dbPTM

SKT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SKT_HUMAN
UniProt AC	Q5T5P2
Protein Name	Sickle tail protein homolog
Gene Name	KIAA1217
Organism	Homo sapiens (Human).
Sequence Length	1943
Subcellular Localization	Cytoplasm .
Protein Description	Required for normal development of intervertebral disks..
Protein Sequence	MEENESQKCEPCLPYSADRRQMQEQGKGNLHVTSPEDAECRRTKERLSNGNSRGSVSKSSRNIPRRHTLGGPRSSKEILGMQTSEMDRKREAFLEHLKQKYPHHASAIMGHQERLRDQTRSPKLSHSPQPPSLGDPVEHLSETSADSLEAMSEGDAPTPFSRGSRTRASLPVVRSTNQTKERSLGVLYLQYGDETKQLRMPNEITSADTIRALFVSAFPQQLTMKMLESPSVAIYIKDESRNVYYELNDVRNIQDRSLLKVYNKDPAHAFNHTPKTMNGDMRMQRELVYARGDGPGAPRPGSTAHPPHAIPNSPPSTPVPHSMPPSPSRIPYGGTRSMVVPGNATIPRDRISSLPVSRPISPSPSAILERRDVKPDEDMSGKNIAMYRNEGFYADPYLYHEGRMSIASSHGGHPLDVPDHIIAYHRTAIRSASAYCNPSMQAEMHMEQSLYRQKSRKYPDSHLPTLGSKTPPASPHRVSDLRMIDMHAHYNAHGPPHTMQPDRASPSRQAFKKEPGTLVYIEKPRSAAGLSSLVDLGPPLMEKQVFAYSTATIPKDRETRERMQAMEKQIASLTGLVQSALFKGPITSYSKDASSEKMMKTTANRNHTDSAGTPHVSGGKMLSALESTVPPSQPPPVGTSAIHMSLLEMRRSVAELRLQLQQMRQLQLQNQELLRAMMKKAELEISGKVMETMKRLEDPVQRQRVLVEQERQKYLHEEEKIVKKLCELEDFVEDLKKDSTAASRLVTLKDVEDGAFLLRQVGEAVATLKGEFPTLQNKMRAILRIEVEAVRFLKEEPHKLDSLLKRVRSMTDVLTMLRRHVTDGLLKGTDAAQAAQYMAMEKATAAEVLKSQEEAAHTSGQPFHSTGAPGDAKSEVVPLSGMMVRHAQSSPVVIQPSQHSVALLNPAQNLPHVASSPAVPQEATSTLQMSQAPQSPQIPMNGSAMQSLFIEEIHSVSAKNRAVSIEKAEKKWEEKRQNLDHYNGKEFEKLLEEAQANIMKSIPNLEMPPATGPLPRGDAPVDKVELSEDSPNSEQDLEKLGGKSPPPPPPPPRRSYLPGSGLTTTRSGDVVYTGRKENITAKASSEDAGPSPQTRATKYPAEEPASAWTPSPPPVTTSSSKDEEEEEEEGDKIMAELQAFQKCSFMDVNSNSHAEPSRADSHVKDTRSGATVPPKEKKNLEFFHEDVRKSDVEYENGPQMEFQKVTTGAVRPSDPPKWERGMENSISDASRTSEYKTEIIMKENSISNMSLLRDSRNYSQETVPKASFGFSGISPLEDEINKGSKISGLQYSIPDTENQTLNYGKTKEMEKQNTDKCHVSSHTRLTESSVHDFKTEDQEVITTDFGQVVLRPKEARHANVNPNEDGESSSSSPTEENAATDNIAFMITETTVQVLSSGEVHDIVSQKGEDIQTVNIDARKEMTPRQEGTDNEDPVVCLDKKPVIIIFDEPMDIRSAYKRLSTIFEECDEELERMMMEEKIEEEEEEENGDSVVQNNNTSQMSHKKVAPGNLRTGQQVETKSQPHSLATETRNPGGQEMNRTELNKFSHVDSPNSECKGEDATDDQFESPKKKFKFKFPKKQLAALTQAIRTGTKTGKKTLQVVVYEEEEEDGTLKQHKEAKRFEIARSQPEDTPENTVRRQEQPSIESTSPISRTDEIRKNTYRTLDSLEQTIKQLENTISEMSPKALVDTSCSSNRDSVASSSHIAQEASPRPLLVPDEGPTALEPPTSIPSASRKGSSGAPQTSRMPVPMSAKNRPGTLDKPGKQSKLQDPRQYRQANGSAKKSGGDFKPTSPSLPASKIPALSPSSGKSSSLPSSSGDSSNLPNPPATKPSIASNPLSPQTGPPAHSASLIPSVSNGSLKFQSLTHTGKGHHLSFSPQSQNGRAPPPLSFSSSPPSPASSVSLNQGAKGTRTIHTPSLTSYKAQNGSSSKATPSTAKETS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	CEPCLPYSADRRQMQ CCCCCCCCCCHHHHH	23.04	27251275
33	Phosphorylation	GKGNLHVTSPEDAEC CCCCCCCCCHHHHHH	28.02	24719451
34	Phosphorylation	KGNLHVTSPEDAECR CCCCCCCCHHHHHHH	25.79	28348404
53	Methylation	RLSNGNSRGSVSKSS HHHCCCCCCCCCCCC	45.46	115917041
55	Phosphorylation	SNGNSRGSVSKSSRN HCCCCCCCCCCCCCC	23.31	24719451
57	Phosphorylation	GNSRGSVSKSSRNIP CCCCCCCCCCCCCCC	28.63	-
