLFQCLLHRALH HHHHHHHHHHHHHHC	3.23	22178444
515	Sulfoxidation	IQQHIWNMLNPPAEV HHHHHHHHCCCCCCC	1.99	28183972
523	Phosphorylation	LNPPAEVTTKSQIPL CCCCCCCCCCCCCCH	21.73	21406692
524	Phosphorylation	NPPAEVTTKSQIPLS CCCCCCCCCCCCCHH	33.60	21406692
525	Ubiquitination	PPAEVTTKSQIPLSK CCCCCCCCCCCCHHH	30.88	21906983
526	Phosphorylation	PAEVTTKSQIPLSKI CCCCCCCCCCCHHHH	31.11	20860994
531	Phosphorylation	TKSQIPLSKIKTLFP CCCCCCHHHHHHHHH	27.29	24719451
532	Sumoylation	KSQIPLSKIKTLFPL CCCCCHHHHHHHHHH	56.77	-
532	Acetylation	KSQIPLSKIKTLFPL CCCCCHHHHHHHHHH	56.77	19608861
532	Malonylation	KSQIPLSKIKTLFPL CCCCCHHHHHHHHHH	56.77	26320211
532	Sumoylation	KSQIPLSKIKTLFPL CCCCCHHHHHHHHHH	56.77	28112733
532	Ubiquitination	KSQIPLSKIKTLFPL CCCCCHHHHHHHHHH	56.77	23000965
534	Sumoylation	QIPLSKIKTLFPLIE CCCHHHHHHHHHHHH	42.80	-
534	2-Hydroxyisobutyrylation	QIPLSKIKTLFPLIE CCCHHHHHHHHHHHH	42.80	-
534	Acetylation	QIPLSKIKTLFPLIE CCCHHHHHHHHHHHH	42.80	26051181
534	Succinylation	QIPLSKIKTLFPLIE CCCHHHHHHHHHHHH	42.80	23954790
534	Sumoylation	QIPLSKIKTLFPLIE CCCHHHHHHHHHHHH	42.80	28112733
534	Ubiquitination	QIPLSKIKTLFPLIE CCCHHHHHHHHHHHH	42.80	23000965
535	Phosphorylation	IPLSKIKTLFPLIEA CCHHHHHHHHHHHHH	36.78	21712546
543	Sumoylation	LFPLIEAKKKDQVTA HHHHHHHHHHCCCCH	47.79	-
543	2-Hydroxyisobutyrylation	LFPLIEAKKKDQVTA HHHHHHHHHHCCCCH	47.79	-
543	Acetylation	LFPLIEAKKKDQVTA HHHHHHHHHHCCCCH	47.79	25953088
543	Malonylation	LFPLIEAKKKDQVTA HHHHHHHHHHCCCCH	47.79	26320211
543	Sumoylation	LFPLIEAKKKDQVTA HHHHHHHHHHCCCCH	47.79	-
543	Ubiquitination	LFPLIEAKKKDQVTA HHHHHHHHHHCCCCH	47.79	23000965
544	Acetylation	FPLIEAKKKDQVTAQ HHHHHHHHHCCCCHH	69.50	25953088
544	Ubiquitination	FPLIEAKKKDQVTAQ HHHHHHHHHCCCCHH	69.50	23000965
545	Ubiquitination	PLIEAKKKDQVTAQE HHHHHHHHCCCCHHH	53.32	23000965
549	Phosphorylation	AKKKDQVTAQEIFQD HHHHCCCCHHHHHCC	19.59	28555341
563	Phosphorylation	DNHEDGPTAKKLKTE CCCCCCCCCCCCEEC	57.55	28555341
565	Acetylation	HEDGPTAKKLKTEQG CCCCCCCCCCEECCC	62.20	23954790
565	Sumoylation	HEDGPTAKKLKTEQG CCCCCCCCCCEECCC	62.20	-
565	Ubiquitination	HEDGPTAKKLKTEQG CCCCCCCCCCEECCC	62.20	21906983
566	Acetylation	EDGPTAKKLKTEQGG CCCCCCCCCEECCCC	53.40	155623
566	Sumoylation	EDGPTAKKLKTEQGG CCCCCCCCCEECCCC	53.40	28112733
566	Ubiquitination	EDGPTAKKLKTEQGG CCCCCCCCCEECCCC	53.40	22817900
