dbPTM

KIF14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KIF14_HUMAN
UniProt AC	Q15058
Protein Name	Kinesin-like protein KIF14 {ECO:0000305}
Gene Name	KIF14 {ECO:0000312\|HGNC:HGNC:19181}
Organism	Homo sapiens (Human).
Sequence Length	1648
Subcellular Localization	Nucleus . Cytoplasm . Cytoplasm, cytoskeleton, spindle . Midbody . Nuclear localization observed during interphase (PubMed:16431929). Nuclear localization triggered by entry into mitosis (PubMed:16648480). Cytoplasmic in interphase (PubMed:16648480).
Protein Description	Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. [PubMed: 24784001]
Protein Sequence	MSLHSTHNRNNSGDILDIPSSQNSSSLNALTHSSRLKLHLKSDMSECENDDPLLRSAGKVRDINRTYVISASRKTADMPLTPNPVGRLALQRRTTRNKESSLLVSELEDTTEKTAETRLTLQRRAKTDSAEKWKTAEIDSVKMTLNVGGETENNGVSKESRTNVRIVNNAKNSFVASSVPLDEDPQVIEMMADKKYKETFSAPSRANENVALKYSSNRPPIASLSQTEVVRSGHLTTKPTQSKLDIKVLGTGNLYHRSIGKEIAKTSNKFGSLEKRTPTKCTTEHKLTTKCSLPQLKSPAPSILKNRMSNLQVKQRPKSSFLANKQERSAENTILPEEETVVQNTSAGKDPLKVENSQVTVAVRVRPFTKREKIEKASQVVFMSGKEITVEHPDTKQVYNFIYDVSFWSFDECHPHYASQTTVYEKLAAPLLERAFEGFNTCLFAYGQTGSGKSYTMMGFSEEPGIIPRFCEDLFSQVARKQTQEVSYHIEMSFFEVYNEKIHDLLVCKDENGQRKQPLRVREHPVYGPYVEALSMNIVSSYADIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCSTAHTNGDRLKEGVSINKSLLTLGKVISALSEQANQRSVFIPYRESVLTWLLKESLGGNSKTAMIATISPAASNIEETLSTLRYANQARLIVNIAKVNEDMNAKLIRELKAEIAKLKAAQRNSRNIDPERYRLCRQEITSLRMKLHQQERDMAEMQRVWKEKFEQAEKRKLQETKELQKAGIMFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGTTTVGKYKPNSSHDIQLSGVLIADDHCTIKNFGGTVSIIPVGEAKTYVNGKHILEITVLRHGDRVILGGDHYFRFNHPVEVQKGKRPSGRDTPISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMMQGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELEKAKQHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRNNRDKTFTVQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDISDKSSSDTSIRVRNLKLGISTFWSLEKFESKLAAMKELYESNGSNRGEDAFCDPEDEWEPDITDAPVSSLSRRRSRSLMKNRRISGCLHDIQVHPIKNLHSSHSSGLMDKSSTIYSNSAESFLPGICKELIGSSLDFFGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQDEESQDNLFSSDRAIQSLTIQTACAFEQLVVLMKHWLSDLLPCTNIARLEDELRQEVKKLGGYLQLFLQGCCLDISSMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAVCDGVGLGMKILLDSGLEKAKELQHELFRQCTKNEVTKEMKTNAMGLIRSLENIFAESKIKSFRRQVQEENFEYQDFKRMVNRAPEFLKLKHCLEKAIEIIISALKGCHSDINLLQTCVESIRNLASDFYSDFSVPSTSVGSYESRVTHIVHQELESLAKSLLFCFESEESPDLLKPWETYNQNTKEEHQQSKSSGIDGSKNKGVPKRVYELHGSSPAVSSEECTPSRIQWV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLHSTHNR ------CCCCCCCCC	46.20	23401153
