NAV1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NAV1_HUMAN
• UniProt AC: Q8NEY1
• Protein Name: Neuron navigator 1
• Gene Name: NAV1
• Organism: Homo sapiens (Human).
• Sequence Length: 1877
• Subcellular Localization: Cytoplasm, cytoskeleton. Associates with a subset of microtubule plus ends. Enriched in neuronal growth cones (By similarity)..
• Protein Description: May be involved in neuronal migration..
• Protein Sequence: MLGSSVKSVQPEVELSSGGGDEGADEPRGAGRKAAAADGRGMLPKRAKAPGGGGGMAKASAAELKVFKSGSVDSRVPGGPPASNLRKQKSLTNLSFLTDSEKKLQLYEPEWSDDMAKAPKGLGKVGSKGREAPLMSKTLSKSEHSLFQAKGSPAGGAKTPLAPLAPNLGKPSRIPRGPYAEVKPLSKAPEAAVSEDGKSDDELLSSKAKAQKSSGPVPSAKGQEERAFLKVDPELVVTVLGDLEQLLFSQMLDPESQRKRTVQNVLDLRQNLEETMSSLRGSQVTHSSLEMTCYDSDDANPRSVSSLSNRSSPLSWRYGQSSPRLQAGDAPSVGGSCRSEGTPAWYMHGERAHYSHTMPMRSPSKLSHISRLELVESLDSDEVDLKSGYMSDSDLMGKTMTEDDDITTGWDESSSISSGLSDASDNLSSEEFNASSSLNSLPSTPTASRRNSTIVLRTDSEKRSLAESGLSWFSESEEKAPKKLEYDSGSLKMEPGTSKWRRERPESCDDSSKGGELKKPISLGHPGSLKKGKTPPVAVTSPITHTAQSALKVAGKPEGKATDKGKLAVKNTGLQRSSSDAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQTGGSATLSKIQKSSGIPVKPVNGRKTSLDVSNSAEPGFLAPGARSNIQYRSLPRPAKSSSMSVTGGRGGPRPVSSSIDPSLLSTKQGGLTPSRLKEPTKVASGRTTPAPVNQTDREKEKAKAKAVALDSDNISLKSIGSPESTPKNQASHPTATKLAELPPTPLRATAKSFVKPPSLANLDKVNSNSLDLPSSSDTTHASKVPDLHATSSASGGPLPSCFTPSPAPILNINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPSAFPSSTPVPTPPAPPAAPTEEETEELTWSGSPRAGQLDSNQRDRNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALPMSLSAKGQLTNIVSPTAATTPRITRSNSIPTHEAAFELYSGSQMGSTLSLAERPKGMIRSGSFRDPTDDVHGSVLSLASSASSTYSSAEERMQSEQIRKLRRELESSQEKVATLTSQLSANANLVAAFEQSLVNMTSRLRHLAETAEEKDTELLDLRETIDFLKKKNSEAQAVIQGALNASETTPKELRIKRQNSSDSISSLNSITSHSSIGSSKDADAKKKKKKSWVYELRSSFNKAFSIKKGPKSASSYSDIEEIATPDSSAPSSPKLQHGSTETASPSIKSSTSSSVGTDVTEGPAHPAPHTRLFHANEEEEPEKKEVSELRSELWEKEMKLTDIRLEALNSAHQLDQLRETMHNMQLEVDLLKAENDRLKVAPGPSSGSTPGQVPGSSALSSPRRSLGLALTHSFGPSLADTDLSPMDGISTCGPKEEVTLRVVVRMPPQHIIKGDLKQQEFFLGCSKVSGKVDWKMLDEAVFQVFKDYISKMDPASTLGLSTESIHGYSISHVKRVLDAEPPEMPPCRRGVNNISVSLKGLKEKCVDSLVFETLIPKPMMQHYISLLLKHRRLVLSGPSGTGKTYLTNRLAEYLVERSGREVTEGIVSTFNMHQQSCKDLQLYLSNLANQIDRETGIGDVPLVILLDDLSEAGSISELVNGALTCKYHKCPYIIGTTNQPVKMTPNHGLHLSFRMLTFSNNVEPANGFLVRYLRRKLVESDSDINANKEELLRVLDWVPKLWYHLHTFLEKHSTSDFLIGPCFFLSCPIGIEDFRTWFIDLWNNSIIPYLQEGAKDGIKVHGQKAAWEDPVEWVRDTLPWPSAQQDQSKLYHLPPPTVGPHSIASPPEDRTVKDSTPSSLDSDPLMAMLLKLQEAANYIESPDRETILDPNLQATL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MLGSSVKS -------CCCCCCCC	41.96	22814378
24 (in isoform 5)	Phosphorylation	-	18.88	-
48	Acetylation	GMLPKRAKAPGGGGG CCCCCCCCCCCCCCH	60.18	7974763
58	Acetylation	GGGGGMAKASAAELK CCCCHHHCCCHHHEE	33.70	7974777
69	Phosphorylation	AELKVFKSGSVDSRV HHEEEEECCCCCCCC	25.49	24719451
71	Phosphorylation	LKVFKSGSVDSRVPG EEEEECCCCCCCCCC	29.82	28348404
83	Phosphorylation	VPGGPPASNLRKQKS CCCCCCHHHHHCCCC	42.02	32142685
88	Ubiquitination	PASNLRKQKSLTNLS CHHHHHCCCCCCCCC	33.85	29967540
90	Phosphorylation	SNLRKQKSLTNLSFL HHHHCCCCCCCCCCC	37.62	19664994
90 (in isoform 2)	Phosphorylation	-	37.62	18669648
92	Phosphorylation	LRKQKSLTNLSFLTD HHCCCCCCCCCCCCC	41.00	30266825
92	Ubiquitination	LRKQKSLTNLSFLTD HHCCCCCCCCCCCCC	41.00	29967540
92 (in isoform 2)	Phosphorylation	-	41.00	18669648
95	Phosphorylation	QKSLTNLSFLTDSEK CCCCCCCCCCCCCHH	21.93	30266825
98	Phosphorylation	LTNLSFLTDSEKKLQ CCCCCCCCCCHHHHH	35.15	23403867
99	Phosphorylation	TNLSFLTDSEKKLQL CCCCCCCCCHHHHHH	57.87	32142685
