dbPTM

PDIA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PDIA3_HUMAN
UniProt AC	P30101
Protein Name	Protein disulfide-isomerase A3
Gene Name	PDIA3
Organism	Homo sapiens (Human).
Sequence Length	505
Subcellular Localization	Endoplasmic reticulum . Endoplasmic reticulum lumen. Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545).
Protein Description
Protein Sequence	MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENIFGICPHMTEDNKDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQREATNPPVIQEEKPKKKKKAQEDL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	LTDDNFESRISDTGS HCCCCHHHHHCCCCC	30.67	27499020
61	Methylation	APWCGHCKRLAPEYE HHCCCHHHHHHHHHH	44.78	24129315
67	Nitration	CKRLAPEYEAAATRL HHHHHHHHHHHHHHH	15.14	-
67	Phosphorylation	CKRLAPEYEAAATRL HHHHHHHHHHHHHHH	15.14	28152594
72	Phosphorylation	PEYEAAATRLKGIVP HHHHHHHHHHCCCCE	31.63	28152594
73	Methylation	EYEAAATRLKGIVPL HHHHHHHHHCCCCEE	29.67	-
75	Ubiquitination	EAAATRLKGIVPLAK HHHHHHHCCCCEEEE	43.21	-
82	Acetylation	KGIVPLAKVDCTANT CCCCEEEEEEECCCC	46.41	25953088
82	Ubiquitination	KGIVPLAKVDCTANT CCCCEEEEEEECCCC	46.41	-
85	S-nitrosylation	VPLAKVDCTANTNTC CEEEEEEECCCCCCC	4.30	2212679
86	Phosphorylation	PLAKVDCTANTNTCN EEEEEEECCCCCCCC	20.62	28102081
89	Phosphorylation	KVDCTANTNTCNKYG EEEECCCCCCCCCCC	29.46	28102081
91	Phosphorylation	DCTANTNTCNKYGVS EECCCCCCCCCCCCC	18.54	28102081
92	S-nitrosylation	CTANTNTCNKYGVSG ECCCCCCCCCCCCCC	4.48	2212679
94	Acetylation	ANTNTCNKYGVSGYP CCCCCCCCCCCCCCC	45.59	25953088
94	Ubiquitination	ANTNTCNKYGVSGYP CCCCCCCCCCCCCCC	45.59	21890473
95	Phosphorylation	NTNTCNKYGVSGYPT CCCCCCCCCCCCCCE	14.58	28152594
98	Phosphorylation	TCNKYGVSGYPTLKI CCCCCCCCCCCEEEE	28.39	28152594
100	Nitration	NKYGVSGYPTLKIFR CCCCCCCCCEEEEEC	5.87	-
100	Phosphorylation	NKYGVSGYPTLKIFR CCCCCCCCCEEEEEC	5.87	28152594
102	O-linked_Glycosylation	YGVSGYPTLKIFRDG CCCCCCCEEEEECCC	32.00	55835629
102	Phosphorylation	YGVSGYPTLKIFRDG CCCCCCCEEEEECCC	32.00	28152594
104	Acetylation	VSGYPTLKIFRDGEE CCCCCEEEEECCCCC	42.13	26051181
104	Ubiquitination	VSGYPTLKIFRDGEE CCCCCEEEEECCCCC	42.13	21890473
115	Phosphorylation	DGEEAGAYDGPRTAD CCCCCCCCCCCCCCH	22.10	-
119	Methylation	AGAYDGPRTADGIVS CCCCCCCCCCHHHHH	48.34	-
120	O-linked_Glycosylation	GAYDGPRTADGIVSH CCCCCCCCCHHHHHH	32.03	28510447
120	Phosphorylation	GAYDGPRTADGIVSH CCCCCCCCCHHHHHH	32.03	20068231
126	O-linked_Glycosylation	RTADGIVSHLKKQAG CCCHHHHHHHHHHCC	22.60	28510447
126	Phosphorylation	RTADGIVSHLKKQAG CCCHHHHHHHHHHCC	22.60	20068231
129	Acetylation	DGIVSHLKKQAGPAS HHHHHHHHHHCCCCC	37.10	25953088
129	Malonylation	DGIVSHLKKQAGPAS HHHHHHHHHHCCCCC	37.10	26320211
129	Succinylation	DGIVSHLKKQAGPAS HHHHHHHHHHCCCCC	37.10	-
