KLH13_HUMAN - dbPTM
KLH13_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KLH13_HUMAN
UniProt AC Q9P2N7
Protein Name Kelch-like protein 13
Gene Name KLHL13
Organism Homo sapiens (Human).
Sequence Length 655
Subcellular Localization
Protein Description Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis..
Protein Sequence MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
20 (in isoform 2)Ubiquitination-4.02-
22PhosphorylationFPVPVLKTSRSTPLS
CCCCEEECCCCCCCC		25.8029083192
23PhosphorylationPVPVLKTSRSTPLSP
CCCEEECCCCCCCCH		23.7329083192
46PhosphorylationEDQHMKLSLGGSEMG
HHCCEEEEECCCCCH		21.3225159151
50PhosphorylationMKLSLGGSEMGLSSH
EEEEECCCCCHHHHH		23.7025159151
55PhosphorylationGGSEMGLSSHLQSSK
CCCCCHHHHHHHCCC		15.2425627689
62UbiquitinationSSHLQSSKAGPTRIF
HHHHHCCCCCCCEEE		63.71-
94 (in isoform 2)Ubiquitination-4.28-
128UbiquitinationAMFTGGMKEQDLMCI
HHHCCCCCHHCEEEE		56.34-
136UbiquitinationEQDLMCIKLHGVSKV
HHCEEEEEECCCCHH		29.51-
141PhosphorylationCIKLHGVSKVGLRKI
EEEECCCCHHHHHHH		26.64-
142UbiquitinationIKLHGVSKVGLRKII
EEECCCCHHHHHHHH		37.61-
171 (in isoform 2)Ubiquitination-7.4621890473
179 (in isoform 2)Ubiquitination-7.7921890473
192 (in isoform 2)Ubiquitination-31.7421890473
197 (in isoform 3)Ubiquitination-9.2921890473
205 (in isoform 3)Ubiquitination-12.5521890473
207 (in isoform 4)Ubiquitination-38.1521890473
213 (in isoform 1)Ubiquitination-57.1621890473
213UbiquitinationYNLTEVDKYVNSFVL
ECCCHHHHHHHHHHH		57.16-
215 (in isoform 4)Ubiquitination-6.2721890473
216 (in isoform 5)Ubiquitination-27.0021890473
218 (in isoform 3)Ubiquitination-6.6921890473
221UbiquitinationYVNSFVLKNFPALLS
HHHHHHHHCCHHHHH		51.76-
221 (in isoform 1)Ubiquitination-51.7621890473
224 (in isoform 5)Ubiquitination-31.2421890473
228 (in isoform 4)Ubiquitination-34.9021890473
234 (in isoform 1)Ubiquitination-60.4821890473
234UbiquitinationLSTGEFLKLPFERLA
HHCCCHHHCCHHHHH		60.48-
235 (in isoform 2)Ubiquitination-6.8121890473
237 (in isoform 5)Ubiquitination-14.3021890473
238 (in isoform 2)Ubiquitination-44.8621890473
261 (in isoform 3)Ubiquitination-11.8221890473
264 (in isoform 3)Ubiquitination-6.4921890473
271 (in isoform 4)Ubiquitination-40.3521890473
274 (in isoform 4)Ubiquitination-5.3521890473
277UbiquitinationPRMDFAAKLMKNIRF
CCHHHHHHHHHHCCC		45.76-
277 (in isoform 1)Ubiquitination-45.7621890473
280UbiquitinationDFAAKLMKNIRFPLM
HHHHHHHHHCCCCCC		60.71-
280 (in isoform 5)Ubiquitination-60.7121890473
280 (in isoform 1)Ubiquitination-60.7121890473
283 (in isoform 5)Ubiquitination-36.2021890473
315 (in isoform 2)Ubiquitination-11.75-
316PhosphorylationVNLLLEASNYQMMPY
HHHHHHHCCCCCCCC		27.0522210691
318PhosphorylationLLLEASNYQMMPYMQ
HHHHHCCCCCCCCCC		8.6922210691
323PhosphorylationSNYQMMPYMQPVMQS
CCCCCCCCCCCCCCC		7.1822210691
328 (in isoform 2)Ubiquitination-3.9321890473