100	Phosphorylation	NLSFLTDSEKKLQLY CCCCCCCCHHHHHHC	46.19	23403867
107	Phosphorylation	SEKKLQLYEPEWSDD CHHHHHHCCCCCCHH	19.24	27642862
112	Phosphorylation	QLYEPEWSDDMAKAP HHCCCCCCHHHHHCC	23.28	30576142
138	Phosphorylation	EAPLMSKTLSKSEHS CCCCCCCCCCCCCHH	29.02	23403867
140	Phosphorylation	PLMSKTLSKSEHSLF CCCCCCCCCCCHHHH	39.09	26055452
142	Phosphorylation	MSKTLSKSEHSLFQA CCCCCCCCCHHHHHC	36.85	30266825
145	Phosphorylation	TLSKSEHSLFQAKGS CCCCCCHHHHHCCCC	27.16	30266825
152	Phosphorylation	SLFQAKGSPAGGAKT HHHHCCCCCCCCCCC	15.74	26055452
152 (in isoform 2)	Phosphorylation	-	15.74	18669648
153	Phosphorylation	LFQAKGSPAGGAKTP HHHCCCCCCCCCCCC	43.52	32142685
158	Sumoylation	GSPAGGAKTPLAPLA CCCCCCCCCCCCCCC	54.68	-
159	Phosphorylation	SPAGGAKTPLAPLAP CCCCCCCCCCCCCCC	24.01	26055452
159 (in isoform 2)	Phosphorylation	-	24.01	18669648
170	Ubiquitination	PLAPNLGKPSRIPRG CCCCCCCCCCCCCCC	42.88	32142685
172	Phosphorylation	APNLGKPSRIPRGPY CCCCCCCCCCCCCCC	46.45	20068231
179	Phosphorylation	SRIPRGPYAEVKPLS CCCCCCCCCCCCCCC	20.44	27642862
186	Phosphorylation	YAEVKPLSKAPEAAV CCCCCCCCCCCCHHC	34.99	-
194	Phosphorylation	KAPEAAVSEDGKSDD CCCCHHCCCCCCCHH	25.83	23927012
199	Phosphorylation	AVSEDGKSDDELLSS HCCCCCCCHHHHHHH	56.68	29255136
199 (in isoform 2)	Phosphorylation	-	56.68	18669648
205	Phosphorylation	KSDDELLSSKAKAQK CCHHHHHHHHHHHHH	42.28	23403867
206	Phosphorylation	SDDELLSSKAKAQKS CHHHHHHHHHHHHHH	36.28	23403867
207	Ubiquitination	DDELLSSKAKAQKSS HHHHHHHHHHHHHHC	51.00	21963094
209	Ubiquitination	ELLSSKAKAQKSSGP HHHHHHHHHHHHCCC	55.90	22817900
212	Ubiquitination	SSKAKAQKSSGPVPS HHHHHHHHHCCCCCC	51.99	22817900
249	Phosphorylation	DLEQLLFSQMLDPES HHHHHHHHCCCCHHH	18.04	27732954
256	Phosphorylation	SQMLDPESQRKRTVQ HCCCCHHHHHHHHHH	40.45	27732954
257	Phosphorylation	QMLDPESQRKRTVQN CCCCHHHHHHHHHHH	53.93	32142685
261	Phosphorylation	PESQRKRTVQNVLDL HHHHHHHHHHHHHHH	29.49	28555341
281	Phosphorylation	ETMSSLRGSQVTHSS HHHHHHCCCCCCCCC	27.94	32645325
282	Phosphorylation	TMSSLRGSQVTHSSL HHHHHCCCCCCCCCE	18.29	21712546
287	Phosphorylation	RGSQVTHSSLEMTCY CCCCCCCCCEEEEEE	27.53	30576142
288	Phosphorylation	GSQVTHSSLEMTCYD CCCCCCCCEEEEEEC	22.27	29214152
292	Phosphorylation	THSSLEMTCYDSDDA CCCCEEEEEECCCCC	9.87	22210691
294	Phosphorylation	SSLEMTCYDSDDANP CCEEEEEECCCCCCC	14.87	29978859
296	Phosphorylation	LEMTCYDSDDANPRS EEEEEECCCCCCCCC	15.77	22167270
296 (in isoform 2)	Phosphorylation	-	15.77	18669648
303	Phosphorylation	SDDANPRSVSSLSNR CCCCCCCCHHHHCCC	27.84	23403867
304	Phosphorylation	DDANPRSVSSLSNRS CCCCCCCHHHHCCCC	4.81	32142685
305	Phosphorylation	DANPRSVSSLSNRSS CCCCCCHHHHCCCCC	27.15	23403867
306	Phosphorylation	ANPRSVSSLSNRSSP CCCCCHHHHCCCCCC	33.39	23403867
308	Phosphorylation	PRSVSSLSNRSSPLS CCCHHHHCCCCCCCC	31.95	26055452
308 (in isoform 2)	Phosphorylation	-	31.95	18669648
311	Phosphorylation	VSSLSNRSSPLSWRY HHHHCCCCCCCCCCC	40.33	30266825
311 (in isoform 2)	Phosphorylation	-	40.33	18669648
312	Phosphorylation	SSLSNRSSPLSWRYG HHHCCCCCCCCCCCC	26.99	30266825
312 (in isoform 2)	Phosphorylation	-	26.99	18669648
315	Phosphorylation	SNRSSPLSWRYGQSS CCCCCCCCCCCCCCC	16.94	30266825
315 (in isoform 2)	Phosphorylation	-	16.94	18669648
318	Phosphorylation	SSPLSWRYGQSSPRL CCCCCCCCCCCCCCC	17.17	27174698
321	Phosphorylation	LSWRYGQSSPRLQAG CCCCCCCCCCCCCCC	37.64	30576142
322	Phosphorylation	SWRYGQSSPRLQAGD CCCCCCCCCCCCCCC	13.22	20815410
332	Phosphorylation	LQAGDAPSVGGSCRS CCCCCCCCCCCCCCC	34.81	22210691
