dbPTM

NCK2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NCK2_HUMAN
UniProt AC	O43639
Protein Name	Cytoplasmic protein NCK2
Gene Name	NCK2
Organism	Homo sapiens (Human).
Sequence Length	380
Subcellular Localization	Cytoplasm . Endoplasmic reticulum .
Protein Description	Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling..
Protein Sequence	MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLSLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPALHPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCIGQRRFHTMDELVEHYKKAPIFTSEHGEKLYLVRALQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTEEVIVIA ------CCEEEEEEE	40.63	22223895
2	Phosphorylation	------MTEEVIVIA ------CCEEEEEEE	40.63	29396449
37	Phosphorylation	WLLDDSKTWWRVRNA EEECCCCCHHHHCCC	33.92	28857561
48	Phosphorylation	VRNAANRTGYVPSNY HCCCCCCCCCCCCHH	32.45	28152594
50	Phosphorylation	NAANRTGYVPSNYVE CCCCCCCCCCCHHHH	14.47	20090780
53	Phosphorylation	NRTGYVPSNYVERKN CCCCCCCCHHHHHCC	30.65	23882029
61	Phosphorylation	NYVERKNSLKKGSLV HHHHHCCCCCCCCHH	44.60	23312004
66	Phosphorylation	KNSLKKGSLVKNLKD CCCCCCCCHHHHHHH	38.58	24719451
74	Phosphorylation	LVKNLKDTLGLGKTR HHHHHHHHCCCCCCC	22.57	28857561
79	Acetylation	KDTLGLGKTRRKTSA HHHCCCCCCCCCCCC	43.85	25953088
80	Phosphorylation	DTLGLGKTRRKTSAR HHCCCCCCCCCCCCC	33.63	28060719
84	Phosphorylation	LGKTRRKTSARDASP CCCCCCCCCCCCCCC	26.30	23090842
85	Phosphorylation	GKTRRKTSARDASPT CCCCCCCCCCCCCCC	25.09	28450419
90	Phosphorylation	KTSARDASPTPSTDA CCCCCCCCCCCCCCC	33.33	19664994
92	Phosphorylation	SARDASPTPSTDAEY CCCCCCCCCCCCCCC	27.63	30266825
94	Phosphorylation	RDASPTPSTDAEYPA CCCCCCCCCCCCCCC	41.20	30266825
95	Phosphorylation	DASPTPSTDAEYPAN CCCCCCCCCCCCCCC	40.19	30266825
99	Phosphorylation	TPSTDAEYPANGSGA CCCCCCCCCCCCCCC	14.90	23927012
104	Phosphorylation	AEYPANGSGADRIYD CCCCCCCCCCCCEEE	30.52	23927012
110	Phosphorylation	GSGADRIYDLNIPAF CCCCCCEEECCCCCE	18.44	29255136
131	Phosphorylation	AEREDELSLVKGSRV ECCCCHHEEECCCEE	29.12	24719451
136	Phosphorylation	ELSLVKGSRVTVMEK HHEEECCCEEEEEEE	20.19	27134283
162	Phosphorylation	GQIGWFPSNYVLEEV CEEEEECCHHEECCH	31.17	28270605
164	Phosphorylation	IGWFPSNYVLEEVDE EEEECCHHEECCHHH	15.68	28270605
176	Phosphorylation	VDEAAAESPSFLSLR HHHHHHHCCCCEEEC	22.55	26074081
178	Phosphorylation	EAAAESPSFLSLRKG HHHHHCCCCEEECCC	48.36	26074081
181	Phosphorylation	AESPSFLSLRKGASL HHCCCCEEECCCCCC	24.90	28270605
187	Phosphorylation	LSLRKGASLSNGQGS EEECCCCCCCCCCCH	40.79	30242111
189	Phosphorylation	LRKGASLSNGQGSRV ECCCCCCCCCCCHHH	36.10	30242111
194	Phosphorylation	SLSNGQGSRVLHVVQ CCCCCCCHHHEEEEE	16.01	27251275
251	Phosphorylation	VGLVPKNYVVVLSDG CEEECCCEEEEECCC	10.76	28442448
256	Phosphorylation	KNYVVVLSDGPALHP CCEEEEECCCCCCCC	28.98	28857561
270	Phosphorylation	PAHAPQISYTGPSSS CCCCCCEEEECCCCC	16.05	26657352
271	Phosphorylation	AHAPQISYTGPSSSG CCCCCEEEECCCCCC	19.83	25884760
272	Phosphorylation	HAPQISYTGPSSSGR CCCCEEEECCCCCCC	35.51	28857561
275	Phosphorylation	QISYTGPSSSGRFAG CEEEECCCCCCCCCC	38.18	28857561
276	Phosphorylation	ISYTGPSSSGRFAGR EEEECCCCCCCCCCC	39.69	28857561
277	Phosphorylation	SYTGPSSSGRFAGRE EEECCCCCCCCCCCE	38.02	28857561
