DYHC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DYHC2_HUMAN
• UniProt AC: Q8NCM8
• Protein Name: Cytoplasmic dynein 2 heavy chain 1
• Gene Name: DYNC2H1
• Organism: Homo sapiens (Human).
• Sequence Length: 4307
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium axoneme . Cell membrane ; Peripheral membrane protein . Cytoplasm . Localizes to the apical cytoplasm (By similarity). According to PubMed:8666668, it localizes to Golgi apparatus, cytoplasmic vesicle and endoplasmic r
• Protein Description: May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity)..
• Protein Sequence: MANGTADVRKLFIFTTTQNYFGLMSELWDQPLLCNCLEINNFLDDGNQMLLRVQRSDAGISFSNTIEFGDTKDKVLVFFKLRPEVITDENLHDNILVSSMLESPISSLYQAVRQVFAPMLLKDQEWSRNFDPKLQNLLSELEAGLGIVLRRSDTNLTKLKFKEDDTRGILTPSDEFQFWIEQAHRGNKQISKERANYFKELFETIAREFYNLDSLSLLEVVDLVETTQDVVDDVWRQTEHDHYPESRMLHLLDIIGGSFGRFVQKKLGTLNLWEDPYYLVKESLKAGISICEQWVIVCNHLTGQVWQRYVPHPWKNEKYFPETLDKLGKRLEEVLAIRTIHEKFLYFLPASEEKIICLTRVFEPFTGLNPVQYNPYTEPLWKAAVSQYEKIIAPAEQKIAGKLKNYISEIQDSPQQLLQAFLKYKELVKRPTISKELMLERETLLARLVDSIKDFRLDFENRCRGIPGDASGPLSGKNLSEVVNSIVWVRQLELKVDDTIKIAEALLSDLPGFRCFHQSAKDLLDQLKLYEQEQFDDWSRDIQSGLSDSRSGLCIEASSRIMELDSNDGLLKVHYSDRLVILLREVRQLSALGFVIPAKIQQVANIAQKFCKQAIILKQVAHFYNSIDQQMIQSQRPMMLQSALAFEQIIKNSKAGSGGKSQITWDNPKELEGYIQKLQNAAERLATENRKLRKWHTTFCEKVVVLMNIDLLRQQQRWKDGLQELRTGLATVEAQGFQASDMHAWKQHWNHQLYKALEHQYQMGLEALNENLPEINIDLTYKQGRLQFRPPFEEIRAKYYREMKRFIGIPNQFKGVGEAGDESIFSIMIDRNASGFLTIFSKAEDLFRRLSAVLHQHKEWIVIGQVDMEALVEKHLFTVHDWEKNFKALKIKGKEVERLPSAVKVDCLNINCNPVKTVIDDLIQKLFDLLVLSLKKSIQAHLHEIDTFVTEAMEVLTIMPQSVEEIGDANLQYSKLQERKPEILPLFQEAEDKNRLLRTVAGGGLETISNLKAKWDKFELMMESHQLMIKDQIEVMKGNVKSRLQIYYQELEKFKARWDQLKPGDDVIETGQHNTLDKSAKLIKEKKIEFDDLEVTRKKLVDDCHHFRLEEPNFSLASSISKDIESCAQIWAFYEEFQQGFQEMANEDWITFRTKTYLFEEFLMNWHDRLRKVEEHSVMTVKLQSEVDKYKIVIPILKYVRGEHLSPDHWLDLFRLLGLPRGTSLEKLLFGDLLRVADTIVAKAADLKDLNSRAQGEVTIREALRELDLWGVGAVFTLIDYEDSQSRTMKLIKDWKDIVNQVGDNRCLLQSLKDSPYYKGFEDKVSIWERKLAELDEYLQNLNHIQRKWVYLEPIFGRGALPKEQTRFNRVDEDFRSIMTDIKKDNRVTTLTTHAGIRNSLLTILDQLQRCQKSLNEFLEEKRSAFPRFYFIGDDDLLEILGQSTNPSVIQSHLKKLFAGINSVCFDEKSKHITAMKSLEGEVVPFKNKVPLSNNVETWLNDLALEMKKTLEQLLKECVTTGRSSQGAVDPSLFPSQILCLAEQIKFTEDVENAIKDHSLHQIETQLVNKLEQYTNIDTSSEDPGNTESGILELKLKALILDIIHNIDVVKQLNQIQVHTTEDWAWKKQLRFYMKSDHTCCVQMVDSEFQYTYEYQGNASKLVYTPLTDKCYLTLTQAMKMGLGGNPYGPAGTGKTESVKALGGLLGRQVLVFNCDEGIDVKSMGRIFVGLVKCGAWGCFDEFNRLEESVLSAVSMQIQTIQDALKNHRTVCELLGKEVEVNSNSGIFITMNPAGKGYGGRQKLPDNLKQLFRPVAMSHPDNELIAEVILYSEGFKDAKVLSRKLVAIFNLSRELLTPQQHYDWGLRALKTVLRGSGNLLRQLNKSGTTQNANESHIVVQALRLNTMSKFTFTDCTRFDALIKDVFPGIELKEVEYDELSAALKQVFEEANYEIIPNQIKKALELYEQLCQRMGVVIVGPSGAGKSTLWRMLRAALCKTGKVVKQYTMNPKAMPRYQLLGHIDMDTREWSDGVLTNSARQVVREPQDVSSWIICDGDIDPEWIESLNSVLDDNRLLTMPSGERIQFGPNVNFVFETHDLSCASPATISRMGMIFLSDEETDLNSLIKSWLRNQPAEYRNNLENWIGDYFEKALQWVLKQNDYVVETSLVGTVMNGLSHLHGCRDHDEFIINLIRGLGGNLNMKSRLEFTKEVFHWARESPPDFHKPMDTYYDSTRGRLATYVLKKPEDLTADDFSNGLTLPVIQTPDMQRGLDYFKPWLSSDTKQPFILVGPEGCGKGMLLRYAFSQLRSTQIATVHCSAQTTSRHLLQKLSQTCMVISTNTGRVYRPKDCERLVLYLKDINLPKLDKWGTSTLVAFLQQVLTYQGFYDENLEWVGLENIQIVASMSAGGRLGRHKLTTRFTSIVRLCSIDYPEREQLQTIYGAYLEPVLHKNLKNHSIWGSSSKIYLLAGSMVQVYEQVRAKFTVDDYSHYFFTPCILTQWVLGLFRYDLEGGSSNHPLDYVLEIVAYEARRLFRDKIVGAKELHLFDIILTSVFQGDWGSDILDNMSDSFYVTWGARHNSGARAAPGQPLPPHGKPLGKLNSTDLKDVIKKGLIHYGRDNQNLDILLFHEVLEYMSRIDRVLSFPGGSLLLAGRSGVGRRTITSLVSHMHGAVLFSPKISRGYELKQFKNDLKHVLQLAGIEAQQVVLLLEDYQFVHPTFLEMINSLLSSGEVPGLYTLEELEPLLLPLKDQASQDGFFGPVFNYFTYRIQQNLHIVLIMDSANSNFMINCESNPALHKKCQVLWMEGWSNSSMKKIPEMLFSETGGGEKYNDKKRKEEKKKNSVDPDFLKSFLLIHESCKAYGATPSRYMTFLHVYSAISSSKKKELLKRQSHLQAGVSKLNEAKALVDELNRKAGEQSVLLKTKQDEADAALQMITVSMQDASEQKTELERLKHRIAEEVVKIEERKNKIDDELKEVQPLVNEAKLAVGNIKPESLSEIRSLRMPPDVIRDILEGVLRLMGIFDTSWVSMKSFLAKRGVREDIATFDARNISKEIRESVEELLFKNKGSFDPKNAKRASTAAAPLAAWVKANIQYSHVLERIHPLETEQAGLESNLKKTEDRKRKLEELLNSVGQKVSELKEKFQSRTSEAAKLEAEVSKAQETIKAAEVLINQLDREHKRWNAQVVEITEELATLPKRAQLAAAFITYLSAAPESLRKTCLEEWTKSAGLEKFDLRRFLCTESEQLIWKSEGLPSDDLSIENALVILQSRVCPFLIDPSSQATEWLKTHLKDSRLEVINQQDSNFITALELAVRFGKTLIIQEMDGVEPVLYPLLRRDLVAQGPRYVVQIGDKIIDYNEEFRLFLSTRNPNPFIPPDAASIVTEVNFTTTRSGLRGQLLALTIQHEKPDLEEQKTKLLQQEEDKKIQLAKLEESLLETLATSQGNILENKDLIESLNQTKASSALIQESLKESYKLQISLDQERDAYLPLAESASKMYFIISDLSKINNMYRFSLAAFLRLFQRALQNKQDSENTEQRIQSLISSLQHMVYEYICRCLFKADQLMFALHFVRGMHPELFQENEWDTFTGVVVGDMLRKADSQQKIRDQLPSWIDQERSWAVATLKIALPSLYQTLCFEDAALWRTYYNNSMCEQEFPSILAKKVSLFQQILVVQALRPDRLQSAMALFACKTLGLKEVSPLPLNLKRLYKETLEIEPILIIISPGADPSQELQELANAERSGECYHQVAMGQGQADLAIQMLKECARNGDWLCLKNLHLVVSWLPVLEKELNTLQPKDTFRLWLTAEVHPNFTPILLQSSLKITYESPPGLKKNLMRTYESWTPEQISKKDNTHRAHALFSLAWFHAACQERRNYIPQGWTKFYEFSLSDLRAGYNIIDRLFDGAKDVQWEFVHGLLENAIYGGRIDNYFDLRVLQSYLKQFFNSSVIDVFNQRNKKSIFPYSVSLPQSCSILDYRAVIEKIPEDDKPSFFGLPANIARSSQRMISSQVISQLRILGRSITAGSKFDREIWSNELSPVLNLWKKLNQNSNLIHQKVPPPNDRQGSPILSFIILEQFNAIRLVQSVHQSLAALSKVIRGTTLLSSEVQKLASALLNQKCPLAWQSKWEGPEDPLQYLRGLVARALAIQNWVDKAEKQALLSETLDLSELFHPDTFLNALRQETARAVGRSVDSLKFVASWKGRLQEAKLQIKISGLLLEGCSFDGNQLSENQLDSPSVSSVLPCFMGWIPQDACGPYSPDECISLPVYTSAERDRVVTNIDVPCGGNQDQWIQCGAALFLKNQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Phosphorylation	MLLRVQRSDAGISFS EEEEEEECCCCCEEE	18.09	21406692
61	Phosphorylation	QRSDAGISFSNTIEF EECCCCCEEECEEEE	23.00	21406692
63	Phosphorylation	SDAGISFSNTIEFGD CCCCCEEECEEEECC	26.69	21406692
65	Phosphorylation	AGISFSNTIEFGDTK CCCEEECEEEECCCC	22.23	21406692
71	Phosphorylation	NTIEFGDTKDKVLVF CEEEECCCCCEEEEE	41.33	21406692
122	Ubiquitination	VFAPMLLKDQEWSRN HHHHHHCCCCHHHHC	54.10	-
152	Phosphorylation	LGIVLRRSDTNLTKL CCEEEECCCCCCCEE	42.21	-
154	Phosphorylation	IVLRRSDTNLTKLKF EEEECCCCCCCEEEC	33.12	28857561
157	Phosphorylation	RRSDTNLTKLKFKED ECCCCCCCEEECCCC	36.08	-
160	Ubiquitination	DTNLTKLKFKEDDTR CCCCCEEECCCCCCC	56.81	-
160 (in isoform 2)	Ubiquitination	-	56.81	-
166	Phosphorylation	LKFKEDDTRGILTPS EECCCCCCCCCCCCC	43.02	24702127
283	Phosphorylation	PYYLVKESLKAGISI HHHHHHHHHHHCCCH	29.47	-
289	Phosphorylation	ESLKAGISICEQWVI HHHHHCCCHHHHHHH	21.92	-
339	Phosphorylation	EEVLAIRTIHEKFLY HHHHHHHHHHHHHHH	22.14	25690035
346	Phosphorylation	TIHEKFLYFLPASEE HHHHHHHHHCCCCCC	13.25	24719451
351	Phosphorylation	FLYFLPASEEKIICL HHHHCCCCCCCEEEE	44.33	24719451
359	Phosphorylation	EEKIICLTRVFEPFT CCCEEEEEEECCCCC	22.00	24719451
390	Ubiquitination	AAVSQYEKIIAPAEQ HHHHHHHHHHCCHHH	34.18	29967540
398	Ubiquitination	IIAPAEQKIAGKLKN HHCCHHHHHHHHHHH	26.48	-
398 (in isoform 2)	Ubiquitination	-	26.48	-
424	Phosphorylation	LLQAFLKYKELVKRP HHHHHHHHHHHHCCC	16.31	24719451
432	Phosphorylation	KELVKRPTISKELML HHHHCCCCCCHHHHH	41.75	24719451
434	Phosphorylation	LVKRPTISKELMLER HHCCCCCCHHHHHCH	23.66	24719451
