dbPTM

UBL4A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBL4A_HUMAN
UniProt AC	P11441
Protein Name	Ubiquitin-like protein 4A {ECO:0000305}
Gene Name	UBL4A {ECO:0000312\|HGNC:HGNC:12505}
Organism	Homo sapiens (Human).
Sequence Length	157
Subcellular Localization	Cytoplasm, cytosol . Nucleus .
Protein Description	As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. [PubMed: 20676083]
Protein Sequence	MQLTVKALQGRECSLQVPEDELVSTLKQLVSEKLNVPVRQQRLLFKGKALADGKRLSDYSIGPNSKLNLVVKPLEKVLLEEGEAQRLADSPPPQVWQLISKVLARHFSAADASRVLEQLQRDYERSLSRLTLDDIERLASRFLHPEVTETMEKGFSK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	PEDELVSTLKQLVSE CHHHHHHHHHHHHHH	30.41	23403867
27	Ubiquitination	DELVSTLKQLVSEKL HHHHHHHHHHHHHHC	41.49	32015554
33	Ubiquitination	LKQLVSEKLNVPVRQ HHHHHHHHCCCCHHH	37.54	-
48	Acetylation	QRLLFKGKALADGKR HHHHHCCCCCCCCCC	40.60	19666589
48	Ubiquitination	QRLLFKGKALADGKR HHHHHCCCCCCCCCC	40.60	PubMed
54	Acetylation	GKALADGKRLSDYSI CCCCCCCCCCCCCCC	51.19	19666589
54	Ubiquitination	GKALADGKRLSDYSI CCCCCCCCCCCCCCC	51.19	24816145
57	Phosphorylation	LADGKRLSDYSIGPN CCCCCCCCCCCCCCC	38.24	28555341
59	Phosphorylation	DGKRLSDYSIGPNSK CCCCCCCCCCCCCCC	9.98	26074081
60	Phosphorylation	GKRLSDYSIGPNSKL CCCCCCCCCCCCCCC	26.51	26074081
65	Phosphorylation	DYSIGPNSKLNLVVK CCCCCCCCCCCEEEE	41.47	26074081
66	Acetylation	YSIGPNSKLNLVVKP CCCCCCCCCCEEEEC	48.29	25953088
66	Ubiquitination	YSIGPNSKLNLVVKP CCCCCCCCCCEEEEC	48.29	23000965
72	Acetylation	SKLNLVVKPLEKVLL CCCCEEEECHHHHHH	36.08	25953088
72	Malonylation	SKLNLVVKPLEKVLL CCCCEEEECHHHHHH	36.08	32601280
72	Ubiquitination	SKLNLVVKPLEKVLL CCCCEEEECHHHHHH	36.08	23000965
76	Ubiquitination	LVVKPLEKVLLEEGE EEEECHHHHHHHCHH	45.96	22053931
90	Phosphorylation	EAQRLADSPPPQVWQ HHHHHCCCCCHHHHH	33.43	30278072
100	Phosphorylation	PQVWQLISKVLARHF HHHHHHHHHHHHHHC	25.88	24719451
101	Ubiquitination	QVWQLISKVLARHFS HHHHHHHHHHHHHCC	33.98	23000965
108	Phosphorylation	KVLARHFSAADASRV HHHHHHCCHHHHHHH	19.20	-
126	Phosphorylation	LQRDYERSLSRLTLD HHHHHHHHHHCCCHH	20.82	20068231
128	Phosphorylation	RDYERSLSRLTLDDI HHHHHHHHCCCHHHH	26.87	23532336
151	Sulfoxidation	HPEVTETMEKGFSK- CHHHHHHHHHCCCC-	4.00	21406390
153	Ubiquitination	EVTETMEKGFSK--- HHHHHHHHCCCC---	55.20	21890473
157	Ubiquitination	TMEKGFSK------- HHHHCCCC-------	63.20	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	AMFR	Q9UKV5	PMID:24424410

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UBL4A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBL4A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASNA_HUMAN	ASNA1	physical	19615732
SGTA_HUMAN	SGTA	physical	19615732
UFD1_HUMAN	UFD1L	physical	19615732
BAG6_HUMAN	BAG6	physical	19615732
HUWE1_HUMAN	HUWE1	physical	19615732
FAF2_HUMAN	FAF2	physical	19615732
GET4_HUMAN	GET4	physical	19615732
NPL4_HUMAN	NPLOC4	physical	19615732
WDR20_HUMAN	WDR20	physical	19615732
PDE12_HUMAN	PDE12	physical	19615732
AMFR_HUMAN	AMFR	physical	21636303
TERA_HUMAN	VCP	physical	21636303
BAG6_HUMAN	BAG6	physical	21636303