336	Phosphorylation	DAPSVGGSCRSEGTP CCCCCCCCCCCCCCC	10.63	22210691
339	Phosphorylation	SVGGSCRSEGTPAWY CCCCCCCCCCCCCEE	44.71	22210691
342	Phosphorylation	GSCRSEGTPAWYMHG CCCCCCCCCCEEECC	13.04	22199227
354	Phosphorylation	MHGERAHYSHTMPMR ECCCCCCCCCCCCCC	10.93	22210691
355	Phosphorylation	HGERAHYSHTMPMRS CCCCCCCCCCCCCCC	11.56	23663014
357	Phosphorylation	ERAHYSHTMPMRSPS CCCCCCCCCCCCCHH	19.61	23663014
362	Phosphorylation	SHTMPMRSPSKLSHI CCCCCCCCHHHCHHH	27.55	23898821
364	Phosphorylation	TMPMRSPSKLSHISR CCCCCCHHHCHHHCH	47.69	22199227
365	Ubiquitination	MPMRSPSKLSHISRL CCCCCHHHCHHHCHH	58.35	29967540
367	Phosphorylation	MRSPSKLSHISRLEL CCCHHHCHHHCHHHH	23.63	27174698
369	Phosphorylation	SPSKLSHISRLELVE CHHHCHHHCHHHHHH	2.00	32142685
370	Phosphorylation	PSKLSHISRLELVES HHHCHHHCHHHHHHH	25.95	27174698
377	Phosphorylation	SRLELVESLDSDEVD CHHHHHHHCCCCCCC	29.96	29507054
380	Phosphorylation	ELVESLDSDEVDLKS HHHHHCCCCCCCCCC	40.75	27732954
387	Phosphorylation	SDEVDLKSGYMSDSD CCCCCCCCCCCCHHH	42.31	23403867
389	Phosphorylation	EVDLKSGYMSDSDLM CCCCCCCCCCHHHHC	10.67	23403867
391	Phosphorylation	DLKSGYMSDSDLMGK CCCCCCCCHHHHCCC	26.02	22617229
391 (in isoform 2)	Phosphorylation	-	26.02	18669648
393	Phosphorylation	KSGYMSDSDLMGKTM CCCCCCHHHHCCCCC	25.90	22617229
406	Phosphorylation	TMTEDDDITTGWDES CCCCCCCCCCCCCCC	4.83	32142685
415	Phosphorylation	TGWDESSSISSGLSD CCCCCCHHHCCCCCC	35.45	-
417	Phosphorylation	WDESSSISSGLSDAS CCCCHHHCCCCCCCC	21.94	32142685
418	Phosphorylation	DESSSISSGLSDASD CCCHHHCCCCCCCCC	41.92	-
435	Phosphorylation	SSEEFNASSSLNSLP CHHHHCCCHHHCCCC	22.89	-
440	Phosphorylation	NASSSLNSLPSTPTA CCCHHHCCCCCCCCC	47.12	22817900
443	Phosphorylation	SSLNSLPSTPTASRR HHHCCCCCCCCCCCC	52.92	-
444	Phosphorylation	SLNSLPSTPTASRRN HHCCCCCCCCCCCCC	23.79	22817900
452	Phosphorylation	PTASRRNSTIVLRTD CCCCCCCCEEEEECC	20.07	23401153
452 (in isoform 2)	Phosphorylation	-	20.07	18669648
453	Phosphorylation	TASRRNSTIVLRTDS CCCCCCCEEEEECCH	20.75	30266825
458	Phosphorylation	NSTIVLRTDSEKRSL CCEEEEECCHHHHHH	39.45	27251275
460	Phosphorylation	TIVLRTDSEKRSLAE EEEEECCHHHHHHHH	44.39	22199227
464	Phosphorylation	RTDSEKRSLAESGLS ECCHHHHHHHHHCCC	42.89	20068231
468	Phosphorylation	EKRSLAESGLSWFSE HHHHHHHHCCCCCCC	39.15	23403867
471	Phosphorylation	SLAESGLSWFSESEE HHHHHCCCCCCCCCC	29.60	23403867
474	Phosphorylation	ESGLSWFSESEEKAP HHCCCCCCCCCCCCC	33.67	22617229
476	Phosphorylation	GLSWFSESEEKAPKK CCCCCCCCCCCCCCC	50.27	21712546
479	Ubiquitination	WFSESEEKAPKKLEY CCCCCCCCCCCCCCC	66.97	29967540
483	Ubiquitination	SEEKAPKKLEYDSGS CCCCCCCCCCCCCCC	45.55	29967540
486	Phosphorylation	KAPKKLEYDSGSLKM CCCCCCCCCCCCCCC	26.33	23403867
488	Phosphorylation	PKKLEYDSGSLKMEP CCCCCCCCCCCCCCC	29.40	23401153
490	Phosphorylation	KLEYDSGSLKMEPGT CCCCCCCCCCCCCCC	28.86	29255136
497	Phosphorylation	SLKMEPGTSKWRRER CCCCCCCCCHHHHCC	37.54	23403867
498	Phosphorylation	LKMEPGTSKWRRERP CCCCCCCCHHHHCCC	35.81	23403867
507	Phosphorylation	WRRERPESCDDSSKG HHHCCCCCCCCCCCC	26.06	30576142
511	Phosphorylation	RPESCDDSSKGGELK CCCCCCCCCCCCCCC	22.24	28102081
512	Phosphorylation	PESCDDSSKGGELKK CCCCCCCCCCCCCCC	42.17	28102081
522	Phosphorylation	GELKKPISLGHPGSL CCCCCCCCCCCCCCC	36.50	28152594
528	Phosphorylation	ISLGHPGSLKKGKTP CCCCCCCCCCCCCCC	41.28	23401153
534	Phosphorylation	GSLKKGKTPPVAVTS CCCCCCCCCCEEEEC	41.30	26055452
534 (in isoform 2)	Phosphorylation	-	41.30	18669648