448	Ubiquitination	RETLLARLVDSIKDF HHHHHHHHHHHHHHH	4.11	23503661
453	Ubiquitination	ARLVDSIKDFRLDFE HHHHHHHHHHCCCCC	55.56	29967540
454	Ubiquitination	RLVDSIKDFRLDFEN HHHHHHHHHCCCCCC	32.03	23503661
463	Ubiquitination	RLDFENRCRGIPGDA CCCCCCCCCCCCCCC	7.62	23503661
544	Phosphorylation	DWSRDIQSGLSDSRS HHHHHHHHCCCCCCC	41.87	21406692
547	Phosphorylation	RDIQSGLSDSRSGLC HHHHHCCCCCCCCCC	36.75	21406692
549	Phosphorylation	IQSGLSDSRSGLCIE HHHCCCCCCCCCCCE	25.60	21406692
576	Phosphorylation	GLLKVHYSDRLVILL CCEEEEHHHHHHHHH	11.02	-
654	Ubiquitination	EQIIKNSKAGSGGKS HHHHHHCCCCCCCCC	67.18	23503661
660	Ubiquitination	SKAGSGGKSQITWDN CCCCCCCCCCCCCCC	42.59	23503661
660 (in isoform 2)	Ubiquitination	-	42.59	-
669	Ubiquitination	QITWDNPKELEGYIQ CCCCCCHHHHHHHHH	79.69	23503661
669 (in isoform 2)	Ubiquitination	-	79.69	-
674	Phosphorylation	NPKELEGYIQKLQNA CHHHHHHHHHHHHHH	7.27	23403867
677	Ubiquitination	ELEGYIQKLQNAAER HHHHHHHHHHHHHHH	42.34	29967540
727	Phosphorylation	DGLQELRTGLATVEA HHHHHHHHCCCCHHH	49.53	23312004
731	Phosphorylation	ELRTGLATVEAQGFQ HHHHCCCCHHHCCCC	24.75	23312004
740	Phosphorylation	EAQGFQASDMHAWKQ HHCCCCCCHHHHHHH	25.36	23312004
799	Phosphorylation	FEEIRAKYYREMKRF HHHHHHHHHHHHHHH	13.53	18083107
800	Phosphorylation	EEIRAKYYREMKRFI HHHHHHHHHHHHHHC	10.21	18083107
841	Phosphorylation	SGFLTIFSKAEDLFR CCCEEEHHHHHHHHH	27.40	24719451
933	Phosphorylation	LFDLLVLSLKKSIQA HHHHHHHHHHHHHHH	30.57	24719451
962	Phosphorylation	VLTIMPQSVEEIGDA HHHHCCCCHHHHCCC	26.14	22210691
973	Phosphorylation	IGDANLQYSKLQERK HCCCCCCHHHHHHCC	15.78	-
974	Phosphorylation	GDANLQYSKLQERKP CCCCCCHHHHHHCCC	17.58	22210691
980	Ubiquitination	YSKLQERKPEILPLF HHHHHHCCCCHHHHH	46.37	29967540
993	Ubiquitination	LFQEAEDKNRLLRTV HHHHHHHHCHHHHHH	35.16	29967540
1024	Phosphorylation	KFELMMESHQLMIKD HHHHHHHHHHHHHHH	9.91	-
1047	Phosphorylation	VKSRLQIYYQELEKF HHHHHHHHHHHHHHH	6.02	24043423
1048	Phosphorylation	KSRLQIYYQELEKFK HHHHHHHHHHHHHHH	9.35	24043423
1087	Ubiquitination	AKLIKEKKIEFDDLE HHHHHHCCCCCCCHH	48.86	29967540
1142	Ubiquitination	EEFQQGFQEMANEDW HHHHHHHHHHHCCCC	46.51	21890473
1177	Phosphorylation	LRKVEEHSVMTVKLQ HHHHHHCCCEEEEEC	19.50	19664994
1180	Phosphorylation	VEEHSVMTVKLQSEV HHHCCCEEEEECCHH	16.60	25954137
