STXB3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STXB3_HUMAN
• UniProt AC: O00186
• Protein Name: Syntaxin-binding protein 3
• Gene Name: STXBP3
• Organism: Homo sapiens (Human).
• Sequence Length: 592
• Subcellular Localization: Cytoplasm, cytosol . Cell membrane . In platelets, predominantly cytosolic. Low amounts membrane-associated.
• Protein Description: Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes..
• Protein Sequence: MAPPVAERGLKSVVWQKIKATVFDDCKKEGEWKIMLLDEFTTKLLASCCKMTDLLEEGITVVENIYKNREPVRQMKALYFITPTSKSVDCFLHDFASKSENKYKAAYIYFTDFCPDNLFNKIKASCSKSIRRCKEINISFIPHESQVYTLDVPDAFYYCYSPDPGNAKGKDAIMETMADQIVTVCATLDENPGVRYKSKPLDNASKLAQLVEKKLEDYYKIDEKSLIKGKTHSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTYKYKTDGKEKEAILEEEDDLWVRIRHRHIAVVLEEIPKLMKEISSTKKATEGKTSLSALTQLMKKMPHFRKQITKQVVHLNLAEDCMNKFKLNIEKLCKTEQDLALGTDAEGQKVKDSMRVLLPVLLNKNHDNCDKIRAILLYIFSINGTTEENLDRLIQNVKIENESDMIRNWSYLGVPIVPQSQQGKPLRKDRSAEETFQLSRWTPFIKDIMEDAIDNRLDSKEWPYCSQCPAVWNGSGAVSARQKPRANYLEDRKNGSKLIVFVIGGITYSEVRCAYEVSQAHKSCEVIIGSTHVLTPKKLLDDIKMLNKPKDKVSLIKDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Methylation	MAPPVAERGLKSVVW CCCCHHHHCHHHHHH	46.11	115917997
11	Ubiquitination	PVAERGLKSVVWQKI CHHHHCHHHHHHHHH	43.99	29967540
11	Methylation	PVAERGLKSVVWQKI CHHHHCHHHHHHHHH	43.99	115980377
17	Ubiquitination	LKSVVWQKIKATVFD HHHHHHHHHHEEEEH	30.38	29967540
19	Ubiquitination	SVVWQKIKATVFDDC HHHHHHHHEEEEHHH	45.07	29967540
27	Ubiquitination	ATVFDDCKKEGEWKI EEEEHHHHHCCCEEE	61.94	27667366
76	Malonylation	REPVRQMKALYFITP CCCHHHCEEEEEECC	27.23	26320211
79	Phosphorylation	VRQMKALYFITPTSK HHHCEEEEEECCCCC	9.59	21406692
82	Phosphorylation	MKALYFITPTSKSVD CEEEEEECCCCCCHH	15.60	21406692
84	Phosphorylation	ALYFITPTSKSVDCF EEEEECCCCCCHHHH	39.89	21406692
85	Phosphorylation	LYFITPTSKSVDCFL EEEECCCCCCHHHHH	24.92	21406692
86	Ubiquitination	YFITPTSKSVDCFLH EEECCCCCCHHHHHH	57.91	21963094
98	Malonylation	FLHDFASKSENKYKA HHHHHHCCCCCCCEE	59.36	26320211
98	Ubiquitination	FLHDFASKSENKYKA HHHHHHCCCCCCCEE	59.36	32015554
103	Phosphorylation	ASKSENKYKAAYIYF HCCCCCCCEEEEEEE	19.90	-
104	Acetylation	SKSENKYKAAYIYFT CCCCCCCEEEEEEEE	28.31	7712229
128	Acetylation	KIKASCSKSIRRCKE HHHHHHHHHHHHCCC	54.98	25953088
170	Acetylation	DPGNAKGKDAIMETM CCCCCCCHHHHHHHH	43.19	19816639
