dbPTM

TTC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TTC3_HUMAN
UniProt AC	P53804
Protein Name	E3 ubiquitin-protein ligase TTC3
Gene Name	TTC3
Organism	Homo sapiens (Human).
Sequence Length	2025
Subcellular Localization	Nucleus .
Protein Description	E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT..
Protein Sequence	MDNFAEGDFTVADYALLEDCPHVDDCVFAAEFMSNDYVRVTQLYCDGVGVQYKDYIQSERNLEFDICSIWCSKPISVLQDYCDAIKINIFWPLLFQHQNSSVISRLHPCVDANNSRASEINLKKLQHLELMEDIVDLAKKVANDSFLIGGLLRIGCKIENKILAMEEALNWIKYAGDVTILTKLGSIDNCWPMLSIFFTEYKYHITKIVMEDCNLLEELKTQSCMDCIEEGELMKMKGNEEFSKERFDIAIIYYTRAIEYRPENYLLYGNRALCFLRTGQFRNALGDGKRATILKNTWPKGHYRYCDALSMLGEYDWALQANIKAQKLCKNDPEGIKDLIQQHVKLQKQIEDLQGRTANKDPIKAFYENRAYTPRSLSAPIFTTSLNFVEKERDFRKINHEMANGGNQNLKVADEALKVDDCDCHPEFSPPSSQPPKHKGKQKSRNNESEKFSSSSPLTLPADLKNILEKQFSKSSRAAHQDFANIMKMLRSLIQDGYMALLEQRCRSAAQAFTELLNGLDPQKIKQLNLAMINYVLVVYGLAISLLGIGQPEELSEAENQFKRIIEHYPSEGLDCLAYCGIGKVYLKKNRFLEALNHFEKARTLIYRLPGVLTWPTSNVIIEESQPQKIKMLLEKFVEECKFPPVPDAICCYQKCHGYSKIQIYITDPDFKGFIRISCCQYCKIEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPDCEGVISKIIIFSSGGEVKCEFEHKVIKEKVPPRPILKQKCSSLEKLRLKEDKKLKRKIQKKEAKKLAQERMEEDLRESNPPKNEEQKETVDNVQRCQFLDDRILQCIKQYADKIKSGIQNTAMLLKELLSWKVLSTEDYTTCFSSRNFLNEAVDYVIRHLIQENNRVKTRIFLHVLSELKEVEPKLAAWIQKLNSFGLDATGTFFSRYGASLKLLDFSIMTFLWNEKYGHKLDSIEGKQLDYFSEPASLKEARCLIWLLEEHRDKFPALHSALDEFFDIMDSRCTVLRKQDSGEAPFSSTKVKNKSKKKKPKDSKPMLVGSGTTSVTSNNEIITSSEDHSNRNSDSAGPFAVPDHLRQDVEEFEALYDQHSNEYVVRNKKLWDMNPKQKCSTLYDYFSQFLEEHGPLDMSNKMFSAEYEFFPEETRQILEKAGGLKPFLLGCPRFVVIDNCIALKKVASRLKKKRKKKNIKTKVEEISKAGEYVRVKLQLNPAAREFKPDVKSKPVSDSSSAPAFENVKPKPVSANSPKPACEDVKAKPVSDNSSRQVSEDGQPKGVSSNSPKPGSEDANYKRVSCNSPKPVLEDVKPTYWAQSHLVTGYCTYLPFQRFDITQTPPAYINVLPGLPQYTSIYTPLASLSPEYQLPRSVPVVPSFVANDRADKNAAAYFEGHHLNAENVAGHQIASETQILEGSLGISVKSHCSTGDAHTVLSESNRNDEHCGNSNNKCEVIPESTSAVTNIPHVQMVAIQVSWNIIHQEVNTEPYNPFEERQGEISRIEKEHQVLQDQLQEVYENYEQIKLKGLEETRDLEEKLKRHLEENKISKTELDWFLQDLEREIKKWQQEKKEIQERLKSLKKKIKKVSNASEMYTQKNDGKEKEHELHLDQSLEISNTLTNEKMKIEEYIKKGKEDYEESHQRAVAAEVSVLENWKESEVYKLQIMESQAEAFLKKLGLISRDPAAYPDMESDIRSWELFLSNVTKEIEKAKSQFEEQIKAIKNGSRLSELSKVQISELSFPACNTVHPELLPESSGDDGQGLVTSASDVTGNHAALHRDPSVFSAGDSPGEAPSALLPGPPPGQPEATQLTGPKRAGQAALSERSPVADRKQPVPPGRAARSSQSPKKPFNSIIEHLSVVFPCYNSTELAGFIKKVRSKNKNSLSGLSIDEIVQRVTEHILDEQKKKKPNPGKDKRTYEPSSATPVTRSSQGSPSVVVAPSPKTKGQKAEDVPVRIALGASSCEICHEVFKSKNVRVLKCGHKYHKGCFKQWLKGQSACPACQGRDLLTEESPSGRGWPSQNQELPSCSSR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Ubiquitination	CPHVDDCVFAAEFMS CCCCCHHHHHHHHHC	4.74	29967540
