dbPTM

MARE1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MARE1_HUMAN
UniProt AC	Q15691
Protein Name	Microtubule-associated protein RP/EB family member 1
Gene Name	MAPRE1
Organism	Homo sapiens (Human).
Sequence Length	268
Subcellular Localization	Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Golgi apparatus . Associated with the microtubule growing distal tips (PubMed:28814570). Recruitment to the Golgi apparatus requires the presence of PDE4DI
Protein Description	Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. [PubMed: 12388762]
Protein Sequence	MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQAKLEHEYIQNFKILQAGFKRMGVDKIIPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKDYDPVAARQGQETAVAPSLVAPALNKPKKPLTSSSAAPQRPISTQRTAAAPKAGPGVVRKNPGVGNGDDEAAELMQQVNVLKLTVEDLEKERDFYFGKLRNIELICQENEGENDPVLQRIVDILYATDEGFVIPDEGGPQEEQEEY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAVNVYSTS ------CCCEEEECC	11.11	22223895
6	Phosphorylation	--MAVNVYSTSVTSD --CCCEEEECCCCCC	10.88	26552605
7	Phosphorylation	-MAVNVYSTSVTSDN -CCCEEEECCCCCCC	15.21	26552605
8	Phosphorylation	MAVNVYSTSVTSDNL CCCEEEECCCCCCCC	14.99	26552605
9	Phosphorylation	AVNVYSTSVTSDNLS CCEEEECCCCCCCCC	19.91	26552605
11	Phosphorylation	NVYSTSVTSDNLSRH EEEECCCCCCCCCHH	30.08	27732954
12	Phosphorylation	VYSTSVTSDNLSRHD EEECCCCCCCCCHHH	23.50	23186163
40	Phosphorylation	TKIEQLCSGAAYCQF HHHHHHHCHHHHHHH	39.81	-
60	Ubiquitination	PGSIALKKVKFQAKL CCCEEEEECCHHHHC	52.05	23000965
60	Acetylation	PGSIALKKVKFQAKL CCCEEEEECCHHHHC	52.05	129905
62	Ubiquitination	SIALKKVKFQAKLEH CEEEEECCHHHHCCH	40.41	23000965
66	Ubiquitination	KKVKFQAKLEHEYIQ EECCHHHHCCHHHHH	43.56	23000965
66	Malonylation	KKVKFQAKLEHEYIQ EECCHHHHCCHHHHH	43.56	26320211
66	Acetylation	KKVKFQAKLEHEYIQ EECCHHHHCCHHHHH	43.56	23236377
71	Phosphorylation	QAKLEHEYIQNFKIL HHHCCHHHHHHHHHH	15.09	28152594
76	Acetylation	HEYIQNFKILQAGFK HHHHHHHHHHHHHHH	50.48	23954790
76	Ubiquitination	HEYIQNFKILQAGFK HHHHHHHHHHHHHHH	50.48	23000965
76	Methylation	HEYIQNFKILQAGFK HHHHHHHHHHHHHHH	50.48	-
83	Acetylation	KILQAGFKRMGVDKI HHHHHHHHHCCCCEE	40.32	23749302
83	Ubiquitination	KILQAGFKRMGVDKI HHHHHHHHHCCCCEE	40.32	23000965
83	Malonylation	KILQAGFKRMGVDKI HHHHHHHHHCCCCEE	40.32	26320211
89	Ubiquitination	FKRMGVDKIIPVDKL HHHCCCCEEEEHHHH	39.88	23000965
89	Acetylation	FKRMGVDKIIPVDKL HHHCCCCEEEEHHHH	39.88	23749302
95	Ubiquitination	DKIIPVDKLVKGKFQ CEEEEHHHHHCCCCC	56.25	23000965
95	Acetylation	DKIIPVDKLVKGKFQ CEEEEHHHHHCCCCC	56.25	25953088
98	Ubiquitination	IPVDKLVKGKFQDNF EEHHHHHCCCCCCCH	67.81	23000965
100	Ubiquitination	VDKLVKGKFQDNFEF HHHHHCCCCCCCHHH	33.85	23000965
100	Acetylation	VDKLVKGKFQDNFEF HHHHHCCCCCCCHHH	33.85	25953088
112	Ubiquitination	FEFVQWFKKFFDANY HHHHHHHHHHHCCCC	45.79	22817900
113	Acetylation	EFVQWFKKFFDANYD HHHHHHHHHHCCCCC	41.61	25953088
113	Ubiquitination	EFVQWFKKFFDANYD HHHHHHHHHHCCCCC	41.61	21890473