568	Sumoylation	GPTAKKLKTEQGGAH CCCCCCCEECCCCCE	59.92	-
568	Sumoylation	GPTAKKLKTEQGGAH CCCCCCCEECCCCCE	59.92	28112733
568	Ubiquitination	GPTAKKLKTEQGGAH CCCCCCCEECCCCCE	59.92	33845483
569	Phosphorylation	PTAKKLKTEQGGAHF CCCCCCEECCCCCEE	43.93	28464451
577	Phosphorylation	EQGGAHFSVSSLAEG CCCCCEEEHHHHCCC	15.95	15941674
579	Phosphorylation	GGAHFSVSSLAEGSV CCCEEEHHHHCCCCC	20.59	28857561
580	Phosphorylation	GAHFSVSSLAEGSVT CCEEEHHHHCCCCCC	29.46	21712546
585	Phosphorylation	VSSLAEGSVTSVGSV HHHHCCCCCCCCCCC	17.46	22817901
587	Phosphorylation	SLAEGSVTSVGSVNP HHCCCCCCCCCCCCH	21.28	27080861
588	Phosphorylation	LAEGSVTSVGSVNPA HCCCCCCCCCCCCHH	23.48	27080861
603	Ubiquitination	ENFRVLVKQKKASFE HHHHHEEECCCCCHH	52.84	27667366
608	Phosphorylation	LVKQKKASFEEASNQ EEECCCCCHHHHHHH	41.91	22115753
613	Phosphorylation	KASFEEASNQLINHI CCCHHHHHHHHHHHH	28.52	22115753
629	Phosphorylation	QFLDTNETPYFMKSI HHHCCCCCCCHHHHH	25.92	25159151
633	Sulfoxidation	TNETPYFMKSIDCIR CCCCCCHHHHHHHHH	2.48	30846556
640	Methylation	MKSIDCIRAFREEAI HHHHHHHHHHHHHHH	33.72	115481513
648	Acetylation	AFREEAIKFSEEQRF HHHHHHHHCCHHHHH	50.30	23749302
648	Ubiquitination	AFREEAIKFSEEQRF HHHHHHHHCCHHHHH	50.30	23000965
660	Sumoylation	QRFNNFLKALQEKVE HHHHHHHHHHHHHHH	42.80	-
660	2-Hydroxyisobutyrylation	QRFNNFLKALQEKVE HHHHHHHHHHHHHHH	42.80	-
660	Acetylation	QRFNNFLKALQEKVE HHHHHHHHHHHHHHH	42.80	19608861
660	Methylation	QRFNNFLKALQEKVE HHHHHHHHHHHHHHH	42.80	22631769
660	Sumoylation	QRFNNFLKALQEKVE HHHHHHHHHHHHHHH	42.80	19608861
660	Ubiquitination	QRFNNFLKALQEKVE HHHHHHHHHHHHHHH	42.80	23000965
665	2-Hydroxyisobutyrylation	FLKALQEKVEIKQLN HHHHHHHHHHHHHCC	32.01	-
665	Acetylation	FLKALQEKVEIKQLN HHHHHHHHHHHHHCC	32.01	19608861
665	Ubiquitination	FLKALQEKVEIKQLN HHHHHHHHHHHHHCC	32.01	23000965
669	Sumoylation	LQEKVEIKQLNHFWE HHHHHHHHHCCCHHE	34.92	28112733
669	Ubiquitination	LQEKVEIKQLNHFWE HHHHHHHHHCCCHHE	34.92	33845483
688	Sumoylation	DGITLITKEEASGSS CCEEEEECCCCCCCC	46.71	28112733
692	Phosphorylation	LITKEEASGSSVTAE EEECCCCCCCCCCHH	42.35	21815630
694	Phosphorylation	TKEEASGSSVTAEEA ECCCCCCCCCCHHHH	21.09	30108239
695	Phosphorylation	KEEASGSSVTAEEAK CCCCCCCCCCHHHHH	27.32	30576142
697	Phosphorylation	EASGSSVTAEEAKKF CCCCCCCCHHHHHHH	30.24	30576142
702	Acetylation	SVTAEEAKKFLAPKD CCCHHHHHHHHCCCC	47.54	23749302
702	Methylation	SVTAEEAKKFLAPKD CCCHHHHHHHHCCCC	47.54	-
