MFS4B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MFS4B_HUMAN
• UniProt AC: Q5TF39
• Protein Name: Sodium-dependent glucose transporter 1 {ECO:0000250|UniProtKB:Q80T22}
• Gene Name: MFSD4B {ECO:0000312|HGNC:HGNC:21053}
• Organism: Homo sapiens (Human).
• Sequence Length: 518
• Subcellular Localization: Apical cell membrane ; Multi-pass membrane protein.
• Protein Description: May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney..
• Protein Sequence: MLCASFLGLGLSVAIVGPTFQDLATNVNRNISSLSFIFVGRALGYLSGSVIGGFLVDVMNYFLLLGISMSATTVGLYLVPFCKTAILLTVMMSIFGVSIGILDTGGNVLILAIWGDKGAPHMQALHFSFALGAFLAPLLAKLALGPTASAENHTESDFHPALNQSSDADSEALFGVPNDKNLLWAYAVIGTYMFLVSVIFFCLFLKNSSKQEKARASAETFRRAKYHNALLCLLFLFFFFYVGAEVTYGSYVFSFATTHAGMKESEAAGLNSIFWGTFAACRGLAIFFATCLQPGTMIVLSNIGSLTSSLFLVLFDKNPICLWIATSVYGASMATTFPSGVSWIEQYTTIHGKSAAFFVIGASLGEMAIPAVIGILQGKYPDLPVVLYTSLGASIATGILFPVLYKLATSPLDRQRKEDRKSEDQKALLSSSGLNEYEEENEEEDAEKWNEMDFEMIETNDTMRHSIIETSRSSLTEPTAEVYNQYPSNALVFESSPFNTGSAHVKHLPETRTKGTNV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	N-linked_Glycosylation	LATNVNRNISSLSFI HHHHHCCCHHHHHHH		UniProtKB CARBOHYD
152	N-linked_Glycosylation	GPTASAENHTESDFH CCCCCCCCCCCCCCC		UniProtKB CARBOHYD
163	N-linked_Glycosylation	SDFHPALNQSSDADS CCCCHHHCCCCCCCH		UniProtKB CARBOHYD
265	Phosphorylation	THAGMKESEAAGLNS CCCCCHHHHHCCCHH		24719451
426	Ubiquitination	DRKSEDQKALLSSSG HCCCHHHHHHHHCCC		-
430	Phosphorylation	EDQKALLSSSGLNEY HHHHHHHHCCCCHHH		25627689
431	Phosphorylation	DQKALLSSSGLNEYE HHHHHHHCCCCHHHH		25627689
432	Phosphorylation	QKALLSSSGLNEYEE HHHHHHCCCCHHHHH		25627689
437	Phosphorylation	SSSGLNEYEEENEEE HCCCCHHHHHHCHHH		24173317
459	Phosphorylation	MDFEMIETNDTMRHS HCHHHHHCCCHHHHH		29083192
462	Phosphorylation	EMIETNDTMRHSIIE HHHHCCCHHHHHHHH		29083192
466	Phosphorylation	TNDTMRHSIIETSRS CCCHHHHHHHHHCCC		26657352
470	Phosphorylation	MRHSIIETSRSSLTE HHHHHHHHCCCCCCC		26434776
471	Phosphorylation	RHSIIETSRSSLTEP HHHHHHHCCCCCCCC		26434776
473	Phosphorylation	SIIETSRSSLTEPTA HHHHHCCCCCCCCCH		21712546
474	Phosphorylation	IIETSRSSLTEPTAE HHHHCCCCCCCCCHH		23898821
476	Phosphorylation	ETSRSSLTEPTAEVY HHCCCCCCCCCHHHH		23663014
479	Phosphorylation	RSSLTEPTAEVYNQY CCCCCCCCHHHHHHC		23663014
483	Phosphorylation	TEPTAEVYNQYPSNA CCCCHHHHHHCCCCC		23663014
486	Phosphorylation	TAEVYNQYPSNALVF CHHHHHHCCCCCEEE		23663014
488	Phosphorylation	EVYNQYPSNALVFES HHHHHCCCCCEEEEC		25850435
495	Phosphorylation	SNALVFESSPFNTGS CCCEEEECCCCCCCC		24905233
496	Phosphorylation	NALVFESSPFNTGSA CCEEEECCCCCCCCC		25159151
500	Phosphorylation	FESSPFNTGSAHVKH EECCCCCCCCCCCCC		27080861
502	Phosphorylation	SSPFNTGSAHVKHLP CCCCCCCCCCCCCCC		27080861

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MFS4B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MFS4B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MFS4B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DYHC2_HUMAN	DYNC2H1	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.