68	Phosphorylation	RNIPRRHTLGGPRSS CCCCCCCCCCCCCCH	25.86	28857561
74	Phosphorylation	HTLGGPRSSKEILGM CCCCCCCCHHHHHCC	49.23	28857561
75	Phosphorylation	TLGGPRSSKEILGMQ CCCCCCCHHHHHCCC	35.27	28857561
84	Phosphorylation	EILGMQTSEMDRKRE HHHCCCCCHHHHHHH	17.65	25332170
121	Phosphorylation	RLRDQTRSPKLSHSP HHHHCCCCCCCCCCC	29.76	24719451
125	Phosphorylation	QTRSPKLSHSPQPPS CCCCCCCCCCCCCCC	28.22	28857561
127	Phosphorylation	RSPKLSHSPQPPSLG CCCCCCCCCCCCCCC	23.12	28857561
132	Phosphorylation	SHSPQPPSLGDPVEH CCCCCCCCCCCCCHH	52.23	28857561
141	Phosphorylation	GDPVEHLSETSADSL CCCCHHHCCCCHHHH	40.51	28857561
143	Phosphorylation	PVEHLSETSADSLEA CCHHHCCCCHHHHHH	26.32	28857561
144	Phosphorylation	VEHLSETSADSLEAM CHHHCCCCHHHHHHH	26.48	28857561
147	Phosphorylation	LSETSADSLEAMSEG HCCCCHHHHHHHHCC	28.03	28348404
152	Phosphorylation	ADSLEAMSEGDAPTP HHHHHHHHCCCCCCC	45.54	27499020
161	Phosphorylation	GDAPTPFSRGSRTRA CCCCCCCCCCCCCCC	36.61	22468782
166	Phosphorylation	PFSRGSRTRASLPVV CCCCCCCCCCCCCEE	32.08	23927012
169	O-linked_Glycosylation	RGSRTRASLPVVRST CCCCCCCCCCEEECC	29.89	28510447
169	Phosphorylation	RGSRTRASLPVVRST CCCCCCCCCCEEECC	29.89	30278072
183	Phosphorylation	TNQTKERSLGVLYLQ CCCCCCCEEEEEEEE	30.48	23898821
205	Phosphorylation	LRMPNEITSADTIRA CCCCCCCCHHHHHHH	16.22	-
206	Phosphorylation	RMPNEITSADTIRAL CCCCCCCHHHHHHHH	29.79	-
209	Phosphorylation	NEITSADTIRALFVS CCCCHHHHHHHHHHH	16.45	28857561
229	Phosphorylation	LTMKMLESPSVAIYI HHHHHHHCCCEEEEE	20.65	25262027
231	Phosphorylation	MKMLESPSVAIYIKD HHHHHCCCEEEEEEE	33.20	30576142
235	Phosphorylation	ESPSVAIYIKDESRN HCCCEEEEEEECCCC	7.68	25262027
244	Phosphorylation	KDESRNVYYELNDVR EECCCCEEEEECCCC	8.51	20007894
245	Phosphorylation	DESRNVYYELNDVRN ECCCCEEEEECCCCC	15.06	28152594
257	Phosphorylation	VRNIQDRSLLKVYNK CCCCCCHHHHHHHCC	46.47	18212344
260	Ubiquitination	IQDRSLLKVYNKDPA CCCHHHHHHHCCCHH	48.22	-
266 (in isoform 3)	Phosphorylation	-	27.79	25159151
266 (in isoform 4)	Phosphorylation	-	27.79	25159151
266 (in isoform 6)	Phosphorylation	-	27.79	25159151
266 (in isoform 8)	Phosphorylation	-	27.79	25159151
270 (in isoform 3)	Phosphorylation	-	5.03	24719451
270 (in isoform 4)	Phosphorylation	-	5.03	24719451
270 (in isoform 6)	Phosphorylation	-	5.03	24719451
270 (in isoform 8)	Phosphorylation	-	5.03	24719451
273	Phosphorylation	PAHAFNHTPKTMNGD HHHHCCCCCCCCCCC	27.82	25056879
289	Phosphorylation	RMQRELVYARGDGPG HHEEEEEECCCCCCC	11.82	26267517
302	Phosphorylation	PGAPRPGSTAHPPHA CCCCCCCCCCCCCCC	25.71	27251275
303	Phosphorylation	GAPRPGSTAHPPHAI CCCCCCCCCCCCCCC	34.59	27251275
313	Phosphorylation	PPHAIPNSPPSTPVP CCCCCCCCCCCCCCC	32.60	23927012
316	Phosphorylation	AIPNSPPSTPVPHSM CCCCCCCCCCCCCCC	49.04	27251275