702	Succinylation	SVTAEEAKKFLAPKD CCCHHHHHHHHCCCC	47.54	23954790
702	Sumoylation	SVTAEEAKKFLAPKD CCCHHHHHHHHCCCC	47.54	-
702	Ubiquitination	SVTAEEAKKFLAPKD CCCHHHHHHHHCCCC	47.54	27667366
703	Acetylation	VTAEEAKKFLAPKDK CCHHHHHHHHCCCCC	53.29	26051181
703	Ubiquitination	VTAEEAKKFLAPKDK CCHHHHHHHHCCCCC	53.29	22817900
710	Ubiquitination	KFLAPKDKPSGDTAA HHHCCCCCCCCCCCH	47.40	-
712	Phosphorylation	LAPKDKPSGDTAAVF HCCCCCCCCCCCHHH	55.85	21712546
715	Phosphorylation	KDKPSGDTAAVFEEG CCCCCCCCCHHHCCC	21.75	28112733
731	Sulfoxidation	DVDDLLDMI------ CHHHHHHCC------	3.85	21406390

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
577	S	Phosphorylation	Kinase	DNAPK	P78527	PSP
579	S	Phosphorylation	Kinase	PRKDC	P78527	Uniprot
580	S	Phosphorylation	Kinase	DNAPK	P78527	PSP
715	T	Phosphorylation	Kinase	DNAPK	P78527	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	FBXL12	Q9NXK8	PMID:24658274
-	K	Ubiquitination	E3 ubiquitin ligase	RNF138	Q8WVD3	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	RNF8	O76064	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of XRCC5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of XRCC5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
XRCC6_HUMAN	XRCC6	physical	10446239
KAT2A_HUMAN	KAT2A	physical	9488450
VAV_HUMAN	VAV1	physical	10673353
TYK2_HUMAN	TYK2	physical	10673353
PRKDC_HUMAN	PRKDC	physical	9312071
XRCC6_HUMAN	XRCC6	physical	10207052
PO2F1_HUMAN	POU2F1	physical	12393188
DPOLA_HUMAN	POLA1	physical	12393188
PCNA_HUMAN	PCNA	physical	12393188
TOP2A_HUMAN	TOP2A	physical	12393188
PRI1_HUMAN	PRIM1	physical	12393188
RPAB1_HUMAN	POLR2E	physical	12393188
RPB4_HUMAN	POLR2D	physical	12393188
ORC2_HUMAN	ORC2	physical	12393188
ORC1_HUMAN	ORC1	physical	12393188
PRKDC_HUMAN	PRKDC	physical	12393188
RFC1_HUMAN	RFC1	physical	12393188
PRKDC_HUMAN	PRKDC	physical	10446239
BRCA1_HUMAN	BRCA1	physical	18936166
BARD1_HUMAN	BARD1	physical	18936166
MSX2_HUMAN	MSX2	physical	12145306
RUNX2_HUMAN	RUNX2	physical	12145306
NAA15_HUMAN	NAA15	physical	12145306
XRCC6_HUMAN	XRCC6	physical	12145306
PRKDC_HUMAN	PRKDC	physical	15520013
DNLI4_HUMAN	LIG4	physical	15520013
XRCC4_HUMAN	XRCC4	physical	15520013
XRCC6_HUMAN	XRCC6	physical	15520013
PARP1_HUMAN	PARP1	physical	10400681
CAF1A_HUMAN	CHAF1A	physical	21209461