12	Phosphorylation	STHNRNNSGDILDIP CCCCCCCCCCCEECC	41.20	23401153
18	Ubiquitination	NSGDILDIPSSQNSS CCCCCEECCCCCCCC	2.98	29967540
20	Phosphorylation	GDILDIPSSQNSSSL CCCEECCCCCCCCHH	44.91	23927012
21	Phosphorylation	DILDIPSSQNSSSLN CCEECCCCCCCCHHH	28.20	23927012
25	Phosphorylation	IPSSQNSSSLNALTH CCCCCCCCHHHHHCH	46.52	-
26	Phosphorylation	PSSQNSSSLNALTHS CCCCCCCHHHHHCHH	26.01	22496350
42	Phosphorylation	RLKLHLKSDMSECEN HHHHHCCCCHHHCCC	44.93	22617229
45	Phosphorylation	LHLKSDMSECENDDP HHCCCCHHHCCCCCH	44.05	22617229
56	Phosphorylation	NDDPLLRSAGKVRDI CCCHHHHCCCCEEEC	41.15	25159151
66	Phosphorylation	KVRDINRTYVISASR CEEECCCEEEEEECC	20.04	23312004
67	Phosphorylation	VRDINRTYVISASRK EEECCCEEEEEECCC	7.79	23312004
70	Phosphorylation	INRTYVISASRKTAD CCCEEEEEECCCCCC	15.33	28555341
70	Ubiquitination	INRTYVISASRKTAD CCCEEEEEECCCCCC	15.33	24816145
81	Phosphorylation	KTADMPLTPNPVGRL CCCCCCCCCCHHHHH	18.36	29255136
85	Ubiquitination	MPLTPNPVGRLALQR CCCCCCHHHHHHHHC	9.90	24816145
86	Ubiquitination	PLTPNPVGRLALQRR CCCCCHHHHHHHHCC	21.82	17203973
94	Phosphorylation	RLALQRRTTRNKESS HHHHHCCCCCCCHHH	32.09	23882029
95	Phosphorylation	LALQRRTTRNKESSL HHHHCCCCCCCHHHC	30.36	23882029
98	Ubiquitination	QRRTTRNKESSLLVS HCCCCCCCHHHCEEE	56.53	29967540
100	Phosphorylation	RTTRNKESSLLVSEL CCCCCCHHHCEEEEC	28.09	22777824
101	Phosphorylation	TTRNKESSLLVSELE CCCCCHHHCEEEECC	27.15	25849741
105	Phosphorylation	KESSLLVSELEDTTE CHHHCEEEECCCCCC	36.11	22777824
110	Phosphorylation	LVSELEDTTEKTAET EEEECCCCCCHHHHH	27.72	26074081
111	Phosphorylation	VSELEDTTEKTAETR EEECCCCCCHHHHHH	48.05	26074081
113	Ubiquitination	ELEDTTEKTAETRLT ECCCCCCHHHHHHHH	51.44	24816145
114	Phosphorylation	LEDTTEKTAETRLTL CCCCCCHHHHHHHHH	24.40	26074081
117	Phosphorylation	TTEKTAETRLTLQRR CCCHHHHHHHHHHHH	28.63	26074081
120	Phosphorylation	KTAETRLTLQRRAKT HHHHHHHHHHHHHCC	19.97	26074081
127	Phosphorylation	TLQRRAKTDSAEKWK HHHHHHCCCCHHHHH	33.91	26074081
129	Phosphorylation	QRRAKTDSAEKWKTA HHHHCCCCHHHHHCC	43.49	26074081
130	Ubiquitination	RRAKTDSAEKWKTAE HHHCCCCHHHHHCCC	25.79	29967540
135	Phosphorylation	DSAEKWKTAEIDSVK CCHHHHHCCCCCEEE	28.54	29396449
