MPP9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MPP9_HUMAN
• UniProt AC: Q99550
• Protein Name: M-phase phosphoprotein 9
• Gene Name: MPHOSPH9
• Organism: Homo sapiens (Human).
• Sequence Length: 1183
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus membrane ; Peripheral membrane protein . Localizes to the distal and proximal end of centriole pairs in duplicated centrosomes. In ciliated cells, localize
• Protein Sequence: MEEFDLVKTLHKTSSSVGSDENSLHSLGLNLNTDRSSPHLSTNGVSSFSGKTRPSVIQGTVEVLTSLMQELQNSGKTDSELWKNCETRWLQLFNLVEKQCQEQIVAQQEQFHNQIQHIQEEIKNLVKLQTSSASLASCEGNSSNKQVSSESQMGFFSLSSERNESVIHYPESTEPEIQQEMSTSQPDCNVDSCSVSSGYGTFCISELNLYKSKDPKEFMEHIDVPKGQYVAPAVPAESLVDGVKNENFYIQTPEECHVSLKEDVSISPGEFEHNFLGENKVSEVYSGKTNSNAITSWAQKLKQNQPKRAHVEDGGSRSKQGNEQSKKTPIEKSDFAAATHPRAFYLSKPDETPNAWMSDSGTGLTYWKLEEKDMHHSLPETLEKTFISLSSTDVSPNQSNTSNEMKLPSLKDIYYKKQRENKQLPERNLTSASNPNHPPEVLTLDPTLHMKPKQQISGIQPHGLPNALDDRISFSPDSVLEPSMSSPSDIDSFSQASNVTSQLPGFPKYPSHTKASPVDSWKNQTFQNESRTSSTFPSVYTITSNDISVNTVDEENTVMVASASVSQSQLPGTANSVPECISLTSLEDPVILSKIRQNLKEKHARHIADLRAYYESEINSLKQKLEAKEISGVEDWKITNQILVDRCGQLDSALHEATSRVRTLENKNNLLEIEVNDLRERFSAASSASKILQERIEEMRTSSKEKDNTIIRLKSRLQDLEEAFENAYKLSDDKEAQLKQENKMFQDLLGEYESLGKEHRRVKDALNTTENKLLDAYTQISDLKRMISKLEAQVKQVEHENMLSLRHNSRIHVRPSRANTLATSDVSRRKWLIPGAEYSIFTGQPLDTQDSNVDNQLEETCSLGHRSPLEKDSSPGSSSTSLLIKKQRETSDTPIMRALKELDEGKIFKNWGTQTEKEDTSNINPRQTETSVNASRSPEKCAQQRQKRLNSASQRSSSLPPSNRKSSTPTKREIMLTPVTVAYSPKRSPKENLSPGFSHLLSKNESSPIRFDILLDDLDTVPVSTLQRTNPRKQLQFLPLDDSEEKTYSEKATDNHVNHSSCPEPVPNGVKKVSVRTAWEKNKSVSYEQCKPVSVTPQGNDFEYTAKIRTLAETERFFDELTKEKDQIEAALSRMPSPGGRITLQTRLNQEALEDRLERINRELGSVRMTLKKFHVLRTSANL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Ubiquitination	MEEFDLVKTLHKTSS CCCHHHHHHHCCCCC	45.96	-
12	Ubiquitination	DLVKTLHKTSSSVGS HHHHHHCCCCCCCCC	53.24	29967540
13	Phosphorylation	LVKTLHKTSSSVGSD HHHHHCCCCCCCCCC	29.89	26471730
14	Phosphorylation	VKTLHKTSSSVGSDE HHHHCCCCCCCCCCC	2.26	26471730
15	Phosphorylation	KTLHKTSSSVGSDEN HHHCCCCCCCCCCCC	3.43	26471730
16	Phosphorylation	TLHKTSSSVGSDENS HHCCCCCCCCCCCCC	29.91	28176443
19	Phosphorylation	KTSSSVGSDENSLHS CCCCCCCCCCCCHHH	64.23	28176443
52	Phosphorylation	VSSFSGKTRPSVIQG CCCCCCCCCCCHHHH	2.91	30622161
55	Phosphorylation	FSGKTRPSVIQGTVE CCCCCCCCHHHHHHH	4.23	30622161
60	Phosphorylation	RPSVIQGTVEVLTSL CCCHHHHHHHHHHHH	28.83	30622161
83	Ubiquitination	KTDSELWKNCETRWL CCCHHHHHHHHHHHH	32.20	-
127	Ubiquitination	EEIKNLVKLQTSSAS HHHHHHHHHHCCCCH	48.51	29967540
134	Phosphorylation	KLQTSSASLASCEGN HHHCCCCHHHHCCCC	38.70	26471730
136	Ubiquitination	QTSSASLASCEGNSS HCCCCHHHHCCCCCC	38.30	-