1185	Phosphorylation	VMTVKLQSEVDKYKI CEEEEECCHHHHCEE	50.45	25954137
1239	Phosphorylation	DLLRVADTIVAKAAD HHHHHHHHHHHHHCC	13.96	29514088
1281	Phosphorylation	AVFTLIDYEDSQSRT EEEEEEECCCCCCHH	18.03	18452278
1286	Phosphorylation	IDYEDSQSRTMKLIK EECCCCCCHHHHHHH	33.40	18452278
1296	Ubiquitination	MKLIKDWKDIVNQVG HHHHHHHHHHHHHHC	47.94	29967540
1306	Methylation	VNQVGDNRCLLQSLK HHHHCCCHHHHHHHC	19.73	-
1311	Phosphorylation	DNRCLLQSLKDSPYY CCHHHHHHHCCCCCC	37.04	16674116
1348	Ubiquitination	NLNHIQRKWVYLEPI HHHHHCHHCHHCCCC	25.33	21890473
1348 (in isoform 1)	Ubiquitination	-	25.33	21890473
1348 (in isoform 2)	Ubiquitination	-	25.33	21890473
1380	Phosphorylation	EDFRSIMTDIKKDNR HHHHHHHHHHCCCCC	32.66	21712546
1383	Acetylation	RSIMTDIKKDNRVTT HHHHHHHCCCCCCEE	57.81	20167786
1414	Phosphorylation	QLQRCQKSLNEFLEE HHHHHHHHHHHHHHH	15.56	27251275
1487	Ubiquitination	EGEVVPFKNKVPLSN CCCEECCCCCCCCCC	50.19	29967540
1489	Ubiquitination	EVVPFKNKVPLSNNV CEECCCCCCCCCCCH	45.91	22817900
1494	Ubiquitination	KNKVPLSNNVETWLN CCCCCCCCCHHHHHH	65.34	22817900
1527	Ubiquitination	TTGRSSQGAVDPSLF HHCCCCCCCCCHHHC	29.52	23503661
1595	Ubiquitination	ESGILELKLKALILD CCCHHHHHHHHHHHH	38.27	-
1636	Phosphorylation	QLRFYMKSDHTCCVQ HHHHHHCCCCEEEEE	20.35	-
1688	Phosphorylation	MGLGGNPYGPAGTGK CCCCCCCCCCCCCCC	39.48	29083192
1693	Phosphorylation	NPYGPAGTGKTESVK CCCCCCCCCCHHHHH	37.30	29083192
1695	Ubiquitination	YGPAGTGKTESVKAL CCCCCCCCHHHHHHH	49.29	22817900
1696	Phosphorylation	GPAGTGKTESVKALG CCCCCCCHHHHHHHH	34.53	29083192
1700	Ubiquitination	TGKTESVKALGGLLG CCCHHHHHHHHHHCC	47.36	22817900
1733	Ubiquitination	RIFVGLVKCGAWGCF HHHHHHHHCCCCCCH	31.80	23503661
1733 (in isoform 2)	Ubiquitination	-	31.80	-
1792	Ubiquitination	SGIFITMNPAGKGYG CCEEEEECCCCCCCC	18.02	23503661
1795	Ubiquitination	FITMNPAGKGYGGRQ EEEECCCCCCCCCCC	25.77	23503661
1798	Ubiquitination	MNPAGKGYGGRQKLP ECCCCCCCCCCCCCC	21.64	23503661
1803	Ubiquitination	KGYGGRQKLPDNLKQ CCCCCCCCCCCHHHH	61.70	29967540
1871	Phosphorylation	WGLRALKTVLRGSGN HHHHHHHHHHHCCCH	26.14	24719451
1886	Phosphorylation	LLRQLNKSGTTQNAN HHHHHCCCCCCCCCC	40.06	26074081
1888	Phosphorylation	RQLNKSGTTQNANES HHHCCCCCCCCCCHH	32.09	26074081