137	Ubiquitination	AEKWKTAEIDSVKMT HHHHHCCCCCEEEEE	53.19	29967540
140	Phosphorylation	WKTAEIDSVKMTLNV HHCCCCCEEEEEEEC	29.33	20068231
144	Phosphorylation	EIDSVKMTLNVGGET CCCEEEEEEECCCCC	14.95	-
151	Phosphorylation	TLNVGGETENNGVSK EEECCCCCCCCCCCC	47.49	-
151	Ubiquitination	TLNVGGETENNGVSK EEECCCCCCCCCCCC	47.49	17203973
173	Phosphorylation	IVNNAKNSFVASSVP EEECCCCCCCCCCCC	22.01	27050516
195	Ubiquitination	IEMMADKKYKETFSA HHHHCCCCCHHHCCC	63.20	-
196	Phosphorylation	EMMADKKYKETFSAP HHHCCCCCHHHCCCC	21.57	20068231
199	Phosphorylation	ADKKYKETFSAPSRA CCCCCHHHCCCCCCC	20.81	20068231
201	Phosphorylation	KKYKETFSAPSRANE CCCHHHCCCCCCCCC	46.84	20068231
204	Phosphorylation	KETFSAPSRANENVA HHHCCCCCCCCCCCE	43.68	20068231
213	Methylation	ANENVALKYSSNRPP CCCCCEEEECCCCCC	33.09	115972043
215	Phosphorylation	ENVALKYSSNRPPIA CCCEEEECCCCCCCC	21.39	28555341
223	Ubiquitination	SNRPPIASLSQTEVV CCCCCCCCCCCCEEE	29.31	29967540
225	Phosphorylation	RPPIASLSQTEVVRS CCCCCCCCCCEEEEC	32.34	29214152
232	Ubiquitination	SQTEVVRSGHLTTKP CCCEEEECCCCCCCC	20.96	17203973
238	Ubiquitination	RSGHLTTKPTQSKLD ECCCCCCCCCCCCCE	40.61	29967540
242	Phosphorylation	LTTKPTQSKLDIKVL CCCCCCCCCCEEEEE	37.35	17081983
243	Ubiquitination	TTKPTQSKLDIKVLG CCCCCCCCCEEEEEC	40.12	29967540
247	Ubiquitination	TQSKLDIKVLGTGNL CCCCCEEEEECCCCC	30.95	17203973
251	Phosphorylation	LDIKVLGTGNLYHRS CEEEEECCCCCCHHH	20.80	21945579
255	Phosphorylation	VLGTGNLYHRSIGKE EECCCCCCHHHHHHH	10.13	21945579
258	Phosphorylation	TGNLYHRSIGKEIAK CCCCCHHHHHHHHHH	23.52	24719451
261	Ubiquitination	LYHRSIGKEIAKTSN CCHHHHHHHHHHHCC	44.25	29967540
263	Ubiquitination	HRSIGKEIAKTSNKF HHHHHHHHHHHCCCC	5.62	29967540
266	Phosphorylation	IGKEIAKTSNKFGSL HHHHHHHHCCCCCCC	28.63	23186163
267	Phosphorylation	GKEIAKTSNKFGSLE HHHHHHHCCCCCCCC	37.00	23186163
269	Acetylation	EIAKTSNKFGSLEKR HHHHHCCCCCCCCCC	51.36	25953088
272	Phosphorylation	KTSNKFGSLEKRTPT HHCCCCCCCCCCCCC	36.17	30266825
275	Ubiquitination	NKFGSLEKRTPTKCT CCCCCCCCCCCCCCC	67.85	21890473
277	Phosphorylation	FGSLEKRTPTKCTTE CCCCCCCCCCCCCCC	46.51	26055452
279	Phosphorylation	SLEKRTPTKCTTEHK CCCCCCCCCCCCCCC	37.83	23186163
290	Acetylation	TEHKLTTKCSLPQLK CCCCCCCCCCCCCCC	19.32	25953088
292	Phosphorylation	HKLTTKCSLPQLKSP CCCCCCCCCCCCCCC	44.64	23186163
