FCGRN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FCGRN_HUMAN
• UniProt AC: P55899
• Protein Name: IgG receptor FcRn large subunit p51
• Gene Name: FCGRT
• Organism: Homo sapiens (Human).
• Sequence Length: 365
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Binds to the Fc region of monomeric immunoglobulins gamma. [PubMed: 7964511]
• Protein Sequence: MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNVIPATA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
125	N-linked_Glycosylation	GCELGPDNTSVPTAK CCEECCCCCCCCCEE	37.07	UniProtKB CARBOHYD
213	Phosphorylation	RLKARPSSPGFSVLT EEEECCCCCCCEEEE	31.55	22210691
225	Phosphorylation	VLTCSAFSFYPPELQ EEEEECCEECCHHHH	24.48	22210691
227	Phosphorylation	TCSAFSFYPPELQLR EEECCEECCHHHHHH	19.38	22210691
262	Phosphorylation	GSFHASSSLTVKSGD CCEEECCCEEECCCC	26.09	-
334	Phosphorylation	GLPAPWISLRGDDTG CCCCCEEEEECCCCE	14.24	24972180
346	O-linked_Glycosylation	DTGVLLPTPGEAQDA CCEEECCCCCCCCCC	43.85	OGP
346	Phosphorylation	DTGVLLPTPGEAQDA CCEEECCCCCCCCCC	43.85	26657352

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FCGRN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FCGRN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FCGRN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TSP1_HUMAN	THBS1	physical	28514442
DUS9_HUMAN	DUSP9	physical	28514442
PRTG_HUMAN	PRTG	physical	28514442
SGCE_HUMAN	SGCE	physical	28514442
FGFR4_HUMAN	FGFR4	physical	28514442
HGFA_HUMAN	HGFAC	physical	28514442
PCDGB_HUMAN	PCDHGA11	physical	28514442
XPO6_HUMAN	XPO6	physical	28514442
PDXL2_HUMAN	PODXL2	physical	28514442
PCD10_HUMAN	PCDH10	physical	28514442
DPS1_HUMAN	PDSS1	physical	28514442
GALA_HUMAN	GAL	physical	28514442
SHLB1_HUMAN	SH3GLB1	physical	28514442
KIF14_HUMAN	KIF14	physical	28514442
LDLR_HUMAN	LDLR	physical	28514442
DYHC2_HUMAN	DYNC2H1	physical	28514442
TTMP_HUMAN	C3orf52	physical	28514442
FGFR2_HUMAN	FGFR2	physical	28514442
TNFL9_HUMAN	TNFSF9	physical	28514442
ULBP3_HUMAN	ULBP3	physical	28514442
COG6_HUMAN	COG6	physical	28514442
B4GT5_HUMAN	B4GALT5	physical	28514442
TIM_HUMAN	TIMELESS	physical	28514442
PTPRS_HUMAN	PTPRS	physical	28514442
RTN4R_HUMAN	RTN4R	physical	28514442
ULBP2_HUMAN	ULBP2	physical	28514442
IQCB1_HUMAN	IQCB1	physical	28514442
LRP4_HUMAN	LRP4	physical	28514442
ANT3_HUMAN	SERPINC1	physical	28514442
CND1_HUMAN	NCAPD2	physical	28514442
EXOC7_HUMAN	EXOC7	physical	28514442
CA112_HUMAN	C1orf112	physical	28514442
SNX3_HUMAN	SNX3	physical	28514442
ANTR1_HUMAN	ANTXR1	physical	28514442
MPZL1_HUMAN	MPZL1	physical	28514442
APLP2_HUMAN	APLP2	physical	28514442
S39A1_HUMAN	SLC39A1	physical	28514442
FGFR1_HUMAN	FGFR1	physical	28514442
LRP5_HUMAN	LRP5	physical	28514442
TNPO2_HUMAN	TNPO2	physical	28514442
LRP6_HUMAN	LRP6	physical	28514442
FURIN_HUMAN	FURIN	physical	28514442
ITM2B_HUMAN	ITM2B	physical	28514442
PCDH7_HUMAN	PCDH7	physical	28514442
GOLI4_HUMAN	GOLIM4	physical	28514442
TNPO3_HUMAN	TNPO3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.