dbPTM

TBA3C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TBA3C_HUMAN
UniProt AC	Q13748
Protein Name	Tubulin alpha-3C/D chain
Gene Name	TUBA3C
Organism	Homo sapiens (Human).
Sequence Length	450
Subcellular Localization	Cytoplasm, cytoskeleton.
Protein Description	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain..
Protein Sequence	MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSVEAEAEEGEEY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MRECISIHVGQAG --CCCEEEEEECCHH	20.50	-
24	Phosphorylation	GNACWELYCLEHGIQ CHHHHHCHHHHCCCC	5.40	-
38	Phosphorylation	QPDGQMPSDKTIGGG CCCCCCCCCCCCCCC	46.53	-
40	Ubiquitination	DGQMPSDKTIGGGDD CCCCCCCCCCCCCCC	46.51	24906155
40	Acetylation	DGQMPSDKTIGGGDD CCCCCCCCCCCCCCC	46.51	24906155
40	Acetylation	DGQMPSDKTIGGGDD CCCCCCCCCCCCCCC	46.51	24906155
41	Phosphorylation	GQMPSDKTIGGGDDS CCCCCCCCCCCCCCC	29.82	-
48	Phosphorylation	TIGGGDDSFNTFFSE CCCCCCCCHHHCCCC	25.74	17924679
51	Phosphorylation	GGDDSFNTFFSETGA CCCCCHHHCCCCCCC	24.85	-
54	Phosphorylation	DSFNTFFSETGAGKH CCHHHCCCCCCCCCC	30.02	-
56	Phosphorylation	FNTFFSETGAGKHVP HHHCCCCCCCCCCCC	31.00	-
60	Sumoylation	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	-
60	Ubiquitination	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	-
60	Acetylation	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	-
60	Acetylation	FSETGAGKHVPRAVF CCCCCCCCCCCEEEE	40.68	19811027
60 (in isoform 1)	Ubiquitination	-	40.68	21890473
60 (in isoform 2)	Ubiquitination	-	40.68	21890473
79	Methylation	PTVVDEVRTGTYRQL CEEEECCCCCCCHHC	25.95	-
94	Phosphorylation	FHPEQLITGKEDAAN CCHHHHCCCCHHHHH	51.28	-
96	Sumoylation	PEQLITGKEDAANNY HHHHCCCCHHHHHHC	43.71	-
96	Ubiquitination	PEQLITGKEDAANNY HHHHCCCCHHHHHHC	43.71	-
96	Acetylation	PEQLITGKEDAANNY HHHHCCCCHHHHHHC	43.71	-
96	Acetylation	PEQLITGKEDAANNY HHHHCCCCHHHHHHC	43.71	30582473
96 (in isoform 1)	Ubiquitination	-	43.71	21890473
96 (in isoform 2)	Ubiquitination	-	43.71	21890473
103	Phosphorylation	KEDAANNYARGHYTI CHHHHHHCCCCCCCC	9.48	-
108	Phosphorylation	NNYARGHYTIGKEIV HHCCCCCCCCCHHHH	11.68	-
109	Phosphorylation	NYARGHYTIGKEIVD HCCCCCCCCCHHHHH	19.99	-
112	Acetylation	RGHYTIGKEIVDLVL CCCCCCCHHHHHHHH	40.18	25038526
156	Methylation	FASLLMERLSVDYGK HHHHHHHHHCCCCCC	20.49	-
156	Methylation	FASLLMERLSVDYGK HHHHHHHHHCCCCCC	20.49	24390935
158	Phosphorylation	SLLMERLSVDYGKKS HHHHHHHCCCCCCCC	21.11	-
161	Phosphorylation	MERLSVDYGKKSKLE HHHHCCCCCCCCCCE	28.79	-
163	Methylation	RLSVDYGKKSKLEFA HHCCCCCCCCCCEEE	47.87	-
163	Ubiquitination	RLSVDYGKKSKLEFA HHCCCCCCCCCCEEE	47.87	-
163	Acetylation	RLSVDYGKKSKLEFA HHCCCCCCCCCCEEE	47.87	-
163	Acetylation	RLSVDYGKKSKLEFA HHCCCCCCCCCCEEE	47.87	130867
163	Methylation	RLSVDYGKKSKLEFA HHCCCCCCCCCCEEE	47.87	130867
163	Ubiquitination	RLSVDYGKKSKLEFA HHCCCCCCCCCCEEE	47.87	21890473
163 (in isoform 1)	Ubiquitination	-	47.87	21890473
163 (in isoform 2)	Ubiquitination	-	47.87	21890473
164	Ubiquitination	LSVDYGKKSKLEFAI HCCCCCCCCCCEEEE	48.75	-
