UniProt ID | UBP11_HUMAN | |
---|---|---|
UniProt AC | P51784 | |
Protein Name | Ubiquitin carboxyl-terminal hydrolase 11 | |
Gene Name | USP11 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 963 | |
Subcellular Localization | Nucleus . Cytoplasm . Chromosome . Predominantly nuclear (PubMed:12084015, PubMed:15314155). Associates with chromatin (PubMed:20601937, PubMed:20233726). | |
Protein Description | Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. [PubMed: 12084015] | |
Protein Sequence | MAVAPRLFGGLCFRFRDQNPEVAVEGRLPISHSCVGCRRERTAMATVAANPAAAAAAVAAAAAVTEDREPQHEELPGLDSQWRQIENGESGRERPLRAGESWFLVEKHWYKQWEAYVQGGDQDSSTFPGCINNATLFQDEINWRLKEGLVEGEDYVLLPAAAWHYLVSWYGLEHGQPPIERKVIELPNIQKVEVYPVELLLVRHNDLGKSHTVQFSHTDSIGLVLRTARERFLVEPQEDTRLWAKNSEGSLDRLYDTHITVLDAALETGQLIIMETRKKDGTWPSAQLHVMNNNMSEEDEDFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADLVKQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLPISHKRVLEVFFIPMDPRRKPEQHRLVVPKKGKISDLCVALSKHTGISPERMMVADVFSHRFYKLYQLEEPLSSILDRDDIFVYEVSGRIEAIEGSREDIVVPVYLRERTPARDYNNSYYGLMLFGHPLLVSVPRDRFTWEGLYNVLMYRLSRYVTKPNSDDEDDGDEKEDDEEDKDDVPGPSTGGSLRDPEPEQAGPSSGVTNRCPFLLDNCLGTSQWPPRRRRKQLFTLQTVNSNGTSDRTTSPEEVHAQPYIAIDWEPEMKKRYYDEVEAEGYVKHDCVGYVMKKAPVRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREKLDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDSGQWHYFDDNSVSPVNENQIESKAAYVLFYQRQDVARRLLSPAGSSGAPASPACSSPPSSEFMDVN | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
31 | Phosphorylation | VEGRLPISHSCVGCR EEEECCCCCCCCCCC | 13.86 | - | |
33 | Phosphorylation | GRLPISHSCVGCRRE EECCCCCCCCCCCCC | 12.05 | - | |
107 | Ubiquitination | ESWFLVEKHWYKQWE CCEEEEEHHHHHHHH | 31.77 | 21890473 | |
182 | Ubiquitination | GQPPIERKVIELPNI CCCCCEEEEEECCCC | 34.47 | - | |
191 | Ubiquitination | IELPNIQKVEVYPVE EECCCCEEEEEEEEE | 36.24 | - | |
195 | Phosphorylation | NIQKVEVYPVELLLV CCEEEEEEEEEEEEE | 6.51 | 20068231 | |
241 | Methylation | VEPQEDTRLWAKNSE CCCCCCCCCEECCCC | 40.32 | 115919581 | |
245 | Acetylation | EDTRLWAKNSEGSLD CCCCCEECCCCCCHH | 49.80 | 19608861 | |
245 | Ubiquitination | EDTRLWAKNSEGSLD CCCCCEECCCCCCHH | 49.80 | 21890473 | |
268 | Phosphorylation | VLDAALETGQLIIME HHHHHHHHCCEEEEE | 30.95 | - | |
276 | Phosphorylation | GQLIIMETRKKDGTW CCEEEEEECCCCCCC | 30.34 | - | |
303 | Sumoylation | SEEDEDFKGQPGICG CCCCCCCCCCCCCCC | 69.80 | - | |
355 | Ubiquitination | FRNPLGMKGEIAEAY CCCCCCCCHHHHHHH | 52.15 | 21890473 | |
362 | Phosphorylation | KGEIAEAYADLVKQA CHHHHHHHHHHHHHH | 7.67 | 28796482 | |
367 | Ubiquitination | EAYADLVKQAWSGHH HHHHHHHHHHHCCCC | 41.41 | 21890473 | |
383 | Ubiquitination | SIVPHVFKNKVGHFA CHHCHHHHCCHHHHH | 55.56 | - | |
383 | Methylation | SIVPHVFKNKVGHFA CHHCHHHHCCHHHHH | 55.56 | 115978921 | |
385 | Ubiquitination | VPHVFKNKVGHFASQ HCHHHHCCHHHHHHH | 50.62 | - | |