197	Ubiquitination	ENPGVRYKSKPLDNA CCCCCCCCCCCCCCH	41.25	29967540
197	Acetylation	ENPGVRYKSKPLDNA CCCCCCCCCCCCCCH	41.25	19816647
198	Phosphorylation	NPGVRYKSKPLDNAS CCCCCCCCCCCCCHH	30.48	24719451
206	Ubiquitination	KPLDNASKLAQLVEK CCCCCHHHHHHHHHH	45.49	29967540
213	Ubiquitination	KLAQLVEKKLEDYYK HHHHHHHHHHHHHHC	56.00	29967540
214	Ubiquitination	LAQLVEKKLEDYYKI HHHHHHHHHHHHHCC	43.53	27667366
218	Phosphorylation	VEKKLEDYYKIDEKS HHHHHHHHHCCCHHH	9.40	22817900
219	Phosphorylation	EKKLEDYYKIDEKSL HHHHHHHHCCCHHHH	17.50	22817900
220	Ubiquitination	KKLEDYYKIDEKSLI HHHHHHHCCCHHHHC	37.14	22817900
224	Ubiquitination	DYYKIDEKSLIKGKT HHHCCCHHHHCCCCC	46.98	21906983
225	Phosphorylation	YYKIDEKSLIKGKTH HHCCCHHHHCCCCCC	33.02	24719451
228	Ubiquitination	IDEKSLIKGKTHSQL CCHHHHCCCCCCCEE	60.70	22817900
230	Ubiquitination	EKSLIKGKTHSQLLI HHHHCCCCCCCEEEE	37.75	30230243
309	Ubiquitination	EEIPKLMKEISSTKK HHHHHHHHHHHCCCC	63.43	29967540
312	Phosphorylation	PKLMKEISSTKKATE HHHHHHHHCCCCCCC	32.80	22817900
313	Phosphorylation	KLMKEISSTKKATEG HHHHHHHCCCCCCCC	50.32	22817900
314	Phosphorylation	LMKEISSTKKATEGK HHHHHHCCCCCCCCC	29.76	22817900
315	Ubiquitination	MKEISSTKKATEGKT HHHHHCCCCCCCCCC	42.21	23000965
316	Ubiquitination	KEISSTKKATEGKTS HHHHCCCCCCCCCCH	61.71	23000965
318	Phosphorylation	ISSTKKATEGKTSLS HHCCCCCCCCCCHHH	54.90	28450419
321	Ubiquitination	TKKATEGKTSLSALT CCCCCCCCCHHHHHH	28.80	23000965
322	Phosphorylation	KKATEGKTSLSALTQ CCCCCCCCHHHHHHH	45.84	25159151
323	Phosphorylation	KATEGKTSLSALTQL CCCCCCCHHHHHHHH	24.66	25159151
325	Phosphorylation	TEGKTSLSALTQLMK CCCCCHHHHHHHHHH	22.47	28450419
328	Phosphorylation	KTSLSALTQLMKKMP CCHHHHHHHHHHHCH	21.26	30108239
332	Malonylation	SALTQLMKKMPHFRK HHHHHHHHHCHHHHH	55.29	26320211
332	Ubiquitination	SALTQLMKKMPHFRK HHHHHHHHHCHHHHH	55.29	21890473
333	Ubiquitination	ALTQLMKKMPHFRKQ HHHHHHHHCHHHHHH	43.64	-
343	Ubiquitination	HFRKQITKQVVHLNL HHHHHHHHHHHHHHH	42.60	32015554
357	Ubiquitination	LAEDCMNKFKLNIEK HHHHHHHHHCCCHHH	19.59	29967540
357	Acetylation	LAEDCMNKFKLNIEK HHHHHHHHHCCCHHH	19.59	26051181
359	Ubiquitination	EDCMNKFKLNIEKLC HHHHHHHCCCHHHHH	42.08	23000965
364	Ubiquitination	KFKLNIEKLCKTEQD HHCCCHHHHHCCHHH	56.22	23000965
364	Malonylation	KFKLNIEKLCKTEQD HHCCCHHHHHCCHHH	56.22	26320211