294	Ubiquitination	LTTKCSLPQLKSPAP CCCCCCCCCCCCCCC	22.59	32015554
297	Methylation	KCSLPQLKSPAPSIL CCCCCCCCCCCCHHH	49.50	115972047
298	Phosphorylation	CSLPQLKSPAPSILK CCCCCCCCCCCHHHH	34.58	21815630
302	Phosphorylation	QLKSPAPSILKNRMS CCCCCCCHHHHHHHC	42.53	21712546
305	Methylation	SPAPSILKNRMSNLQ CCCCHHHHHHHCCCC	40.62	115972053
305	Ubiquitination	SPAPSILKNRMSNLQ CCCCHHHHHHHCCCC	40.62	32015554
309	Phosphorylation	SILKNRMSNLQVKQR HHHHHHHCCCCCCCC	31.02	24173317
320	Phosphorylation	VKQRPKSSFLANKQE CCCCCHHHCCCCCHH	30.33	24719451
325	Ubiquitination	KSSFLANKQERSAEN HHHCCCCCHHHCCCC	48.18	32015554
329	Phosphorylation	LANKQERSAENTILP CCCCHHHCCCCCCCC	38.90	29396449
333	Phosphorylation	QERSAENTILPEEET HHHCCCCCCCCHHHH	18.52	29255136
340	Phosphorylation	TILPEEETVVQNTSA CCCCHHHHCCCCCCC	29.29	23663014
345	Phosphorylation	EETVVQNTSAGKDPL HHHCCCCCCCCCCCC	11.67	29255136
346	Phosphorylation	ETVVQNTSAGKDPLK HHCCCCCCCCCCCCE	42.44	29255136
349	Ubiquitination	VQNTSAGKDPLKVEN CCCCCCCCCCCEEEC	56.75	29967540
357	Phosphorylation	DPLKVENSQVTVAVR CCCEEECCEEEEEEE	16.72	29978859
360	Phosphorylation	KVENSQVTVAVRVRP EEECCEEEEEEEECC	8.63	29978859
378	Phosphorylation	REKIEKASQVVFMSG HHHHHHHCEEEEECC	34.28	20068231
384	Phosphorylation	ASQVVFMSGKEITVE HCEEEEECCCEEEEE	34.94	20068231
431	Ubiquitination	YEKLAAPLLERAFEG HHHHHHHHHHHHHCC	7.13	29967540
437	Ubiquitination	PLLERAFEGFNTCLF HHHHHHHCCCCEEEE	62.99	29967540
449	Phosphorylation	CLFAYGQTGSGKSYT EEEEECCCCCCCCEE	29.02	-
451	Phosphorylation	FAYGQTGSGKSYTMM EEECCCCCCCCEEEE	46.57	-
453	Ubiquitination	YGQTGSGKSYTMMGF ECCCCCCCCEEEEEC	41.82	29967540
471	Ubiquitination	PGIIPRFCEDLFSQV CCCHHHHHHHHHHHH	4.14	29967540
490	Ubiquitination	TQEVSYHIEMSFFEV HHHHEEEEEEEHHHH	3.45	29967540
509	Ubiquitination	IHDLLVCKDENGQRK HCEEEEEECCCCCCC	61.67	29967540
546	Ubiquitination	VSSYADIQSWLELGN HHHHHHHHHHHHHCC	29.15	29967540
558	Phosphorylation	LGNKQRATAATGMND HCCHHHHHHCCCCCC	21.00	29978859
561	Phosphorylation	KQRATAATGMNDKSS HHHHHHCCCCCCCHH	34.20	29978859
567	Phosphorylation	ATGMNDKSSRSHSVF CCCCCCCHHCCCCEE	33.57	29978859
567	Ubiquitination	ATGMNDKSSRSHSVF CCCCCCCHHCCCCEE	33.57	29967540
568	Phosphorylation	TGMNDKSSRSHSVFT CCCCCCHHCCCCEEE	43.47	29978859
572	Ubiquitination	DKSSRSHSVFTLVMT CCHHCCCCEEEEEEE	21.85	29967540
607	Phosphorylation	NLIDLAGSERCSTAH EEEECCCCCCCCCCC	19.09	-