317	Phosphorylation	IPNSPPSTPVPHSMP CCCCCCCCCCCCCCC	33.79	23927012
322	Phosphorylation	PSTPVPHSMPPSPSR CCCCCCCCCCCCCCC	27.24	23927012
326	Phosphorylation	VPHSMPPSPSRIPYG CCCCCCCCCCCCCCC	29.63	23927012
328	Phosphorylation	HSMPPSPSRIPYGGT CCCCCCCCCCCCCCC	47.37	27251275
337	Phosphorylation	IPYGGTRSMVVPGNA CCCCCCCCEEECCCC	18.77	18212344
345	Phosphorylation	MVVPGNATIPRDRIS EEECCCCCCCHHHHC	35.20	28857561
352	Phosphorylation	TIPRDRISSLPVSRP CCCHHHHCCCCCCCC	27.07	30266825
353	Phosphorylation	IPRDRISSLPVSRPI CCHHHHCCCCCCCCC	34.03	30266825
357	O-linked_Glycosylation	RISSLPVSRPISPSP HHCCCCCCCCCCCCH	30.33	28510447
357	Phosphorylation	RISSLPVSRPISPSP HHCCCCCCCCCCCCH	30.33	30266825
361	Phosphorylation	LPVSRPISPSPSAIL CCCCCCCCCCHHHHH	23.23	19664994
363	Phosphorylation	VSRPISPSPSAILER CCCCCCCCHHHHHHH	25.38	30266825
365	Phosphorylation	RPISPSPSAILERRD CCCCCCHHHHHHHCC	32.07	30266825
380	Phosphorylation	VKPDEDMSGKNIAMY CCCCCCCCCCEEEEC	59.96	24719451
387	Phosphorylation	SGKNIAMYRNEGFYA CCCEEEECCCCCCCC	10.98	27259358
393	Phosphorylation	MYRNEGFYADPYLYH ECCCCCCCCCCCEEE	22.43	21945579
397	Phosphorylation	EGFYADPYLYHEGRM CCCCCCCCEEECCCC	22.05	21945579
399	Phosphorylation	FYADPYLYHEGRMSI CCCCCCEEECCCCCC	7.62	21945579
405	Phosphorylation	LYHEGRMSIASSHGG EEECCCCCCCCCCCC	17.40	28857561
408	Phosphorylation	EGRMSIASSHGGHPL CCCCCCCCCCCCCCC	22.61	28857561
409	Phosphorylation	GRMSIASSHGGHPLD CCCCCCCCCCCCCCC	19.68	28348404
424	Phosphorylation	VPDHIIAYHRTAIRS CCHHHHHHHHHHHHH	4.96	27259358
431	Phosphorylation	YHRTAIRSASAYCNP HHHHHHHHHHHHCCH	22.06	28857561
433	Phosphorylation	RTAIRSASAYCNPSM HHHHHHHHHHCCHHH	22.48	28857561
435	Phosphorylation	AIRSASAYCNPSMQA HHHHHHHHCCHHHHH	7.11	27259358
455	Phosphorylation	QSLYRQKSRKYPDSH HHHHHHHHCCCCCCC	26.18	24719451
458	Phosphorylation	YRQKSRKYPDSHLPT HHHHHCCCCCCCCCC	15.91	23927012
461	Phosphorylation	KSRKYPDSHLPTLGS HHCCCCCCCCCCCCC	23.55	23927012
465	Phosphorylation	YPDSHLPTLGSKTPP CCCCCCCCCCCCCCC	50.54	25394399
468	Phosphorylation	SHLPTLGSKTPPASP CCCCCCCCCCCCCCC	36.15	22496350
470	Phosphorylation	LPTLGSKTPPASPHR CCCCCCCCCCCCCCC	35.88	23927012
474	Phosphorylation	GSKTPPASPHRVSDL CCCCCCCCCCCCCCC	27.32	23927012
479	Phosphorylation	PASPHRVSDLRMIDM CCCCCCCCCCEEEEC	30.77	26437602
490	Phosphorylation	MIDMHAHYNAHGPPH EEECHHHCCCCCCCC	18.15	20068231
498	Phosphorylation	NAHGPPHTMQPDRAS CCCCCCCCCCCCCCC	24.23	24719451
505	Phosphorylation	TMQPDRASPSRQAFK CCCCCCCCCCHHHHH	25.05	20068231
507	Phosphorylation	QPDRASPSRQAFKKE CCCCCCCCHHHHHCC	34.23	20068231
517	Phosphorylation	AFKKEPGTLVYIEKP HHHCCCCEEEEECCC	24.62	28857561
520	Phosphorylation	KEPGTLVYIEKPRSA CCCCEEEEECCCCCC	13.38	25106551
526	Phosphorylation	VYIEKPRSAAGLSSL EEECCCCCCCCHHHH	30.88	26657352