129	Succinylation	DGIVSHLKKQAGPAS HHHHHHHHHHCCCCC	37.10	-
136	Phosphorylation	KKQAGPASVPLRTEE HHHCCCCCCCCCCHH	27.66	22468782
140	Methylation	GPASVPLRTEEEFKK CCCCCCCCCHHHHHH	33.74	-
141	Phosphorylation	PASVPLRTEEEFKKF CCCCCCCCHHHHHHH	56.27	22817900
146	Acetylation	LRTEEEFKKFISDKD CCCHHHHHHHCCCCC	50.48	26051181
152	Acetylation	FKKFISDKDASIVGF HHHHCCCCCCCEEEE	48.69	-
163	Phosphorylation	IVGFFDDSFSEAHSE EEEEECCCCHHHHHH	32.30	25159151
165	Phosphorylation	GFFDDSFSEAHSEFL EEECCCCHHHHHHHH	37.51	-
173	Ubiquitination	EAHSEFLKAASNLRD HHHHHHHHHHHCCHH	47.42	-
176	Phosphorylation	SEFLKAASNLRDNYR HHHHHHHHCCHHCCC	41.06	24719451
179	Methylation	LKAASNLRDNYRFAH HHHHHCCHHCCCCCC	34.09	-
187	Phosphorylation	DNYRFAHTNVESLVN HCCCCCCCCHHHHHH	37.21	21406692
191	Phosphorylation	FAHTNVESLVNEYDD CCCCCHHHHHHHCCC	33.08	21406692
196	Phosphorylation	VESLVNEYDDNGEGI HHHHHHHCCCCCCEE	24.32	21406692
209	Phosphorylation	GIILFRPSHLTNKFE EEEEECHHHHCCCCC	27.20	21406692
212	Phosphorylation	LFRPSHLTNKFEDKT EECHHHHCCCCCCCC	30.82	21406692
214	Acetylation	RPSHLTNKFEDKTVA CHHHHCCCCCCCCEE	44.91	26822725
214	Ubiquitination	RPSHLTNKFEDKTVA CHHHHCCCCCCCCEE	44.91	-
218	Acetylation	LTNKFEDKTVAYTEQ HCCCCCCCCEEEECC	37.39	23236377
218	Succinylation	LTNKFEDKTVAYTEQ HCCCCCCCCEEEECC	37.39	-
218	Succinylation	LTNKFEDKTVAYTEQ HCCCCCCCCEEEECC	37.39	27452117
219	O-linked_Glycosylation	TNKFEDKTVAYTEQK CCCCCCCCEEEECCC	23.77	OGP
219	Phosphorylation	TNKFEDKTVAYTEQK CCCCCCCCEEEECCC	23.77	28152594
222	Phosphorylation	FEDKTVAYTEQKMTS CCCCCEEEECCCCCC	13.38	28152594
223	Phosphorylation	EDKTVAYTEQKMTSG CCCCEEEECCCCCCC	23.39	28152594
226	Acetylation	TVAYTEQKMTSGKIK CEEEECCCCCCCHHH	37.60	20167786
226	Malonylation	TVAYTEQKMTSGKIK CEEEECCCCCCCHHH	37.60	26320211
226	Succinylation	TVAYTEQKMTSGKIK CEEEECCCCCCCHHH	37.60	27452117
226	Ubiquitination	TVAYTEQKMTSGKIK CEEEECCCCCCCHHH	37.60	-
234	Malonylation	MTSGKIKKFIQENIF CCCCHHHHHHHHCCC	51.69	26320211
244	S-nitrosocysteine	QENIFGICPHMTEDN HHCCCCCCCCCCCCC	1.61	-
244	S-nitrosylation	QENIFGICPHMTEDN HHCCCCCCCCCCCCC	1.61	20140087
252	Acetylation	PHMTEDNKDLIQGKD CCCCCCCCHHHCCCC	67.25	25038526
269	Phosphorylation	IAYYDVDYEKNAKGS EEEEECCCCCCCCCC	28.75	-
271	Acetylation	YYDVDYEKNAKGSNY EEECCCCCCCCCCCH	56.85	26051181
289	Acetylation	RVMMVAKKFLDAGHK HHHHHHHHHHHHHHH	41.23	27178108
289	Ubiquitination	RVMMVAKKFLDAGHK HHHHHHHHHHHHHHH	41.23	-
296	Acetylation	KFLDAGHKLNFAVAS HHHHHHHHHHEEHHC	44.18	25953088
296	Malonylation	KFLDAGHKLNFAVAS HHHHHHHHHHEEHHC	44.18	26320211
296	Ubiquitination	KFLDAGHKLNFAVAS HHHHHHHHHHEEHHC	44.18	21890473
303	Phosphorylation	KLNFAVASRKTFSHE HHHEEHHCCCCCCCH	27.93	23911959
305	Ubiquitination	NFAVASRKTFSHELS HEEHHCCCCCCCHHH	51.96	21890473
306	Phosphorylation	FAVASRKTFSHELSD EEHHCCCCCCCHHHH	29.29	30622161