1889	Phosphorylation	QLNKSGTTQNANESH HHCCCCCCCCCCHHH	24.29	26074081
1911	Phosphorylation	LNTMSKFTFTDCTRF CCCCCCCCCCCCHHH	29.39	18452278
1916	Phosphorylation	KFTFTDCTRFDALIK CCCCCCCHHHHHHHC	36.86	18452278
1923	Ubiquitination	TRFDALIKDVFPGIE HHHHHHHCHHCCCCE	49.00	-
1932	Ubiquitination	VFPGIELKEVEYDEL HCCCCEEEEECHHHH	47.10	-
1936	Phosphorylation	IELKEVEYDELSAAL CEEEEECHHHHHHHH	21.64	-
1960	Ubiquitination	EIIPNQIKKALELYE CCCCHHHHHHHHHHH	23.41	-
1981	Phosphorylation	GVVIVGPSGAGKSTL CCEEECCCCCCHHHH	35.03	21857030
1985	Ubiquitination	VGPSGAGKSTLWRML ECCCCCCHHHHHHHH	39.47	-
1998	Ubiquitination	MLRAALCKTGKVVKQ HHHHHHHHHCCCEEE	62.25	23503661
2001	Ubiquitination	AALCKTGKVVKQYTM HHHHHHCCCEEEEEC	49.43	23503661
2004	Ubiquitination	CKTGKVVKQYTMNPK HHHCCCEEEEECCCC	40.34	23503661
2004 (in isoform 2)	Ubiquitination	-	40.34	-
2124	Phosphorylation	DEETDLNSLIKSWLR CCCCCHHHHHHHHHH	38.48	24719451
2203	Ubiquitination	LGGNLNMKSRLEFTK CCCCCCHHHHHHHHH	31.20	-
2204	Phosphorylation	GGNLNMKSRLEFTKE CCCCCHHHHHHHHHH	31.18	30266825
2230	Phosphorylation	FHKPMDTYYDSTRGR CCCCCCCCCCCCCCC	10.87	-
2231	Phosphorylation	HKPMDTYYDSTRGRL CCCCCCCCCCCCCCE	12.90	-
2241	Phosphorylation	TRGRLATYVLKKPED CCCCEEEEEECCCCC	9.74	-
2276	Ubiquitination	QRGLDYFKPWLSSDT HCCCCCCCCCCCCCC	29.11	-
2306	Phosphorylation	MLLRYAFSQLRSTQI HHHHHHHHHHCCCEE	21.82	24719451
2346	Phosphorylation	STNTGRVYRPKDCER ECCCCCCCCCCCCCE	21.60	-
2359	Ubiquitination	ERLVLYLKDINLPKL CEEEEEHHHCCCCCC	42.90	-
2452	Ubiquitination	YLEPVLHKNLKNHSI HHHHHHCCCCCCCCC	60.87	-
2458	Phosphorylation	HKNLKNHSIWGSSSK CCCCCCCCCCCCCCE	29.45	26657352
2464	Phosphorylation	HSIWGSSSKIYLLAG CCCCCCCCEEEEECC	25.44	26657352
2509	Phosphorylation	WVLGLFRYDLEGGSS HHHHHHCCCCCCCCC	19.97	-
2522	Phosphorylation	SSNHPLDYVLEIVAY CCCCCHHHHHHHHHH	18.02	-
2608	Ubiquitination	KLNSTDLKDVIKKGL CCCCCCHHHHHHHCC	53.40	29967540
2678	Phosphorylation	MHGAVLFSPKISRGY CCCCCCCCCCCCCCC	22.56	24719451
2682	Phosphorylation	VLFSPKISRGYELKQ CCCCCCCCCCCCHHH	26.27	23403867
2685	Phosphorylation	SPKISRGYELKQFKN CCCCCCCCCHHHHHH	19.58	23403867
2688	Ubiquitination	ISRGYELKQFKNDLK CCCCCCHHHHHHHHH	41.57	29967540
2818	Ubiquitination	WSNSSMKKIPEMLFS CCCCHHHHHHHHHHC	55.65	-
