S61A1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S61A1_HUMAN
• UniProt AC: P61619
• Protein Name: Protein transport protein Sec61 subunit alpha isoform 1
• Gene Name: SEC61A1
• Organism: Homo sapiens (Human).
• Sequence Length: 476
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Localizes exclusively in granular structures in the endoplasmic reticulum (ER).
• Protein Description: Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. [PubMed: 28782633 Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins. Plays a role in pronephric kidney tubule development (By similarity]
• Protein Sequence: MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Ubiquitination	----MAIKFLEVIKP ----CCHHHHHHHHH	34.07	-
4 (in isoform 1)	Ubiquitination	-	34.07	21890473
10	Ubiquitination	IKFLEVIKPFCVILP HHHHHHHHHHEEECC	36.90	21890473
10 (in isoform 1)	Ubiquitination	-	36.90	21890473
10	Acetylation	IKFLEVIKPFCVILP HHHHHHHHHHEEECC	36.90	26051181
13	S-palmitoylation	LEVIKPFCVILPEIQ HHHHHHHEEECCCCC	2.23	29575903
21	Ubiquitination	VILPEIQKPERKIQF EECCCCCCCCHHHCH	55.28	21890473
21 (in isoform 1)	Ubiquitination	-	55.28	21890473
21	Acetylation	VILPEIQKPERKIQF EECCCCCCCCHHHCH	55.28	26051181
55	Phosphorylation	IPLFGIMSSDSADPF CHHHCCCCCCCCCCC	29.13	-
75	Phosphorylation	ILASNRGTLMELGIS HHHCCCCCCHHCCCC	21.50	-
82	Phosphorylation	TLMELGISPIVTSGL CCHHCCCCHHHCHHH	13.53	-
86	Phosphorylation	LGISPIVTSGLIMQL CCCCHHHCHHHHHHH	20.14	-
87	Phosphorylation	GISPIVTSGLIMQLL CCCHHHCHHHHHHHH	22.25	-
105	Phosphorylation	KIIEVGDTPKDRALF EEEEECCCHHHHHHH	26.72	21815630
107	Ubiquitination	IEVGDTPKDRALFNG EEECCCHHHHHHHCH	63.04	-
107	Succinylation	IEVGDTPKDRALFNG EEECCCHHHHHHHCH	63.04	23954790
107	Acetylation	IEVGDTPKDRALFNG EEECCCHHHHHHHCH	63.04	26051181
148 (in isoform 3)	Ubiquitination	-	2.18	21890473
194	Ubiquitination	ICETIVWKAFSPTTV CCCCCHHHHCCCCCC	28.76	-
197	Phosphorylation	TIVWKAFSPTTVNTG CCHHHHCCCCCCCCC	26.62	-
268	Ubiquitination	FRVDLPIKSARYRGQ CCCCCEECCCCCCCC	35.80	21906983
268 (in isoform 3)	Ubiquitination	-	35.80	21890473
272 (in isoform 3)	Ubiquitination	-	20.86	21890473
272	Phosphorylation	LPIKSARYRGQYNTY CEECCCCCCCCCCCC	20.86	-
273	Methylation	PIKSARYRGQYNTYP EECCCCCCCCCCCCC	21.86	115493583
275 (in isoform 3)	Ubiquitination	-	21.21	21890473
276	Phosphorylation	SARYRGQYNTYPIKL CCCCCCCCCCCCEEE	16.58	28152594
285	Phosphorylation	TYPIKLFYTSNIPII CCCEEEEEECCCCHH	21.50	24043423
286	Phosphorylation	YPIKLFYTSNIPIIL CCEEEEEECCCCHHH	14.15	24043423
287	Phosphorylation	PIKLFYTSNIPIILQ CEEEEEECCCCHHHH	22.76	24043423
295	Phosphorylation	NIPIILQSALVSNLY CCCHHHHHHHHHHHH	21.81	24043423
299	Phosphorylation	ILQSALVSNLYVISQ HHHHHHHHHHHHHHH	23.20	24043423
302	Phosphorylation	SALVSNLYVISQMLS HHHHHHHHHHHHHHH	10.45	24043423
305	Phosphorylation	VSNLYVISQMLSARF HHHHHHHHHHHHHHH	10.25	24043423
309	Phosphorylation	YVISQMLSARFSGNL HHHHHHHHHHHCCCE	16.44	24043423
344	Phosphorylation	PVGGLCYYLSPPESF EECCEEEEECCCHHH	10.33	-
346	Phosphorylation	GGLCYYLSPPESFGS CCEEEEECCCHHHHH	23.45	-
350	Phosphorylation	YYLSPPESFGSVLED EEECCCHHHHHHHCC	40.45	-
388	Ubiquitination	EVSGSSAKDVAKQLK ECCCCCHHHHHHHHH	55.47	21890473
388 (in isoform 1)	Ubiquitination	-	55.47	21890473
392	Ubiquitination	SSAKDVAKQLKEQQM CCHHHHHHHHHHHHH	56.88	21890473
392 (in isoform 1)	Ubiquitination	-	56.88	21890473
395	Malonylation	KDVAKQLKEQQMVMR HHHHHHHHHHHHHHH	51.49	26320211
395	Ubiquitination	KDVAKQLKEQQMVMR HHHHHHHHHHHHHHH	51.49	-
395 (in isoform 1)	Ubiquitination	-	51.49	21890473
407	Phosphorylation	VMRGHRETSMVHELN HHHCCHHHHHHHHHH	23.29	30266825
408	Phosphorylation	MRGHRETSMVHELNR HHCCHHHHHHHHHHH	17.66	23401153
471	Sulfoxidation	EQSEVGSMGALLF-- HHCCCCCCCHHCC--	2.75	21406390

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S61A1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S61A1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S61A1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APOB_HUMAN	APOB	physical	9565615
1A02_HUMAN	HLA-A	physical	14644099
1A03_HUMAN	HLA-A	physical	14644099
1A01_HUMAN	HLA-A	physical	14644099
1A26_HUMAN	HLA-A	physical	14644099
PDIA3_HUMAN	PDIA3	physical	14644099
BAP31_HUMAN	BCAP31	physical	18555783
SC61B_HUMAN	SEC61B	physical	18555783
CLGN_HUMAN	CLGN	physical	26344197
MAGT1_HUMAN	MAGT1	physical	26344197
RL13A_HUMAN	RPL13A	physical	26344197
SEC63_HUMAN	SEC63	physical	26344197
SC61G_HUMAN	SEC61G	physical	24497544

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.