BAZ1A_HUMAN	BAZ1A	physical	21172662
SMCA5_HUMAN	SMARCA5	physical	21172662
CHRC1_HUMAN	CHRAC1	physical	21172662
DPOE3_HUMAN	POLE3	physical	21172662
XRCC6_HUMAN	XRCC6	physical	21172662
APLF_HUMAN	APLF	physical	17396150
XRCC6_HUMAN	XRCC6	physical	10783163
WRN_HUMAN	WRN	physical	10783163
XRCC6_HUMAN	XRCC6	physical	21070772
COIL_HUMAN	COIL	physical	21070772
RPB1_HUMAN	POLR2A	physical	12391174
HXB7_HUMAN	HOXB7	physical	17308091
XRCC6_HUMAN	XRCC6	physical	15367688
TYY1_HUMAN	YY1	physical	15367688
PRKDC_HUMAN	PRKDC	physical	15758953
ATM_HUMAN	ATM	physical	15758953
ATR_HUMAN	ATR	physical	15758953
NBN_HUMAN	NBN	physical	15758953
XRCC6_HUMAN	XRCC6	physical	15910003
ORC3_HUMAN	ORC3	physical	15910003
ORC2_HUMAN	ORC2	physical	15910003
ORC6_HUMAN	ORC6	physical	15910003
ORC4_HUMAN	ORC4	physical	15910003
HXC4_HUMAN	HOXC4	physical	12672812
PARP1_HUMAN	PARP1	physical	16490787
DHX9_HUMAN	DHX9	physical	14704337
DNLI4_HUMAN	LIG4	physical	10757784
XRCC6_HUMAN	XRCC6	physical	10757784
SP16H_HUMAN	SUPT16H	physical	21679440
XRCC6_HUMAN	XRCC6	physical	21679440
WRN_HUMAN	WRN	physical	21679440
DHX9_HUMAN	DHX9	physical	21679440
SSRP1_HUMAN	SSRP1	physical	21679440
H2AX_HUMAN	H2AFX	physical	21679440
PRKDC_HUMAN	PRKDC	physical	21679440
LAP2A_HUMAN	TMPO	physical	21679440
LAP2B_HUMAN	TMPO	physical	21679440
TOP1_HUMAN	TOP1	physical	21679440
PARP1_HUMAN	PARP1	physical	21679440
DDX17_HUMAN	DDX17	physical	21679440
WRN_HUMAN	WRN	physical	12937274
TFAP4_HUMAN	TFAP4	physical	22939629
PAF1_HUMAN	PAF1	physical	22939629
PTER_HUMAN	PTER	physical	22939629
SYYC_HUMAN	YARS	physical	22939629
PRGR_HUMAN	PGR	physical	10750018
XRCC6_HUMAN	XRCC6	physical	10750018
XRCC5_HUMAN	XRCC5	physical	10750018
PRKDC_HUMAN	PRKDC	physical	10750018
GRAA_HUMAN	GZMA	physical	16440001
DCR1C_HUMAN	DCLRE1C	physical	16857680
PRKDC_HUMAN	PRKDC	physical	16857680
XRCC6_HUMAN	XRCC6	physical	11196700
C1QBP_HUMAN	C1QBP	physical	22863883
CUL2_HUMAN	CUL2	physical	22863883
CSDE1_HUMAN	CSDE1	physical	22863883
DNMBP_HUMAN	DNMBP	physical	22863883
EIF3J_HUMAN	EIF3J	physical	22863883
IF4B_HUMAN	EIF4B	physical	22863883
GANAB_HUMAN	GANAB	physical	22863883
HSP74_HUMAN	HSPA4	physical	22863883
PLAK_HUMAN	JUP	physical	22863883
MSH2_HUMAN	MSH2	physical	22863883
SYNC_HUMAN	NARS	physical	22863883
NUCL_HUMAN	NCL	physical	22863883
PLCB3_HUMAN	PLCB3	physical	22863883