164	Ubiquitination	LSVDYGKKSKLEFAI HCCCCCCCCCCEEEE	48.75	20972266
164 (in isoform 1)	Ubiquitination	-	48.75	21890473
164 (in isoform 2)	Ubiquitination	-	48.75	21890473
165	Phosphorylation	SVDYGKKSKLEFAIY CCCCCCCCCCEEEEE	46.06	-
210	Phosphorylation	MVDNEAIYDICRRNL EECHHHHHHHHHCCC	13.30	-
223	Phosphorylation	NLDIERPTYTNLNRL CCCCCCCCCCCHHHH	49.55	-
224	Phosphorylation	LDIERPTYTNLNRLI CCCCCCCCCCHHHHH	9.05	-
225	Phosphorylation	DIERPTYTNLNRLIG CCCCCCCCCHHHHHH	35.39	-
253	Phosphorylation	GALNVDLTEFQTNLV CCCCCCCCEEECCCC	30.23	-
257	Phosphorylation	VDLTEFQTNLVPYPR CCCCEEECCCCCCCC	35.52	-
272	Phosphorylation	IHFPLATYAPVISAE CCCCCCCCCCCCCHH	11.87	-
277	Phosphorylation	ATYAPVISAEKAYHE CCCCCCCCHHHHHHH	30.52	-
280	Ubiquitination	APVISAEKAYHEQLS CCCCCHHHHHHHHCC	54.70	-
280	Acetylation	APVISAEKAYHEQLS CCCCCHHHHHHHHCC	54.70	88229
280	Ubiquitination	APVISAEKAYHEQLS CCCCCHHHHHHHHCC	54.70	21906983
280 (in isoform 1)	Ubiquitination	-	54.70	21890473
280 (in isoform 2)	Ubiquitination	-	54.70	21890473
282	Phosphorylation	VISAEKAYHEQLSVA CCCHHHHHHHHCCHH	19.56	17016520
282	Nitration	VISAEKAYHEQLSVA CCCHHHHHHHHCCHH	19.56	-
287	Phosphorylation	KAYHEQLSVAEITNA HHHHHHCCHHHHHHH	20.98	-
304	Ubiquitination	EPANQMVKCDPRHGK CCHHHCCCCCCCCCC	27.81	-
304	Ubiquitination	EPANQMVKCDPRHGK CCHHHCCCCCCCCCC	27.81	21890473
304 (in isoform 1)	Ubiquitination	-	27.81	21890473
304 (in isoform 2)	Ubiquitination	-	27.81	21890473
311	Acetylation	KCDPRHGKYMACCML CCCCCCCCEEEEHHH	26.23	25038526
326	Sumoylation	YRGDVVPKDVNAAIA CCCCCCCCCCCHHHH	63.80	-
326	Ubiquitination	YRGDVVPKDVNAAIA CCCCCCCCCCCHHHH	63.80	-
326	Acetylation	YRGDVVPKDVNAAIA CCCCCCCCCCCHHHH	63.80	-
326	Acetylation	YRGDVVPKDVNAAIA CCCCCCCCCCCHHHH	63.80	22632571
326 (in isoform 1)	Ubiquitination	-	63.80	21890473
326 (in isoform 2)	Ubiquitination	-	63.80	21890473
334	Phosphorylation	DVNAAIATIKTKRTI CCCHHHHHCCCCCEE	19.52	-
336	Sumoylation	NAAIATIKTKRTIQF CHHHHHCCCCCEEEE	43.57	-
336	Ubiquitination	NAAIATIKTKRTIQF CHHHHHCCCCCEEEE	43.57	-
336	Acetylation	NAAIATIKTKRTIQF CHHHHHCCCCCEEEE	43.57	-
336	Acetylation	NAAIATIKTKRTIQF CHHHHHCCCCCEEEE	43.57	23749302
336	Ubiquitination	NAAIATIKTKRTIQF CHHHHHCCCCCEEEE	43.57	20639865
336 (in isoform 1)	Ubiquitination	-	43.57	21890473
336 (in isoform 2)	Ubiquitination	-	43.57	21890473
337	Phosphorylation	AAIATIKTKRTIQFV HHHHHCCCCCEEEEE	23.16	-
338	Methylation	AIATIKTKRTIQFVD HHHHCCCCCEEEEEE	42.41	-
338	Ubiquitination	AIATIKTKRTIQFVD HHHHCCCCCEEEEEE	42.41	-
338	Methylation	AIATIKTKRTIQFVD HHHHCCCCCEEEEEE	42.41	184311
338	Ubiquitination	AIATIKTKRTIQFVD HHHHCCCCCEEEEEE	42.41	21890473
338 (in isoform 1)	Ubiquitination	-	42.41	21890473
338 (in isoform 2)	Ubiquitination	-	42.41	21890473
340	Phosphorylation	ATIKTKRTIQFVDWC HHCCCCCEEEEEEEC	22.23	-
347	S-palmitoylation	TIQFVDWCPTGFKVG EEEEEEECCCCEEEE	1.55	29575903
349	Phosphorylation	QFVDWCPTGFKVGIN EEEEECCCCEEEEEE	52.71	-
352	Sumoylation	DWCPTGFKVGINYQP EECCCCEEEEEECCC	40.68	-