396 | Phosphorylation | FASQFLGYQQHDSQE HHHHHHCCCCCCHHH | 13.72 | - | |
422 | Ubiquitination | DLNRVKKKEYVELCD HHHHHCHHHHHHHHH | 48.86 | - | |
447 | Ubiquitination | QEAWQNHKRRNDSVI HHHHHHHHHHCCCEE | 61.68 | - | |
452 | Phosphorylation | NHKRRNDSVIVDTFH HHHHHCCCEEEECCC | 19.79 | 28464451 | |
493 | Ubiquitination | VPLPISHKRVLEVFF CCCCCCCCCEEEEEE | 37.09 | - | |
503 | Sulfoxidation | LEVFFIPMDPRRKPE EEEEEEECCCCCCHH | 10.67 | 21406390 | |
519 | Ubiquitination | HRLVVPKKGKISDLC CCEECCCCCCHHHHH | 60.41 | - | |
521 | Ubiquitination | LVVPKKGKISDLCVA EECCCCCCHHHHHHH | 48.17 | - | |
531 | Acetylation | DLCVALSKHTGISPE HHHHHHHHCCCCCHH | 46.14 | 25953088 | |
531 | Ubiquitination | DLCVALSKHTGISPE HHHHHHHHCCCCCHH | 46.14 | 21890473 | |
584 | Phosphorylation | RIEAIEGSREDIVVP CEEEEECCHHHEEEE | 21.51 | 21406692 | |
593 | Phosphorylation | EDIVVPVYLRERTPA HHEEEEEEEECCCCC | 8.25 | - | |
603 | Phosphorylation | ERTPARDYNNSYYGL CCCCCCCCCCCEEEH | 15.64 | 28450419 | |
606 | Phosphorylation | PARDYNNSYYGLMLF CCCCCCCCEEEHHCC | 18.98 | 28450419 | |
607 | Phosphorylation | ARDYNNSYYGLMLFG CCCCCCCEEEHHCCC | 12.04 | 28450419 | |
608 | Phosphorylation | RDYNNSYYGLMLFGH CCCCCCEEEHHCCCC | 12.01 | 28450419 | |
640 | Phosphorylation | NVLMYRLSRYVTKPN HHHHHHHHHHCCCCC | 16.74 | 21406692 | |
642 | Phosphorylation | LMYRLSRYVTKPNSD HHHHHHHHCCCCCCC | 14.75 | 30576142 | |
644 | Phosphorylation | YRLSRYVTKPNSDDE HHHHHHCCCCCCCCC | 31.67 | 28787133 | |
648 | Phosphorylation | RYVTKPNSDDEDDGD HHCCCCCCCCCCCCC | 55.77 | 28355574 | |
664 | Ubiquitination | KEDDEEDKDDVPGPS CCCCCCCCCCCCCCC | 60.14 | - | |
671 | Phosphorylation | KDDVPGPSTGGSLRD CCCCCCCCCCCCCCC | 45.67 | 21659604 | |
672 | Phosphorylation | DDVPGPSTGGSLRDP CCCCCCCCCCCCCCC | 49.01 | 21659604 | |
675 | Phosphorylation | PGPSTGGSLRDPEPE CCCCCCCCCCCCCHH | 22.90 | 21659604 | |
677 | Methylation | PSTGGSLRDPEPEQA CCCCCCCCCCCHHHC | 60.17 | 115919585 | |
714 | Ubiquitination | WPPRRRRKQLFTLQT CCCCHHHHCCEEEEE | 49.93 | 21890473 | |
718 | Phosphorylation | RRRKQLFTLQTVNSN HHHHCCEEEEEECCC | 26.92 | 29083192 | |
721 | Phosphorylation | KQLFTLQTVNSNGTS HCCEEEEEECCCCCC | 25.43 | 29083192 | |
724 | Phosphorylation | FTLQTVNSNGTSDRT EEEEEECCCCCCCCC | 32.09 | 29083192 | |
727 | Phosphorylation | QTVNSNGTSDRTTSP EEECCCCCCCCCCCH | 31.53 | 29083192 | |
728 | Phosphorylation | TVNSNGTSDRTTSPE EECCCCCCCCCCCHH | 26.88 | 29083192 | |
731 | Phosphorylation | SNGTSDRTTSPEEVH CCCCCCCCCCHHHHC | 36.29 | 26074081 | |
732 | Phosphorylation | NGTSDRTTSPEEVHA CCCCCCCCCHHHHCC | 43.08 | 26074081 | |
733 | Phosphorylation | GTSDRTTSPEEVHAQ CCCCCCCCHHHHCCC | 29.69 | 25159151 | |
742 | Phosphorylation | EEVHAQPYIAIDWEP HHHCCCCCEEECCCH | 7.30 | 29523821 | |
752 | Ubiquitination | IDWEPEMKKRYYDEV ECCCHHHHHHHCCHH | 32.22 | - | |