621	Ubiquitination	HTNGDRLKEGVSINK CCCCCHHHCCCCCCH	54.00	29967540
628	Ubiquitination	KEGVSINKSLLTLGK HCCCCCCHHHHHHHH	40.59	29967540
632	Phosphorylation	SINKSLLTLGKVISA CCCHHHHHHHHHHHH	38.46	-
641	Phosphorylation	GKVISALSEQANQRS HHHHHHHHHHHHCCC	27.64	22210691
648	Phosphorylation	SEQANQRSVFIPYRE HHHHHCCCCCCCHHH	16.18	26074081
653	Phosphorylation	QRSVFIPYRESVLTW CCCCCCCHHHHHHHH	23.38	26074081
655	Ubiquitination	SVFIPYRESVLTWLL CCCCCHHHHHHHHHH	39.08	29967540
656	Phosphorylation	VFIPYRESVLTWLLK CCCCHHHHHHHHHHH	17.27	26074081
659	Phosphorylation	PYRESVLTWLLKESL CHHHHHHHHHHHHHC	16.35	26074081
670	Phosphorylation	KESLGGNSKTAMIAT HHHCCCCCCEEEEEE	34.36	20068231
714	Ubiquitination	VNEDMNAKLIRELKA HCHHHHHHHHHHHHH	39.17	29967540
725	Acetylation	ELKAEIAKLKAAQRN HHHHHHHHHHHHHHH	57.07	7706971
734	Ubiquitination	KAAQRNSRNIDPERY HHHHHHCCCCCHHHH	47.90	29967540
741	Phosphorylation	RNIDPERYRLCRQEI CCCCHHHHHHHHHHH	13.28	28555341
754	Ubiquitination	EITSLRMKLHQQERD HHHHHHHHHHHHHHH	36.06	29967540
785	Acetylation	KRKLQETKELQKAGI HHHHHHHHHHHHHCC	56.53	7927327
785	Ubiquitination	KRKLQETKELQKAGI HHHHHHHHHHHHHCC	56.53	32015554
813	Phosphorylation	LNEDPQLSEMLLYMI CCCCCCHHHHHHHHH	18.73	24043423
818	Phosphorylation	QLSEMLLYMIKEGTT CHHHHHHHHHHHCCC	7.88	24043423
868	Ubiquitination	IIPVGEAKTYVNGKH EEECCEEEEEECCEE	35.77	-
901	Ubiquitination	HYFRFNHPVEVQKGK EEEECCCCEEECCCC	25.68	29967540
906	Ubiquitination	NHPVEVQKGKRPSGR CCCEEECCCCCCCCC	72.13	-
908	Acetylation	PVEVQKGKRPSGRDT CEEECCCCCCCCCCC	69.07	156411
911	Phosphorylation	VQKGKRPSGRDTPIS ECCCCCCCCCCCCCC	50.96	25159151
914	Ubiquitination	GKRPSGRDTPISEGP CCCCCCCCCCCCCCC	61.43	32015554
915	Phosphorylation	KRPSGRDTPISEGPK CCCCCCCCCCCCCCC	22.59	29255136
918	Phosphorylation	SGRDTPISEGPKDFE CCCCCCCCCCCCCHH	37.39	29255136
922	Ubiquitination	TPISEGPKDFEFAKN CCCCCCCCCHHHHHH	82.80	29967540
928	Ubiquitination	PKDFEFAKNELLMAQ CCCHHHHHHHHHHHH	57.16	29967540
937	Phosphorylation	ELLMAQRSQLEAEIK HHHHHHHHHHHHHHH	27.34	29978859
944	Ubiquitination	SQLEAEIKEAQLKAK HHHHHHHHHHHHHHH	38.20	29967540
946	Ubiquitination	LEAEIKEAQLKAKEE HHHHHHHHHHHHHHH	18.27	29967540
949	Acetylation	EIKEAQLKAKEEMMQ HHHHHHHHHHHHHHH	45.38	11793373
951	Ubiquitination	KEAQLKAKEEMMQGI HHHHHHHHHHHHHHH	53.25	-
958	Ubiquitination	KEEMMQGIQIAKEMA HHHHHHHHHHHHHHH	1.18	29967540