330PhosphorylationYMQPVMQSDRTAIRS
CCCCCCCCCCCEECC		15.8022210691
354 (in isoform 3)Ubiquitination-3.8721890473
357UbiquitinationRQQLVVSKELRMYDE
HHHHHHCCHHHCCCC		49.51-
363 (in isoform 2)Ubiquitination-41.39-
364 (in isoform 4)Ubiquitination-34.3521890473
365UbiquitinationELRMYDEKAHEWKSL
HHHCCCCCCCCCHHC		52.74-
370UbiquitinationDEKAHEWKSLAPMDA
CCCCCCCHHCCCCCC		32.38-
370 (in isoform 1)Ubiquitination-32.3821890473
373 (in isoform 5)Ubiquitination-12.4021890473
388 (in isoform 2)Ubiquitination-16.55-
400PhosphorylationVVGGQSNYDTKGKTA
EECCCCCCCCCCCCH		30.18-
402PhosphorylationGGQSNYDTKGKTAVD
CCCCCCCCCCCCHHH		31.19-
405UbiquitinationSNYDTKGKTAVDTVF
CCCCCCCCCHHHEEE		34.56-
420UbiquitinationRFDPRYNKWMQVASL
ECCCCCCCCEEEECC		34.80-
426PhosphorylationNKWMQVASLNEKRTF
CCCEEEECCCCCCEE		32.6328509920
432PhosphorylationASLNEKRTFFHLSAL
ECCCCCCEEEEHHHH		41.5421406692
437PhosphorylationKRTFFHLSALKGYLY
CCEEEEHHHHCCHHH		24.0021406692
512PhosphorylationLMCFDPDTDKWIQKA
ECEECCCCCHHHHHC		44.8826074081
522PhosphorylationWIQKAPMTTVRGLHC
HHHHCCCCCCCCEEE		22.5326074081
523PhosphorylationIQKAPMTTVRGLHCM
HHHCCCCCCCCEEEE		11.2726074081
596PhosphorylationIYVVGGYSWNNRCMV
EEEECCCCCCCEEEE		26.9723532336
618UbiquitinationPDKDEWHKVFDLPES
CCCCHHHEHHCCCHH		45.75-
635PhosphorylationGIRACTLTVFPPEET
CEEEEEEEEECCCCC		11.27-
642PhosphorylationTVFPPEETTPSPSRE
EEECCCCCCCCCCCC		42.2023663014
643PhosphorylationVFPPEETTPSPSRES
EECCCCCCCCCCCCC		25.6723663014
645PhosphorylationPPEETTPSPSRESPL
CCCCCCCCCCCCCCC		33.1523663014
647PhosphorylationEETTPSPSRESPLSA
CCCCCCCCCCCCCCC		53.6823663014
653PhosphorylationPSRESPLSAP-----
CCCCCCCCCC-----		41.7125627689
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KLH13_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KLH13_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KLH13_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MD2L1_HUMANMAD2L1physical
19615732
UBP11_HUMANUSP11physical
19615732
ZMYM4_HUMANZMYM4physical
19615732
ZMYM6_HUMANZMYM6physical
19615732
CSN2_HUMANCOPS2physical
19615732
NUDC3_HUMANNUDCD3physical
19615732
CSN4_HUMANCOPS4physical
19615732
KLHL9_HUMANKLHL9physical
19615732
KLH22_HUMANKLHL22physical
19615732
CSN5_HUMANCOPS5physical
19615732
UBP25_HUMANUSP25physical
19615732
AURKB_HUMANAURKBphysical
19995937
CUL3_HUMANCUL3physical
17543862
AURKB_HUMANAURKBphysical
17543862
KLHL9_HUMANKLHL9physical
17543862
CUL3_HUMANCUL3physical
19295130
UB2D1_HUMANUBE2D1physical
17543862
KLH22_HUMANKLHL22physical
19995937
KLH21_HUMANKLHL21physical
19995937
CUL3_HUMANCUL3physical
19995937
KLHL9_HUMANKLHL9physical
19995937
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KLH13_HUMAN

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Related Literatures of Post-Translational Modification

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