531	Phosphorylation	PRSAAGLSSLVDLGP CCCCCCHHHHHHCCC	22.25	28857561
532	Phosphorylation	RSAAGLSSLVDLGPP CCCCCHHHHHHCCCC	37.14	26657352
548	Phosphorylation	MEKQVFAYSTATIPK CCEEEEEEECCCCCC	8.62	21945579
548 (in isoform 10)	Phosphorylation	-	8.62	25159151
548 (in isoform 7)	Phosphorylation	-	8.62	25159151
549	Phosphorylation	EKQVFAYSTATIPKD CEEEEEEECCCCCCC	14.24	21945579
550	Phosphorylation	KQVFAYSTATIPKDR EEEEEEECCCCCCCH	18.36	21945579
552	Phosphorylation	VFAYSTATIPKDRET EEEEECCCCCCCHHH	37.59	21945579
552 (in isoform 10)	Phosphorylation	-	37.59	24719451
552 (in isoform 7)	Phosphorylation	-	37.59	24719451
568	Acetylation	ERMQAMEKQIASLTG HHHHHHHHHHHHHHH	33.64	7380013
572	Phosphorylation	AMEKQIASLTGLVQS HHHHHHHHHHHHHHH	28.26	27251275
574	Phosphorylation	EKQIASLTGLVQSAL HHHHHHHHHHHHHHH	26.44	27251275
583	Methylation	LVQSALFKGPITSYS HHHHHHHHCCCCCCC	65.71	115981147
588	Phosphorylation	LFKGPITSYSKDASS HHHCCCCCCCCCCCC	28.29	24275569
601	Phosphorylation	SSEKMMKTTANRNHT CCHHHHHHHCCCCCC	17.16	22210691
602	Phosphorylation	SEKMMKTTANRNHTD CHHHHHHHCCCCCCC	19.20	22210691
608	Phosphorylation	TTANRNHTDSAGTPH HHCCCCCCCCCCCCC	34.89	22210691
610	Phosphorylation	ANRNHTDSAGTPHVS CCCCCCCCCCCCCCC	29.74	22210691
613	Phosphorylation	NHTDSAGTPHVSGGK CCCCCCCCCCCCCCC	15.22	22210691
627	Phosphorylation	KMLSALESTVPPSQP CCHHHHHCCCCCCCC	35.24	22210691
628	Phosphorylation	MLSALESTVPPSQPP CHHHHHCCCCCCCCC	27.88	22210691
639	Phosphorylation	SQPPPVGTSAIHMSL CCCCCCCCCHHHHHH	18.41	22210691
640	Phosphorylation	QPPPVGTSAIHMSLL CCCCCCCCHHHHHHH	21.21	22210691
652	Phosphorylation	SLLEMRRSVAELRLQ HHHHHHHHHHHHHHH	18.47	24702127
724	Ubiquitination	EEEKIVKKLCELEDF HHHHHHHHHHHHHHH	47.69	-
743	O-linked_Glycosylation	KKDSTAASRLVTLKD HCCCCCHHHCEEHHH	24.55	28510447
794	Malonylation	VEAVRFLKEEPHKLD HHHHHHHHHCCCHHH	58.27	32601280
802	Phosphorylation	EEPHKLDSLLKRVRS HCCCHHHHHHHHHHH	46.14	24719451
809	Phosphorylation	SLLKRVRSMTDVLTM HHHHHHHHHHHHHHH	24.15	26657352
815	Phosphorylation	RSMTDVLTMLRRHVT HHHHHHHHHHHHHHC	17.63	-
823 (in isoform 4)	Phosphorylation	-	44.66	24043423
824 (in isoform 4)	Phosphorylation	-	24.44	24043423
829 (in isoform 4)	Phosphorylation	-	22.37	24043423
830 (in isoform 4)	Phosphorylation	-	48.88	24043423
837	Phosphorylation	DAAQAAQYMAMEKAT HHHHHHHHHHHHHHH	5.11	21945579
837 (in isoform 4)	Phosphorylation	-	5.11	24043423
865	Phosphorylation	TSGQPFHSTGAPGDA HCCCCCCCCCCCCCC	28.99	-
880	O-linked_Glycosylation	KSEVVPLSGMMVRHA CCCEEECCCCEEECC	20.69	28510447
964	Phosphorylation	SAKNRAVSIEKAEKK CCCCCCCCHHHHHHH	24.85	18669648
970	Ubiquitination	VSIEKAEKKWEEKRQ CCHHHHHHHHHHHHH	68.96	-
982	Phosphorylation	KRQNLDHYNGKEFEK HHHCCCCCCHHHHHH	25.85	-
992 (in isoform 10)	Phosphorylation	-	62.82	23927012