119	Phosphorylation	KKFFDANYDGKDYDP HHHHCCCCCCCCCCH	28.00	26552605
122	Ubiquitination	FDANYDGKDYDPVAA HCCCCCCCCCCHHHH	50.66	32015554
122	Acetylation	FDANYDGKDYDPVAA HCCCCCCCCCCHHHH	50.66	26051181
124	Phosphorylation	ANYDGKDYDPVAARQ CCCCCCCCCHHHHHC	26.15	28674151
135	Phosphorylation	AARQGQETAVAPSLV HHHCCCCCCCCCHHH	20.67	23312004
140	Phosphorylation	QETAVAPSLVAPALN CCCCCCCHHHHHHHC	26.24	26657352
148	Acetylation	LVAPALNKPKKPLTS HHHHHHCCCCCCCCC	60.09	23236377
148	Ubiquitination	LVAPALNKPKKPLTS HHHHHHCCCCCCCCC	60.09	23000965
150	Ubiquitination	APALNKPKKPLTSSS HHHHCCCCCCCCCCC	69.50	23000965
151	Ubiquitination	PALNKPKKPLTSSSA HHHCCCCCCCCCCCC	54.51	23000965
151	Acetylation	PALNKPKKPLTSSSA HHHCCCCCCCCCCCC	54.51	26051181
151	Methylation	PALNKPKKPLTSSSA HHHCCCCCCCCCCCC	54.51	-
154	Phosphorylation	NKPKKPLTSSSAAPQ CCCCCCCCCCCCCCC	34.78	20201521
154	O-linked_Glycosylation	NKPKKPLTSSSAAPQ CCCCCCCCCCCCCCC	34.78	30059200
155	Phosphorylation	KPKKPLTSSSAAPQR CCCCCCCCCCCCCCC	29.94	23927012
155	O-linked_Glycosylation	KPKKPLTSSSAAPQR CCCCCCCCCCCCCCC	29.94	30059200
156	O-linked_Glycosylation	PKKPLTSSSAAPQRP CCCCCCCCCCCCCCC	20.82	30059200
156	Phosphorylation	PKKPLTSSSAAPQRP CCCCCCCCCCCCCCC	20.82	23927012
157	Phosphorylation	KKPLTSSSAAPQRPI CCCCCCCCCCCCCCC	28.37	23927012
157	O-linked_Glycosylation	KKPLTSSSAAPQRPI CCCCCCCCCCCCCCC	28.37	30059200
165	Phosphorylation	AAPQRPISTQRTAAA CCCCCCCCCCCCCCC	22.59	12857735
166	Phosphorylation	APQRPISTQRTAAAP CCCCCCCCCCCCCCC	23.84	23927012
174	Ubiquitination	QRTAAAPKAGPGVVR CCCCCCCCCCCCCEE	62.34	23000965
182	Ubiquitination	AGPGVVRKNPGVGNG CCCCCEECCCCCCCC	56.75	29967540
197	Sulfoxidation	DDEAAELMQQVNVLK CHHHHHHHHHHCCEE	1.65	21406390
204	Ubiquitination	MQQVNVLKLTVEDLE HHHHCCEEEEHHHHH	37.52	32015554
206	Phosphorylation	QVNVLKLTVEDLEKE HHCCEEEEHHHHHHH	21.91	-
212	Ubiquitination	LTVEDLEKERDFYFG EEHHHHHHHCCEEEE	66.40	21906983
212	Sumoylation	LTVEDLEKERDFYFG EEHHHHHHHCCEEEE	66.40	-
212	Sumoylation	LTVEDLEKERDFYFG EEHHHHHHHCCEEEE	66.40	-
217	Phosphorylation	LEKERDFYFGKLRNI HHHHCCEEEEEEECE	18.73	-
220	Ubiquitination	ERDFYFGKLRNIELI HCCEEEEEEECEEEE	34.08	22817900
220	Acetylation	ERDFYFGKLRNIELI HCCEEEEEEECEEEE	34.08	19608861
228	Glutathionylation	LRNIELICQENEGEN EECEEEEEECCCCCC	6.93	22555962
247	Phosphorylation	QRIVDILYATDEGFV HHHHHHHHHCCCCCC	14.06	26552605
249	Phosphorylation	IVDILYATDEGFVIP HHHHHHHCCCCCCCC	22.49	26552605
268	Phosphorylation	PQEEQEEY------- CHHHHHCC-------	24.09	26552605

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
40	S	Phosphorylation	Kinase	MAP3K5	Q99683	GPS
154	T	Phosphorylation	Kinase	MAP3K5	Q99683	GPS
155	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
156	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
206	T	Phosphorylation	Kinase	MAP3K5	Q99683	GPS
247	Y	Phosphorylation	Kinase	SRC	P12931	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MARE1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MARE1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TERF1_HUMAN	TERF1	physical	11943150