962	Ubiquitination	MQGIQIAKEMAQQEL HHHHHHHHHHHHHHH	50.04	29967540
964	Sulfoxidation	GIQIAKEMAQQELSS HHHHHHHHHHHHHHH	3.93	21406390
973	Acetylation	QQELSSQKAAYESKI HHHHHHHHHHHHHHH	36.61	7676465
981	Ubiquitination	AAYESKIKALEAELR HHHHHHHHHHHHHHH	51.13	29967540
984	Ubiquitination	ESKIKALEAELREES HHHHHHHHHHHHHHH	44.98	29967540
986	Ubiquitination	KIKALEAELREESQR HHHHHHHHHHHHHHH	38.70	29967540
1003	Ubiquitination	MQEINNQKANHKIEE HHHHHHHHHHHHHHH	53.96	21890473
1014	Ubiquitination	KIEELEKAKQHLEQE HHHHHHHHHHHHHHH	13.83	29967540
1023	Phosphorylation	QHLEQEIYVNKKRLE HHHHHHHHHCHHHHH	9.38	28152594
1037	Acetylation	EMETLATKQALEDHS HHHHHHHHHHHHHCC	28.15	7664441
1037	Ubiquitination	EMETLATKQALEDHS HHHHHHHHHHHHHCC	28.15	29967540
1044	Phosphorylation	KQALEDHSIRHARIL HHHHHHCCHHHHHHH	33.37	23312004
1058	Ubiquitination	LEALETEKQKIAKEV HHHHHHHHHHHHHHH	65.40	29967540
1060	Ubiquitination	ALETEKQKIAKEVQI HHHHHHHHHHHHHHH	56.55	-
1063	Ubiquitination	TEKQKIAKEVQILQQ HHHHHHHHHHHHHHH	62.99	29967540
1078	Phosphorylation	NRNNRDKTFTVQTTW CCCCCCCCEEEEECH	28.91	-
1102	Phosphorylation	QEANAISSKLKTYYV HHHHHHHHHCHHEEE	35.57	-
1107	Phosphorylation	ISSKLKTYYVFGRHD HHHHCHHEEEEECCC	8.95	20090780
1118	Ubiquitination	GRHDISDKSSSDTSI ECCCCCCCCCCCCCE	45.51	-
1119	Phosphorylation	RHDISDKSSSDTSIR CCCCCCCCCCCCCEE	39.81	20860994
1121	Phosphorylation	DISDKSSSDTSIRVR CCCCCCCCCCCEEEE	52.58	22468782
1135	Phosphorylation	RNLKLGISTFWSLEK EEEEECCCCCCCHHH	18.76	30387612
1136	Phosphorylation	NLKLGISTFWSLEKF EEEECCCCCCCHHHH	27.48	30387612
1145	Phosphorylation	WSLEKFESKLAAMKE CCHHHHHHHHHHHHH	35.78	30387612
1146	Ubiquitination	SLEKFESKLAAMKEL CHHHHHHHHHHHHHH	34.64	29967540
1151	Ubiquitination	ESKLAAMKELYESNG HHHHHHHHHHHHHCC	39.58	-
1183	Phosphorylation	DITDAPVSSLSRRRS CCCCCCCHHHCHHHH	25.22	25627689
1186	Phosphorylation	DAPVSSLSRRRSRSL CCCCHHHCHHHHHHH	26.20	25627689
1187	Methylation	APVSSLSRRRSRSLM CCCHHHCHHHHHHHH	43.24	24391461
1188	Methylation	PVSSLSRRRSRSLMK CCHHHCHHHHHHHHH	37.23	24391469
1189	Methylation	VSSLSRRRSRSLMKN CHHHCHHHHHHHHHC	35.00	24391477
1190	Phosphorylation	SSLSRRRSRSLMKNR HHHCHHHHHHHHHCC	25.14	21406692
1192	Phosphorylation	LSRRRSRSLMKNRRI HCHHHHHHHHHCCCC	33.78	21406692
1200	Phosphorylation	LMKNRRISGCLHDIQ HHHCCCCCCCCCCCE	22.95	29255136
1216	Phosphorylation	HPIKNLHSSHSSGLM EECCCCCCCCCCCCC	32.67	29759185
