TCAL4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCAL4_HUMAN
• UniProt AC: Q96EI5
• Protein Name: Transcription elongation factor A protein-like 4
• Gene Name: TCEAL4
• Organism: Homo sapiens (Human).
• Sequence Length: 215
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MEKLYSENEGMASNQGKMENEEQPQDERKPEVTCTLEDKKLENEGKTENKGKTGDEEMLKDKGKPESEGEAKEGKSEREGESEMEGGSEREGKPEIEGKPESEGEPGSETRAAGKRPAEDDVPRKAKRKTNKGLAHYLKEYKEAIHDMNFSNEDMIREFDNMAKVQDEKRKSKQKLGAFLWMQRNLQDPFYPRGPREFRGGCRAPRRDIEDIPYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEKLYSEN -------CCHHCCCC	10.39	22814378
5	Phosphorylation	---MEKLYSENEGMA ---CCHHCCCCCCCC	25.63	17053785
6	Phosphorylation	--MEKLYSENEGMAS --CCHHCCCCCCCCC	44.36	29978859
13	Phosphorylation	SENEGMASNQGKMEN CCCCCCCCCCCCCCC	22.31	23401153
17	Acetylation	GMASNQGKMENEEQP CCCCCCCCCCCCCCC	33.02	26051181
33	Phosphorylation	DERKPEVTCTLEDKK CCCCCCCEEEEEHHH	9.71	20068231
35	Phosphorylation	RKPEVTCTLEDKKLE CCCCCEEEEEHHHCC	24.66	20068231
40	Ubiquitination	TCTLEDKKLENEGKT EEEEEHHHCCCCCCC	73.65	-
62	Acetylation	DEEMLKDKGKPESEG CHHHHHCCCCCCCCC	68.21	11792825
64	Acetylation	EMLKDKGKPESEGEA HHHHCCCCCCCCCCC	51.88	11792833
67	Phosphorylation	KDKGKPESEGEAKEG HCCCCCCCCCCCCCC	60.47	30576142
76	Phosphorylation	GEAKEGKSEREGESE CCCCCCCCCCCCCCC	53.39	23186163
82	Phosphorylation	KSEREGESEMEGGSE CCCCCCCCCCCCCCC	53.77	29255136
88	Phosphorylation	ESEMEGGSEREGKPE CCCCCCCCCCCCCCC	44.32	29255136
102	Phosphorylation	EIEGKPESEGEPGSE CCCCCCCCCCCCCCC	60.47	29255136
108	Phosphorylation	ESEGEPGSETRAAGK CCCCCCCCCCCCCCC	46.65	30278072
110	Phosphorylation	EGEPGSETRAAGKRP CCCCCCCCCCCCCCC	27.57	30206219
115	Ubiquitination	SETRAAGKRPAEDDV CCCCCCCCCCCCCCC	50.94	-
127	Acetylation	DDVPRKAKRKTNKGL CCCCHHHHHHCCHHH	58.42	7407653
132	Ubiquitination	KAKRKTNKGLAHYLK HHHHHCCHHHHHHHH	61.61	-
132	Acetylation	KAKRKTNKGLAHYLK HHHHHCCHHHHHHHH	61.61	20167786
137	Phosphorylation	TNKGLAHYLKEYKEA CCHHHHHHHHHHHHH	17.54	28152594
139	Ubiquitination	KGLAHYLKEYKEAIH HHHHHHHHHHHHHHH	52.40	21890473
139 (in isoform 1)	Ubiquitination	-	52.40	21890473
139	Acetylation	KGLAHYLKEYKEAIH HHHHHHHHHHHHHHH	52.40	20167786
142 (in isoform 1)	Ubiquitination	-	41.58	21890473
142	Ubiquitination	AHYLKEYKEAIHDMN HHHHHHHHHHHHHCC	41.58	21890473
142	Sumoylation	AHYLKEYKEAIHDMN HHHHHHHHHHHHHCC	41.58	-
148 (in isoform 2)	Phosphorylation	-	3.18	28985074
148	Sulfoxidation	YKEAIHDMNFSNEDM HHHHHHHCCCCCHHH	3.18	30846556
149 (in isoform 2)	Phosphorylation	-	43.16	25159151
155	Sulfoxidation	MNFSNEDMIREFDNM CCCCCHHHHHHHHHH	2.25	30846556
156 (in isoform 2)	Phosphorylation	-	6.21	25159151
164	Ubiquitination	REFDNMAKVQDEKRK HHHHHHHHHHHHHHH	29.65	-
175	Ubiquitination	EKRKSKQKLGAFLWM HHHHHHHHHHHHHHH	53.26	-
175 (in isoform 1)	Ubiquitination	-	53.26	21890473
193	Methylation	LQDPFYPRGPREFRG CCCCCCCCCCCCCCC	57.26	-
199	Methylation	PRGPREFRGGCRAPR CCCCCCCCCCCCCCC	35.52	-
245 (in isoform 2)	Phosphorylation	-		21406692
251 (in isoform 2)	Phosphorylation	-		21406692
280 (in isoform 2)	Phosphorylation	-		27642862
282 (in isoform 2)	Ubiquitination	-		21890473
285 (in isoform 2)	Ubiquitination	-		21890473
318 (in isoform 2)	Ubiquitination	-		21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCAL4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCAL4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCAL4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBP7_HUMAN	USP7	physical	19615732
UBP11_HUMAN	USP11	physical	19615732
TCAL2_HUMAN	TCEAL2	physical	19615732
HECD1_HUMAN	HECTD1	physical	22863883
IFRD1_HUMAN	IFRD1	physical	26496610
TRI27_HUMAN	TRIM27	physical	26496610
HLTF_HUMAN	HLTF	physical	26496610
UBP7_HUMAN	USP7	physical	26496610
UBP11_HUMAN	USP11	physical	26496610
RBCC1_HUMAN	RB1CC1	physical	26496610
UBP15_HUMAN	USP15	physical	26496610
SPTC1_HUMAN	SPTLC1	physical	26496610
ATX2L_HUMAN	ATXN2L	physical	26496610
VPS41_HUMAN	VPS41	physical	26496610
S35F6_HUMAN	SLC35F6	physical	26496610
CAMP3_HUMAN	CAMSAP3	physical	26496610
ACTL8_HUMAN	ACTL8	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, AND MASSSPECTROMETRY.
PubMed: 19413330

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102, AND MASSSPECTROMETRY.
PubMed: 17081983

"Tyrosine phosphorylated Par3 regulates epithelial tight junctionassembly promoted by EGFR signaling.";
Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A.,Lottspeich F., Chen Z.;
EMBO J. 25:5058-5070(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-5, AND MASSSPECTROMETRY.
PubMed: 17053785