CSN5_HUMAN	COPS5	physical	17350042
CSN8_HUMAN	COPS8	physical	17350042
CASK_HUMAN	CSN3	physical	17350042
TBB5_HUMAN	TUBB	physical	23128140
A4_HUMAN	APP	physical	21832049
SPTN1_HUMAN	SPTAN1	physical	22939629
AURKB_HUMAN	AURKB	physical	18477699
TBB5_PIG	TUBB2A	physical	23864329
LIS1_HUMAN	PAFAH1B1	physical	22863883
NAV1_HUMAN	NAV1	physical	25065758
NAV2_HUMAN	NAV2	physical	25065758
NAV3_HUMAN	NAV3	physical	25065758
TRIO_HUMAN	TRIO	physical	25065758
MARE1_HUMAN	MAPRE1	physical	25416956
MARE3_HUMAN	MAPRE3	physical	25416956
SPDE2_HUMAN	SPDYE2	physical	25416956
CYLD_HUMAN	CYLD	physical	24552808
NEMO_HUMAN	IKBKG	physical	24552808
TRAF2_HUMAN	TRAF2	physical	24552808
MDR1_HUMAN	ABCB1	physical	24552808
STK11_HUMAN	STK11	physical	24552808
BCL3_HUMAN	BCL3	physical	24552808
KAT2B_HUMAN	KAT2B	physical	23001180
KAT5_HUMAN	KAT5	physical	23001180
MARE1_HUMAN	MAPRE1	physical	23001180
MARE3_HUMAN	MAPRE3	physical	23001180
MTUS2_HUMAN	MTUS2	physical	23001180
KIF2C_HUMAN	KIF2C	physical	23001180
MACF1_HUMAN	MACF1	physical	23001180
CLAP1_HUMAN	CLASP1	physical	23001180
CLAP2_HUMAN	CLASP2	physical	23001180
APC_HUMAN	APC	physical	23001180
DYST_HUMAN	DST	physical	26186194
MACF1_HUMAN	MACF1	physical	26186194
IASPP_HUMAN	PPP1R13L	physical	26186194
AKAP9_HUMAN	AKAP9	physical	26186194
CLAP2_HUMAN	CLASP2	physical	26186194
MARE2_HUMAN	MAPRE2	physical	26186194
MARE3_HUMAN	MAPRE3	physical	26186194
KI18B_HUMAN	KIF18B	physical	26186194
MYOME_HUMAN	PDE4DIP	physical	26186194
IPL1_YEAST	IPL1	physical	22696216
ACTN4_HUMAN	ACTN4	physical	26496610
ACTN1_HUMAN	ACTN1	physical	26496610
ADDA_HUMAN	ADD1	physical	26496610
ADDG_HUMAN	ADD3	physical	26496610
APC_HUMAN	APC	physical	26496610
BLMH_HUMAN	BLMH	physical	26496610
DYST_HUMAN	DST	physical	26496610
CALL3_HUMAN	CALML3	physical	26496610
CAZA1_HUMAN	CAPZA1	physical	26496610
CD59_HUMAN	CD59	physical	26496610
CLCA_HUMAN	CLTA	physical	26496610
CLCB_HUMAN	CLTB	physical	26496610
CLH1_HUMAN	CLTC	physical	26496610
CBPM_HUMAN	CPM	physical	26496610
CTNA1_HUMAN	CTNNA1	physical	26496610
CTNB1_HUMAN	CTNNB1	physical	26496610
DAB2_HUMAN	DAB2	physical	26496610
DREB_HUMAN	DBN1	physical	26496610
DCTN1_HUMAN	DCTN1	physical	26496610
DYHC1_HUMAN	DYNC1H1	physical	26496610
DC1I2_HUMAN	DYNC1I2	physical	26496610
EPS15_HUMAN	EPS15	physical	26496610
FLNA_HUMAN	FLNA	physical	26496610
FYN_HUMAN	FYN	physical	26496610
GNAI2_HUMAN	GNAI2	physical	26496610
HS90B_HUMAN	HSP90AB1	physical	26496610
ABLM1_HUMAN	ABLIM1	physical	26496610
MYO1E_HUMAN	MYO1E	physical	26496610
PCM1_HUMAN	PCM1	physical	26496610
PCNT_HUMAN	PCNT	physical	26496610
PLEC_HUMAN	PLEC	physical	26496610
KAPCB_HUMAN	PRKACB	physical	26496610
KAP2_HUMAN	PRKAR2A	physical	26496610
SYQ_HUMAN	QARS	physical	26496610
CLIP1_HUMAN	CLIP1	physical	26496610
SPTN1_HUMAN	SPTAN1	physical	26496610