1217	Phosphorylation	PIKNLHSSHSSGLMD ECCCCCCCCCCCCCC	19.35	29759185
1219	Phosphorylation	KNLHSSHSSGLMDKS CCCCCCCCCCCCCCC	28.22	29759185
1220	Phosphorylation	NLHSSHSSGLMDKSS CCCCCCCCCCCCCCC	30.44	-
1225	Ubiquitination	HSSGLMDKSSTIYSN CCCCCCCCCCCCCCC	32.13	29967540
1226	Phosphorylation	SSGLMDKSSTIYSNS CCCCCCCCCCCCCCC	28.57	21945579
1227	Phosphorylation	SGLMDKSSTIYSNSA CCCCCCCCCCCCCCH	25.27	21945579
1228	Phosphorylation	GLMDKSSTIYSNSAE CCCCCCCCCCCCCHH	30.90	21945579
1230	Phosphorylation	MDKSSTIYSNSAESF CCCCCCCCCCCHHHH	11.24	21945579
1231	Phosphorylation	DKSSTIYSNSAESFL CCCCCCCCCCHHHHH	22.06	21945579
1233	Phosphorylation	SSTIYSNSAESFLPG CCCCCCCCHHHHHHH	27.72	21945579
1236	Phosphorylation	IYSNSAESFLPGICK CCCCCHHHHHHHHHH	31.62	21945579
1249	Phosphorylation	CKELIGSSLDFFGQS HHHHHCCCCCCCCCC	27.09	22817900
1256	Phosphorylation	SLDFFGQSYDEERTI CCCCCCCCCCHHHHH	34.62	22817900
1262	Phosphorylation	QSYDEERTIADSLIN CCCCHHHHHHHHHHH	24.64	21712546
1270	Phosphorylation	IADSLINSFLKIYNG HHHHHHHHHHHHHHH	25.59	24719451
1275	Phosphorylation	INSFLKIYNGLFAIS HHHHHHHHHHHHHHH	11.11	-
1282	Phosphorylation	YNGLFAISKAHEEQD HHHHHHHHHHHHHCC	21.99	-
1292	Phosphorylation	HEEQDEESQDNLFSS HHHCCHHHHHCCCCC	40.56	22167270
1305	Ubiquitination	SSDRAIQSLTIQTAC CCHHHHHHHHHHHHH	22.74	21890473
1370	Ubiquitination	ISSMIKEAQKNAIQI HHHHHHHHHHHHHHH	22.20	21890473
1392	Ubiquitination	VGQLAVLKGSKLHFL HHHHHHHCCCEEEEE	55.32	29967540
1394	Phosphorylation	QLAVLKGSKLHFLEN HHHHHCCCEEEEEEC	30.38	-
1405	Ubiquitination	FLENGNNKAASVQEE EEECCCCCCHHHHHH	49.70	32015554
1431	Phosphorylation	GMKILLDSGLEKAKE HHHHHHHHCHHHHHH	45.29	-
1435	Ubiquitination	LLDSGLEKAKELQHE HHHHCHHHHHHHHHH	70.56	29967540
1437	Ubiquitination	DSGLEKAKELQHELF HHCHHHHHHHHHHHH	70.76	29967540
1449	Ubiquitination	ELFRQCTKNEVTKEM HHHHHHCHHHHCHHH	59.75	29967540
1451	Ubiquitination	FRQCTKNEVTKEMKT HHHHCHHHHCHHHHH	53.79	21890473
1454	Ubiquitination	CTKNEVTKEMKTNAM HCHHHHCHHHHHHHH	62.07	-
1457	Ubiquitination	NEVTKEMKTNAMGLI HHHCHHHHHHHHHHH	39.45	-
1466	Phosphorylation	NAMGLIRSLENIFAE HHHHHHHHHHHHHHH	32.80	20873877
1466	Ubiquitination	NAMGLIRSLENIFAE HHHHHHHHHHHHHHH	32.80	21890473
1475	Ubiquitination	ENIFAESKIKSFRRQ HHHHHHHHHHHHHHH	45.73	29967540
1477	Ubiquitination	IFAESKIKSFRRQVQ HHHHHHHHHHHHHHH	47.48	29967540
