dbPTM

RS21_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RS21_HUMAN
UniProt AC	P63220
Protein Name	40S ribosomal protein S21
Gene Name	RPS21
Organism	Homo sapiens (Human).
Sequence Length	83
Subcellular Localization	Cytoplasm, cytosol . Cytoplasm . Rough endoplasmic reticulum . Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Protein Description
Protein Sequence	MQNDAGEFVDLYVPRKCSASNRIIGAKDHASIQMNVAEVDKVTGRFNGQFKTYAICGAIRRMGESDDSILRLAKADGIVSKNF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Sulfoxidation	-------MQNDAGEF -------CCCCCCCE	8.29	28183972
1	Acetylation	-------MQNDAGEF -------CCCCCCCE	8.29	19413330
12	Phosphorylation	AGEFVDLYVPRKCSA CCCEEEEEECCCCCC	12.16	26657352
12	Nitration	AGEFVDLYVPRKCSA CCCEEEEEECCCCCC	12.16	-
27	Acetylation	SNRIIGAKDHASIQM CCCCCCCCCCEEEEE	44.85	23954790
27	Ubiquitination	SNRIIGAKDHASIQM CCCCCCCCCCEEEEE	44.85	21890473
34	Sulfoxidation	KDHASIQMNVAEVDK CCCEEEEEEEEEHHE	4.09	30846556
41	Sumoylation	MNVAEVDKVTGRFNG EEEEEHHEEEEEECC	47.04	25114211
41	Malonylation	MNVAEVDKVTGRFNG EEEEEHHEEEEEECC	47.04	26320211
41	Ubiquitination	MNVAEVDKVTGRFNG EEEEEHHEEEEEECC	47.04	-
41	Acetylation	MNVAEVDKVTGRFNG EEEEEHHEEEEEECC	47.04	23954790
51	Ubiquitination	GRFNGQFKTYAICGA EEECCCEEHHHHHHH	32.51	21890473
51	Acetylation	GRFNGQFKTYAICGA EEECCCEEHHHHHHH	32.51	25953088
51	Methylation	GRFNGQFKTYAICGA EEECCCEEHHHHHHH	32.51	30592059
52	Phosphorylation	RFNGQFKTYAICGAI EECCCEEHHHHHHHH	21.34	23403867
53	Phosphorylation	FNGQFKTYAICGAIR ECCCEEHHHHHHHHH	8.44	25394399
56	Glutathionylation	QFKTYAICGAIRRMG CEEHHHHHHHHHHHC	1.99	22555962
56	S-palmitoylation	QFKTYAICGAIRRMG CEEHHHHHHHHHHHC	1.99	29575903
62	Sulfoxidation	ICGAIRRMGESDDSI HHHHHHHHCCCCHHH	5.12	21406390
65	Phosphorylation	AIRRMGESDDSILRL HHHHHCCCCHHHHHH	40.77	22617229
68	Phosphorylation	RMGESDDSILRLAKA HHCCCCHHHHHHHHH	28.63	20068231
71	Methylation	ESDDSILRLAKADGI CCCHHHHHHHHHCCC	30.81	115492605
74	2-Hydroxyisobutyrylation	DSILRLAKADGIVSK HHHHHHHHHCCCCCC	52.15	-
74	Ubiquitination	DSILRLAKADGIVSK HHHHHHHHHCCCCCC	52.15	2190698
74	Acetylation	DSILRLAKADGIVSK HHHHHHHHHCCCCCC	52.15	26051181
80	Phosphorylation	AKADGIVSKNF---- HHHCCCCCCCC----	21.69	27251275
81	Ubiquitination	KADGIVSKNF----- HHCCCCCCCC-----	52.02	21890473
81	Acetylation	KADGIVSKNF----- HHCCCCCCCC-----	52.02	19608861

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RS21_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RS21_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RS21_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RSSA_HUMAN	RPSA	physical	16169070
A4_HUMAN	APP	physical	21832049
RSSA_HUMAN	RPSA	physical	22939629
RS23_HUMAN	RPS23	physical	22939629
RS28_HUMAN	RPS28	physical	22939629
RS3A_HUMAN	RPS3A	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
RS6_HUMAN	RPS6	physical	22939629
RS8_HUMAN	RPS8	physical	22939629
RS26_HUMAN	RPS26	physical	22939629
RS25_HUMAN	RPS25	physical	22939629
RS24_HUMAN	RPS24	physical	22939629
RS2_HUMAN	RPS2	physical	22939629
RS5_HUMAN	RPS5	physical	22939629
RS3_HUMAN	RPS3	physical	22939629
RS29_HUMAN	RPS29	physical	22939629
RS7_HUMAN	RPS7	physical	22939629
RL40_HUMAN	UBA52	physical	22939629
RS27L_HUMAN	RPS27L	physical	22939629
RT21_HUMAN	MRPS21	physical	22939629
UB2V2_HUMAN	UBE2V2	physical	22939629
ADRM1_HUMAN	ADRM1	physical	22863883
DYL1_HUMAN	DYNLL1	physical	22863883
RACK1_HUMAN	GNB2L1	physical	22863883
RSSA_HUMAN	RPSA	physical	22863883
C1TC_HUMAN	MTHFD1	physical	22863883
PRS4_HUMAN	PSMC1	physical	22863883
PRS7_HUMAN	PSMC2	physical	22863883
PRS10_HUMAN	PSMC6	physical	22863883
PSD11_HUMAN	PSMD11	physical	22863883
PSMD1_HUMAN	PSMD1	physical	22863883
PSMD3_HUMAN	PSMD3	physical	22863883
PSMD8_HUMAN	PSMD8	physical	22863883
RS10_HUMAN	RPS10	physical	22863883
RS13_HUMAN	RPS13	physical	22863883
RS15A_HUMAN	RPS15A	physical	22863883
RS16_HUMAN	RPS16	physical	22863883
RS27L_HUMAN	RPS27L	physical	22863883
RS28_HUMAN	RPS28	physical	22863883
RS2_HUMAN	RPS2	physical	22863883
RS3_HUMAN	RPS3	physical	22863883
RS5_HUMAN	RPS5	physical	22863883
RS8_HUMAN	RPS8	physical	22863883
HNRPQ_HUMAN	SYNCRIP	physical	22863883
UCHL5_HUMAN	UCHL5	physical	22863883
ZUFSP_HUMAN	ZUFSP	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RS21_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-81, AND MASS SPECTROMETRY.	19608861 [Abstract]