137	Phosphorylation	TSSASLASCEGNSSN CCCCHHHHCCCCCCC	47.61	26471730
148	Ubiquitination	NSSNKQVSSESQMGF CCCCCCCCCHHHHCE	50.32	-
172	Phosphorylation	SVIHYPESTEPEIQQ CEECCCCCCCHHHHH	65.63	26074081
173	Phosphorylation	VIHYPESTEPEIQQE EECCCCCCCHHHHHH	29.91	26074081
216	Ubiquitination	LYKSKDPKEFMEHID CCCCCCHHHHHHHCC	35.29	29967540
244	Ubiquitination	ESLVDGVKNENFYIQ HHHCCCCCCCCCEEC	42.60	29967540
252	Phosphorylation	NENFYIQTPEECHVS CCCCEECCHHHCCEE	37.15	25159151
265	Phosphorylation	VSLKEDVSISPGEFE EEECCCCCCCCCCCC	38.17	22199227
267	Phosphorylation	LKEDVSISPGEFEHN ECCCCCCCCCCCCCC	59.33	22199227
280	Ubiquitination	HNFLGENKVSEVYSG CCCCCCCCCEEECCC	14.21	29967540
285	Phosphorylation	ENKVSEVYSGKTNSN CCCCEEECCCCCCHH	40.32	29496907
288	Ubiquitination	VSEVYSGKTNSNAIT CEEECCCCCCHHHHH	55.39	29967540
300	Ubiquitination	AITSWAQKLKQNQPK HHHHHHHHHHHCCCC	31.92	29967540
328	Phosphorylation	GNEQSKKTPIEKSDF CCCCCCCCCCCHHHH	10.43	-
332	Ubiquitination	SKKTPIEKSDFAAAT CCCCCCCHHHHHHCC	7.23	29967540
333	Phosphorylation	KKTPIEKSDFAAATH CCCCCCHHHHHHCCC	43.35	-
333	Ubiquitination	KKTPIEKSDFAAATH CCCCCCHHHHHHCCC	43.35	24816145
362	Ubiquitination	AWMSDSGTGLTYWKL CCCCCCCCCCCEEEE	41.25	-
370	Ubiquitination	GLTYWKLEEKDMHHS CCCEEEECHHHCCCC	43.03	-
372	Ubiquitination	TYWKLEEKDMHHSLP CEEEECHHHCCCCCC	39.71	29967540
377	Phosphorylation	EEKDMHHSLPETLEK CHHHCCCCCCHHHHH	30.71	25849741
381	Phosphorylation	MHHSLPETLEKTFIS CCCCCCHHHHHHEEE	26.69	30108239
392	Phosphorylation	TFISLSSTDVSPNQS HEEECCCCCCCCCCC	28.75	-
395	Phosphorylation	SLSSTDVSPNQSNTS ECCCCCCCCCCCCCC	6.07	21815630
409	Phosphorylation	SNEMKLPSLKDIYYK CCCCCCCHHHHHHHH	4.93	24719451
433	Phosphorylation	ERNLTSASNPNHPPE CCCCCCCCCCCCCCC	34.75	22210691
443	Phosphorylation	NHPPEVLTLDPTLHM CCCCCCCCCCCCCCC	5.01	22210691
447	Phosphorylation	EVLTLDPTLHMKPKQ CCCCCCCCCCCCCHH	6.00	22210691
453	Ubiquitination	PTLHMKPKQQISGIQ CCCCCCCHHHCCCCC	22.82	29967540
470	Ubiquitination	GLPNALDDRISFSPD CCCCCCCCCCCCCCC	45.25	-
514	Ubiquitination	PKYPSHTKASPVDSW CCCCCCCCCCCCCHH	56.31	29967540
516	Phosphorylation	YPSHTKASPVDSWKN CCCCCCCCCCCHHCC	56.83	21815630
522	Ubiquitination	ASPVDSWKNQTFQNE CCCCCHHCCCCCCCC	26.37	-
554	Ubiquitination	ISVNTVDEENTVMVA EEECCCCCCCEEEEE	61.08	24816145
587	Ubiquitination	CISLTSLEDPVILSK HHCCCCCCCHHHHHH	43.41	-
597	Ubiquitination	VILSKIRQNLKEKHA HHHHHHHHHHHHHHH	7.06	24816145
628	Ubiquitination	LKQKLEAKEISGVED HHHHHHHHHCCCCCC	2.39	29967540
637	Ubiquitination	ISGVEDWKITNQILV CCCCCCCHHHCCHHH	39.15	29967540
654	Ubiquitination	CGQLDSALHEATSRV CCCHHHHHHHHHHHH	24.46	24816145
664	Ubiquitination	ATSRVRTLENKNNLL HHHHHHHHCCCCCEE	33.20	24816145