308	Phosphorylation	VASRKTFSHELSDFG HHCCCCCCCHHHHHC	22.68	26657352
312	Phosphorylation	KTFSHELSDFGLEST CCCCCHHHHHCCCCC	28.10	-
318	Phosphorylation	LSDFGLESTAGEIPV HHHHCCCCCCCCCCE	28.71	-
319	Phosphorylation	SDFGLESTAGEIPVV HHHCCCCCCCCCCEE	29.34	24275569
329	Methylation	EIPVVAIRTAKGEKF CCCEEEEEECCCCEE	20.92	-
330	Phosphorylation	IPVVAIRTAKGEKFV CCEEEEEECCCCEEE	26.97	28787133
335	Acetylation	IRTAKGEKFVMQEEF EEECCCCEEEEEEEC	52.51	26822725
335	Ubiquitination	IRTAKGEKFVMQEEF EEECCCCEEEEEEEC	52.51	21890473
338	Sulfoxidation	AKGEKFVMQEEFSRD CCCCEEEEEEECCCC	4.70	21406390
343	Phosphorylation	FVMQEEFSRDGKALE EEEEEECCCCHHHHH	32.51	21712546
356	Phosphorylation	LERFLQDYFDGNLKR HHHHHHHHCCCCHHH	7.21	28152594
362	Acetylation	DYFDGNLKRYLKSEP HHCCCCHHHHHHCCC	42.89	129487
362	Ubiquitination	DYFDGNLKRYLKSEP HHCCCCHHHHHHCCC	42.89	21890473
366	Ubiquitination	GNLKRYLKSEPIPES CCHHHHHHCCCCCCC	43.78	-
367	Phosphorylation	NLKRYLKSEPIPESN CHHHHHHCCCCCCCC	46.11	23911959
373	Phosphorylation	KSEPIPESNDGPVKV HCCCCCCCCCCCEEE	34.56	23911959
402	Phosphorylation	KDVLIEFYAPWCGHC CCEEEEEECCCCCCC	10.04	24719451
415	Acetylation	HCKNLEPKYKELGEK CCCCCCHHHHHHHHH	60.63	26210075
417	Acetylation	KNLEPKYKELGEKLS CCCCHHHHHHHHHHC	53.22	26210075
424	Phosphorylation	KELGEKLSKDPNIVI HHHHHHHCCCCCEEE	46.19	-
425	Acetylation	ELGEKLSKDPNIVIA HHHHHHCCCCCEEEE	83.84	23236377
425	Malonylation	ELGEKLSKDPNIVIA HHHHHHCCCCCEEEE	83.84	26320211
425	Ubiquitination	ELGEKLSKDPNIVIA HHHHHHCCCCCEEEE	83.84	21890473
433	Ubiquitination	DPNIVIAKMDATAND CCCEEEEEEECCCCC	26.62	-
434	Sulfoxidation	PNIVIAKMDATANDV CCEEEEEEECCCCCC	2.91	30846556
437	Phosphorylation	VIAKMDATANDVPSP EEEEEECCCCCCCCC	23.02	21406692
443	Phosphorylation	ATANDVPSPYEVRGF CCCCCCCCCCEECCC	39.71	28152594
445	Phosphorylation	ANDVPSPYEVRGFPT CCCCCCCCEECCCCE	31.24	28152594
448	Methylation	VPSPYEVRGFPTIYF CCCCCEECCCCEEEE	29.15	-
452	O-linked_Glycosylation	YEVRGFPTIYFSPAN CEECCCCEEEECCCC	26.50	55835567
452	Phosphorylation	YEVRGFPTIYFSPAN CEECCCCEEEECCCC	26.50	28152594
454	Phosphorylation	VRGFPTIYFSPANKK ECCCCEEEECCCCCC	10.65	21406692
456	O-linked_Glycosylation	GFPTIYFSPANKKLN CCCEEEECCCCCCCC	13.21	7926229
456	Phosphorylation	GFPTIYFSPANKKLN CCCEEEECCCCCCCC	13.21	28152594
474	Phosphorylation	YEGGRELSDFISYLQ CCCCCCHHHHHHHHH	26.23	28152594
478	Phosphorylation	RELSDFISYLQREAT CCHHHHHHHHHHHCC	21.56	28152594
479	Phosphorylation	ELSDFISYLQREATN CHHHHHHHHHHHCCC	11.31	28152594
485	O-linked_Glycosylation	SYLQREATNPPVIQE HHHHHHCCCCCCCCC	43.43	28510447
485	Phosphorylation	SYLQREATNPPVIQE HHHHHHCCCCCCCCC	43.43	-
494	Acetylation	PPVIQEEKPKKKKKA CCCCCCCCCHHHHHH	62.48	26051181
494	Succinylation	PPVIQEEKPKKKKKA CCCCCCCCCHHHHHH	62.48	27452117