994 (in isoform 10)	Phosphorylation	-	12.38	25159151
1001	Phosphorylation	AQANIMKSIPNLEMP HHHHHHHHCCCCCCC	26.37	28857561
1027	Phosphorylation	PVDKVELSEDSPNSE CCCEEECCCCCCCCH	26.33	26657352
1030	Phosphorylation	KVELSEDSPNSEQDL EEECCCCCCCCHHHH	23.17	30266825
1033	Phosphorylation	LSEDSPNSEQDLEKL CCCCCCCCHHHHHHC	39.76	26657352
1044	Phosphorylation	LEKLGGKSPPPPPPP HHHCCCCCCCCCCCC	46.01	30266825
1055	Phosphorylation	PPPPPRRSYLPGSGL CCCCCCCCCCCCCCC	32.09	28555341
1056	Phosphorylation	PPPPRRSYLPGSGLT CCCCCCCCCCCCCCC	18.33	28555341
1060	Phosphorylation	RRSYLPGSGLTTTRS CCCCCCCCCCCCCCC	28.79	24719451
1060 (in isoform 9)	Phosphorylation	-	28.79	24043423
1061 (in isoform 9)	Phosphorylation	-	32.72	24043423
1063	Phosphorylation	YLPGSGLTTTRSGDV CCCCCCCCCCCCCCE	29.64	28857561
1066 (in isoform 9)	Phosphorylation	-	36.23	24043423
1067	Phosphorylation	SGLTTTRSGDVVYTG CCCCCCCCCCEEEEC	36.93	28348404
1067 (in isoform 9)	Phosphorylation	-	36.93	24043423
1072	Phosphorylation	TRSGDVVYTGRKENI CCCCCEEEECCCCCE	11.88	22817900
1073	Phosphorylation	RSGDVVYTGRKENIT CCCCEEEECCCCCEE	20.92	-
1074 (in isoform 9)	Phosphorylation	-	22.45	24043423
1080	Phosphorylation	TGRKENITAKASSED ECCCCCEEEECCCCC	33.42	28857561
1082	Methylation	RKENITAKASSEDAG CCCCEEEECCCCCCC	39.90	116252865
1084	Phosphorylation	ENITAKASSEDAGPS CCEEEECCCCCCCCC	33.29	24670416
1085	Phosphorylation	NITAKASSEDAGPSP CEEEECCCCCCCCCC	44.34	29496963
1091	Phosphorylation	SSEDAGPSPQTRATK CCCCCCCCCCCCCCC	28.81	25159151
1094	Phosphorylation	DAGPSPQTRATKYPA CCCCCCCCCCCCCCC	26.17	27251275
1097	Phosphorylation	PSPQTRATKYPAEEP CCCCCCCCCCCCCCC	28.02	30631047
1099	Phosphorylation	PQTRATKYPAEEPAS CCCCCCCCCCCCCCC	11.88	23090842
1106	Phosphorylation	YPAEEPASAWTPSPP CCCCCCCCCCCCCCC	34.75	27251275
1109	Phosphorylation	EEPASAWTPSPPPVT CCCCCCCCCCCCCCC	17.38	25159151
1111	Phosphorylation	PASAWTPSPPPVTTS CCCCCCCCCCCCCCC	42.54	28355574
1116	Phosphorylation	TPSPPPVTTSSSKDE CCCCCCCCCCCCCCH	27.08	21955146
1117	Phosphorylation	PSPPPVTTSSSKDEE CCCCCCCCCCCCCHH	27.18	21955146
1118	Phosphorylation	SPPPVTTSSSKDEEE CCCCCCCCCCCCHHH	24.21	21955146
1119	Phosphorylation	PPPVTTSSSKDEEEE CCCCCCCCCCCHHHH	39.04	27251275
1120	Phosphorylation	PPVTTSSSKDEEEEE CCCCCCCCCCHHHHH	43.84	23090842
1140 (in isoform 2)	Phosphorylation	-	4.62	24043423
1141 (in isoform 2)	Phosphorylation	-	49.19	24043423
1144	Phosphorylation	LQAFQKCSFMDVNSN HHHHHHCCCCCCCCC	30.55	27251275
1146 (in isoform 2)	Phosphorylation	-	3.02	24043423
1147 (in isoform 2)	Phosphorylation	-	34.14	24043423
1154 (in isoform 2)	Phosphorylation	-	30.16	24043423
1175	Ubiquitination	SGATVPPKEKKNLEF CCCCCCCHHHCCHHH	75.89	-
1177	Ubiquitination	ATVPPKEKKNLEFFH CCCCCHHHCCHHHCC	53.76	-