2818 (in isoform 1)	Ubiquitination	-	55.65	21890473
2818 (in isoform 2)	Ubiquitination	-	55.65	21890473
2825	Phosphorylation	KIPEMLFSETGGGEK HHHHHHHCCCCCCCC	30.22	25627689
2832	Ubiquitination	SETGGGEKYNDKKRK CCCCCCCCCCHHHHH	53.26	-
2832 (in isoform 1)	Ubiquitination	-	53.26	21890473
2832 (in isoform 2)	Ubiquitination	-	53.26	21890473
2836	Ubiquitination	GGEKYNDKKRKEEKK CCCCCCHHHHHHHHH	51.33	-
2836 (in isoform 1)	Ubiquitination	-	51.33	21890473
2836 (in isoform 2)	Ubiquitination	-	51.33	21890473
2917	Ubiquitination	LVDELNRKAGEQSVL HHHHHHHHHCCCCEE	60.72	29967540
2966	Methylation	RIAEEVVKIEERKNK HHHHHHHHHHHHHCC	49.96	-
2996	Ubiquitination	KLAVGNIKPESLSEI HHHHCCCCHHHHHHH	46.89	-
2996 (in isoform 1)	Ubiquitination	-	46.89	21890473
2996 (in isoform 2)	Ubiquitination	-	46.89	21890473
2999	Phosphorylation	VGNIKPESLSEIRSL HCCCCHHHHHHHHHC	45.80	23403867
3001	Phosphorylation	NIKPESLSEIRSLRM CCCHHHHHHHHHCCC	40.01	24719451
3005	Phosphorylation	ESLSEIRSLRMPPDV HHHHHHHHCCCCHHH	26.45	29496963
3036	Phosphorylation	TSWVSMKSFLAKRGV CCCHHHHHHHHHCCC	19.49	24719451
3212	Phosphorylation	QLAAAFITYLSAAPE HHHHHHHHHHHCCCH	16.38	23403867
3213	Phosphorylation	LAAAFITYLSAAPES HHHHHHHHHHCCCHH	8.21	23403867
3223	Ubiquitination	AAPESLRKTCLEEWT CCCHHHHHHHHHHHH	49.21	-
3223 (in isoform 2)	Ubiquitination	-	49.21	-
3231	Ubiquitination	TCLEEWTKSAGLEKF HHHHHHHHHCCCCCC	39.11	29967540
3237	Ubiquitination	TKSAGLEKFDLRRFL HHHCCCCCCCHHHHH	49.58	29967540
3246	Phosphorylation	DLRRFLCTESEQLIW CHHHHHCCCCHHHHH	44.70	-
3255	Phosphorylation	SEQLIWKSEGLPSDD CHHHHHHCCCCCCCC	23.15	-
3264	Phosphorylation	GLPSDDLSIENALVI CCCCCCCCHHHHHHH	34.55	24719451
3284	Phosphorylation	CPFLIDPSSQATEWL CCEECCCCHHHHHHH	31.19	21406692
3285	Phosphorylation	PFLIDPSSQATEWLK CEECCCCHHHHHHHH	29.26	21406692
3288	Phosphorylation	IDPSSQATEWLKTHL CCCCHHHHHHHHHHH	21.76	21406692
3308	Phosphorylation	EVINQQDSNFITALE EECCCCCCCHHHHHH	29.33	22210691
3342	Dimethylation	VLYPLLRRDLVAQGP CHHHHHCCHHHHCCC	41.40	-
3429	Ubiquitination	LLQQEEDKKIQLAKL HHHHHHHHHHHHHHH	55.87	30230243
3436	Ubiquitination	KKIQLAKLEESLLET HHHHHHHHHHHHHHH	8.00	30230243
3436 (in isoform 2)	Ubiquitination	-	8.00	-
