dbPTM

UB2D2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UB2D2_HUMAN
UniProt AC	P62837
Protein Name	Ubiquitin-conjugating enzyme E2 D2
Gene Name	UBE2D2
Organism	Homo sapiens (Human).
Sequence Length	147
Subcellular Localization
Protein Description	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3..
Protein Sequence	MALKRIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNRIAREWTQKYAM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Acetylation	MALKRIHKELNDLAR CCHHHHHHHHHHHHH	62.62	21791702
8	Ubiquitination	MALKRIHKELNDLAR CCHHHHHHHHHHHHH	62.62	33845483
74	Phosphorylation	VAFTTRIYHPNINSN EEEEEEEECCCCCCC	14.13	28152594
80	Phosphorylation	IYHPNINSNGSICLD EECCCCCCCCEEHHH	38.48	24076635
83	Phosphorylation	PNINSNGSICLDILR CCCCCCCEEHHHHHH	17.87	25849741
94	Phosphorylation	DILRSQWSPALTISK HHHHHCCCCCHHHHH	7.83	-
98	Phosphorylation	SQWSPALTISKVLLS HCCCCCHHHHHHHHH	25.88	21712546
101	Ubiquitination	SPALTISKVLLSICS CCCHHHHHHHHHHHH	32.81	-
105	Phosphorylation	TISKVLLSICSLLCD HHHHHHHHHHHHHCC	19.86	-
115	Ubiquitination	SLLCDPNPDDPLVPE HHHCCCCCCCCCHHH	53.41	21963094
115	Acetylation	SLLCDPNPDDPLVPE HHHCCCCCCCCCHHH	53.41	19608861
128	Ubiquitination	PEIARIYKTDREKYN HHHHHHHHHCHHHHH	41.39	-
144	Acetylation	IAREWTQKYAM---- HHHHHHHHHCC----	27.83	21791702
144	Ubiquitination	IAREWTQKYAM---- HHHHHHHHHCC----	27.83	21963094
145	Phosphorylation	AREWTQKYAM----- HHHHHHHHCC-----	9.70	20736484
170	Ubiquitination	------------------------------ ------------------------------		21963094

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UB2D2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UB2D2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UB2D2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEDD4_HUMAN	NEDD4	physical	9990509
UBE3A_HUMAN	UBE3A	physical	9990509
CBL_HUMAN	CBL	physical	10514377
FBW1A_HUMAN	BTRC	physical	10531035
FBXW2_HUMAN	FBXW2	physical	10531035
FBX7_HUMAN	FBXO7	physical	10531035
FBXL3_HUMAN	FBXL3	physical	10531035
FBX4_HUMAN	FBXO4	physical	10531035
RAF1_HUMAN	RAF1	physical	11676916
CHIP_HUMAN	STUB1	physical	11676916
PJA2_HUMAN	PJA2	physical	12036302
PJA1_HUMAN	PJA1	physical	12036302
CDN1B_HUMAN	CDKN1B	physical	19123975
DDX58_HUMAN	DDX58	physical	17719635
STAM2_HUMAN	STAM2	physical	17588522
EPS15_HUMAN	EPS15	physical	17588522
DPOLM_HUMAN	POLM	physical	17588522
DPOLL_HUMAN	POLL	physical	17588522
UBS3B_HUMAN	UBASH3B	physical	17588522
UFM1_HUMAN	UFM1	physical	19690564
AMFR_HUMAN	AMFR	physical	19690564
MUL1_HUMAN	MUL1	physical	19690564
CAPS2_HUMAN	CADPS2	physical	19690564
CNOT4_HUMAN	CNOT4	physical	19690564
DTX1_HUMAN	DTX1	physical	19690564
UBE4A_HUMAN	UBE4A	physical	19690564
RN103_HUMAN	RNF103	physical	19690564
RN181_HUMAN	RNF181	physical	19690564
M3K1_HUMAN	MAP3K1	physical	19690564
MIB1_HUMAN	MIB1	physical	19690564
PJA2_HUMAN	PJA2	physical	19690564
RFWD3_HUMAN	RFWD3	physical	19690564
RMD5B_HUMAN	RMND5B	physical	19690564
RNF11_HUMAN	RNF11	physical	19690564
RN111_HUMAN	RNF111	physical	19690564
RNF13_HUMAN	RNF13	physical	19690564
GOLI_HUMAN	RNF130	physical	19690564
RN150_HUMAN	RNF150	physical	19690564