313	Phosphorylation	GDFLIRDSESSPSDF CCEEEECCCCCCCCE	29.54	23186163
315	Phosphorylation	FLIRDSESSPSDFSV EEEECCCCCCCCEEE	52.05	27732954
316	Phosphorylation	LIRDSESSPSDFSVS EEECCCCCCCCEEEE	25.11	27732954
318	Phosphorylation	RDSESSPSDFSVSLK ECCCCCCCCEEEEEE	53.92	27732954
321	Phosphorylation	ESSPSDFSVSLKASG CCCCCCEEEEEEECC	18.78	23186163
323	Phosphorylation	SPSDFSVSLKASGKN CCCCEEEEEEECCCC	23.97	23186163
342	Phosphorylation	VQLVDNVYCIGQRRF EEEECCEEECCCCEE	5.65	28152594

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NCK2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NCK2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NCK2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ABI2_HUMAN	ABI2	physical	16189514
SKT_HUMAN	KIAA1217	physical	16189514
SPN90_HUMAN	NCKIPSD	physical	16189514
SF3B4_HUMAN	SF3B4	physical	16189514
WBP11_HUMAN	WBP11	physical	16189514
CPSF6_HUMAN	CPSF6	physical	16189514
FXR2_HUMAN	FXR2	physical	16189514
CPSF7_HUMAN	CPSF7	physical	16189514
EF1G_HUMAN	EEF1G	physical	16169070
EGFR_HUMAN	EGFR	physical	9737977
PGFRB_HUMAN	PDGFRB	physical	9737977
DOK1_HUMAN	DOK1	physical	9737977
DOCK1_HUMAN	DOCK1	physical	11240126
PGFRB_HUMAN	PDGFRB	physical	11027258
CD3E_HUMAN	CD3E	physical	12110186
FAK1_HUMAN	PTK2	physical	11950595
PAK1_HUMAN	PAK1	physical	10026169
PKN2_HUMAN	PKN2	physical	10026169
SOS1_HUMAN	SOS1	physical	10026169
EGFR_HUMAN	EGFR	physical	10026169
PGFRB_HUMAN	PDGFRB	physical	10026169
LIMS1_HUMAN	LIMS1	physical	10022929
ILK_HUMAN	ILK	physical	10022929
LIMS1_HUMAN	LIMS1	physical	9843575
EGFR_HUMAN	EGFR	physical	9843575
PGFRB_MOUSE	Pdgfrb	physical	9843575
IRS1_HUMAN	IRS1	physical	9843575
MASP1_HUMAN	MASP1	physical	21900206
EFNB1_HUMAN	EFNB1	physical	11557983
ERBB2_HUMAN	ERBB2	physical	16273093
ERBB3_HUMAN	ERBB3	physical	16273093
CBL_HUMAN	CBL	physical	24287595
NCK2_HUMAN	NCK2	physical	25416956
SRBS2_HUMAN	SORBS2	physical	25416956
EIF3H_HUMAN	EIF3H	physical	25416956
WASL_HUMAN	WASL	physical	25416956
RHG32_HUMAN	ARHGAP32	physical	25416956
ABI2_HUMAN	ABI2	physical	25416956
SPY2_HUMAN	SPRY2	physical	25416956
SF3B4_HUMAN	SF3B4	physical	25416956
NC2A_HUMAN	DRAP1	physical	25416956
ZBT7B_HUMAN	ZBTB7B	physical	25416956
ABI3_HUMAN	ABI3	physical	25416956
FA53C_HUMAN	FAM53C	physical	25416956
BC11A_HUMAN	BCL11A	physical	25416956
SYVM_HUMAN	VARS2	physical	25416956
HOMEZ_HUMAN	HOMEZ	physical	25416956
RBM26_HUMAN	RBM26	physical	25416956
FCRL2_HUMAN	FCRL2	physical	25416956
VP37B_HUMAN	VPS37B	physical	25416956
CPSF7_HUMAN	CPSF7	physical	25416956
CCD33_HUMAN	CCDC33	physical	25416956
EFHC2_HUMAN	EFHC2	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956
LNX1_HUMAN	LNX1	physical	25416956
TRI41_HUMAN	TRIM41	physical	25416956
PR20E_HUMAN	PRR20A	physical	25416956
PR20C_HUMAN	PRR20A	physical	25416956
PR20D_HUMAN	PRR20A	physical	25416956
PR20B_HUMAN	PRR20A	physical	25416956
PR20A_HUMAN	PRR20A	physical	25416956
LRIQ3_HUMAN	LRRIQ3	physical	25416956
WIPF2_HUMAN	WIPF2	physical	26186194
NCK1_HUMAN	NCK1	physical	26186194
SPD2B_HUMAN	SH3PXD2B	physical	26186194
ARAP1_HUMAN	ARAP1	physical	26186194
NCKP1_HUMAN	NCKAP1	physical	26186194
ABL2_HUMAN	ABL2	physical	26186194
WASL_HUMAN	WASL	physical	26186194
CBLB_HUMAN	CBLB	physical	26186194