1194	Phosphorylation	VRKSDVEYENGPQME HHHHHCCCCCCCCCE	17.97	25394399
1204	Acetylation	GPQMEFQKVTTGAVR CCCCEEEEECCCCCC	47.04	30589701
1213	Phosphorylation	TTGAVRPSDPPKWER CCCCCCCCCCCHHHH	52.78	28555341
1225	Phosphorylation	WERGMENSISDASRT HHHHCCCCCCCHHCC	15.34	28857561
1235	Phosphorylation	DASRTSEYKTEIIMK CHHCCCCHHHHEEEC	23.99	22817900
1237	Phosphorylation	SRTSEYKTEIIMKEN HCCCCHHHHEEECCC	31.36	-
1245	Phosphorylation	EIIMKENSISNMSLL HEEECCCCCCCHHHH	28.60	28857561
1247	Phosphorylation	IMKENSISNMSLLRD EECCCCCCCHHHHHC	26.71	23312004
1250	Phosphorylation	ENSISNMSLLRDSRN CCCCCCHHHHHCCCC	28.62	28857561
1255	Phosphorylation	NMSLLRDSRNYSQET CHHHHHCCCCCCCCC	18.91	29083192
1258	Phosphorylation	LLRDSRNYSQETVPK HHHCCCCCCCCCCCC	15.60	29083192
1259	Phosphorylation	LRDSRNYSQETVPKA HHCCCCCCCCCCCCC	25.70	28857561
1262	Phosphorylation	SRNYSQETVPKASFG CCCCCCCCCCCCCCC	34.18	24719451
1271	Phosphorylation	PKASFGFSGISPLED CCCCCCCCCCCCCHH	35.28	28102081
1274	Phosphorylation	SFGFSGISPLEDEIN CCCCCCCCCCHHHHC	27.27	30087585
1284	Phosphorylation	EDEINKGSKISGLQY HHHHCCCCCCCCCCE	28.55	-
1287	Phosphorylation	INKGSKISGLQYSIP HCCCCCCCCCCEECC	36.87	21945579
1291	Phosphorylation	SKISGLQYSIPDTEN CCCCCCCEECCCCCC	17.38	21945579
1292	Phosphorylation	KISGLQYSIPDTENQ CCCCCCEECCCCCCC	18.06	21945579
1296	Phosphorylation	LQYSIPDTENQTLNY CCEECCCCCCCEECC	31.33	28634120
1300	Phosphorylation	IPDTENQTLNYGKTK CCCCCCCEECCCCCH	28.66	28634120
1303	Phosphorylation	TENQTLNYGKTKEME CCCCEECCCCCHHHH	24.10	28634120
1328	Phosphorylation	SHTRLTESSVHDFKT CCCCCCCCCCCCCCC	32.21	23312004
1329	Phosphorylation	HTRLTESSVHDFKTE CCCCCCCCCCCCCCC	19.76	23312004
1368	Phosphorylation	NPNEDGESSSSSPTE CCCCCCCCCCCCCCH	40.84	28348404
1369	Phosphorylation	PNEDGESSSSSPTEE CCCCCCCCCCCCCHH	29.91	28348404
1370	Phosphorylation	NEDGESSSSSPTEEN CCCCCCCCCCCCHHH	44.08	27251275
1371	Phosphorylation	EDGESSSSSPTEENA CCCCCCCCCCCHHHC	42.14	27251275
1372	Phosphorylation	DGESSSSSPTEENAA CCCCCCCCCCHHHCC	37.48	28348404
1374	Phosphorylation	ESSSSSPTEENAATD CCCCCCCCHHHCCCC	58.86	27251275
1380	Phosphorylation	PTEENAATDNIAFMI CCHHHCCCCCEEEEE	27.45	28348404
1423	Phosphorylation	IDARKEMTPRQEGTD CCCCCCCCCCCCCCC	19.19	20068231
1461	Phosphorylation	RSAYKRLSTIFEECD HHHHHHHHHHHHHHH	24.40	30266825
1462	Phosphorylation	SAYKRLSTIFEECDE HHHHHHHHHHHHHHH	33.99	30266825
1541	Phosphorylation	GGQEMNRTELNKFSH CCCCCCHHHHHHCCC	39.56	18767875
1547	Phosphorylation	RTELNKFSHVDSPNS HHHHHHCCCCCCCCC	24.98	23927012
1551	Phosphorylation	NKFSHVDSPNSECKG HHCCCCCCCCCCCCC	25.54	25159151
1554	Phosphorylation	SHVDSPNSECKGEDA CCCCCCCCCCCCCCC	47.99	23927012
1562	Phosphorylation	ECKGEDATDDQFESP CCCCCCCCCCCCCCC	53.05	29496963
1568	Phosphorylation	ATDDQFESPKKKFKF CCCCCCCCCCHHCCC	43.22	28355574
