GCC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GCC1_HUMAN
• UniProt AC: Q96CN9
• Protein Name: GRIP and coiled-coil domain-containing protein 1
• Gene Name: GCC1
• Organism: Homo sapiens (Human).
• Sequence Length: 775
• Subcellular Localization: Cytoplasm . Golgi apparatus membrane; Peripheral membrane protein.
• Protein Description: Probably involved in maintaining Golgi structure..
• Protein Sequence: MEKFGMNFGGGPSKKDLLETIETQKKQLLQYQARLKDVVRAYKSLLKEKEALEASIKVLSVSHEADVGLAGVQLPGLTFPDSVDDRCSTHSEDSTGTATSLDTAASLTSTKGEFGVEDDRPARGPPPPKSEEASWSESGVSSSSGDGPFAGGEVDKRLHQLKTQLATLTSSLATVTQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHDRAQEQSDHALMLRELQKLLQEERTQRQDLELRLEETREALAGRAYAAEQMEGFELQTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAEDQLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLALAASSRSPLDSHGEESSLDVNVLKDKMEKLKRLLQVAARKSQVTLDVEKLCDLEIMPSSEAADGEKATALYYQQELKQLKEEFERYKMRAQVVLKSKNTKDGNLGKELEAAQEQLAELKEKYISLRLSCEELEHQHQQEADDWKQELARLQQLHRQELERCQLDFRDRTLKLEEELHKQRDRALAVLTEKDLELEQLRSVALASGLPGRRSPVGGGGPGDPADTSSSDSLTQALQLAAANEPTFFLYAEQLARKEVEITSLRKQKHRLEVEVHQLQDRLLEEGERHREEVAALQSHIEKNIRDQSREGANLEYLKNIIYRFLTLPDSLGRQQTLTAILTILHFSPEEKQVIMRLPTSASWWPSGKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	DVVRAYKSLLKEKEA HHHHHHHHHHHHHHH	26.68	24719451
88	Phosphorylation	DSVDDRCSTHSEDST CCCCCCCCCCCCCCC	30.01	29449344
89	Phosphorylation	SVDDRCSTHSEDSTG CCCCCCCCCCCCCCC	32.80	29449344
91	Phosphorylation	DDRCSTHSEDSTGTA CCCCCCCCCCCCCCC	43.09	28450419
94	Phosphorylation	CSTHSEDSTGTATSL CCCCCCCCCCCCCHH	25.37	28450419
95	Phosphorylation	STHSEDSTGTATSLD CCCCCCCCCCCCHHH	51.37	28450419
97	Phosphorylation	HSEDSTGTATSLDTA CCCCCCCCCCHHHHH	27.18	28450419
99	Phosphorylation	EDSTGTATSLDTAAS CCCCCCCCHHHHHHH	29.66	28450419
100	Phosphorylation	DSTGTATSLDTAASL CCCCCCCHHHHHHHC	23.06	28450419
134	Phosphorylation	PPKSEEASWSESGVS CCCCCCCCCCCCCCC	34.12	22210691
136	Phosphorylation	KSEEASWSESGVSSS CCCCCCCCCCCCCCC	21.27	22210691
138	Phosphorylation	EEASWSESGVSSSSG CCCCCCCCCCCCCCC	38.69	27251275
141	Phosphorylation	SWSESGVSSSSGDGP CCCCCCCCCCCCCCC	28.20	27251275
142	Phosphorylation	WSESGVSSSSGDGPF CCCCCCCCCCCCCCC	26.56	27251275
143	Phosphorylation	SESGVSSSSGDGPFA CCCCCCCCCCCCCCC	30.73	27251275
144	Phosphorylation	ESGVSSSSGDGPFAG CCCCCCCCCCCCCCC	42.74	27251275
163	Phosphorylation	KRLHQLKTQLATLTS HHHHHHHHHHHHHHH	37.09	-
167	Phosphorylation	QLKTQLATLTSSLAT HHHHHHHHHHHHHHH	38.88	-
216	Ubiquitination	ARLEGELKGLQEQIA HHHHHHHHHHHHHHH	53.96	-
226	Ubiquitination	QEQIAETKARLITQQ HHHHHHHHHHHHHHH	24.02	-
246	Sulfoxidation	EQSDHALMLRELQKL HHHHHHHHHHHHHHH	3.26	21406390
252	Ubiquitination	LMLRELQKLLQEERT HHHHHHHHHHHHHHH	64.88	-
356	Phosphorylation	EDQLRQQSQVEEQRV HHHHHHHHHHHHHHH	28.05	25332170
374	Phosphorylation	ENQISEVSELLGTYE HHHHHHHHHHHCHHH	20.62	25332170
380	Phosphorylation	VSELLGTYEKAKQKD HHHHHCHHHHHHHHH	17.40	25332170
382	Ubiquitination	ELLGTYEKAKQKDQL HHHCHHHHHHHHHHH	50.93	-