540	O-linked_Glycosylation	KTPPVAVTSPITHTA CCCCEEEECCCCHHH	21.03	30059200
540	Phosphorylation	KTPPVAVTSPITHTA CCCCEEEECCCCHHH	21.03	26055452
540 (in isoform 2)	Phosphorylation	-	21.03	18669648
541	Phosphorylation	TPPVAVTSPITHTAQ CCCEEEECCCCHHHH	14.01	26055452
541 (in isoform 2)	Phosphorylation	-	14.01	18669648
544	Phosphorylation	VAVTSPITHTAQSAL EEEECCCCHHHHHHH	19.29	21712546
546	Phosphorylation	VTSPITHTAQSALKV EECCCCHHHHHHHHH	20.10	30576142
549	Phosphorylation	PITHTAQSALKVAGK CCCHHHHHHHHHCCC	32.86	30576142
556	Acetylation	SALKVAGKPEGKATD HHHHHCCCCCCCCCC	30.11	19811901
566	Acetylation	GKATDKGKLAVKNTG CCCCCCCCEEEECCC	38.73	19811913
570	Acetylation	DKGKLAVKNTGLQRS CCCCEEEECCCCCCC	43.09	19811925
572	Phosphorylation	GKLAVKNTGLQRSSS CCEEEECCCCCCCCC	33.29	18669648
572 (in isoform 2)	Phosphorylation	-	33.29	18669648
578	Phosphorylation	NTGLQRSSSDAGRDR CCCCCCCCCHHCHHH	34.13	22210691
579	Phosphorylation	TGLQRSSSDAGRDRL CCCCCCCCHHCHHHH	32.50	28985074
587	Phosphorylation	DAGRDRLSDAKKPPS HHCHHHHHCCCCCCC	36.09	21712546
590	Phosphorylation	RDRLSDAKKPPSGIA HHHHHCCCCCCCCCC	71.45	32142685
594	Phosphorylation	SDAKKPPSGIARPST HCCCCCCCCCCCCCC	51.89	27251275
600	Phosphorylation	PSGIARPSTSGSFGY CCCCCCCCCCCCCCC	29.65	27251275
601	Phosphorylation	SGIARPSTSGSFGYK CCCCCCCCCCCCCCC	39.53	29978859
602	Phosphorylation	GIARPSTSGSFGYKK CCCCCCCCCCCCCCC	36.46	28348404
604	Phosphorylation	ARPSTSGSFGYKKPP CCCCCCCCCCCCCCC	18.44	29978859
609	Phosphorylation	SGSFGYKKPPPATGT CCCCCCCCCCCCCCC	55.03	32142685
622	Phosphorylation	GTATVMQTGGSATLS CCEEEEECCCCEEHH	25.97	29514088
625	Phosphorylation	TVMQTGGSATLSKIQ EEEECCCCEEHHHHH	21.30	29514088
626	Phosphorylation	VMQTGGSATLSKIQK EEECCCCEEHHHHHH	18.81	32142685
627	Phosphorylation	MQTGGSATLSKIQKS EECCCCEEHHHHHHH	33.01	30576142
629	Phosphorylation	TGGSATLSKIQKSSG CCCCEEHHHHHHHCC	24.29	29514088
635	Phosphorylation	LSKIQKSSGIPVKPV HHHHHHHCCCCCCCC	48.02	24719451
641	Phosphorylation	SSGIPVKPVNGRKTS HCCCCCCCCCCCEEE	25.66	32142685
647	Phosphorylation	KPVNGRKTSLDVSNS CCCCCCEEEEECCCC	32.91	23401153
647 (in isoform 2)	Phosphorylation	-	32.91	18669648
648	Phosphorylation	PVNGRKTSLDVSNSA CCCCCEEEEECCCCC	26.13	28355574
648 (in isoform 2)	Phosphorylation	-	26.13	18669648
652	Phosphorylation	RKTSLDVSNSAEPGF CEEEEECCCCCCCCC	25.41	23927012
652 (in isoform 2)	Phosphorylation	-	25.41	18669648
654	Phosphorylation	TSLDVSNSAEPGFLA EEEECCCCCCCCCCC	26.88	23927012
654 (in isoform 2)	Phosphorylation	-	26.88	18669648
672	Phosphorylation	RSNIQYRSLPRPAKS CCCCEEECCCCCCCC	37.48	30266825
679	Phosphorylation	SLPRPAKSSSMSVTG CCCCCCCCCCCCCCC	29.74	20860994
680	Phosphorylation	LPRPAKSSSMSVTGG CCCCCCCCCCCCCCC	29.38	27251275
681	Phosphorylation	PRPAKSSSMSVTGGR CCCCCCCCCCCCCCC	23.36	27251275
683	Phosphorylation	PAKSSSMSVTGGRGG CCCCCCCCCCCCCCC	20.62	-
685	Phosphorylation	KSSSMSVTGGRGGPR CCCCCCCCCCCCCCC	26.98	20860994
688	Methylation	SMSVTGGRGGPRPVS CCCCCCCCCCCCCCC	48.52	24394831
692	Methylation	TGGRGGPRPVSSSID CCCCCCCCCCCCCCC	47.75	12019751
695	Phosphorylation	RGGPRPVSSSIDPSL CCCCCCCCCCCCHHH	22.50	29255136
696	Phosphorylation	GGPRPVSSSIDPSLL CCCCCCCCCCCHHHH	31.39	23403867
697	Phosphorylation	GPRPVSSSIDPSLLS CCCCCCCCCCHHHHC	24.41	23403867
701	Phosphorylation	VSSSIDPSLLSTKQG CCCCCCHHHHCCCCC	37.89	30576142
704	Phosphorylation	SIDPSLLSTKQGGLT CCCHHHHCCCCCCCC	38.56	24719451
706	Methylation	DPSLLSTKQGGLTPS CHHHHCCCCCCCCHH	43.50	115484523
723	Phosphorylation	KEPTKVASGRTTPAP CCCCCCCCCCCCCCC	31.62	23403867