SPTB2_HUMAN	SPTBN1	physical	26496610
SSFA2_HUMAN	SSFA2	physical	26496610
SVIL_HUMAN	SVIL	physical	26496610
TMOD1_HUMAN	TMOD1	physical	26496610
TPM4_HUMAN	TPM4	physical	26496610
CLIP2_HUMAN	CLIP2	physical	26496610
YES_HUMAN	YES1	physical	26496610
LUZP1_HUMAN	LUZP1	physical	26496610
AXIN1_HUMAN	AXIN1	physical	26496610
SRBS2_HUMAN	SORBS2	physical	26496610
OFD1_HUMAN	OFD1	physical	26496610
TAOK2_HUMAN	TAOK2	physical	26496610
MYOME_HUMAN	PDE4DIP	physical	26496610
CE350_HUMAN	CEP350	physical	26496610
CE170_HUMAN	CEP170	physical	26496610
SC16A_HUMAN	SEC16A	physical	26496610
WDR1_HUMAN	WDR1	physical	26496610
ACTZ_HUMAN	ACTR1A	physical	26496610
AKAP9_HUMAN	AKAP9	physical	26496610
PIBF1_HUMAN	PIBF1	physical	26496610
DCTN2_HUMAN	DCTN2	physical	26496610
SPAG5_HUMAN	SPAG5	physical	26496610
GA2L1_HUMAN	GAS2L1	physical	26496610
IASPP_HUMAN	PPP1R13L	physical	26496610
KIF2C_HUMAN	KIF2C	physical	26496610
RAB35_HUMAN	RAB35	physical	26496610
FR1OP_HUMAN	FGFR1OP	physical	26496610
SYNPO_HUMAN	SYNPO	physical	26496610
CE162_HUMAN	CEP162	physical	26496610
CP131_HUMAN	CEP131	physical	26496610
RB6I2_HUMAN	ERC1	physical	26496610
CLAP2_HUMAN	CLASP2	physical	26496610
COBL_HUMAN	COBL	physical	26496610
CLAP1_HUMAN	CLASP1	physical	26496610
LIMA1_HUMAN	LIMA1	physical	26496610
SYBU_HUMAN	SYBU	physical	26496610
CEP72_HUMAN	CEP72	physical	26496610
CK5P2_HUMAN	CDK5RAP2	physical	26496610
MIB1_HUMAN	MIB1	physical	26496610
AFAP1_HUMAN	AFAP1	physical	26496610
HYI_HUMAN	HYI	physical	26496610
DLRB1_HUMAN	DYNLRB1	physical	26496610
CCD77_HUMAN	CCDC77	physical	26496610
SKAP_HUMAN	KNSTRN	physical	26496610
NEXN_HUMAN	NEXN	physical	26496610
CYTSB_HUMAN	SPECC1	physical	26496610
TBC31_HUMAN	TBC1D31	physical	26496610
ADIP_HUMAN	SSX2IP	physical	26496610
MISP_HUMAN	MISP	physical	26496610
CD109_HUMAN	CD109	physical	26496610
KI18B_HUMAN	KIF18B	physical	26496610
WDR90_HUMAN	WDR90	physical	26496610
TPRN_HUMAN	TPRN	physical	26496610
KAPCA_HUMAN	PRKACA	physical	26496610
KLH21_HUMAN	KLHL21	physical	27641145
DYST_HUMAN	DST	physical	28514442
MARE3_HUMAN	MAPRE3	physical	28514442
CLAP2_HUMAN	CLASP2	physical	28514442
MARE2_HUMAN	MAPRE2	physical	28514442
MYOME_HUMAN	PDE4DIP	physical	28514442
KI18B_HUMAN	KIF18B	physical	28514442
IASPP_HUMAN	PPP1R13L	physical	28514442
MACF1_HUMAN	MACF1	physical	28514442
AKAP9_HUMAN	AKAP9	physical	28514442
KAP3_HUMAN	PRKAR2B	physical	28514442
CLAP2_HUMAN	CLASP2	physical	27173435
MARE3_HUMAN	MAPRE3	physical	27173435
MARE2_HUMAN	MAPRE2	physical	27173435
DCTN1_HUMAN	DCTN1	physical	27173435
DCTN2_HUMAN	DCTN2	physical	27173435
IFT52_HUMAN	IFT52	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MARE1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-66, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-155 AND THR-166, ANDMASS SPECTROMETRY.	17287340 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-124, AND MASSSPECTROMETRY.	15592455 [Abstract]