35	Ubiquitination	FAAEFMSNDYVRVTQ HHHHHHCCCCEEEEE	32.61	29967540
38	Ubiquitination	EFMSNDYVRVTQLYC HHHCCCCEEEEEEEE	4.41	29967540
53	Ubiquitination	DGVGVQYKDYIQSER CCCCCCHHHHHHCCC	27.28	-
123	Ubiquitination	RASEINLKKLQHLEL CHHHCCHHHHHHHHH	47.12	-
124	Ubiquitination	ASEINLKKLQHLELM HHHCCHHHHHHHHHH	57.45	29967540
140	Ubiquitination	DIVDLAKKVANDSFL HHHHHHHHHCCCCCH	40.76	-
141	Ubiquitination	IVDLAKKVANDSFLI HHHHHHHHCCCCCHH	6.24	29967540
146	Ubiquitination	KKVANDSFLIGGLLR HHHCCCCCHHHHHHH	6.85	29967540
155	Ubiquitination	IGGLLRIGCKIENKI HHHHHHCCCEEHHHH	10.55	22817900
160	Ubiquitination	RIGCKIENKILAMEE HCCCEEHHHHHHHHH	39.89	21890473
160 (in isoform 3)	Ubiquitination	-	39.89	21890473
164	Ubiquitination	KIENKILAMEEALNW EEHHHHHHHHHHHHH	13.55	22817900
204	Ubiquitination	FFTEYKYHITKIVME HHHHCHHHHHHHHHH	19.65	22817900
209	Ubiquitination	KYHITKIVMEDCNLL HHHHHHHHHHCCCHH	3.51	21890473
213	Ubiquitination	TKIVMEDCNLLEELK HHHHHHCCCHHHHHH	2.17	22817900
221	Phosphorylation	NLLEELKTQSCMDCI CHHHHHHHCCHHHHH	38.04	-
223	Phosphorylation	LEELKTQSCMDCIEE HHHHHHCCHHHHHHH	19.35	-
232	Ubiquitination	MDCIEEGELMKMKGN HHHHHHCCHHHCCCC	49.31	22817900
237	Ubiquitination	EGELMKMKGNEEFSK HCCHHHCCCCHHHHH	53.73	21890473
237 (in isoform 2)	Ubiquitination	-	53.73	21890473
241	Ubiquitination	MKMKGNEEFSKERFD HHCCCCHHHHHHHHE	60.25	22817900
244	Ubiquitination	KGNEEFSKERFDIAI CCCHHHHHHHHEEEE	59.22	-
268	Phosphorylation	RPENYLLYGNRALCF CCCCEEEECCEEEEE	15.12	25884760
295	Ubiquitination	GKRATILKNTWPKGH CCCEEECCCCCCCCC	48.78	29967540
310	Phosphorylation	YRYCDALSMLGEYDW HHCCCHHHHHCCCCH	17.43	-
317	Ubiquitination	SMLGEYDWALQANIK HHHCCCCHHHHHHHH	9.66	29967540
337	Ubiquitination	KNDPEGIKDLIQQHV CCCHHHHHHHHHHHH	58.29	29967540
345	Ubiquitination	DLIQQHVKLQKQIED HHHHHHHHHHHHHHH	42.97	29967540
348	Ubiquitination	QQHVKLQKQIEDLQG HHHHHHHHHHHHHCC	64.77	29967540
359	Ubiquitination	DLQGRTANKDPIKAF HHCCCCCCCCHHHHH	48.96	29967540
360	Ubiquitination	LQGRTANKDPIKAFY HCCCCCCCCHHHHHH	63.52	-
