| UniProt ID | KLH21_HUMAN | |
|---|---|---|
| UniProt AC | Q9UJP4 | |
| Protein Name | Kelch-like protein 21 | |
| Gene Name | KLHL21 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 597 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, spindle . Localizes to the spindle midzone and targets CUL3 to this region. | |
| Protein Description | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.. | |
| Protein Sequence | MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAADSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSIFRQFMPQTFSGGRGFELDSGSDDMDPGRPRPPRDPDELH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 26 | Phosphorylation | LSLLRGLSQLRAERK HHHHHHHHHHHHHHH | 29.96 | 27251275 | |
| 33 | Ubiquitination | SQLRAERKFLDVTLE HHHHHHHHHHHHHHH | 41.61 | - | |
| 194 | Ubiquitination | DDGLCVPKEEAAYQL HCCCCCCHHHHHHHH | 48.03 | - | |
| 370 | Ubiquitination | AEVAPMLKAREYHSS HHHHHHHHHHHHCCC | 38.86 | 21963094 | |
| 370 (in isoform 2) | Ubiquitination | - | 38.86 | - | |
| 370 (in isoform 1) | Ubiquitination | - | 38.86 | 21906983 | |
| 494 | Ubiquitination | PTRNEWDKIPSMNQV CCCCCHHCCCCCCEE | 58.55 | 29967540 | |
| 568 | Phosphorylation | QFMPQTFSGGRGFEL HHCCCCCCCCCCEEC | 43.66 | - | |
| 577 | Phosphorylation | GRGFELDSGSDDMDP CCCEECCCCCCCCCC | 53.47 | 28555341 | |
| 579 | Phosphorylation | GFELDSGSDDMDPGR CEECCCCCCCCCCCC | 34.10 | 29449344 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KLH21_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KLH21_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KLH21_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CUL3_HUMAN | CUL3 | physical | 19995937 | |
| KLHL9_HUMAN | KLHL9 | physical | 19995937 | |
| KLH13_HUMAN | KLHL13 | physical | 19995937 | |
| AURKB_HUMAN | AURKB | physical | 19995937 | |
| PLK1_HUMAN | PLK1 | physical | 23455478 | |
| CUL3_HUMAN | CUL3 | physical | 27387502 | |
| IKKB_HUMAN | IKBKB | physical | 27387502 | |
| MARE1_HUMAN | MAPRE1 | physical | 27641145 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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