TCAL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCAL2_HUMAN
• UniProt AC: Q9H3H9
• Protein Name: Transcription elongation factor A protein-like 2
• Gene Name: TCEAL2
• Organism: Homo sapiens (Human).
• Sequence Length: 227
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MEKLFNENEGMPSNQGKIDNEEQPPHEGKPEVACILEDKKLENEGNTENTGKRVEEPLKDKEKPESAGKAKGEGKSERKGKSEMQGGSKTEGKPERGGRAEGEGEPDSEREPESEGEPESETRAAGKRPAEDDIPRKAKRKTNKGLAQYLKQYKEAIHDMNFSNEDMIREFDNMARVEDKRRKSKQKLGAFLWMQRNLQDPFYPRGPREFRGGCRAPRRDTEDIPYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
69	Acetylation	EKPESAGKAKGEGKS CCCHHHCCCCCCCCC	46.79	7408271
75	Acetylation	GKAKGEGKSERKGKS CCCCCCCCCCCCCCC	44.86	7408279
79	Ubiquitination	GEGKSERKGKSEMQG CCCCCCCCCCCCCCC	67.64	-
108	Phosphorylation	EGEGEPDSEREPESE CCCCCCCCCCCCCCC	49.63	29523821
114	Phosphorylation	DSEREPESEGEPESE CCCCCCCCCCCCHHH	62.71	28857561
120	Phosphorylation	ESEGEPESETRAAGK CCCCCCHHHHHHCCC	55.79	29523821
122	Phosphorylation	EGEPESETRAAGKRP CCCCHHHHHHCCCCC	34.58	29523821
149	Phosphorylation	TNKGLAQYLKQYKEA CHHHHHHHHHHHHHH	15.40	22817900
151	Ubiquitination	KGLAQYLKQYKEAIH HHHHHHHHHHHHHHH	46.80	23000965
153	Phosphorylation	LAQYLKQYKEAIHDM HHHHHHHHHHHHHHC	14.81	22817900
154	Ubiquitination	AQYLKQYKEAIHDMN HHHHHHHHHHHHHCC	37.87	23000965
183	Ubiquitination	RVEDKRRKSKQKLGA HHHHHHHHHHHHHHH	67.07	22817900
185	Ubiquitination	EDKRRKSKQKLGAFL HHHHHHHHHHHHHHH	55.26	22817900
187	Ubiquitination	KRRKSKQKLGAFLWM HHHHHHHHHHHHHHH	53.26	21890473
205	Methylation	LQDPFYPRGPREFRG CCCCCCCCCCCCCCC	57.26	-
211	Methylation	PRGPREFRGGCRAPR CCCCCCCCCCCCCCC	35.52	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCAL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCAL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCAL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.