367	Ubiquitination	KDPIKAFYENRAYTP CCHHHHHHHCCCCCC	19.70	29967540
370	Ubiquitination	IKAFYENRAYTPRSL HHHHHHCCCCCCCCC	19.61	29967540
376	Phosphorylation	NRAYTPRSLSAPIFT CCCCCCCCCCCCEEE	28.07	-
378	Phosphorylation	AYTPRSLSAPIFTTS CCCCCCCCCCEEECC	32.99	26657352
393	Ubiquitination	LNFVEKERDFRKINH CHHHHHHHHHHHHHH	60.48	29967540
396	Ubiquitination	VEKERDFRKINHEMA HHHHHHHHHHHHHHH	43.14	29967540
397	Ubiquitination	EKERDFRKINHEMAN HHHHHHHHHHHHHHC	48.10	-
429	Phosphorylation	CDCHPEFSPPSSQPP CCCCCCCCCCCCCCC	33.95	25850435
432	Phosphorylation	HPEFSPPSSQPPKHK CCCCCCCCCCCCCCC	45.01	25850435
433	Phosphorylation	PEFSPPSSQPPKHKG CCCCCCCCCCCCCCC	53.10	25850435
451	Ubiquitination	SRNNESEKFSSSSPL CCCCCCCCCCCCCCC	60.88	29967540
453	Phosphorylation	NNESEKFSSSSPLTL CCCCCCCCCCCCCCC	40.14	25850435
454	Phosphorylation	NESEKFSSSSPLTLP CCCCCCCCCCCCCCC	37.66	25850435
455	Phosphorylation	ESEKFSSSSPLTLPA CCCCCCCCCCCCCCH	34.47	21712546
456	Phosphorylation	SEKFSSSSPLTLPAD CCCCCCCCCCCCCHH	26.36	25850435
459	Phosphorylation	FSSSSPLTLPADLKN CCCCCCCCCCHHHHH	33.80	25850435
465	Ubiquitination	LTLPADLKNILEKQF CCCCHHHHHHHHHHC	42.35	22817900
470	Ubiquitination	DLKNILEKQFSKSSR HHHHHHHHHCCHHHH	53.88	22817900
470 (in isoform 1)	Ubiquitination	-	53.88	21890473
473	Ubiquitination	NILEKQFSKSSRAAH HHHHHHCCHHHHHHH	29.18	29967540
474	Ubiquitination	ILEKQFSKSSRAAHQ HHHHHCCHHHHHHHH	54.46	22817900
481	Ubiquitination	KSSRAAHQDFANIMK HHHHHHHHHHHHHHH	42.67	22817900
486	Ubiquitination	AHQDFANIMKMLRSL HHHHHHHHHHHHHHH	2.23	21890473
487	Ubiquitination	HQDFANIMKMLRSLI HHHHHHHHHHHHHHH	1.78	22817900
488	Ubiquitination	QDFANIMKMLRSLIQ HHHHHHHHHHHHHHH	30.87	-
490	Ubiquitination	FANIMKMLRSLIQDG HHHHHHHHHHHHHHH	2.54	22817900
492	Ubiquitination	NIMKMLRSLIQDGYM HHHHHHHHHHHHHHH	26.34	21890473
496	Ubiquitination	MLRSLIQDGYMALLE HHHHHHHHHHHHHHH	43.10	22817900
503	Ubiquitination	DGYMALLEQRCRSAA HHHHHHHHHHHHHHH	36.51	22817900
508	Ubiquitination	LLEQRCRSAAQAFTE HHHHHHHHHHHHHHH	31.42	21890473
512	Ubiquitination	RCRSAAQAFTELLNG HHHHHHHHHHHHHCC	14.49	22817900
515	Ubiquitination	SAAQAFTELLNGLDP HHHHHHHHHHCCCCH	44.82	29967540
592	Ubiquitination	VYLKKNRFLEALNHF HHHCHHHHHHHHHHH	11.47	29967540
601	Ubiquitination	EALNHFEKARTLIYR HHHHHHHHHHHHHHH	42.07	-