3437 (in isoform 2)	Ubiquitination	-	44.85	-
3465	Ubiquitination	IESLNQTKASSALIQ HHHHHHHHHHHHHHH	36.19	29967540
3472	Ubiquitination	KASSALIQESLKESY HHHHHHHHHHHHHHH	34.77	29967540
3476	Ubiquitination	ALIQESLKESYKLQI HHHHHHHHHHHCEEE	54.62	-
3534	Ubiquitination	FQRALQNKQDSENTE HHHHHHCCCCCCCHH	42.39	-
3650	Phosphorylation	EDAALWRTYYNNSMC HHHHHHHHHCCCCCC	20.83	-
3711	Ubiquitination	SPLPLNLKRLYKETL CCCCCCHHHHHHHHC	39.00	29967540
3718	Ubiquitination	KRLYKETLEIEPILI HHHHHHHCCCCCEEE	7.00	29967540
3746	Phosphorylation	ELANAERSGECYHQV HHHHHHHCCCHHHHH	30.37	26074081
3750	Phosphorylation	AERSGECYHQVAMGQ HHHCCCHHHHHHCCC	7.32	26074081
3846	Phosphorylation	NLMRTYESWTPEQIS HHHHHHHCCCHHHHC	26.32	30631047
3854	Ubiquitination	WTPEQISKKDNTHRA CCHHHHCCCCCCCHH	66.82	-
3889	Phosphorylation	PQGWTKFYEFSLSDL CCCHHEEEEEEHHHH	20.02	26434776
3892	Phosphorylation	WTKFYEFSLSDLRAG HHEEEEEEHHHHHCC	18.28	26434776
3894	Phosphorylation	KFYEFSLSDLRAGYN EEEEEEHHHHHCCCC	33.14	24719451
3900	Phosphorylation	LSDLRAGYNIIDRLF HHHHHCCCCHHHHHH	11.38	-
4011	Phosphorylation	RSSQRMISSQVISQL HHHHHHHHHHHHHHH	12.84	23607784
4012	Phosphorylation	SSQRMISSQVISQLR HHHHHHHHHHHHHHH	19.97	23607784
4016	Phosphorylation	MISSQVISQLRILGR HHHHHHHHHHHHHCC	25.06	23607784
4024	Phosphorylation	QLRILGRSITAGSKF HHHHHCCCCCCCCCC	23.61	23607784
4026	Phosphorylation	RILGRSITAGSKFDR HHHCCCCCCCCCCCH	26.64	23607784
4029	Phosphorylation	GRSITAGSKFDREIW CCCCCCCCCCCHHHH	27.90	23607784
4030	Ubiquitination	RSITAGSKFDREIWS CCCCCCCCCCHHHHC	50.82	-
4187	Phosphorylation	LNALRQETARAVGRS HHHHHHHHHHHHCCC	17.07	23403867
4203	Phosphorylation	DSLKFVASWKGRLQE HHHHHHHHCCCHHHH	24.82	24719451
4205	Ubiquitination	LKFVASWKGRLQEAK HHHHHHCCCHHHHHH	31.49	29967540
4212	Ubiquitination	KGRLQEAKLQIKISG CCHHHHHHHHHEEEE	39.92	29967540
4219	Ubiquitination	KLQIKISGLLLEGCS HHHHEEEEEEEECCC	24.66	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DYHC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DYHC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DYHC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DC2L1_HUMAN	DYNC2LI1	physical	11907264
DC2L1_HUMAN	DYNC2LI1	physical	12432068

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.