ANM3_HUMAN	PRMT3	physical	22863883
RL24_HUMAN	RPL24	physical	22863883
SAMH1_HUMAN	SAMHD1	physical	22863883
SF01_HUMAN	SF1	physical	22863883
TRM1_HUMAN	TRMT1	physical	22863883
XRCC6_HUMAN	XRCC6	physical	22863883
BRCA1_HUMAN	BRCA1	physical	23344954
PRKDC_HUMAN	PRKDC	physical	26344197
XRCC6_HUMAN	XRCC6	physical	26344197
CBL_HUMAN	CBL	physical	26496610
CX6B1_HUMAN	COX6B1	physical	26496610
DC1I2_HUMAN	DYNC1I2	physical	26496610
ERF_HUMAN	ERF	physical	26496610
XRCC6_HUMAN	XRCC6	physical	26496610
NDST1_HUMAN	NDST1	physical	26496610
MPRI_HUMAN	IGF2R	physical	26496610
LIMS1_HUMAN	LIMS1	physical	26496610
MSH5_HUMAN	MSH5	physical	26496610
NFIB_HUMAN	NFIB	physical	26496610
PCDH7_HUMAN	PCDH7	physical	26496610
PPM1A_HUMAN	PPM1A	physical	26496610
PRKDC_HUMAN	PRKDC	physical	26496610
ABCE1_HUMAN	ABCE1	physical	26496610
ROCK1_HUMAN	ROCK1	physical	26496610
WRN_HUMAN	WRN	physical	26496610
BRPF1_HUMAN	BRPF1	physical	26496610
NCOA3_HUMAN	NCOA3	physical	26496610
MPDZ_HUMAN	MPDZ	physical	26496610
M3K6_HUMAN	MAP3K6	physical	26496610
GOGA5_HUMAN	GOLGA5	physical	26496610
SPN1_HUMAN	SNUPN	physical	26496610
SMYD5_HUMAN	SMYD5	physical	26496610
WWP1_HUMAN	WWP1	physical	26496610
ZZEF1_HUMAN	ZZEF1	physical	26496610
RTEL1_HUMAN	RTEL1	physical	26496610
LTOR1_HUMAN	LAMTOR1	physical	26496610
ASAP3_HUMAN	ASAP3	physical	26496610
PEAK1_HUMAN	PEAK1	physical	26496610
NAA15_HUMAN	NAA15	physical	26496610
BAP18_HUMAN	C17orf49	physical	26496610
MITD1_HUMAN	MITD1	physical	26496610
MIB2_HUMAN	MIB2	physical	26496610
CE128_HUMAN	CEP128	physical	26496610
AP2A_HUMAN	TFAP2A	physical	19906305
XRCC6_HUMAN	XRCC6	physical	19906305
SPTA1_HUMAN	SPTA1	physical	16889989
EP300_HUMAN	EP300	physical	29049411
DDB2_HUMAN	DDB2	physical	28035050
DDB1_HUMAN	DDB1	physical	28035050
XRCC6_HUMAN	XRCC6	physical	28035050

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of XRCC5_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-144; LYS-195; LYS-265;LYS-332; LYS-660 AND LYS-665, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258, AND MASSSPECTROMETRY.	19690332 [Abstract]
"DNA-dependent protein kinase phosphorylation sites in Ku 70/80heterodimer."; Chan D.W., Ye R., Veillette C.J., Lees-Miller S.P.; Biochemistry 38:1819-1828(1999). Cited for: PHOSPHORYLATION AT SER-577; SER-579; SER-580 AND THR-715.	10026262 [Abstract]