A4_HUMAN	APP	physical	21832049
BAG6_HUMAN	BAG6	physical	23246001
HSP74_HUMAN	HSPA4	physical	23246001
GET4_HUMAN	GET4	physical	23246001
MOGS_HUMAN	MOGS	physical	23246001
FAF2_HUMAN	FAF2	physical	23246001
SRPRB_HUMAN	SRPRB	physical	23246001
CBPD_HUMAN	CPD	physical	23246001
FDFT_HUMAN	FDFT1	physical	23246001
PLOD2_HUMAN	PLOD2	physical	23246001
SC22B_HUMAN	SEC22B	physical	23246001
HACD3_HUMAN	PTPLAD1	physical	23246001
ATP5H_HUMAN	ATP5H	physical	23246001
XYLK_HUMAN	FAM20B	physical	23246001
LAMP1_HUMAN	LAMP1	physical	23246001
PGRC1_HUMAN	PGRMC1	physical	23246001
RAB10_HUMAN	RAB10	physical	23246001
RAB15_HUMAN	RAB15	physical	23246001
RAB1A_HUMAN	RAB1A	physical	23246001
RAB1B_HUMAN	RAB1B	physical	23246001
RAB35_HUMAN	RAB35	physical	23246001
RAB8A_HUMAN	RAB8A	physical	23246001
RAB8B_HUMAN	RAB8B	physical	23246001
RN126_HUMAN	RNF126	physical	23246001
SRPRA_HUMAN	SRPR	physical	23246001
SURF4_HUMAN	SURF4	physical	23246001
UBQL1_HUMAN	UBQLN1	physical	23246001
ILVBL_HUMAN	ILVBL	physical	23246001
BAP31_HUMAN	BCAP31	physical	23246001
CD320_HUMAN	CD320	physical	23246001
PRAF3_HUMAN	ARL6IP5	physical	23246001
F162A_HUMAN	FAM162A	physical	23246001
RER1_HUMAN	RER1	physical	23246001
RAB14_HUMAN	RAB14	physical	23246001
RB39A_HUMAN	RAB39A	physical	23246001
SSBP_HUMAN	SSBP1	physical	23246001
SGTA_HUMAN	SGTA	physical	23246001
STX7_HUMAN	STX7	physical	23246001
VAPB_HUMAN	VAPB	physical	23246001
DHC24_HUMAN	DHCR24	physical	23246001
AUP1_HUMAN	AUP1	physical	23246001
CDIPT_HUMAN	CDIPT	physical	23246001
HSPB1_HUMAN	HSPB1	physical	23246001
ILF2_HUMAN	ILF2	physical	23246001
M2OM_HUMAN	SLC25A11	physical	23246001
NDUA4_HUMAN	NDUFA4	physical	23246001
P4HA1_HUMAN	P4HA1	physical	23246001
PDIA1_HUMAN	P4HB	physical	23246001
RAB13_HUMAN	RAB13	physical	23246001
STX4_HUMAN	STX4	physical	23246001
STXB3_HUMAN	STXBP3	physical	23246001
TECR_HUMAN	TECR	physical	23246001
SSRD_HUMAN	SSR4	physical	23246001
TMED1_HUMAN	TMED1	physical	23246001
TMED9_HUMAN	TMED9	physical	23246001
UB2G2_HUMAN	UBE2G2	physical	23246001
ASNA_HUMAN	ASNA1	physical	23246001
IMA1_HUMAN	KPNA2	physical	23246001
IMB1_HUMAN	KPNB1	physical	23246001
ANM5_HUMAN	PRMT5	physical	23246001
HSP7C_HUMAN	HSPA8	physical	23246001
MEP50_HUMAN	WDR77	physical	23246001
HS71L_HUMAN	HSPA1L	physical	23246001
HSP76_HUMAN	HSPA6	physical	23246001
OGT1_HUMAN	OGT	physical	23246001
SPTN1_HUMAN	SPTAN1	physical	23246001
ACTB_HUMAN	ACTB	physical	23246001
ACTG_HUMAN	ACTG1	physical	23246001
GRP78_HUMAN	HSPA5	physical	23246001
HSP72_HUMAN	HSPA2	physical	23246001
SPTB2_HUMAN	SPTBN1	physical	23246001
ATPB_HUMAN	ATP5B	physical	23246001
GEMI4_HUMAN	GEMIN4	physical	23246001
ADT2_HUMAN	SLC25A5	physical	23246001
ATPA_HUMAN	ATP5A1	physical	23246001
ACTC_HUMAN	ACTC1	physical	23246001
ACTS_HUMAN	ACTA1	physical	23246001
ACTA_HUMAN	ACTA2	physical	23246001
ACTH_HUMAN	ACTG2	physical	23246001
CH60_HUMAN	HSPD1	physical	23246001
GRP75_HUMAN	HSPA9	physical	23246001
GEMI5_HUMAN	GEMIN5	physical	23246001
DDX20_HUMAN	DDX20	physical	23246001