726	Phosphorylation	TKVASGRTTPAPVNQ CCCCCCCCCCCCCCC	40.43	23403867
727	Phosphorylation	KVASGRTTPAPVNQT CCCCCCCCCCCCCCC	18.98	23403867
734	Phosphorylation	TPAPVNQTDREKEKA CCCCCCCCHHHHHHH	31.64	28985074
744	Acetylation	EKEKAKAKAVALDSD HHHHHHHHEEEECCC	42.56	7410065
750	Phosphorylation	AKAVALDSDNISLKS HHEEEECCCCCCCCC	33.15	23927012
754	Phosphorylation	ALDSDNISLKSIGSP EECCCCCCCCCCCCC	35.68	29255136
754 (in isoform 2)	Phosphorylation	-	35.68	18669648
756	Ubiquitination	DSDNISLKSIGSPES CCCCCCCCCCCCCCC	32.98	29967540
757	Phosphorylation	SDNISLKSIGSPEST CCCCCCCCCCCCCCC	37.16	29255136
759	Ubiquitination	NISLKSIGSPESTPK CCCCCCCCCCCCCCC	44.21	32142685
760	Phosphorylation	ISLKSIGSPESTPKN CCCCCCCCCCCCCCC	24.67	29255136
760 (in isoform 2)	Phosphorylation	-	24.67	18669648
763	Phosphorylation	KSIGSPESTPKNQAS CCCCCCCCCCCCCCC	54.09	29255136
763 (in isoform 2)	Phosphorylation	-	54.09	18669648
764	Phosphorylation	SIGSPESTPKNQASH CCCCCCCCCCCCCCC	36.30	29255136
764 (in isoform 2)	Phosphorylation	-	36.30	18669648
766	Acetylation	GSPESTPKNQASHPT CCCCCCCCCCCCCCC	62.88	7410079
770	Phosphorylation	STPKNQASHPTATKL CCCCCCCCCCCCHHH	21.89	21712546
773	Phosphorylation	KNQASHPTATKLAEL CCCCCCCCCHHHCCC	41.35	-
775	Phosphorylation	QASHPTATKLAELPP CCCCCCCHHHCCCCC	29.12	21712546
783	Phosphorylation	KLAELPPTPLRATAK HHCCCCCCCCCCHHH	32.77	28674419
788	Phosphorylation	PPTPLRATAKSFVKP CCCCCCCHHHHHCCC	28.34	22199227
790	Phosphorylation	TPLRATAKSFVKPPS CCCCCHHHHHCCCHH	39.82	32142685
791	Phosphorylation	PLRATAKSFVKPPSL CCCCHHHHHCCCHHH	32.57	23403867
797	Phosphorylation	KSFVKPPSLANLDKV HHHCCCHHHCCCCCC	48.95	23403867
806	Phosphorylation	ANLDKVNSNSLDLPS CCCCCCCCCCCCCCC	30.68	23401153
808	Phosphorylation	LDKVNSNSLDLPSSS CCCCCCCCCCCCCCC	24.07	29255136
808 (in isoform 2)	Phosphorylation	-	24.07	18669648
813	Phosphorylation	SNSLDLPSSSDTTHA CCCCCCCCCCCCCCH	50.17	23403867
813	Ubiquitination	SNSLDLPSSSDTTHA CCCCCCCCCCCCCCH	50.17	24816145
814	Phosphorylation	NSLDLPSSSDTTHAS CCCCCCCCCCCCCHH	30.23	23403867
815	Phosphorylation	SLDLPSSSDTTHASK CCCCCCCCCCCCHHH	43.23	23403867
817	Phosphorylation	DLPSSSDTTHASKVP CCCCCCCCCCHHHCC	23.56	23312004
821 (in isoform 5)	Phosphorylation	-	26.95	-
825 (in isoform 5)	Phosphorylation	-	54.82	28450419
826 (in isoform 5)	Phosphorylation	-	2.13	28450419
859	Phosphorylation	NSASFSQGLELMSGF CCCCHHHCCHHHCCC	21.66	32142685
871	Phosphorylation	SGFSVPKETRMYPKL CCCCCCCHHCCCCCC	35.26	32142685
884	Phosphorylation	KLSGLHRSMESLQMP CCCCHHHCHHHHCCC	19.02	28348404
893	Phosphorylation	ESLQMPMSLPSAFPS HHHCCCCCCCCCCCC	31.12	-
903	Ubiquitination	SAFPSSTPVPTPPAP CCCCCCCCCCCCCCC	31.85	24816145
906	Ubiquitination	PSSTPVPTPPAPPAA CCCCCCCCCCCCCCC	41.98	24816145
911	Ubiquitination	VPTPPAPPAAPTEEE CCCCCCCCCCCCHHH	43.06	24816145
914	Ubiquitination	PPAPPAAPTEEETEE CCCCCCCCCHHHHCC	42.31	24816145
925	Phosphorylation	ETEELTWSGSPRAGQ HHCCCCCCCCCCCCC	24.94	28348404
927	Phosphorylation	EELTWSGSPRAGQLD CCCCCCCCCCCCCCC	13.00	27251275
935	Phosphorylation	PRAGQLDSNQRDRNT CCCCCCCCCCCCCCC	43.38	28555341
942	Phosphorylation	SNQRDRNTLPKKGLR CCCCCCCCCCCCHHH	45.38	23403867
950	Phosphorylation	LPKKGLRYQLQSQEE CCCCHHHHHHHCHHH	20.72	29083192
954	Phosphorylation	GLRYQLQSQEETKER HHHHHHHCHHHHHHH	48.42	22617229
958	Phosphorylation	QLQSQEETKERRHSH HHHCHHHHHHHHHHH	37.14	29083192
964	Phosphorylation	ETKERRHSHTIGGLP HHHHHHHHHCCCCCC	22.10	23403867
966	Phosphorylation	KERRHSHTIGGLPES HHHHHHHCCCCCCCC	25.08	23403867