367	Ubiquitination	LNIEKLCKTEQDLAL CCHHHHHCCHHHHCC	66.58	23000965
376	Phosphorylation	EQDLALGTDAEGQKV HHHHCCCCCCCCCCH	32.65	23401153
382	Ubiquitination	GTDAEGQKVKDSMRV CCCCCCCCHHHHHHH	63.21	21906983
384	Ubiquitination	DAEGQKVKDSMRVLL CCCCCCHHHHHHHHH	51.63	22817900
397	Ubiquitination	LLPVLLNKNHDNCDK HHHHHHCCCCCCHHH	56.48	32015554
404	Ubiquitination	KNHDNCDKIRAILLY CCCCCHHHHHHHHHH	35.97	-
431	Ubiquitination	DRLIQNVKIENESDM HHHHHHCCCCCHHHH	52.42	21963094
438	Sulfoxidation	KIENESDMIRNWSYL CCCCHHHHCCCCEEC	4.28	21406390
457	Ubiquitination	VPQSQQGKPLRKDRS CCHHHCCCCCCCCCC	36.22	21890473
464	Phosphorylation	KPLRKDRSAEETFQL CCCCCCCCHHHHHHH	50.60	26471730
468	Phosphorylation	KDRSAEETFQLSRWT CCCCHHHHHHHHCCC	14.26	28857561
479	Ubiquitination	SRWTPFIKDIMEDAI HCCCHHHHHHHHHHH	41.40	21963094
493	Ubiquitination	IDNRLDSKEWPYCSQ HHCCCCCCCCCCCCC	64.56	21963094
508	Phosphorylation	CPAVWNGSGAVSARQ CCCEECCCCCCCCCC	21.99	25159151
512	Phosphorylation	WNGSGAVSARQKPRA ECCCCCCCCCCCCCC	19.73	26434776
521	Phosphorylation	RQKPRANYLEDRKNG CCCCCCCCHHHCCCC	15.52	21945579
542	Phosphorylation	VIGGITYSEVRCAYE EECCCCHHHHHHHHH	22.44	-
556	Phosphorylation	EVSQAHKSCEVIIGS HHHHHHHCCEEEECC	12.97	-
570	Acetylation	STHVLTPKKLLDDIK CCCCCCHHHHHHHHH	51.31	25953088
571	Acetylation	THVLTPKKLLDDIKM CCCCCHHHHHHHHHH	56.33	7668015
571	Ubiquitination	THVLTPKKLLDDIKM CCCCCHHHHHHHHHH	56.33	-
577	Acetylation	KKLLDDIKMLNKPKD HHHHHHHHHHCCCHH	44.31	20167786
577	Ubiquitination	KKLLDDIKMLNKPKD HHHHHHHHHHCCCHH	44.31	29967540
581	Acetylation	DDIKMLNKPKDKVSL HHHHHHCCCHHHCCC	49.86	20167786
583	Acetylation	IKMLNKPKDKVSLIK HHHHCCCHHHCCCCC	72.32	20167786
585	Ubiquitination	MLNKPKDKVSLIKDE HHCCCHHHCCCCCCC	39.59	29967540
587	Phosphorylation	NKPKDKVSLIKDE-- CCCHHHCCCCCCC--	30.07	28355574
590	Ubiquitination	KDKVSLIKDE----- HHHCCCCCCC-----	62.18	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STXB3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STXB3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STXB3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STX4_HUMAN	STX4	physical	12773094
STX2_HUMAN	STX2	physical	12773094
SNP23_HUMAN	SNAP23	physical	12773094
STX4_HUMAN	STX4	physical	28514442
TBA3C_HUMAN	TUBA3C	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.