407	Phosphorylation	QLDLENKTLALAASS HCCCCCCHHHHHHHC	28.92	27251275
413	Phosphorylation	KTLALAASSRSPLDS CHHHHHHHCCCCCCC	22.22	29978859
414	Phosphorylation	TLALAASSRSPLDSH HHHHHHHCCCCCCCC	31.86	29978859
416	Phosphorylation	ALAASSRSPLDSHGE HHHHHCCCCCCCCCC	31.59	25849741
420	Phosphorylation	SSRSPLDSHGEESSL HCCCCCCCCCCCCCC	40.86	29978859
425	Phosphorylation	LDSHGEESSLDVNVL CCCCCCCCCCCHHHH	31.72	29978859
426	Phosphorylation	DSHGEESSLDVNVLK CCCCCCCCCCHHHHH	31.69	29978859
449	Acetylation	LLQVAARKSQVTLDV HHHHHHHHCCCEECH	40.28	24884233
450	Phosphorylation	LQVAARKSQVTLDVE HHHHHHHCCCEECHH	25.08	23312004
453	Phosphorylation	AARKSQVTLDVEKLC HHHHCCCEECHHHHC	15.03	23312004
504	Ubiquitination	MRAQVVLKSKNTKDG HHHHHEEECCCCCCC	48.01	-
578	Phosphorylation	QLDFRDRTLKLEEEL CCHHHHCHHHHHHHH	32.31	-
597	Phosphorylation	DRALAVLTEKDLELE HHHHHHHCHHHHCHH	34.10	20068231
599	Ubiquitination	ALAVLTEKDLELEQL HHHHHCHHHHCHHHH	63.48	-
608	Phosphorylation	LELEQLRSVALASGL HCHHHHHHHHHHCCC	21.97	26074081
613	Phosphorylation	LRSVALASGLPGRRS HHHHHHHCCCCCCCC	41.53	26074081
620	Phosphorylation	SGLPGRRSPVGGGGP CCCCCCCCCCCCCCC	23.68	25159151
633	Phosphorylation	GPGDPADTSSSDSLT CCCCCCCCCCCHHHH	32.39	23663014
634	Phosphorylation	PGDPADTSSSDSLTQ CCCCCCCCCCHHHHH	28.52	23663014
635	Phosphorylation	GDPADTSSSDSLTQA CCCCCCCCCHHHHHH	40.01	23663014
636	Phosphorylation	DPADTSSSDSLTQAL CCCCCCCCHHHHHHH	30.87	23663014
638	Phosphorylation	ADTSSSDSLTQALQL CCCCCCHHHHHHHHH	34.95	23663014
640	Phosphorylation	TSSSDSLTQALQLAA CCCCHHHHHHHHHHH	18.75	23663014
652	Phosphorylation	LAAANEPTFFLYAEQ HHHHCCCCCHHHHHH	22.35	20068231
656	Phosphorylation	NEPTFFLYAEQLARK CCCCCHHHHHHHHHC	11.70	20068231
668	Phosphorylation	ARKEVEITSLRKQKH HHCCCCHHHHHHHHH	14.27	22210691
669	Phosphorylation	RKEVEITSLRKQKHR HCCCCHHHHHHHHHH	31.66	22210691
714	Phosphorylation	EKNIRDQSREGANLE HHHHHHCCCCCCCHH	36.27	29083192
722	Phosphorylation	REGANLEYLKNIIYR CCCCCHHHHHHHHHH	26.58	21406692
732	Phosphorylation	NIIYRFLTLPDSLGR HHHHHHHCCCHHCCC	33.27	-
766	Phosphorylation	VIMRLPTSASWWPSG EEEECCCCCCCCCCC	20.54	-
768	Phosphorylation	MRLPTSASWWPSGKR EECCCCCCCCCCCCC	29.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GCC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GCC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GCC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
USBP1_HUMAN	USHBP1	physical	16189514
FBF1_HUMAN	FBF1	physical	16189514
CPSF7_HUMAN	CPSF7	physical	16189514
A4_HUMAN	APP	physical	21832049
MTDC_HUMAN	MTHFD2	physical	22939629
SMRD1_HUMAN	SMARCD1	physical	21988832
NEMO_HUMAN	IKBKG	physical	21988832
CEP70_HUMAN	CEP70	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956
CA094_HUMAN	C1orf94	physical	25416956
NAV1_HUMAN	NAV1	physical	25416956
ZN276_HUMAN	ZNF276	physical	25416956
BRCA1_HUMAN	BRCA1	physical	25184681
SPOP_HUMAN	SPOP	physical	21516116
CA094_HUMAN	C1orf94	physical	21516116
ZN276_HUMAN	ZNF276	physical	21516116
CEP57_HUMAN	CEP57	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.