TERA_HUMAN	VCP	physical	23246001
EF2_HUMAN	EEF2	physical	23246001
DBLOH_HUMAN	DIABLO	physical	23246001
DHB12_HUMAN	HSD17B12	physical	23246001
RS27A_HUMAN	RPS27A	physical	23246001
HNRPK_HUMAN	HNRNPK	physical	23246001
CISY_HUMAN	CS	physical	23246001
RPN1_HUMAN	RPN1	physical	23246001
TBA1B_HUMAN	TUBA1B	physical	23246001
TBA1C_HUMAN	TUBA1C	physical	23246001
RL40_HUMAN	UBA52	physical	23246001
HNRPU_HUMAN	HNRNPU	physical	23246001
RLA0_HUMAN	RPLP0	physical	23246001
TBB5_HUMAN	TUBB	physical	23246001
ADT1_HUMAN	SLC25A4	physical	23246001
TBA1A_HUMAN	TUBA1A	physical	23246001
RL4_HUMAN	RPL4	physical	23246001
HNRH1_HUMAN	HNRNPH1	physical	23246001
ADT3_HUMAN	SLC25A6	physical	23246001
EFTU_HUMAN	TUFM	physical	23246001
MPCP_HUMAN	SLC25A3	physical	23246001
RSSA_HUMAN	RPSA	physical	23246001
RL9_HUMAN	RPL9	physical	23246001
RS8_HUMAN	RPS8	physical	23246001
NUCL_HUMAN	NCL	physical	23246001
CLH1_HUMAN	CLTC	physical	23246001
HNRPC_HUMAN	HNRNPC	physical	23246001
CALX_HUMAN	CANX	physical	23246001
RL7_HUMAN	RPL7	physical	23246001
TBA3C_HUMAN	TUBA3C	physical	23246001
TBA3E_HUMAN	TUBA3E	physical	23246001
TBB4B_HUMAN	TUBB4B	physical	23246001
RS18_HUMAN	RPS18	physical	23246001
RL12_HUMAN	RPL12	physical	23246001
TBB4A_HUMAN	TUBB4A	physical	23246001
RS3A_HUMAN	RPS3A	physical	23246001
EF1A1_HUMAN	EEF1A1	physical	23246001
HNRPF_HUMAN	HNRNPF	physical	23246001
PRP31_HUMAN	PRPF31	physical	23246001
SPIN1_HUMAN	SPIN1	physical	23246001
CK084_HUMAN	C11orf84	physical	23246001
RIOK1_HUMAN	RIOK1	physical	23246001
RS3_HUMAN	RPS3	physical	23246001
RS4X_HUMAN	RPS4X	physical	23246001
RS2_HUMAN	RPS2	physical	23246001
RL13A_HUMAN	RPL13A	physical	23246001
RL7A_HUMAN	RPL7A	physical	23246001
RS12_HUMAN	RPS12	physical	23246001
RL10_HUMAN	RPL10	physical	23246001
RS10_HUMAN	RPS10	physical	23246001
RL28_HUMAN	RPL28	physical	23246001
RL24_HUMAN	RPL24	physical	23246001
HNRH2_HUMAN	HNRNPH2	physical	23246001
HNRPM_HUMAN	HNRNPM	physical	23246001
PHB2_HUMAN	PHB2	physical	23246001
CCAR1_HUMAN	CCAR1	physical	23246001
C1QBP_HUMAN	C1QBP	physical	23246001
HNRPQ_HUMAN	SYNCRIP	physical	23246001
ICLN_HUMAN	CLNS1A	physical	23246001
RL6_HUMAN	RPL6	physical	23246001
RACK1_HUMAN	GNB2L1	physical	23246001
RL18_HUMAN	RPL18	physical	23246001
RLA2_HUMAN	RPLP2	physical	23246001
RS7_HUMAN	RPS7	physical	23246001
RL13_HUMAN	RPL13	physical	23246001
SMN_HUMAN	SMN1	physical	23246001
HS90A_HUMAN	HSP90AA1	physical	23246001
RS6_HUMAN	RPS6	physical	23246001
ILF3_HUMAN	ILF3	physical	23246001
COR1C_HUMAN	CORO1C	physical	23246001
ROA2_HUMAN	HNRNPA2B1	physical	23246001
HNRPL_HUMAN	HNRNPL	physical	23246001
PHB_HUMAN	PHB	physical	23246001
RS9_HUMAN	RPS9	physical	23246001
RS5_HUMAN	RPS5	physical	23246001
RL15_HUMAN	RPL15	physical	23246001
RS16_HUMAN	RPS16	physical	23246001
RS15A_HUMAN	RPS15A	physical	23246001
RL14_HUMAN	RPL14	physical	23246001
RL21_HUMAN	RPL21	physical	23246001
RL31_HUMAN	RPL31	physical	23246001
RL10A_HUMAN	RPL10A	physical	23246001
HS90B_HUMAN	HSP90AB1	physical	23246001
RU17_HUMAN	SNRNP70	physical	23246001