1580	Acetylation	FKFKFPKKQLAALTQ CCCCCCHHHHHHHHH	51.27	25825284
1591	Phosphorylation	ALTQAIRTGTKTGKK HHHHHHHHCCCCCCE	42.99	-
1605	Phosphorylation	KTLQVVVYEEEEEDG EEEEEEEEEECCCCC	13.15	27642862
1628	Phosphorylation	KRFEIARSQPEDTPE HHHHHHHCCCCCCCC	40.85	27251275
1633	Phosphorylation	ARSQPEDTPENTVRR HHCCCCCCCCHHCCC	30.73	26462736
1645	Phosphorylation	VRRQEQPSIESTSPI CCCCCCCCCCCCCCC	38.39	23663014
1648	Phosphorylation	QEQPSIESTSPISRT CCCCCCCCCCCCCCC	32.30	23927012
1649	Phosphorylation	EQPSIESTSPISRTD CCCCCCCCCCCCCCH	26.23	30266825
1650	Phosphorylation	QPSIESTSPISRTDE CCCCCCCCCCCCCHH	29.52	30266825
1653	Phosphorylation	IESTSPISRTDEIRK CCCCCCCCCCHHHHH	32.29	23663014
1655	Phosphorylation	STSPISRTDEIRKNT CCCCCCCCHHHHHHH	31.06	30576142
1663	Phosphorylation	DEIRKNTYRTLDSLE HHHHHHHHHHHHHHH	15.82	22817900
1668	Phosphorylation	NTYRTLDSLEQTIKQ HHHHHHHHHHHHHHH	36.60	28857561
1679	Phosphorylation	TIKQLENTISEMSPK HHHHHHHHHHHCCHH	19.26	25627689
1681	Phosphorylation	KQLENTISEMSPKAL HHHHHHHHHCCHHHH	25.80	25106551
1684	Phosphorylation	ENTISEMSPKALVDT HHHHHHCCHHHHHCC	21.14	28355574
1699	Phosphorylation	SCSSNRDSVASSSHI CCCCCCHHCCCCHHH	19.15	23312004
1702	Phosphorylation	SNRDSVASSSHIAQE CCCHHCCCCHHHHHH	30.16	23312004
1703	Phosphorylation	NRDSVASSSHIAQEA CCHHCCCCHHHHHHC	19.05	23312004
1704	Phosphorylation	RDSVASSSHIAQEAS CHHCCCCHHHHHHCC	19.20	23312004
1711	Phosphorylation	SHIAQEASPRPLLVP HHHHHHCCCCCCCCC	22.23	25159151
1739	Phosphorylation	PSASRKGSSGAPQTS CCCCCCCCCCCCCCC	28.74	28857561
1740	Phosphorylation	SASRKGSSGAPQTSR CCCCCCCCCCCCCCC	47.87	30576142
1745	Phosphorylation	GSSGAPQTSRMPVPM CCCCCCCCCCCCCCC	19.76	28102081
1753	Phosphorylation	SRMPVPMSAKNRPGT CCCCCCCCCCCCCCC	29.98	28857561
1760	Phosphorylation	SAKNRPGTLDKPGKQ CCCCCCCCCCCCCCC	34.17	26437602
1776	Phosphorylation	KLQDPRQYRQANGSA CCCCHHHHHHHCCCC	13.13	19413330
1782	Phosphorylation	QYRQANGSAKKSGGD HHHHHCCCCCCCCCC	36.40	19413330
1786	Phosphorylation	ANGSAKKSGGDFKPT HCCCCCCCCCCCCCC	47.50	23403867
1793	Phosphorylation	SGGDFKPTSPSLPAS CCCCCCCCCCCCCHH	54.59	23927012
1794	Phosphorylation	GGDFKPTSPSLPASK CCCCCCCCCCCCHHH	22.48	23927012
1796	Phosphorylation	DFKPTSPSLPASKIP CCCCCCCCCCHHHCC	46.91	23927012
1800	Phosphorylation	TSPSLPASKIPALSP CCCCCCHHHCCCCCC	29.22	23403867
1806	Phosphorylation	ASKIPALSPSSGKSS HHHCCCCCCCCCCCC	25.49	30266825
1808	Phosphorylation	KIPALSPSSGKSSSL HCCCCCCCCCCCCCC	48.63	30266825
1809	Phosphorylation	IPALSPSSGKSSSLP CCCCCCCCCCCCCCC	54.33	30266825
1841	Phosphorylation	SIASNPLSPQTGPPA CHHCCCCCCCCCCCC	19.07	25159151
1866	Phosphorylation	NGSLKFQSLTHTGKG CCCEEEEEEEECCCC	38.07	22985185
1868	Phosphorylation	SLKFQSLTHTGKGHH CEEEEEEEECCCCCC	23.73	23312004
1872	Methylation	QSLTHTGKGHHLSFS EEEEECCCCCCEEEC	57.11	115981131