753 | Ubiquitination | DWEPEMKKRYYDEVE CCCHHHHHHHCCHHC | 44.30 | - | |
756 | Phosphorylation | PEMKKRYYDEVEAEG HHHHHHHCCHHCCCC | 15.06 | 27642862 | |
766 | Ubiquitination | VEAEGYVKHDCVGYV HCCCCEECCCHHHHH | 25.83 | - | |
772 | Phosphorylation | VKHDCVGYVMKKAPV ECCCHHHHHHHHCCC | 4.13 | 27642862 | |
775 | Ubiquitination | DCVGYVMKKAPVRLQ CHHHHHHHHCCCCHH | 35.42 | - | |
776 | Ubiquitination | CVGYVMKKAPVRLQE HHHHHHHHCCCCHHH | 39.57 | - | |
806 | Ubiquitination | PWYCPSCKQHQLATK CCCCCCHHHHCCCCC | 55.97 | 21890473 | |
813 | Ubiquitination | KQHQLATKKLDLWML HHHCCCCCCCCHHHC | 45.81 | - | |
835 | Ubiquitination | LKRFSYTKFSREKLD HHCCCCCCCCHHHHH | 32.86 | 21890473 | |
840 | Ubiquitination | YTKFSREKLDTLVEF CCCCCHHHHHHEEEE | 51.02 | 21890473 | |
865 | Phosphorylation | VIQPQNESNPELYKY EECCCCCCCHHHEEE | 66.29 | 19845377 | |
871 | Ubiquitination | ESNPELYKYDLIAVS CCCHHHEEEEEEEEE | 44.93 | - | |
896 | Ubiquitination | YTTFACNKDSGQWHY EEEEEEECCCCCEEE | 53.83 | - | |
898 | Phosphorylation | TFACNKDSGQWHYFD EEEEECCCCCEEECC | 34.20 | 29978859 | |
903 | Phosphorylation | KDSGQWHYFDDNSVS CCCCCEEECCCCCCC | 13.02 | 29978859 | |
905 | Phosphorylation | SGQWHYFDDNSVSPV CCCEEECCCCCCCCC | 47.19 | 18669648 | |
908 | Phosphorylation | WHYFDDNSVSPVNEN EEECCCCCCCCCCHH | 30.85 | 29978859 | |
910 | Phosphorylation | YFDDNSVSPVNENQI ECCCCCCCCCCHHHH | 23.97 | 29978859 | |
919 | Phosphorylation | VNENQIESKAAYVLF CCHHHHHHHHEEEEE | 29.26 | 29978859 | |
920 | Ubiquitination | NENQIESKAAYVLFY CHHHHHHHHEEEEEC | 25.01 | - | |
923 | Phosphorylation | QIESKAAYVLFYQRQ HHHHHHEEEEECCHH | 11.53 | 28152594 | |
927 | Phosphorylation | KAAYVLFYQRQDVAR HHEEEEECCHHHHHH | 9.91 | 29978859 | |
938 | Phosphorylation | DVARRLLSPAGSSGA HHHHHHHCCCCCCCC | 19.80 | 28674151 | |
942 | Phosphorylation | RLLSPAGSSGAPASP HHHCCCCCCCCCCCC | 27.92 | 28674151 | |
943 | Phosphorylation | LLSPAGSSGAPASPA HHCCCCCCCCCCCCC | 37.75 | 30177828 | |
948 | Phosphorylation | GSSGAPASPACSSPP CCCCCCCCCCCCCCC | 16.39 | 27362937 | |
952 | Phosphorylation | APASPACSSPPSSEF CCCCCCCCCCCCHHH | 48.24 | 27362937 | |
953 | Phosphorylation | PASPACSSPPSSEFM CCCCCCCCCCCHHHC | 40.49 | 21712546 | |
956 | Phosphorylation | PACSSPPSSEFMDVN CCCCCCCCHHHCCCC | 45.98 | 28674151 | |
957 | Phosphorylation | ACSSPPSSEFMDVN- CCCCCCCHHHCCCC- | 40.40 | 28674151 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UBP11_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UBP11_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UBP11_HUMAN !! |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Acetylation | |
Reference | PubMed |
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-245, AND MASS SPECTROMETRY. | |
Phosphorylation | |
Reference | PubMed |
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-948 AND SER-953, ANDMASS SPECTROMETRY. |