HXC4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXC4_HUMAN
• UniProt AC: P09017
• Protein Name: Homeobox protein Hox-C4
• Gene Name: HOXC4
• Organism: Homo sapiens (Human).
• Sequence Length: 264
• Subcellular Localization: Nucleus.
• Protein Description: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis..
• Protein Sequence: MIMSSYLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGRTRESGFQHHHQELYPPPPPRPSYPERQYSCTSLQGPGNSRGHGPAQAGHHHPEKSQSLCEPAPLSGASASPSPAPPACSQPAPDHPSSAASKQPIVYPWMKKIHVSTVNPNYNGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLPNTKVRSAPPAGAAPSTLSAATPGTSEDHSQSATPPEQQRAEDITRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MIMSSYLMDSN ----CCCCCCCCCCC	12.61	23663014
5	Phosphorylation	---MIMSSYLMDSNY ---CCCCCCCCCCCC	12.61	23663014
6	Phosphorylation	--MIMSSYLMDSNYI --CCCCCCCCCCCCC	9.95	23663014
10	Phosphorylation	MSSYLMDSNYIDPKF CCCCCCCCCCCCCCC	19.98	23663014
12	Phosphorylation	SYLMDSNYIDPKFPP CCCCCCCCCCCCCCC	15.62	23663014
33	Phosphorylation	NSYIPEHSPEYYGRT CCCCCCCCHHHCCCC	20.12	26074081
67	Phosphorylation	PSYPERQYSCTSLQG CCCCCCCEECEECCC	16.37	24043423
68	Phosphorylation	SYPERQYSCTSLQGP CCCCCCEECEECCCC	11.54	24043423
70	Phosphorylation	PERQYSCTSLQGPGN CCCCEECEECCCCCC	26.91	24043423
71	Phosphorylation	ERQYSCTSLQGPGNS CCCEECEECCCCCCC	24.03	24043423
78	Phosphorylation	SLQGPGNSRGHGPAQ ECCCCCCCCCCCCCC	45.62	24043423
79	Methylation	LQGPGNSRGHGPAQA CCCCCCCCCCCCCCC	45.16	115479615
94	Phosphorylation	GHHHPEKSQSLCEPA CCCCCHHHCCCCCCC	24.28	26074081
96	Phosphorylation	HHPEKSQSLCEPAPL CCCHHHCCCCCCCCC	41.92	26074081
104	Phosphorylation	LCEPAPLSGASASPS CCCCCCCCCCCCCCC	31.11	26074081
107	Phosphorylation	PAPLSGASASPSPAP CCCCCCCCCCCCCCC	32.57	26074081
109	Phosphorylation	PLSGASASPSPAPPA CCCCCCCCCCCCCCC	24.34	26074081
111	Phosphorylation	SGASASPSPAPPACS CCCCCCCCCCCCCCC	31.06	26074081
118	Phosphorylation	SPAPPACSQPAPDHP CCCCCCCCCCCCCCC	41.11	26074081
126	Phosphorylation	QPAPDHPSSAASKQP CCCCCCCCCHHHCCC	29.23	26074081
127	Phosphorylation	PAPDHPSSAASKQPI CCCCCCCCHHHCCCC	32.10	26074081
130	Phosphorylation	DHPSSAASKQPIVYP CCCCCHHHCCCCCCC	31.38	26074081
179	Methylation	EKEFHYNRYLTRRRR HHHHHHHHHHHHHHH	22.22	-
224	Phosphorylation	LPNTKVRSAPPAGAA CCCCCCCCCCCCCCC	48.38	25002506
233	Phosphorylation	PPAGAAPSTLSAATP CCCCCCCCCCCCCCC	36.94	29255136
234	Phosphorylation	PAGAAPSTLSAATPG CCCCCCCCCCCCCCC	24.55	29255136
236	Phosphorylation	GAAPSTLSAATPGTS CCCCCCCCCCCCCCC	18.88	29255136
239	Phosphorylation	PSTLSAATPGTSEDH CCCCCCCCCCCCCCC	23.20	29255136
242	Phosphorylation	LSAATPGTSEDHSQS CCCCCCCCCCCCCCC	30.10	29255136
243	Phosphorylation	SAATPGTSEDHSQSA CCCCCCCCCCCCCCC	47.11	29255136
247	Phosphorylation	PGTSEDHSQSATPPE CCCCCCCCCCCCCHH	37.85	29255136
249	Phosphorylation	TSEDHSQSATPPEQQ CCCCCCCCCCCHHHH	36.81	29255136
251	Phosphorylation	EDHSQSATPPEQQRA CCCCCCCCCHHHHHH	44.62	29255136

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXC4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXC4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXC4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PO2F1_HUMAN	POU2F1	physical	12672812
SUV91_HUMAN	SUV39H1	physical	23455924
NSD3_HUMAN	WHSC1L1	physical	23455924
RNF32_HUMAN	RNF32	physical	21988832
ANM5_HUMAN	PRMT5	physical	23455924
ANM6_HUMAN	PRMT6	physical	23455924
NCK2_HUMAN	NCK2	physical	25416956
ANR17_HUMAN	ANKRD17	physical	26186194
ANKH1_HUMAN	ANKHD1	physical	26186194
RBG10_HUMAN	RABGAP1L	physical	26186194
RBG1L_HUMAN	RABGAP1L	physical	26186194
RBGP1_HUMAN	RABGAP1	physical	26186194
ANR28_HUMAN	ANKRD28	physical	26186194
ERBIN_HUMAN	ERBB2IP	physical	26186194
ZN363_HUMAN	RCHY1	physical	26496426
RBGP1_HUMAN	RABGAP1	physical	28514442
RBG10_HUMAN	RABGAP1L	physical	28514442
RBG1L_HUMAN	RABGAP1L	physical	28514442
ANKH1_HUMAN	ANKHD1	physical	28514442
ANR17_HUMAN	ANKRD17	physical	28514442
ERBIN_HUMAN	ERBB2IP	physical	28514442
ANR28_HUMAN	ANKRD28	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.