dbPTM

1B07_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	1B07_HUMAN
UniProt AC	P01889
Protein Name	HLA class I histocompatibility antigen, B-7 alpha chain
Gene Name	HLA-B
Organism	Homo sapiens (Human).
Sequence Length	362
Subcellular Localization	Membrane Single-pass type I membrane protein.
Protein Description	Involved in the presentation of foreign antigens to the immune system..
Protein Sequence	MLVMAPRTVLLLLSAALALTETWAGSHSMRYFYTSVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAGSHTLQSMYGCDVGPDGRLLRGHDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPSSQSTVPIVGIVAGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQGSDVSLTA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
332	S-palmitoylation	AVVAAVMCRRKSSGG HHHHHHHHCCCCCCC	2.82	17785801
349	S-palmitoylation	GSYSQAACSDSAQGS CCCCCCCCCCCCCCC	5.35	17785801

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
344	Y	Phosphorylation	Kinase	SRC	P12931	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of 1B07_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
86	Methylation	91 (5)	Y ⇒ S;C;F	rs1071816	Anti-thyroid drug induced agranulocytosis	27157822
92	Ubiquitination	91 (1)	Y ⇒ S;C;F	rs1071816	Anti-thyroid drug induced agranulocytosis	27157822
200	Ubiquitination	201 (1)	D ⇒ E	rs1131275	Autism spectrum disorder or schizophrenia	28540026
211	Phosphorylation	201 (10)	D ⇒ E	rs1131275	Autism spectrum disorder or schizophrenia	28540026

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PUR4_HUMAN	PFAS	physical	17353931
TERA_HUMAN	VCP	physical	17353931
SAHH_HUMAN	AHCY	physical	17353931
SYVC_HUMAN	VARS	physical	17353931
EZRI_HUMAN	EZR	physical	17353931
SYTC_HUMAN	TARS	physical	17353931
PLST_HUMAN	PLS3	physical	17353931
PUR6_HUMAN	PAICS	physical	17353931
RUVB1_HUMAN	RUVBL1	physical	17353931
PSMD1_HUMAN	PSMD1	physical	17353931
TIF1B_HUMAN	TRIM28	physical	17353931
MOES_HUMAN	MSN	physical	17353931
CD8A_HUMAN	CD8A	physical	10809759
KI3S1_HUMAN	KIR3DS1	genetic	12134147
B2MG_HUMAN	B2M	physical	17057332
NDUA9_HUMAN	NDUFA9	physical	22939629
STAT1_HUMAN	STAT1	physical	21988832
GRP78_HUMAN	HSPA5	physical	24155957
1B07_HUMAN	HLA-B	physical	25132672
1B18_HUMAN	HLA-B	physical	25132672
GCP2_HUMAN	TUBGCP2	physical	26186194
AT1A3_HUMAN	ATP1A3	physical	26186194
AT12A_HUMAN	ATP12A	physical	26186194
1C07_HUMAN	HLA-C	physical	26186194
1A02_HUMAN	HLA-A	physical	26186194
1A03_HUMAN	HLA-A	physical	26186194
1A01_HUMAN	HLA-A	physical	26186194
1A26_HUMAN	HLA-A	physical	26186194
HLAE_HUMAN	HLA-E	physical	26186194
INT5_HUMAN	INTS5	physical	26186194
HEAT1_HUMAN	HEATR1	physical	26186194
IPO13_HUMAN	IPO13	physical	26186194
BIG1_HUMAN	ARFGEF1	physical	26186194
BIG2_HUMAN	ARFGEF2	physical	26186194
HEAT6_HUMAN	HEATR6	physical	26186194
WDR11_HUMAN	WDR11	physical	26186194
LTN1_HUMAN	LTN1	physical	26186194
WDFY3_HUMAN	WDFY3	physical	26186194
PDK1_HUMAN	PDK1	physical	26186194
S39A3_HUMAN	SLC39A3	physical	26186194
CNDH2_HUMAN	NCAPH2	physical	26186194
INT4_HUMAN	INTS4	physical	26186194
ERAP1_HUMAN	ERAP1	physical	26186194
CLH2_HUMAN	CLTCL1	physical	26186194
CA112_HUMAN	C1orf112	physical	26186194
FCGRN_HUMAN	FCGRT	physical	26186194
TTC28_HUMAN	TTC28	physical	26186194
UXS1_HUMAN	UXS1	physical	26186194
B2MG_HUMAN	B2M	physical	26186194
HD_HUMAN	HTT	physical	26186194
SGSM3_HUMAN	SGSM3	physical	26186194
NEK4_HUMAN	NEK4	physical	26186194
F91A1_HUMAN	FAM91A1	physical	26186194
HLAE_HUMAN	HLA-E	physical	28514442
1C07_HUMAN	HLA-C	physical	28514442
SGSM3_HUMAN	SGSM3	physical	28514442
BIG2_HUMAN	ARFGEF2	physical	28514442
ERAP1_HUMAN	ERAP1	physical	28514442
WDFY3_HUMAN	WDFY3	physical	28514442
BIG1_HUMAN	ARFGEF1	physical	28514442
F91A1_HUMAN	FAM91A1	physical	28514442
1A02_HUMAN	HLA-A	physical	28514442
1A03_HUMAN	HLA-A	physical	28514442
1A01_HUMAN	HLA-A	physical	28514442
1A26_HUMAN	HLA-A	physical	28514442
AT12A_HUMAN	ATP12A	physical	28514442
CA112_HUMAN	C1orf112	physical	28514442
INT5_HUMAN	INTS5	physical	28514442
HD_HUMAN	HTT	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
LTN1_HUMAN	LTN1	physical	28514442
B2MG_HUMAN	B2M	physical	28514442
PDK1_HUMAN	PDK1	physical	28514442
CLH2_HUMAN	CLTCL1	physical	28514442
CNDH2_HUMAN	NCAPH2	physical	28514442
TTC28_HUMAN	TTC28	physical	28514442
INT4_HUMAN	INTS4	physical	28514442
HEAT6_HUMAN	HEATR6	physical	28514442
B2MG_HUMAN	B2M	physical	11823531
B2MG_HUMAN	B2M	physical	12244049

Drug and Disease Associations

Kegg Disease
H00344	Leprosy; Hansen disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of 1B07_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110, AND MASSSPECTROMETRY.	19159218 [Abstract]