629	Ubiquitination	IEESQPQKIKMLLEK ECCCCHHHHHHHHHH	51.48	-
638	Ubiquitination	KMLLEKFVEECKFPP HHHHHHHHHHCCCCC	10.04	29967540
645	Ubiquitination	VEECKFPPVPDAICC HHHCCCCCCCCEEEE	54.10	29967540
703	Ubiquitination	KTTTFNDKIDKDFLQ CCCCCCCCCCHHHHC	54.64	29967540
706	Ubiquitination	TFNDKIDKDFLQGIC CCCCCCCHHHHCCCC	54.58	29967540
708	Ubiquitination	NDKIDKDFLQGICLT CCCCCHHHHCCCCCC	7.27	29967540
725	Ubiquitination	CEGVISKIIIFSSGG CCCEEEEEEEEECCC	2.03	29967540
728	Ubiquitination	VISKIIIFSSGGEVK EEEEEEEEECCCEEE	3.15	29967540
758	Phosphorylation	PILKQKCSSLEKLRL HHHHHHCCHHHHHHC	45.02	26437602
759	Phosphorylation	ILKQKCSSLEKLRLK HHHHHCCHHHHHHCH	50.44	26437602
799	Ubiquitination	LRESNPPKNEEQKET HHHHCCCCCHHHHHH	77.56	-
804	Ubiquitination	PPKNEEQKETVDNVQ CCCCHHHHHHHHHHH	59.64	-
825	Ubiquitination	DRILQCIKQYADKIK HHHHHHHHHHHHHHH	44.90	29967540
847	Ubiquitination	MLLKELLSWKVLSTE HHHHHHHHCCCCCCC	37.16	29967540
902	Ubiquitination	ELKEVEPKLAAWIQK HHHHCCHHHHHHHHH	36.93	29967540
924	Ubiquitination	ATGTFFSRYGASLKL CCCCCHHHHCCHHHH	28.84	29967540
948	Ubiquitination	WNEKYGHKLDSIEGK HCHHHCCCCCCCCCC	50.02	29967540
955	Ubiquitination	KLDSIEGKQLDYFSE CCCCCCCCCCCCCCC	34.59	29967540
967	Ubiquitination	FSEPASLKEARCLIW CCCCCCHHHHHHHHH	47.00	-
970	Ubiquitination	PASLKEARCLIWLLE CCCHHHHHHHHHHHH	19.50	29967540
977	Ubiquitination	RCLIWLLEEHRDKFP HHHHHHHHHCHHHCH	49.97	29967540
1006	Ubiquitination	SRCTVLRKQDSGEAP HCCEEEEECCCCCCC	55.05	-
1009	Phosphorylation	TVLRKQDSGEAPFSS EEEEECCCCCCCCCC	35.72	25159151
1015	Phosphorylation	DSGEAPFSSTKVKNK CCCCCCCCCCCCCCC	35.72	23927012
1018	Ubiquitination	EAPFSSTKVKNKSKK CCCCCCCCCCCCCCC	53.83	29967540
1036	Ubiquitination	KDSKPMLVGSGTTSV CCCCCCEECCCEEEE	4.70	29967540
1040	Phosphorylation	PMLVGSGTTSVTSNN CCEECCCEEEECCCC	20.00	22210691
1058	Ubiquitination	TSSEDHSNRNSDSAG CCCCCCCCCCCCCCC	43.67	29967540
1061	Phosphorylation	EDHSNRNSDSAGPFA CCCCCCCCCCCCCCC	29.70	22210691
1097	Ubiquitination	EYVVRNKKLWDMNPK CEEEECCCHHCCCHH	59.36	-
1111	Phosphorylation	KQKCSTLYDYFSQFL HHHHHHHHHHHHHHH	14.53	30576142
1132	Phosphorylation	DMSNKMFSAEYEFFP CCCCCCCCEEEECCC	19.38	30576142
1142	Phosphorylation	YEFFPEETRQILEKA EECCCHHHHHHHHHC	26.64	30576142
1153	Ubiquitination	LEKAGGLKPFLLGCP HHHCCCCCHHHCCCC	36.68	-