667	Ubiquitination	RVRTLENKNNLLEIE HHHHHCCCCCEEEEE	34.22	29967540
690	Ubiquitination	SAASSASKILQERIE HHHHHHHHHHHHHHH	32.98	29967540
701	O-linked_Glycosylation	ERIEEMRTSSKEKDN HHHHHHHHCCHHHCC	9.41	30379171
706	Ubiquitination	MRTSSKEKDNTIIRL HHHCCHHHCCHHHHH	41.31	24816145
728	Phosphorylation	EEAFENAYKLSDDKE HHHHHHHHHCCCCHH	25.91	17693683
729	Acetylation	EAFENAYKLSDDKEA HHHHHHHHCCCCHHH	24.11	12654809
729	Ubiquitination	EAFENAYKLSDDKEA HHHHHHHHCCCCHHH	24.11	29967540
731	Phosphorylation	FENAYKLSDDKEAQL HHHHHHCCCCHHHHH	5.59	29396449
739	Acetylation	DDKEAQLKQENKMFQ CCHHHHHHHHHHHHH	34.43	19824823
743	Acetylation	AQLKQENKMFQDLLG HHHHHHHHHHHHHHH	2.95	15606689
789	Ubiquitination	DLKRMISKLEAQVKQ HHHHHHHHHHHHHHH	3.84	29967540
820	Phosphorylation	VRPSRANTLATSDVS ECCCCCCCCCCCCCC	40.95	29255136
823	Phosphorylation	SRANTLATSDVSRRK CCCCCCCCCCCCCCC	2.67	23312004
824	Phosphorylation	RANTLATSDVSRRKW CCCCCCCCCCCCCCC	6.34	23312004
827	Phosphorylation	TLATSDVSRRKWLIP CCCCCCCCCCCCCCC	5.91	23312004
838	Phosphorylation	WLIPGAEYSIFTGQP CCCCCCEEEEEECCC	61.55	-
839	Phosphorylation	LIPGAEYSIFTGQPL CCCCCEEEEEECCCC	67.78	-
842	Phosphorylation	GAEYSIFTGQPLDTQ CCEEEEEECCCCCCC	34.26	-
867	Phosphorylation	TCSLGHRSPLEKDSS HHHCCCCCCCCCCCC	53.29	23312004
873	Phosphorylation	RSPLEKDSSPGSSST CCCCCCCCCCCCCHH	27.43	23911959
874	Phosphorylation	SPLEKDSSPGSSSTS CCCCCCCCCCCCHHH	2.24	25159151
877	Phosphorylation	EKDSSPGSSSTSLLI CCCCCCCCCHHHEEE	36.29	22199227
878	Phosphorylation	KDSSPGSSSTSLLIK CCCCCCCCHHHEEEE	36.25	22199227
879	Phosphorylation	DSSPGSSSTSLLIKK CCCCCCCHHHEEEEE	44.21	23312004
880	Phosphorylation	SSPGSSSTSLLIKKQ CCCCCCHHHEEEEEH	41.23	28985074
881	Phosphorylation	SPGSSSTSLLIKKQR CCCCCHHHEEEEEHH	57.53	23312004
881	Ubiquitination	SPGSSSTSLLIKKQR CCCCCHHHEEEEEHH	57.53	-
886	Methylation	STSLLIKKQRETSDT HHHEEEEEHHCCCCC	2.38	115973225
893	Phosphorylation	KQRETSDTPIMRALK EHHCCCCCHHHHHHH	55.43	28674419
906	Ubiquitination	LKELDEGKIFKNWGT HHHHHCCCCCCCCCC	23.05	29967540
909	Ubiquitination	LDEGKIFKNWGTQTE HHCCCCCCCCCCCCC	26.58	29967540
917	Ubiquitination	NWGTQTEKEDTSNIN CCCCCCCCCCCCCCC	26.93	29967540
928	Phosphorylation	SNINPRQTETSVNAS CCCCCCCCCCCCCCC	44.26	21406692
930	Phosphorylation	INPRQTETSVNASRS CCCCCCCCCCCCCCC	30.25	28450419
931	Phosphorylation	NPRQTETSVNASRSP CCCCCCCCCCCCCCH	64.40	28450419
935	Phosphorylation	TETSVNASRSPEKCA CCCCCCCCCCHHHHH	14.09	25849741
937	Phosphorylation	TSVNASRSPEKCAQQ CCCCCCCCHHHHHHH	32.09	25159151
939	Ubiquitination	VNASRSPEKCAQQRQ CCCCCCHHHHHHHHH	48.42	-
955	Ubiquitination	RLNSASQRSSSLPPS HHHHHHHHHHCCCCC	25.56	-