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
456	S	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PDIA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PDIA3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CALR_HUMAN	CALR	physical	10436013
GLPC_HUMAN	GYPC	physical	9153243
GTR1_HUMAN	SLC2A1	physical	9153243
STAT3_HUMAN	STAT3	physical	12060494
PLAP_HUMAN	PLAA	physical	22484374
CAV1_HUMAN	CAV1	physical	22484374
A4_HUMAN	APP	physical	21832049
VIME_HUMAN	VIM	physical	22939629
PPIB_HUMAN	PPIB	physical	22939629
GARS_HUMAN	GARS	physical	22939629
RPN2_HUMAN	RPN2	physical	22939629
A4_HUMAN	APP	physical	15896298
ITA2_HUMAN	ITGA2	physical	17170699
ITA3_HUMAN	ITGA3	physical	17170699
ITA6_HUMAN	ITGA6	physical	17170699
ITB1_HUMAN	ITGB1	physical	17170699
ITB5_HUMAN	ITGB5	physical	17170699
CO6A1_HUMAN	COL6A1	physical	17170699
LAMB1_HUMAN	LAMB1	physical	17170699
LAMB3_HUMAN	LAMB3	physical	17170699
LAMC1_HUMAN	LAMC1	physical	17170699
LAMC2_HUMAN	LAMC2	physical	17170699
PLXA1_HUMAN	PLXNA1	physical	17170699
AGRIN_HUMAN	AGRN	physical	17170699
FBLN3_HUMAN	EFEMP1	physical	17170699
LDLR_HUMAN	LDLR	physical	17170699
DCBD1_HUMAN	DCBLD1	physical	17170699
CLUS_HUMAN	CLU	physical	17170699
LOXL2_HUMAN	LOXL2	physical	17170699
ADA17_HUMAN	ADAM17	physical	17170699
ADA10_HUMAN	ADAM10	physical	17170699
TRFM_HUMAN	MFI2	physical	17170699
PLOD1_HUMAN	PLOD1	physical	17170699
TPSN_HUMAN	TAPBP	physical	17170699
PDIA4_HUMAN	PDIA4	physical	17170699
ERO1A_HUMAN	ERO1L	physical	17170699
MTOR_HUMAN	MTOR	physical	21321085
RPTOR_HUMAN	RPTOR	physical	21321085
RICTR_HUMAN	RICTOR	physical	21321085
BCCIP_HUMAN	BCCIP	physical	22863883
CNDP2_HUMAN	CNDP2	physical	22863883
XPO2_HUMAN	CSE1L	physical	22863883
LDHA_HUMAN	LDHA	physical	22863883
MTPN_HUMAN	MTPN	physical	22863883
SIAS_HUMAN	NANS	physical	22863883
PSA_HUMAN	NPEPPS	physical	22863883
6PGD_HUMAN	PGD	physical	22863883
RL23_HUMAN	RPL23	physical	22863883
NHRF1_HUMAN	SLC9A3R1	physical	22863883
SPSY_HUMAN	SMS	physical	22863883
ATPO_HUMAN	ATP5O	physical	26344197
CALR_HUMAN	CALR	physical	26344197
DDX17_HUMAN	DDX17	physical	26344197
FLNA_HUMAN	FLNA	physical	26344197
HEM3_HUMAN	HMBS	physical	26344197
NMD3_HUMAN	NMD3	physical	26344197
PDIA1_HUMAN	P4HB	physical	26344197
PSB5_HUMAN	PSMB5	physical	26344197
RD23B_HUMAN	RAD23B	physical	26344197
TAGL2_HUMAN	TAGLN2	physical	26344197
XRCC6_HUMAN	XRCC6	physical	26344197
JMJD8_HUMAN	JMJD8	physical	28514442
CALR_HUMAN	CALR	physical	11823531
TAP1_HUMAN	TAP1	physical	11823531
1B07_HUMAN	HLA-B	physical	11823531
1B18_HUMAN	HLA-B	physical	11823531
TPSN_HUMAN	TAPBP	physical	11823531

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PDIA3_HUMAN

Related Literatures of Post-Translational Modification