973	Phosphorylation	TIGGLPESDDQSELP CCCCCCCCCCCCCCC	44.54	29255136
977	Phosphorylation	LPESDDQSELPSPPA CCCCCCCCCCCCCCC	48.36	29255136
981	Phosphorylation	DDQSELPSPPALPMS CCCCCCCCCCCCCCC	57.02	29255136
987	Phosphorylation	PSPPALPMSLSAKGQ CCCCCCCCCCCCCCC	7.00	32142685
988	Phosphorylation	SPPALPMSLSAKGQL CCCCCCCCCCCCCCE	19.75	29255136
990	Phosphorylation	PALPMSLSAKGQLTN CCCCCCCCCCCCEEE	22.19	29255136
996	Phosphorylation	LSAKGQLTNIVSPTA CCCCCCEEEECCCCC	18.27	23403867
1000	Phosphorylation	GQLTNIVSPTAATTP CCEEEECCCCCCCCC	16.85	26055452
1000 (in isoform 2)	Phosphorylation	-	16.85	18669648
1002	Phosphorylation	LTNIVSPTAATTPRI EEEECCCCCCCCCCC	22.78	22617229
1005	Phosphorylation	IVSPTAATTPRITRS ECCCCCCCCCCCCCC	34.56	21712546
1006	Phosphorylation	VSPTAATTPRITRSN CCCCCCCCCCCCCCC	13.07	26055452
1006 (in isoform 2)	Phosphorylation	-	13.07	18669648
1010	Phosphorylation	AATTPRITRSNSIPT CCCCCCCCCCCCCCC	29.35	30576142
1011	Phosphorylation	ATTPRITRSNSIPTH CCCCCCCCCCCCCCC	31.31	32142685
1012	Phosphorylation	TTPRITRSNSIPTHE CCCCCCCCCCCCCCH	26.69	30576142
1014	Phosphorylation	PRITRSNSIPTHEAA CCCCCCCCCCCCHHH	31.06	22199227
1017	Phosphorylation	TRSNSIPTHEAAFEL CCCCCCCCCHHHHHH	30.58	30576142
1025	Phosphorylation	HEAAFELYSGSQMGS CHHHHHHHCCCCCCC	12.09	22199227
1026	Phosphorylation	EAAFELYSGSQMGST HHHHHHHCCCCCCCC	44.59	30301811
1028	Phosphorylation	AFELYSGSQMGSTLS HHHHHCCCCCCCCCH	15.85	30301811
1032	Phosphorylation	YSGSQMGSTLSLAER HCCCCCCCCCHHHHC	22.34	23186163
1033	Phosphorylation	SGSQMGSTLSLAERP CCCCCCCCCHHHHCC	18.03	23186163
1035	Phosphorylation	SQMGSTLSLAERPKG CCCCCCCHHHHCCCC	26.14	23186163
1046	Phosphorylation	RPKGMIRSGSFRDPT CCCCCCCCCCCCCCC	28.06	30576142
1046 (in isoform 2)	Phosphorylation	-	28.06	26699800
1046 (in isoform 6)	Phosphorylation	-	28.06	26699800
1048	Phosphorylation	KGMIRSGSFRDPTDD CCCCCCCCCCCCCCC	20.53	30576142
1048 (in isoform 2)	Phosphorylation	-	20.53	26699800
1048 (in isoform 6)	Phosphorylation	-	20.53	26699800
1053	Phosphorylation	SGSFRDPTDDVHGSV CCCCCCCCCCCCHHH	49.47	26434776
1053 (in isoform 2)	Phosphorylation	-	49.47	26699800
1053 (in isoform 6)	Phosphorylation	-	49.47	26699800
1059	Phosphorylation	PTDDVHGSVLSLASS CCCCCCHHHHHHHHC	12.66	27080861
1059 (in isoform 2)	Phosphorylation	-	12.66	26699800
1059 (in isoform 6)	Phosphorylation	-	12.66	26699800
1062	Phosphorylation	DVHGSVLSLASSASS CCCHHHHHHHHCCCC	21.53	27732954
1065	Phosphorylation	GSVLSLASSASSTYS HHHHHHHHCCCCCCC	31.56	27732954
1066	Phosphorylation	SVLSLASSASSTYSS HHHHHHHCCCCCCCC	26.94	27732954
1147 (in isoform 7)	Phosphorylation	-	50.69	-
1150	Ubiquitination	RETIDFLKKKNSEAQ HHHHHHHHHCCHHHH	62.79	32142685
1151 (in isoform 7)	Phosphorylation	-	60.37	28450419
1152 (in isoform 7)	Phosphorylation	-	65.21	28450419
1154	Phosphorylation	DFLKKKNSEAQAVIQ HHHHHCCHHHHHHHH	43.09	26270265
1155 (in isoform 4)	Phosphorylation	-	54.95	-
1159 (in isoform 4)	Phosphorylation	-	1.92	28450419
1160 (in isoform 4)	Phosphorylation	-	3.33	28450419
1167	Phosphorylation	IQGALNASETTPKEL HHHHHHCCCCCCHHH	34.11	22199227
1169	Phosphorylation	GALNASETTPKELRI HHHHCCCCCCHHHHE	46.00	22199227
1170	Phosphorylation	ALNASETTPKELRIK HHHCCCCCCHHHHEE	28.45	26055452
1180 (in isoform 6)	Phosphorylation	-	47.73	20860994
1181	Phosphorylation	LRIKRQNSSDSISSL HHEEECCCCCCHHHH	27.47	22167270
1182	Phosphorylation	RIKRQNSSDSISSLN HEEECCCCCCHHHHH	42.82	22167270