957	Phosphorylation	NSASQRSSSLPPSNR HHHHHHHHCCCCCCC	23.99	23312004
958	Phosphorylation	SASQRSSSLPPSNRK HHHHHHHCCCCCCCC	33.52	24719451
968	Phosphorylation	PSNRKSSTPTKREIM CCCCCCCCCCCCEEE	53.86	30576142
970	Phosphorylation	NRKSSTPTKREIMLT CCCCCCCCCCEEEEE	34.80	29116813
977	Phosphorylation	TKREIMLTPVTVAYS CCCEEEEEEEEEECC	23.43	25159151
980	Phosphorylation	EIMLTPVTVAYSPKR EEEEEEEEEECCCCC	4.26	25850435
983	Phosphorylation	LTPVTVAYSPKRSPK EEEEEEECCCCCCCC	3.28	25850435
984	Phosphorylation	TPVTVAYSPKRSPKE EEEEEECCCCCCCCC	35.94	25159151
988	Phosphorylation	VAYSPKRSPKENLSP EECCCCCCCCCCCCC	22.62	28464451
994	Phosphorylation	RSPKENLSPGFSHLL CCCCCCCCCCHHHHH	39.99	30266825
998	Phosphorylation	ENLSPGFSHLLSKNE CCCCCCHHHHHCCCC	41.76	30266825
1006	Phosphorylation	HLLSKNESSPIRFDI HHHCCCCCCCCEEEE	53.03	28450419
1007	Phosphorylation	LLSKNESSPIRFDIL HHCCCCCCCCEEEEE	35.75	28450419
1033	Ubiquitination	LQRTNPRKQLQFLPL HCCCCCCCCCEEEEC		29967540
1046	Ubiquitination	PLDDSEEKTYSEKAT ECCCCCCCCCCCCCC		29967540
1087	Phosphorylation	EKNKSVSYEQCKPVS HHCCCCCHHHCCCEE		29496907
1091	Ubiquitination	SVSYEQCKPVSVTPQ CCCHHHCCCEEECCC		29967540
1096	Phosphorylation	QCKPVSVTPQGNDFE HCCCEEECCCCCCCE		25159151
1107	Ubiquitination	NDFEYTAKIRTLAET CCCEEEEEEEHHHHH		29967540
1114	Phosphorylation	KIRTLAETERFFDEL EEEHHHHHHHHHHHH		28509920
1122	Phosphorylation	ERFFDELTKEKDQIE HHHHHHHHHCHHHHH		28509920
1123	Ubiquitination	RFFDELTKEKDQIEA HHHHHHHHCHHHHHH		29967540
1125	Ubiquitination	FDELTKEKDQIEAAL HHHHHHCHHHHHHHH		29967540
1133	Phosphorylation	DQIEAALSRMPSPGG HHHHHHHHCCCCCCC		23879269
1137	Phosphorylation	AALSRMPSPGGRITL HHHHCCCCCCCCEEE		-
1143	Phosphorylation	PSPGGRITLQTRLNQ CCCCCCEEEEHHHCH		22210691
1146	Phosphorylation	GGRITLQTRLNQEAL CCCEEEEHHHCHHHH		22210691
1166	Phosphorylation	RINRELGSVRMTLKK HHHHHHHHHHHHHHH		24719451
1172	Acetylation	GSVRMTLKKFHVLRT HHHHHHHHHHHHHHC		7833859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MPP9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MPP9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MPP9_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MPP9_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteome profiling of Wnt3a-mediated signalingnetwork: indicating the involvement of ribonucleoside-diphosphatereductase M2 subunit phosphorylation at residue serine 20 in canonicalWnt signal transduction.";
Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S.,Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.;
Mol. Cell. Proteomics 6:1952-1967(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-576, AND MASSSPECTROMETRY.
PubMed: 17693683