PABP1_HUMAN	PABPC1	physical	23246001
SMD2_HUMAN	SNRPD2	physical	23246001
PABP4_HUMAN	PABPC4	physical	23246001
FUS_HUMAN	FUS	physical	23246001
HNRPR_HUMAN	HNRNPR	physical	23246001
RPN2_HUMAN	RPN2	physical	23246001
TMEDA_HUMAN	TMED10	physical	23246001
LMAN2_HUMAN	LMAN2	physical	23246001
TMED2_HUMAN	TMED2	physical	23246001
RL5_HUMAN	RPL5	physical	23246001
RL8_HUMAN	RPL8	physical	23246001
SMD3_HUMAN	SNRPD3	physical	23246001
RS19_HUMAN	RPS19	physical	23246001
RL18A_HUMAN	RPL18A	physical	23246001
RL23_HUMAN	RPL23	physical	23246001
RL19_HUMAN	RPL19	physical	23246001
RL30_HUMAN	RPL30	physical	23246001
RL26_HUMAN	RPL26	physical	23246001
RLA1_HUMAN	RPLP1	physical	23246001
RL23A_HUMAN	RPL23A	physical	23246001
RL36_HUMAN	RPL36	physical	23246001
RS21_HUMAN	RPS21	physical	23246001
RS24_HUMAN	RPS24	physical	23246001
RL27A_HUMAN	RPL27A	physical	23246001
RS14_HUMAN	RPS14	physical	23246001
RS27_HUMAN	RPS27	physical	23246001
RL38_HUMAN	RPL38	physical	23246001
RL29_HUMAN	RPL29	physical	23246001
THIO_HUMAN	TXN	physical	23246001
1433E_HUMAN	YWHAE	physical	23246001
PRDX1_HUMAN	PRDX1	physical	23246001
NPM_HUMAN	NPM1	physical	23246001
ERH_HUMAN	ERH	physical	23246001
PCBP1_HUMAN	PCBP1	physical	23246001
PCBP2_HUMAN	PCBP2	physical	23246001
QCR1_HUMAN	UQCRC1	physical	23246001
JAK1_HUMAN	JAK1	physical	23246001
RUXE_HUMAN	SNRPE	physical	23246001
ERLN2_HUMAN	ERLIN2	physical	23246001
LRC59_HUMAN	LRRC59	physical	23246001
PRDX4_HUMAN	PRDX4	physical	23246001
RT22_HUMAN	MRPS22	physical	23246001
ATPO_HUMAN	ATP5O	physical	23246001
FUBP2_HUMAN	KHSRP	physical	23246001
USMG5_HUMAN	USMG5	physical	23246001
ROAA_HUMAN	HNRNPAB	physical	23246001
RL3_HUMAN	RPL3	physical	23246001
RS11_HUMAN	RPS11	physical	23246001
RL11_HUMAN	RPL11	physical	23246001
RS26_HUMAN	RPS26	physical	23246001
RL32_HUMAN	RPL32	physical	23246001
RL37A_HUMAN	RPL37A	physical	23246001
RS20_HUMAN	RPS20	physical	23246001
RL36L_HUMAN	RPL36AL	physical	23246001
PA2G4_HUMAN	PA2G4	physical	23246001
RS17_HUMAN	RPS17	physical	23246001
RL22_HUMAN	RPL22	physical	23246001
RL27_HUMAN	RPL27	physical	23246001
TBB8_HUMAN	TUBB8	physical	23246001
RS25_HUMAN	RPS25	physical	23246001
RL34_HUMAN	RPL34	physical	23246001
LDHB_HUMAN	LDHB	physical	23246001
SGTA_HUMAN	SGTA	physical	23533635
TRAF4_HUMAN	TRAF4	physical	25416956
CDA7L_HUMAN	CDCA7L	physical	25416956
SGTA_HUMAN	SGTA	physical	25415308
UBP13_HUMAN	USP13	physical	24424410
BAG6_HUMAN	BAG6	physical	25535373
BAG6_HUMAN	BAG6	physical	26344197
TRAF4_HUMAN	TRAF4	physical	21516116
KS6B1_HUMAN	RPS6KB1	physical	28514442
BAG6_HUMAN	BAG6	physical	28514442
RN126_HUMAN	RNF126	physical	27193484

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBL4A_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey."; Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.; Mol. Cell 23:607-618(2006). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-48 AND LYS-54, AND MASSSPECTROMETRY.	16916647 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-126, AND MASSSPECTROMETRY.	17081983 [Abstract]