1182 (in isoform 6)	Phosphorylation	-	42.82	20860994
1184	Phosphorylation	KRQNSSDSISSLNSI EECCCCCCHHHHHHH	26.73	22167270
1184 (in isoform 6)	Phosphorylation	-	26.73	20860994
1186	Phosphorylation	QNSSDSISSLNSITS CCCCCCHHHHHHHHC	32.50	23403867
1187	Phosphorylation	NSSDSISSLNSITSH CCCCCHHHHHHHHCC	29.87	22167270
1187 (in isoform 6)	Phosphorylation	-	29.87	20860994
1190	Phosphorylation	DSISSLNSITSHSSI CCHHHHHHHHCCCCC	32.32	26657352
1192	Phosphorylation	ISSLNSITSHSSIGS HHHHHHHHCCCCCCC	21.87	23403867
1193	Phosphorylation	SSLNSITSHSSIGSS HHHHHHHCCCCCCCC	21.50	23403867
1195	Phosphorylation	LNSITSHSSIGSSKD HHHHHCCCCCCCCCC	24.34	23403867
1196	Phosphorylation	NSITSHSSIGSSKDA HHHHCCCCCCCCCCC	26.08	28387310
1199	Phosphorylation	TSHSSIGSSKDADAK HCCCCCCCCCCCCHH	32.32	28387310
1200	Phosphorylation	SHSSIGSSKDADAKK CCCCCCCCCCCCHHH	29.37	23403867
1212	Phosphorylation	AKKKKKKSWVYELRS HHHHHCHHHHHHHHH	30.56	27251275
1212 (in isoform 3)	Phosphorylation	-	30.56	-
1216 (in isoform 3)	Phosphorylation	-	28.25	28450419
1217 (in isoform 3)	Phosphorylation	-	3.35	28450419
1219	Phosphorylation	SWVYELRSSFNKAFS HHHHHHHHHHHHHHC	52.48	-
1220	Phosphorylation	WVYELRSSFNKAFSI HHHHHHHHHHHHHCC	26.80	-
1226	Phosphorylation	SSFNKAFSIKKGPKS HHHHHHHCCCCCCCC	38.06	29214152
1233	Phosphorylation	SIKKGPKSASSYSDI CCCCCCCCCCCCCCH	36.19	23403867
1235	Phosphorylation	KKGPKSASSYSDIEE CCCCCCCCCCCCHHH	36.58	23403867
1236	Phosphorylation	KGPKSASSYSDIEEI CCCCCCCCCCCHHHH	28.51	23403867
1237	Phosphorylation	GPKSASSYSDIEEIA CCCCCCCCCCHHHHC	14.10	23403867
1237	Ubiquitination	GPKSASSYSDIEEIA CCCCCCCCCCHHHHC	14.10	24816145
1238	Phosphorylation	PKSASSYSDIEEIAT CCCCCCCCCHHHHCC	33.78	23403867
1240	Ubiquitination	SASSYSDIEEIATPD CCCCCCCHHHHCCCC	4.15	24816145
1245	Phosphorylation	SDIEEIATPDSSAPS CCHHHHCCCCCCCCC	33.03	23403867
1245	Ubiquitination	SDIEEIATPDSSAPS CCHHHHCCCCCCCCC	33.03	24816145
1248	Phosphorylation	EEIATPDSSAPSSPK HHHCCCCCCCCCCCC	29.60	21712546
1248	Ubiquitination	EEIATPDSSAPSSPK HHHCCCCCCCCCCCC	29.60	24816145
1249	Phosphorylation	EIATPDSSAPSSPKL HHCCCCCCCCCCCCC	52.13	25554490
1252	Phosphorylation	TPDSSAPSSPKLQHG CCCCCCCCCCCCCCC	60.01	25554490
1253	Phosphorylation	PDSSAPSSPKLQHGS CCCCCCCCCCCCCCC	25.62	28355574
1260	Phosphorylation	SPKLQHGSTETASPS CCCCCCCCCCCCCCC	22.42	26055452
1261	Phosphorylation	PKLQHGSTETASPSI CCCCCCCCCCCCCCC	41.78	20068231
1263	Phosphorylation	LQHGSTETASPSIKS CCCCCCCCCCCCCCC	32.30	19691289
1265	Phosphorylation	HGSTETASPSIKSST CCCCCCCCCCCCCCC	26.97	26055452
1267	Phosphorylation	STETASPSIKSSTSS CCCCCCCCCCCCCCC	39.90	22617229
1270	Phosphorylation	TASPSIKSSTSSSVG CCCCCCCCCCCCCCC	36.86	23312004
1271	Phosphorylation	ASPSIKSSTSSSVGT CCCCCCCCCCCCCCC	27.57	28348404
1272	Phosphorylation	SPSIKSSTSSSVGTD CCCCCCCCCCCCCCC	39.45	28348404
1273	Phosphorylation	PSIKSSTSSSVGTDV CCCCCCCCCCCCCCC	23.67	28348404
1274	Phosphorylation	SIKSSTSSSVGTDVT CCCCCCCCCCCCCCC	29.18	28348404
1275	Phosphorylation	IKSSTSSSVGTDVTE CCCCCCCCCCCCCCC	25.08	28348404
1278	Phosphorylation	STSSSVGTDVTEGPA CCCCCCCCCCCCCCC	25.74	30576142
1281	Phosphorylation	SSVGTDVTEGPAHPA CCCCCCCCCCCCCCC	37.73	23312004
1291	Phosphorylation	PAHPAPHTRLFHANE CCCCCCCCCCCCCCC	28.19	23312004
1294	Ubiquitination	PAPHTRLFHANEEEE CCCCCCCCCCCCCCC	4.63	24816145
1297	Ubiquitination	HTRLFHANEEEEPEK CCCCCCCCCCCCHHH	48.95	24816145
1302	Ubiquitination	HANEEEEPEKKEVSE CCCCCCCHHHHHHHH	63.08	24816145
1305	Ubiquitination	EEEEPEKKEVSELRS CCCCHHHHHHHHHHH	62.78	24816145