1189	Phosphorylation	RKKKNIKTKVEEISK HHHHCCCHHHHHHHH	36.20	-
1190	Ubiquitination	KKKNIKTKVEEISKA HHHCCCHHHHHHHHH	42.52	-
1195	Phosphorylation	KTKVEEISKAGEYVR CHHHHHHHHHCCEEE	21.52	25137130
1196	Ubiquitination	TKVEEISKAGEYVRV HHHHHHHHHCCEEEE	67.10	-
1204	Ubiquitination	AGEYVRVKLQLNPAA HCCEEEEEEEECHHH	21.68	-
1207	Ubiquitination	YVRVKLQLNPAAREF EEEEEEEECHHHHHC	13.86	29967540
1209	Ubiquitination	RVKLQLNPAAREFKP EEEEEECHHHHHCCC	35.57	29967540
1215	2-Hydroxyisobutyrylation	NPAAREFKPDVKSKP CHHHHHCCCCCCCCC	35.24	-
1241	Phosphorylation	NVKPKPVSANSPKPA CCCCCCCCCCCCCCC	30.20	22617229
1244	Phosphorylation	PKPVSANSPKPACED CCCCCCCCCCCCCCC	33.73	30576142
1275	Phosphorylation	DGQPKGVSSNSPKPG CCCCCCCCCCCCCCC	32.25	29449344
1276	Phosphorylation	GQPKGVSSNSPKPGS CCCCCCCCCCCCCCC	38.63	29449344
1278	Phosphorylation	PKGVSSNSPKPGSED CCCCCCCCCCCCCCC	35.93	25159151
1283	Phosphorylation	SNSPKPGSEDANYKR CCCCCCCCCCCCCCE	40.61	29449344
1288	Phosphorylation	PGSEDANYKRVSCNS CCCCCCCCCEECCCC	11.24	17360941
1292	Phosphorylation	DANYKRVSCNSPKPV CCCCCEECCCCCCCC	16.18	29449344
1295	Phosphorylation	YKRVSCNSPKPVLED CCEECCCCCCCCHHC	38.33	29449344
1517	Ubiquitination	YENYEQIKLKGLEET HHCHHHHHHCCHHHH	43.79	29967540
1519	Ubiquitination	NYEQIKLKGLEETRD CHHHHHHCCHHHHCC	57.35	29967540
1530	Ubiquitination	ETRDLEEKLKRHLEE HHCCHHHHHHHHHHH	50.35	-
1535	Ubiquitination	EEKLKRHLEENKISK HHHHHHHHHHCCCCH	11.66	29967540
1537	Ubiquitination	KLKRHLEENKISKTE HHHHHHHHCCCCHHH	70.90	29967540
1557	Ubiquitination	QDLEREIKKWQQEKK HHHHHHHHHHHHHHH	43.11	29967540
1559	Ubiquitination	LEREIKKWQQEKKEI HHHHHHHHHHHHHHH	10.49	29967540
1581	Phosphorylation	KKKIKKVSNASEMYT HHHHHHHHCHHHHHH	35.24	-
1584	Phosphorylation	IKKVSNASEMYTQKN HHHHHCHHHHHHCCC	27.44	-
1596	Acetylation	QKNDGKEKEHELHLD CCCCCCCCEEEHHHH	68.78	20167786
1651	Phosphorylation	VLENWKESEVYKLQI HHHHCCCCCCEEHHH	28.74	-
1669	Acetylation	QAEAFLKKLGLISRD HHHHHHHHCCCCCCC	50.35	27452117
1695	Phosphorylation	RSWELFLSNVTKEIE HHHHHHHHHHHHHHH	23.17	-
1703	Acetylation	NVTKEIEKAKSQFEE HHHHHHHHHHHHHHH	67.77	11922571
1705	Acetylation	TKEIEKAKSQFEEQI HHHHHHHHHHHHHHH	56.72	11922581
1730	Phosphorylation	ELSKVQISELSFPAC HHCCCCHHHCCCCCC	18.52	-
1733	Phosphorylation	KVQISELSFPACNTV CCCHHHCCCCCCCCC	25.73	-
1778	Phosphorylation	HRDPSVFSAGDSPGE CCCCCHHCCCCCCCC	29.23	26657352