352	Ubiquitination	DWCPTGFKVGINYQP EECCCCEEEEEECCC	40.68	-
352	Acetylation	DWCPTGFKVGINYQP EECCCCEEEEEECCC	40.68	130869
357	Phosphorylation	GFKVGINYQPPTVVP CEEEEEECCCCEECC	22.07	-
361	Phosphorylation	GINYQPPTVVPGGDL EEECCCCEECCCCCH	40.60	-
370	Sumoylation	VPGGDLAKVQRAVCM CCCCCHHHHHHHHHH	46.31	-
370	Ubiquitination	VPGGDLAKVQRAVCM CCCCCHHHHHHHHHH	46.31	-
370	Acetylation	VPGGDLAKVQRAVCM CCCCCHHHHHHHHHH	46.31	-
370	Acetylation	VPGGDLAKVQRAVCM CCCCCHHHHHHHHHH	46.31	184313
370 (in isoform 1)	Ubiquitination	-	46.31	21890473
370 (in isoform 2)	Ubiquitination	-	46.31	21890473
379	Phosphorylation	QRAVCMLSNTTAIAE HHHHHHHCCHHHHHH	12.78	-
394	Sumoylation	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	-
394	Ubiquitination	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	-
394	Acetylation	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	-
394	Acetylation	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	134085
394	Ubiquitination	AWARLDHKFDLMYAK HHHHCCCCCCHHHEE	39.99	21890473
394 (in isoform 1)	Ubiquitination	-	39.99	21890473
399	Phosphorylation	DHKFDLMYAKRAFVH CCCCCHHHEEEHHHH	19.10	-
401	Sumoylation	KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH	27.11	-
401	Ubiquitination	KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH	27.11	-
401	Acetylation	KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH	27.11	-
401	Acetylation	KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH	27.11	130865
401	Ubiquitination	KFDLMYAKRAFVHWY CCCHHHEEEHHHHHH	27.11	21890473
401 (in isoform 1)	Ubiquitination	-	27.11	21890473
419	Phosphorylation	GMEEGEFSEAREDLA CCCCCCHHHHHHHHH	26.50	-
439	Phosphorylation	YEEVGVDSVEAEAEE HHHHCCCCCCCHHHC	21.32	-
450	Nitration	EAEEGEEY------- HHHCCCCC-------	21.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TBA3C_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
40	K	Acetylation	24906155
Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen.
40	K	Methylation	24906155
Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TBA3C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NMI_HUMAN	NMI	physical	16189514
TCPG_HUMAN	CCT3	physical	26186194
TTC5_HUMAN	TTC5	physical	26186194
TXND9_HUMAN	TXNDC9	physical	26186194
T11L2_HUMAN	TCP11L2	physical	26186194
TBA1A_HUMAN	TUBA1A	physical	26186194
TBA1C_HUMAN	TUBA1C	physical	26186194
MFS4B_HUMAN	KIAA1919	physical	26186194
TBB4B_HUMAN	TUBB4B	physical	26344197
T11L2_HUMAN	TCP11L2	physical	28514442
TXND9_HUMAN	TXNDC9	physical	28514442
TTC5_HUMAN	TTC5	physical	28514442
TBA1A_HUMAN	TUBA1A	physical	28514442
MFS4B_HUMAN	KIAA1919	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442
TCPG_HUMAN	CCT3	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TBA3C_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48 AND THR-51, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48, AND MASSSPECTROMETRY.	17924679 [Abstract]

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