1315	Ubiquitination	SELRSELWEKEMKLT HHHHHHHHHHHHCHH	15.57	29967540
1317	Methylation	LRSELWEKEMKLTDI HHHHHHHHHHCHHHH	52.07	23644510
1320	Methylation	ELWEKEMKLTDIRLE HHHHHHHCHHHHHHH	49.69	23644510
1366	Phosphorylation	LKVAPGPSSGSTPGQ CEECCCCCCCCCCCC	53.93	23403867
1367	Phosphorylation	KVAPGPSSGSTPGQV EECCCCCCCCCCCCC	39.64	23403867
1369	Phosphorylation	APGPSSGSTPGQVPG CCCCCCCCCCCCCCC	33.12	23403867
1370	Phosphorylation	PGPSSGSTPGQVPGS CCCCCCCCCCCCCCC	34.66	23403867
1377	Phosphorylation	TPGQVPGSSALSSPR CCCCCCCCCCCCCCC	13.33	23927012
1378	Phosphorylation	PGQVPGSSALSSPRR CCCCCCCCCCCCCCH	38.86	23927012
1381	Phosphorylation	VPGSSALSSPRRSLG CCCCCCCCCCCHHHH	37.70	23927012
1382	Phosphorylation	PGSSALSSPRRSLGL CCCCCCCCCCHHHHH	24.23	23927012
1386	Phosphorylation	ALSSPRRSLGLALTH CCCCCCHHHHHHHHH	28.24	20068231
1392	Phosphorylation	RSLGLALTHSFGPSL HHHHHHHHHCCCCCC	15.18	28857561
1394	Phosphorylation	LGLALTHSFGPSLAD HHHHHHHCCCCCCCC	27.02	28857561
1398	Phosphorylation	LTHSFGPSLADTDLS HHHCCCCCCCCCCCC	36.25	28348404
1402	Phosphorylation	FGPSLADTDLSPMDG CCCCCCCCCCCCCCC	32.98	26434776
1405	Phosphorylation	SLADTDLSPMDGIST CCCCCCCCCCCCCCC	22.46	22199227
1411	Phosphorylation	LSPMDGISTCGPKEE CCCCCCCCCCCCCCE	24.15	26434776
1412	Phosphorylation	SPMDGISTCGPKEEV CCCCCCCCCCCCCEE	21.40	26434776
1432	Phosphorylation	VRMPPQHIIKGDLKQ EECCCHHEEECCCCC	2.68	32142685
1465	Phosphorylation	LDEAVFQVFKDYISK HHHHHHHHHHHHHHH	4.35	32142685
1665	Phosphorylation	TNQPVKMTPNHGLHL CCCCCEECCCCCEEE	18.41	28555341
1709	Ubiquitination	DSDINANKEELLRVL CCCCCCCHHHHHHHH	50.59	29967540
1818	Phosphorylation	LYHLPPPTVGPHSIA HCCCCCCCCCCCCCC	43.82	30576142
1823	Phosphorylation	PPTVGPHSIASPPED CCCCCCCCCCCCCCC	24.00	30576142
1826	Phosphorylation	VGPHSIASPPEDRTV CCCCCCCCCCCCCCC	39.04	20068231
1832	Phosphorylation	ASPPEDRTVKDSTPS CCCCCCCCCCCCCCC	44.20	22199227
1836	Phosphorylation	EDRTVKDSTPSSLDS CCCCCCCCCCCCCCC	36.18	22199227
1837	Phosphorylation	DRTVKDSTPSSLDSD CCCCCCCCCCCCCCC	37.01	22199227
1839	Phosphorylation	TVKDSTPSSLDSDPL CCCCCCCCCCCCCHH	43.55	22199227
1840	Phosphorylation	VKDSTPSSLDSDPLM CCCCCCCCCCCCHHH	37.08	22199227
1843	Phosphorylation	STPSSLDSDPLMAML CCCCCCCCCHHHHHH	46.55	26657352
1859	Phosphorylation	KLQEAANYIESPDRE HHHHHHHHCCCCCHH	11.01	22199227
1862	Phosphorylation	EAANYIESPDRETIL HHHHHCCCCCHHHCC	23.65	19691289
1867	Phosphorylation	IESPDRETILDPNLQ CCCCCHHHCCCCCCC	27.95	22199227
1876	Phosphorylation	LDPNLQATL------ CCCCCCCCC------	21.75	22199227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NAV1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NAV1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NAV1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
MARE1_HUMAN	MAPRE1	physical	25065758
TRIO_HUMAN	TRIO	physical	25065758
IPYR_HUMAN	PPA1	physical	26344197
IPYR2_HUMAN	PPA2	physical	26344197
CING_HUMAN	CGN	physical	27173435
SYDE1_HUMAN	SYDE1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-750, AND MASSSPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-391; SER-760; SER-1000;THR-1002; SER-1253 AND SER-1382, AND MASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152; THR-159; SER-199;SER-296; SER-308; SER-311; SER-391; SER-452; THR-534; SER-541;THR-572; SER-760; SER-808; THR-1170; SER-1181 AND SER-1382, AND MASSSPECTROMETRY.
PubMed: 18669648

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-726, AND MASSSPECTROMETRY.
PubMed: 19007248