VPS41_HUMAN - dbPTM
VPS41_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VPS41_HUMAN
UniProt AC P49754
Protein Name Vacuolar protein sorting-associated protein 41 homolog
Gene Name VPS41
Organism Homo sapiens (Human).
Sequence Length 854
Subcellular Localization Endosome membrane . Late endosome . Lysosome . Golgi apparatus, trans-Golgi network . Early endosome . Cytoplasmic vesicle, clathrin-coated vesicle .
Protein Description Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. [PubMed: 23351085 Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo]
Protein Sequence MAEAEEQETGSLEESTDESEEEESEEEPKLKYERLSNGVTEILQKDAASCMTVHDKFLALGTHYGKVYLLDVQGNITQKFDVSPVKINQISLDESGEHMGVCSEDGKVQVFGLYSGEEFHETFDCPIKIIAVHPHFVRSSCKQFVTGGKKLLLFERSWMNRWKSAVLHEGEGNIRSVKWRGHLIAWANNMGVKIFDIISKQRITNVPRDDISLRPDMYPCSLCWKDNVTLIIGWGTSVKVCSVKERHASEMRDLPSRYVEIVSQFETEFYISGLAPLCDQLVVLSYVKEISEKTEREYCARPRLDIIQPLSETCEEISSDALTVRGFQENECRDYHLEYSEGESLFYIVSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISQKNIKRHKILDIGLAYINHLVERGDYDIAARKCQKILGKNAALWEYEVYKFKEIGQLKAISPYLPRGDPVLKPLIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRDHLKKDSQNKTLLKTLAELYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDKIVLLMDFDSEKAVDMLLDNEDKISIKKVVEELEDRPELQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKALEICQQRNFVEETVYLLSRMGNSRSALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDKPPFITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSLLKKMHRTQMKGVLVDEENICESCLSPILPSDAAKPFSVVVFHCRHMFHKECLPMPSMNSAAQFCNICSAKNRGPGSAILEMKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
49PhosphorylationILQKDAASCMTVHDK
HHHHCHHHCCCHHHH		13.2226074081
52PhosphorylationKDAASCMTVHDKFLA
HCHHHCCCHHHHHHH		21.0026074081
62PhosphorylationDKFLALGTHYGKVYL
HHHHHHCCCCCEEEE		16.8726074081
64PhosphorylationFLALGTHYGKVYLLD
HHHHCCCCCEEEEEE		20.6226074081
68PhosphorylationGTHYGKVYLLDVQGN
CCCCCEEEEEECCCC		12.6726074081
83PhosphorylationITQKFDVSPVKINQI
EEEEECCCCEEEEEE		26.3126074081
86UbiquitinationKFDVSPVKINQISLD
EECCCCEEEEEEEEC		39.0529967540
91PhosphorylationPVKINQISLDESGEH
CEEEEEEEECCCCCC		21.7226074081
95PhosphorylationNQISLDESGEHMGVC
EEEEECCCCCCCEEE		49.5026074081
103PhosphorylationGEHMGVCSEDGKVQV
CCCCEEECCCCCEEE		35.9926074081
114PhosphorylationKVQVFGLYSGEEFHE
CEEEEEEECCCCHHH		18.2726074081
115PhosphorylationVQVFGLYSGEEFHET
EEEEEEECCCCHHHH		44.7826074081
168UbiquitinationRWKSAVLHEGEGNIR
HHHHHHEECCCCCEE		34.1222817900
170UbiquitinationKSAVLHEGEGNIRSV
HHHHEECCCCCEEEE		37.0522817900
200UbiquitinationKIFDIISKQRITNVP
CHHHHHCCCCCCCCC		32.94-
229PhosphorylationLCWKDNVTLIIGWGT
EECCCCEEEEEECCC		20.6321406692
236PhosphorylationTLIIGWGTSVKVCSV
EEEEECCCCEEEEEH		24.6821406692
237PhosphorylationLIIGWGTSVKVCSVK
EEEECCCCEEEEEHH		18.9221406692
249PhosphorylationSVKERHASEMRDLPS
EHHHHHHHHHHCCCH		26.2929449344
268UbiquitinationIVSQFETEFYISGLA
HHHHHCCEEECCCHH		29.2932142685
286UbiquitinationDQLVVLSYVKEISEK
HHHHHHHHHHHHCHH		16.0422817900
293UbiquitinationYVKEISEKTEREYCA
HHHHHCHHHHHHHHC		49.2332142685
333UbiquitinationGFQENECRDYHLEYS
CCCCCCCCCEEEEEE		41.15-
333UbiquitinationGFQENECRDYHLEYS
CCCCCCCCCEEEEEE		41.1533845483
347UbiquitinationSEGESLFYIVSPRDV
ECCCEEEEEECCCCE		13.0029967540
358UbiquitinationPRDVVVAKERDQDDH
CCCEEEEECCCCCCC		41.4933845483
362UbiquitinationVVAKERDQDDHIDWL
EEEECCCCCCCHHHH		65.3429967540
372UbiquitinationHIDWLLEKKKYEEAL
CHHHHHHHHHHHHHH		55.3129967540
375PhosphorylationWLLEKKKYEEALMAA
HHHHHHHHHHHHHHH		28.0723403867
376UbiquitinationLLEKKKYEEALMAAE
HHHHHHHHHHHHHHH		45.7522817900
377UbiquitinationLEKKKYEEALMAAEI
HHHHHHHHHHHHHHH		43.9721890473
385PhosphorylationALMAAEISQKNIKRH
HHHHHHHHHHHHHHH		26.9722210691
387AcetylationMAAEISQKNIKRHKI