1877	Phosphorylation	TGKGHHLSFSPQSQN CCCCCCEEECCCCCC	21.22	20068231
1879	Phosphorylation	KGHHLSFSPQSQNGR CCCCEEECCCCCCCC	20.75	20068231
1882	Phosphorylation	HLSFSPQSQNGRAPP CEEECCCCCCCCCCC	29.06	20068231
1892	Phosphorylation	GRAPPPLSFSSSPPS CCCCCCCCCCCCCCC	28.93	22199227
1894	Phosphorylation	APPPLSFSSSPPSPA CCCCCCCCCCCCCCC	26.91	22199227
1895	Phosphorylation	PPPLSFSSSPPSPAS CCCCCCCCCCCCCCC	44.87	22199227
1896	Phosphorylation	PPLSFSSSPPSPASS CCCCCCCCCCCCCCC	39.36	26462736
1899	Phosphorylation	SFSSSPPSPASSVSL CCCCCCCCCCCCCCC	36.16	25159151
1902	Phosphorylation	SSPPSPASSVSLNQG CCCCCCCCCCCCCCC	34.36	22199227
1903	Phosphorylation	SPPSPASSVSLNQGA CCCCCCCCCCCCCCC	20.17	27251275
1905	Phosphorylation	PSPASSVSLNQGAKG CCCCCCCCCCCCCCC	24.45	27251275
1915	Phosphorylation	QGAKGTRTIHTPSLT CCCCCEEEEECCCCC	19.56	29438985
1918	Phosphorylation	KGTRTIHTPSLTSYK CCEEEEECCCCCCEE	15.66	29438985
1920	Phosphorylation	TRTIHTPSLTSYKAQ EEEEECCCCCCEECC	45.49	28857561
1922	Phosphorylation	TIHTPSLTSYKAQNG EEECCCCCCEECCCC	34.06	28857561
1923	Phosphorylation	IHTPSLTSYKAQNGS EECCCCCCEECCCCC	29.90	28857561
1924	Phosphorylation	HTPSLTSYKAQNGSS ECCCCCCEECCCCCC	12.71	29438985
1925	Methylation	TPSLTSYKAQNGSSS CCCCCCEECCCCCCC	43.17	115981139
1930	Phosphorylation	SYKAQNGSSSKATPS CEECCCCCCCCCCCC	38.70	18669648
1938	Phosphorylation	SSKATPSTAKETS-- CCCCCCCCCCCCC--	42.84	28787133

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SKT_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SKT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SKT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EXOS5_HUMAN	EXOSC5	physical	16189514
GCC1_HUMAN	GCC1	physical	16189514
HNRLL_HUMAN	HNRNPLL	physical	26344197
SYNC_HUMAN	NARS	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SKT_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1044, AND MASSSPECTROMETRY.	18669648 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-244; TYR-393 ANDTYR-837, AND MASS SPECTROMETRY.	19534553 [Abstract]
"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks."; Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.; Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-244 AND TYR-393, ANDMASS SPECTROMETRY.	17389395 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-244, AND MASSSPECTROMETRY.	18083107 [Abstract]
"Time-resolved mass spectrometry of tyrosine phosphorylation sites inthe epidermal growth factor receptor signaling network reveals dynamicmodules."; Zhang Y., Wolf-Yadlin A., Ross P.L., Pappin D.J., Rush J.,Lauffenburger D.A., White F.M.; Mol. Cell. Proteomics 4:1240-1250(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-393, AND MASSSPECTROMETRY.	15951569 [Abstract]