CBL_HUMAN	CBL	physical	26186194
GIT2_HUMAN	GIT2	physical	26186194
GIT1_HUMAN	GIT1	physical	26186194
RAPH1_HUMAN	RAPH1	physical	26186194
BAIP2_HUMAN	BAIAP2	physical	26186194
ASAP2_HUMAN	ASAP2	physical	26186194
ASAP1_HUMAN	ASAP1	physical	26186194
CYFP2_HUMAN	CYFIP2	physical	26186194
CYFP1_HUMAN	CYFIP1	physical	26186194
PRC2A_HUMAN	PRRC2A	physical	26186194
ACK1_HUMAN	TNK2	physical	26186194
M4K4_HUMAN	MAP4K4	physical	26186194
MINK1_HUMAN	MINK1	physical	26186194
TNIK_HUMAN	TNIK	physical	26186194
PAK2_HUMAN	PAK2	physical	26186194
PAK1_HUMAN	PAK1	physical	26186194
NHSL1_HUMAN	NHSL1	physical	26186194
CSKI2_HUMAN	CASKIN2	physical	26186194
ABI1_HUMAN	ABI1	physical	26186194
ABI2_HUMAN	ABI2	physical	26186194
PEAK1_HUMAN	PEAK1	physical	26186194
ARHG7_HUMAN	ARHGEF7	physical	26186194
ARHG6_HUMAN	ARHGEF6	physical	26186194
WASF1_HUMAN	WASF1	physical	26186194
WASF2_HUMAN	WASF2	physical	26186194
WASF3_HUMAN	WASF3	physical	26186194
TTC28_HUMAN	TTC28	physical	26186194
BCAP_HUMAN	PIK3AP1	physical	26186194
SHB_HUMAN	SHB	physical	26186194
WIPF1_HUMAN	WIPF1	physical	26186194
K1522_HUMAN	KIAA1522	physical	26186194
DOK1_HUMAN	DOK1	physical	26186194
AFAD_HUMAN	MLLT4	physical	26186194
WIPF3_HUMAN	WIPF3	physical	26186194
LZTR1_HUMAN	LZTR1	physical	26186194
SEM6A_HUMAN	SEMA6A	physical	26186194
FA83H_HUMAN	FAM83H	physical	26186194
BRK1_HUMAN	BRK1	physical	26186194
CBLB_HUMAN	CBLB	physical	21516116
WASL_HUMAN	WASL	physical	28514442
WIPF1_HUMAN	WIPF1	physical	28514442
CSKI2_HUMAN	CASKIN2	physical	28514442
WIPF2_HUMAN	WIPF2	physical	28514442
RAPH1_HUMAN	RAPH1	physical	28514442
BCAP_HUMAN	PIK3AP1	physical	28514442
PAK1_HUMAN	PAK1	physical	28514442
SPD2B_HUMAN	SH3PXD2B	physical	28514442
WIPF3_HUMAN	WIPF3	physical	28514442
TNIK_HUMAN	TNIK	physical	28514442
CBL_HUMAN	CBL	physical	28514442
ASAP2_HUMAN	ASAP2	physical	28514442
MINK1_HUMAN	MINK1	physical	28514442
WASF1_HUMAN	WASF1	physical	28514442
CBLB_HUMAN	CBLB	physical	28514442
ARAP1_HUMAN	ARAP1	physical	28514442
ACK1_HUMAN	TNK2	physical	28514442
GIT1_HUMAN	GIT1	physical	28514442
SHB_HUMAN	SHB	physical	28514442
NCK1_HUMAN	NCK1	physical	28514442
GIT2_HUMAN	GIT2	physical	28514442
NHSL1_HUMAN	NHSL1	physical	28514442
ABL2_HUMAN	ABL2	physical	28514442
ABI1_HUMAN	ABI1	physical	28514442
PAK2_HUMAN	PAK2	physical	28514442
ARHG6_HUMAN	ARHGEF6	physical	28514442
WASF2_HUMAN	WASF2	physical	28514442
AFAD_HUMAN	MLLT4	physical	28514442
ARHG7_HUMAN	ARHGEF7	physical	28514442
SEM6A_HUMAN	SEMA6A	physical	28514442
TTC28_HUMAN	TTC28	physical	28514442
ABI2_HUMAN	ABI2	physical	28514442
NCKP1_HUMAN	NCKAP1	physical	28514442
PRC2A_HUMAN	PRRC2A	physical	28514442
K1522_HUMAN	KIAA1522	physical	28514442
CYFP2_HUMAN	CYFIP2	physical	28514442
WASF3_HUMAN	WASF3	physical	28514442
PEAK1_HUMAN	PEAK1	physical	28514442
BAIP2_HUMAN	BAIAP2	physical	28514442
CYFP1_HUMAN	CYFIP1	physical	28514442
BRK1_HUMAN	BRK1	physical	28514442
LZTR1_HUMAN	LZTR1	physical	28514442
ASAP1_HUMAN	ASAP1	physical	28514442
DOK1_HUMAN	DOK1	physical	28514442
YLPM1_HUMAN	YLPM1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NCK2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-92 AND TYR-110, AND MASSSPECTROMETRY.	18088087 [Abstract]