HHHHHHHHHHHHHCH		54.587965435
387UbiquitinationMAAEISQKNIKRHKI
HHHHHHHHHHHHHCH		54.5829967540
390AcetylationEISQKNIKRHKILDI
HHHHHHHHHHCHHHH		58.827965445
446PhosphorylationIGQLKAISPYLPRGD
HCCCEECCCCCCCCC		16.61-
508MalonylationLKKDSQNKTLLKTLA
HCHHHCCHHHHHHHH		32.6726320211
528UbiquitinationDKNYGNALEIYLTLR
CCCCCCEEEEEEEEE		4.8222817900
528UbiquitinationDKNYGNALEIYLTLR
CCCCCCEEEEEEEEE		4.82-
530UbiquitinationNYGNALEIYLTLRHK
CCCCEEEEEEEEECH		3.3822817900
533PhosphorylationNALEIYLTLRHKDVF
CEEEEEEEEECHHHH		12.55-
553 (in isoform 1)Ubiquitination-55.7221890473
553 (in isoform 2)Ubiquitination-55.7221890473
553UbiquitinationHNLFSSIKDKIVLLM
CCCCHHCCCEEEEEE		55.7221906983
555UbiquitinationLFSSIKDKIVLLMDF
CCHHCCCEEEEEEEC		29.7022817900
557UbiquitinationSSIKDKIVLLMDFDS
HHCCCEEEEEEECCH		4.0729967540
575UbiquitinationVDMLLDNEDKISIKK
HHHHCCCCCCCCHHH		61.4229967540
582UbiquitinationEDKISIKKVVEELED
CCCCCHHHHHHHHCC		50.2529967540
600UbiquitinationLQHVYLHKLFKRDHH
HHHHHHHHHHCCCCC		53.6929967540
608AcetylationLFKRDHHKGQRYHEK
HHCCCCCCCCCCCHH		54.0130593369
617UbiquitinationQRYHEKQISLYAEYD
CCCCHHHEEEEEEEC		4.54-
623PhosphorylationQISLYAEYDRPNLLP
HEEEEEEECCCCCHH		14.7430576142
642UbiquitinationSTHCPLEKALEICQQ
CCCCCHHHHHHHHHH		66.99-
646UbiquitinationPLEKALEICQQRNFV
CHHHHHHHHHHCCCH		2.4022817900
646UbiquitinationPLEKALEICQQRNFV
CHHHHHHHHHHCCCH		2.40-
658PhosphorylationNFVEETVYLLSRMGN
CCHHHHHHHHHHCCC		14.89-
671UbiquitinationGNSRSALKMIMEELH
CCHHHHHHHHHHHHC		26.5422817900
671 (in isoform 2)Ubiquitination-26.5421890473
671 (in isoform 1)Ubiquitination-26.5421890473
706UbiquitinationLILYSIDKPPFITGL
EEEEECCCCCCHHHH		53.58-
731UbiquitinationILLIHRIKEGMEIPN
HHHHHHHHCCCCCCC		48.44-
736AcetylationRIKEGMEIPNLRDSL
HHHCCCCCCCHHHHH		1.7219608861
736UbiquitinationRIKEGMEIPNLRDSL
HHHCCCCCCCHHHHH		1.7222817900
737UbiquitinationIKEGMEIPNLRDSLV
HHCCCCCCCHHHHHH		22.09-
737UbiquitinationIKEGMEIPNLRDSLV
HHCCCCCCCHHHHHH		22.0921890473
748UbiquitinationDSLVKILQDYNLQIL
HHHHHHHHHCCHHHH		55.4029967540
750PhosphorylationLVKILQDYNLQILLR
HHHHHHHCCHHHHHC		12.5721406692
761UbiquitinationILLREGCKKILVADS
HHHCCCCCHHHHHHH		54.4222817900
761AcetylationILLREGCKKILVADS
HHHCCCCCHHHHHHH		54.4219608861
762UbiquitinationLLREGCKKILVADSL
HHCCCCCHHHHHHHH		45.4022817900
762 (in isoform 1)Ubiquitination-45.4021890473
762 (in isoform 2)Ubiquitination-45.4021890473
768PhosphorylationKKILVADSLSLLKKM
CHHHHHHHHHHHHHH		15.3229396449
770PhosphorylationILVADSLSLLKKMHR
HHHHHHHHHHHHHHH		35.2924719451
773UbiquitinationADSLSLLKKMHRTQM
HHHHHHHHHHHHHCC		54.0329967540
847PhosphorylationAKNRGPGSAILEMKK
HCCCCCCCCCEEECC		18.4425159151
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VPS41_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VPS41_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VPS41_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SPE39_HUMANVIPAS39physical
19109425
VP33B_HUMANVPS33Bphysical
19109425
A4_HUMANAPPphysical
21832049
XRCC4_HUMANXRCC4physical
22939629
TGFA1_HUMANTGFBRAP1physical
26186194
VP33A_HUMANVPS33Aphysical
26186194
VPS16_HUMANVPS16physical
26186194
VPS18_HUMANVPS18physical
26186194
VPS11_HUMANVPS11physical
26186194
VPS16_HUMANVPS16physical
26463206
VP33A_HUMANVPS33Aphysical
26463206
VPS18_HUMANVPS18physical
26463206
VPS18_HUMANVPS18physical
28514442
TGFA1_HUMANTGFBRAP1physical
28514442
VPS11_HUMANVPS11physical
28514442
VPS16_HUMANVPS16physical
28514442
VP33A_HUMANVPS33Aphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VPS41_HUMAN

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Related Literatures of Post-Translational Modification

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