ATP5I_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATP5I_HUMAN
• UniProt AC: P56385
• Protein Name: ATP synthase subunit e, mitochondrial
• Gene Name: ATP5I
• Organism: Homo sapiens (Human).
• Sequence Length: 69
• Subcellular Localization: Mitochondrion. Mitochondrion inner membrane.
• Protein Description: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane..
• Protein Sequence: MVPPVQVSPLIKLGRYSALFLGVAYGATRYNYLKPRAEEERRIAAEEKKKQDELKRIARELAEDDSILK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MVPPVQVSPLIKLGR CCCCCCCCHHHHHCH	9.26	26074081
12	Ubiquitination	VQVSPLIKLGRYSAL CCCCHHHHHCHHHHH	53.20	24816145
17	O-linked_Glycosylation	LIKLGRYSALFLGVA HHHHCHHHHHHHHHH	19.69	30379171
25	Phosphorylation	ALFLGVAYGATRYNY HHHHHHHHCHHHHHC	12.60	-
28	Phosphorylation	LGVAYGATRYNYLKP HHHHHCHHHHHCCCH	29.35	-
30	Phosphorylation	VAYGATRYNYLKPRA HHHCHHHHHCCCHHH	12.10	22817900
32	Phosphorylation	YGATRYNYLKPRAEE HCHHHHHCCCHHHHH	13.73	22817900
34	Succinylation	ATRYNYLKPRAEEER HHHHHCCCHHHHHHH	23.30	23954790
34	Ubiquitination	ATRYNYLKPRAEEER HHHHHCCCHHHHHHH	23.30	-
34	Acetylation	ATRYNYLKPRAEEER HHHHHCCCHHHHHHH	23.30	25825284
48	2-Hydroxyisobutyrylation	RRIAAEEKKKQDELK HHHHHHHHHHHHHHH	57.69	-
49	Ubiquitination	RIAAEEKKKQDELKR HHHHHHHHHHHHHHH	59.97	24816145
50	Ubiquitination	IAAEEKKKQDELKRI HHHHHHHHHHHHHHH	74.23	24816145
55	Ubiquitination	KKKQDELKRIARELA HHHHHHHHHHHHHHH	39.45	25015289
55	2-Hydroxyisobutyrylation	KKKQDELKRIARELA HHHHHHHHHHHHHHH	39.45	-
66	Phosphorylation	RELAEDDSILK---- HHHHHHCCCCC----	41.99	25850435
69	Acetylation	AEDDSILK------- HHHCCCCC-------	57.53	68909
69	Ubiquitination	AEDDSILK------- HHHCCCCC-------	57.53	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATP5I_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATP5I_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATP5I_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RS16_HUMAN	RPS16	physical	22939629
RS21_HUMAN	RPS21	physical	22939629
RER1_HUMAN	RER1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.