RS28_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RS28_HUMAN
• UniProt AC: P62857
• Protein Name: 40S ribosomal protein S28
• Gene Name: RPS28
• Organism: Homo sapiens (Human).
• Sequence Length: 69
• Subcellular Localization: Cytoplasm, cytosol . Cytoplasm . Rough endoplasmic reticulum . Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
• Protein Sequence: MDTSRVQPIKLARVTKVLGRTGSQGQCTQVRVEFMDDTSRSIIRNVKGPVREGDVLTLLESEREARRLR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDTSRVQP -------CCCCCCCC	13.15	-
3	Phosphorylation	-----MDTSRVQPIK -----CCCCCCCCHH	19.68	25849741
4	Phosphorylation	----MDTSRVQPIKL ----CCCCCCCCHHH	26.62	20068231
10	Acetylation	TSRVQPIKLARVTKV CCCCCCHHHHHHEEE	42.66	25953088
10	2-Hydroxyisobutyrylation	TSRVQPIKLARVTKV CCCCCCHHHHHHEEE	42.66	-
10	Ubiquitination	TSRVQPIKLARVTKV CCCCCCHHHHHHEEE	42.66	21890473
16	Acetylation	IKLARVTKVLGRTGS HHHHHHEEECCCCCC	32.38	26051181
16	Malonylation	IKLARVTKVLGRTGS HHHHHHEEECCCCCC	32.38	26320211
16	2-Hydroxyisobutyrylation	IKLARVTKVLGRTGS HHHHHHEEECCCCCC	32.38	-
16	Ubiquitination	IKLARVTKVLGRTGS HHHHHHEEECCCCCC	32.38	-
21	Phosphorylation	VTKVLGRTGSQGQCT HEEECCCCCCCCCEE	39.11	22617229
23	Phosphorylation	KVLGRTGSQGQCTQV EECCCCCCCCCEEEE	30.44	23401153
27	S-nitrosocysteine	RTGSQGQCTQVRVEF CCCCCCCEEEEEEEE	3.53	-
27	S-nitrosylation	RTGSQGQCTQVRVEF CCCCCCCEEEEEEEE	3.53	19483679
28	Phosphorylation	TGSQGQCTQVRVEFM CCCCCCEEEEEEEEC	23.39	29396449
35	Sulfoxidation	TQVRVEFMDDTSRSI EEEEEEECCCCCCHH	2.63	21406390
38	Phosphorylation	RVEFMDDTSRSIIRN EEEECCCCCCHHHHH	23.06	23312004
39	Phosphorylation	VEFMDDTSRSIIRNV EEECCCCCCHHHHHC	30.90	21712546
41	Phosphorylation	FMDDTSRSIIRNVKG ECCCCCCHHHHHCCC	23.33	23186163
47	2-Hydroxyisobutyrylation	RSIIRNVKGPVREGD CHHHHHCCCCCCCCC	62.13	-
47	Ubiquitination	RSIIRNVKGPVREGD CHHHHHCCCCCCCCC	62.13	-
47	Succinylation	RSIIRNVKGPVREGD CHHHHHCCCCCCCCC	62.13	27452117
57	Phosphorylation	VREGDVLTLLESERE CCCCCHHHHHHHHHH	29.19	21712546
61	Phosphorylation	DVLTLLESEREARRL CHHHHHHHHHHHHHC	41.76	30624053
63	Methylation	LTLLESEREARRLR- HHHHHHHHHHHHCC-	52.75	115492667

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RS28_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RS28_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RS28_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR412_HUMAN	KRTAP4-12	physical	16189514
EF1G_HUMAN	EEF1G	physical	16169070
RS3_HUMAN	RPS3	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
RS6_HUMAN	RPS6	physical	22939629
RS8_HUMAN	RPS8	physical	22939629
RSSA_HUMAN	RPSA	physical	22939629
RS2_HUMAN	RPS2	physical	22939629
RS9_HUMAN	RPS9	physical	22939629
RT28_HUMAN	MRPS28	physical	22939629
UBL4A_HUMAN	UBL4A	physical	22939629
ROA2_HUMAN	HNRNPA2B1	physical	22863883
RSSA_HUMAN	RPSA	physical	22863883
PSMD3_HUMAN	PSMD3	physical	22863883
RS10_HUMAN	RPS10	physical	22863883
RS12_HUMAN	RPS12	physical	22863883
RS13_HUMAN	RPS13	physical	22863883
RS14_HUMAN	RPS14	physical	22863883
RS16_HUMAN	RPS16	physical	22863883
RS19_HUMAN	RPS19	physical	22863883
RS20_HUMAN	RPS20	physical	22863883
RS23_HUMAN	RPS23	physical	22863883
RS24_HUMAN	RPS24	physical	22863883
RS25_HUMAN	RPS25	physical	22863883
RS27L_HUMAN	RPS27L	physical	22863883
RS27_HUMAN	RPS27	physical	22863883
RS2_HUMAN	RPS2	physical	22863883
RS3_HUMAN	RPS3	physical	22863883
RS6_HUMAN	RPS6	physical	22863883
TSR1_HUMAN	TSR1	physical	22863883
PYM1_HUMAN	WIBG	physical	22863883
CCDB1_HUMAN	CCNDBP1	physical	25416956
KRA23_HUMAN	KRTAP2-4	physical	25416956
KRA24_HUMAN	KRTAP2-4	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
NHRF2_HUMAN	SLC9A3R2	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 606164: Diamond-Blackfan anemia 15, with mandibulofacial dysostosis (DBA15)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-23, AND MASS SPECTROMETRY.
PubMed: 19413330

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-23, AND MASS SPECTROMETRY.
PubMed: 19413330