1816	Phosphorylation	RAGQAALSERSPVAD HHHHHHHHCCCCCCC	26.66	29255136
1819	Phosphorylation	QAALSERSPVADRKQ HHHHHCCCCCCCCCC	21.48	29255136
1911	Phosphorylation	NPGKDKRTYEPSSAT CCCCCCCCCCCCCCC	37.67	28348404
1915	Phosphorylation	DKRTYEPSSATPVTR CCCCCCCCCCCCCCC	22.21	28348404
1916	Phosphorylation	KRTYEPSSATPVTRS CCCCCCCCCCCCCCC	47.04	28348404
1918	Phosphorylation	TYEPSSATPVTRSSQ CCCCCCCCCCCCCCC	21.90	28348404
1921	Phosphorylation	PSSATPVTRSSQGSP CCCCCCCCCCCCCCC	26.49	28348404
1923	Phosphorylation	SATPVTRSSQGSPSV CCCCCCCCCCCCCCE	20.04	22199227
1924	Phosphorylation	ATPVTRSSQGSPSVV CCCCCCCCCCCCCEE	34.96	22199227
1927	Phosphorylation	VTRSSQGSPSVVVAP CCCCCCCCCCEEECC	13.33	22199227
1929	Phosphorylation	RSSQGSPSVVVAPSP CCCCCCCCEEECCCC	29.28	22199227
1935	Phosphorylation	PSVVVAPSPKTKGQK CCEEECCCCCCCCCC	29.32	25159151
1938	Phosphorylation	VVAPSPKTKGQKAED EECCCCCCCCCCCCC	43.73	22817900
2003	Phosphorylation	CQGRDLLTEESPSGR CCCCCCCCCCCCCCC	45.03	-
2006	Phosphorylation	RDLLTEESPSGRGWP CCCCCCCCCCCCCCC	20.38	21815630

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
378	S	Phosphorylation	Kinase	AKT1	P31749	PSP
378	S	Phosphorylation	Kinase	AKT2	P31751	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
378	S	Phosphorylation	20059950
Phosphorylation on Ser-378 by Akt is required for ubiquitin ligase activity.
378	S	ubiquitylation	20059950
Phosphorylation on Ser-378 by Akt is required for ubiquitin ligase activity.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TTC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
AKT1_HUMAN	AKT1	physical	20059950
UB2D2_HUMAN	UBE2D2	physical	20059950

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TTC3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The E3 ligase TTC3 facilitates ubiquitination and degradation ofphosphorylated Akt."; Suizu F., Hiramuki Y., Okumura F., Matsuda M., Okumura A.J.,Hirata N., Narita M., Kohno T., Yokota J., Bohgaki M., Obuse C.,Hatakeyama S., Obata T., Noguchi M.; Dev. Cell 17:800-810(2009). Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH AKT1; AKT2 AND AKT3,PHOSPHORYLATION AT SER-378, AND MUTAGENESIS OF SER-378.	20059950 [Abstract]

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