DC2L1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DC2L1_HUMAN
• UniProt AC: Q8TCX1
• Protein Name: Cytoplasmic dynein 2 light intermediate chain 1
• Gene Name: DYNC2LI1
• Organism: Homo sapiens (Human).
• Sequence Length: 351
• Subcellular Localization: Cytoplasm . Cell projection, cilium . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, cilium axoneme . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localizes to the apical cytoplasm.
• Protein Description: Required for correct intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Involved in the regulation of ciliary length..
• Protein Sequence: MPSETLWEIAKAEVEKRGINGSEGDGAEIAEKFVFFIGSKNGGKTTIILRCLDRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPDHELIDPFPVPLVIIGSKYDVFQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLAFGIDKSKSICVDQNKPLFITAGLDSFGQIGSPPVPENDIGKLHAHSPMELWKKVYEKLFPPKSINTLKDIKDPARDPQYAENEVDEMRIQKDLELEQYKRSSSKSWKQIELDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11 (in isoform 2)	Ubiquitination	-	51.22	-
11	Ubiquitination	ETLWEIAKAEVEKRG HHHHHHHHHHHHHCC	51.22	29967540
39	Phosphorylation	KFVFFIGSKNGGKTT HEEEEEECCCCCEEE	20.38	28348404
61	Phosphorylation	RDEPPKPTLALEYTY CCCCCCCEEEEEEEE	30.68	24260401
66	Phosphorylation	KPTLALEYTYGRRAK CCEEEEEEEECCCCC	13.20	24260401
67	Phosphorylation	PTLALEYTYGRRAKG CEEEEEEEECCCCCC	15.32	24260401
134	Phosphorylation	MENLLQATKSHVDKV HHHHHHHHHHHHHHH	21.81	26029660
151	Ubiquitination	KLGKTNAKAVSEMRQ HHCCCCHHHHHHHHH	51.93	-
151 (in isoform 2)	Ubiquitination	-	51.93	-
154	Phosphorylation	KTNAKAVSEMRQKIW CCCHHHHHHHHHHHH	30.45	21712546
198	Ubiquitination	FQDFESEKRKVICKT CCCCCHHHHHHHHHH	67.79	29967540
199	Ubiquitination	QDFESEKRKVICKTL CCCCHHHHHHHHHHH	34.13	29967540
220	Phosphorylation	YGASLMFTSKSEALL HCCEEEEECHHHHHH	22.68	-
221	Phosphorylation	GASLMFTSKSEALLL CCEEEEECHHHHHHH	23.95	-
329	Ubiquitination	VDEMRIQKDLELEQY HHHHHHHHHHHHHHH	63.01	29967540
329 (in isoform 1)	Ubiquitination	-	63.01	21890473
330	Ubiquitination	DEMRIQKDLELEQYK HHHHHHHHHHHHHHH	29.06	21890473
330 (in isoform 2)	Ubiquitination	-	29.06	21890473
337	Ubiquitination	DLELEQYKRSSSKSW HHHHHHHHHHCCCCC	45.56	29967540
338	Ubiquitination	LELEQYKRSSSKSWK HHHHHHHHHCCCCCE	36.52	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DC2L1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DC2L1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DC2L1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DYHC2_HUMAN	DYNC2H1	physical	11907264
DYHC2_HUMAN	DYNC2H1	physical	28514442
PCYOX_HUMAN	PCYOX1	physical	28514442
TTC3_HUMAN	TTC3	physical	28514442
TTC19_HUMAN	TTC19	physical	28514442
LAMP2_HUMAN	LAMP2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.