1478	Phosphorylation	FAESKIKSFRRQVQE HHHHHHHHHHHHHHH	27.71	-
1490	Phosphorylation	VQEENFEYQDFKRMV HHHHCCCHHHHHHHH	14.83	27642862
1494	Acetylation	NFEYQDFKRMVNRAP CCCHHHHHHHHHCCH	48.12	24468135
1494	Ubiquitination	NFEYQDFKRMVNRAP CCCHHHHHHHHHCCH	48.12	22817900
1505	Ubiquitination	NRAPEFLKLKHCLEK HCCHHHHHHHHHHHH	61.89	29967540
1543	Phosphorylation	ESIRNLASDFYSDFS HHHHHHHHHHHCCCC	31.27	-
1547	Phosphorylation	NLASDFYSDFSVPST HHHHHHHCCCCCCCC	31.97	-
1553	Phosphorylation	YSDFSVPSTSVGSYE HCCCCCCCCCCCCCH	31.03	-
1626	Phosphorylation	KGVPKRVYELHGSSP CCCCCCEEEECCCCC	19.46	21945579
1631	Phosphorylation	RVYELHGSSPAVSSE CEEEECCCCCCCCCC	23.54	21945579
1632	Phosphorylation	VYELHGSSPAVSSEE EEEECCCCCCCCCCC	22.82	21945579
1636	Phosphorylation	HGSSPAVSSEECTPS CCCCCCCCCCCCCHH	33.85	21945579
1637	Phosphorylation	GSSPAVSSEECTPSR CCCCCCCCCCCCHHH	30.71	21945579
1641	Phosphorylation	AVSSEECTPSRIQWV CCCCCCCCHHHCCCC	27.81	21815630

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
56	S	Phosphorylation	Kinase	NEK7	Q8TDX7	PSP
607	S	Phosphorylation	Kinase	NEK7	Q8TDX7	PSP
1217	S	Phosphorylation	Kinase	NEK7	Q8TDX7	PSP
1219	S	Phosphorylation	Kinase	NEK7	Q8TDX7	PSP
1220	S	Phosphorylation	Kinase	NEK7	Q8TDX7	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KIF14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KIF14_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATP5I_HUMAN	ATP5I	physical	26496610
NPA1P_HUMAN	URB1	physical	26496610
KBP_HUMAN	KIAA1279	physical	26496610
TMCO1_HUMAN	TMCO1	physical	26496610
GCP2_HUMAN	TUBGCP2	physical	25348260
TBG1_HUMAN	TUBG1	physical	25348260

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
616258	Meckel syndrome 12 (MKS12)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KIF14_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-196; SER-1200 ANDSER-1292, AND MASS SPECTROMETRY.	17081983 [Abstract]
Ubiquitylation
Reference	PubMed
"The proteomic reactor facilitates the analysis of affinity-purifiedproteins by mass spectrometry: application for identifyingubiquitinated proteins in human cells."; Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M.,Haines D.S., Figeys D.; J. Proteome Res. 6:298-305(2007). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-275, AND MASSSPECTROMETRY.	17203973 [Abstract]