RN165_HUMAN	RNF165	physical	19690564
RN167_HUMAN	RNF167	physical	19690564
RN186_HUMAN	RNF186	physical	19690564
RNF25_HUMAN	RNF25	physical	19690564
RNF26_HUMAN	RNF26	physical	19690564
RNF43_HUMAN	RNF43	physical	19690564
SIAH1_HUMAN	SIAH1	physical	19690564
RNF4_HUMAN	RNF4	physical	19690564
TOPRS_HUMAN	TOPORS	physical	19690564
UHRF2_HUMAN	UHRF2	physical	19690564
LTN1_HUMAN	LTN1	physical	19690564
RN115_HUMAN	RNF115	physical	19690564
ZNRF1_HUMAN	ZNRF1	physical	19690564
ZNRF2_HUMAN	ZNRF2	physical	19690564
ZNRF4_HUMAN	ZNRF4	physical	19690564
XIAP_HUMAN	XIAP	physical	19549727
RN125_HUMAN	RNF125	physical	19549727
RN126_HUMAN	RNF126	physical	19549727
RNF37_HUMAN	UBOX5	physical	19549727
RNF5_HUMAN	RNF5	physical	19549727
RING1_HUMAN	RING1	physical	19549727
DTX3_HUMAN	DTX3	physical	19549727
RNF14_HUMAN	RNF14	physical	19549727
ZNRF1_HUMAN	ZNRF1	physical	19549727
RN114_HUMAN	RNF114	physical	19549727
RNF11_HUMAN	RNF11	physical	19549727
TRIM8_HUMAN	TRIM8	physical	19549727
DTX3L_HUMAN	DTX3L	physical	19549727
DZIP3_HUMAN	DZIP3	physical	19549727
TRI18_HUMAN	MID1	physical	19549727
MKRN3_HUMAN	MKRN3	physical	19549727
TRI39_HUMAN	TRIM39	physical	19549727
TRI27_HUMAN	TRIM27	physical	19549727
RFWD3_HUMAN	RFWD3	physical	19549727
RNF10_HUMAN	RNF10	physical	19549727
RN111_HUMAN	RNF111	physical	19549727
RN166_HUMAN	RNF166	physical	19549727
RN185_HUMAN	RNF185	physical	19549727
RING2_HUMAN	RNF2	physical	19549727
RNF25_HUMAN	RNF25	physical	19549727
TRI43_HUMAN	TRIM43	physical	19549727
TRAF6_HUMAN	TRAF6	physical	19549727
BIRC8_HUMAN	BIRC8	physical	19549727
RN138_HUMAN	RNF138	physical	19549727
BFAR_HUMAN	BFAR	physical	19549727
RNF4_HUMAN	RNF4	physical	19549727
TRAF7_HUMAN	TRAF7	physical	19549727
MARH3_HUMAN	MARCH3	physical	19549727
RSPRY_HUMAN	RSPRY1	physical	19549727
RNF12_HUMAN	RLIM	physical	19549727
LRSM1_HUMAN	LRSAM1	physical	19549727
AMFR_HUMAN	AMFR	physical	19549727
SIAH1_HUMAN	SIAH1	physical	19549727
CHFR_HUMAN	CHFR	physical	19549727
ARI2_HUMAN	ARIH2	physical	19549727
MGRN1_HUMAN	MGRN1	physical	19549727
TRI55_HUMAN	TRIM55	physical	19549727
RNF38_HUMAN	RNF38	physical	19549727
RBX2_HUMAN	RNF7	physical	19549727
TRI17_HUMAN	TRIM17	physical	19549727
TRIM2_HUMAN	TRIM2	physical	19549727
TRI25_HUMAN	TRIM25	physical	19549727
TRI26_HUMAN	TRIM26	physical	19549727
TRI31_HUMAN	TRIM31	physical	19549727
TRI35_HUMAN	TRIM35	physical	19549727
TRIM5_HUMAN	TRIM5	physical	19549727
TAU_HUMAN	MAPT	physical	14612456
CHIP_HUMAN	STUB1	physical	14612456
IKBA_HUMAN	NFKBIA	physical	10329681
TRIM1_HUMAN	MID2	physical	21143188
TRI10_HUMAN	TRIM10	physical	21143188
TRI11_HUMAN	TRIM11	physical	21143188
TRI18_HUMAN	MID1	physical	21143188
TRI50_HUMAN	TRIM50	physical	21143188
TRI37_HUMAN	TRIM37	physical	21143188
TRI27_HUMAN	TRIM27	physical	21143188
UBC_HUMAN	UBC	physical	22325355
UB2D2_HUMAN	UBE2D2	physical	22582951
CNOT4_HUMAN	CNOT4	physical	15062086
TF65_HUMAN	RELA	physical	14690596
STK11_HUMAN	STK11	physical	21860411
NED4L_HUMAN	NEDD4L	physical	20064473
UB2D2_HUMAN	UBE2D2	physical	20484052
CNOT4_HUMAN	CNOT4	physical	15001359
CNOT4_HUMAN	CNOT4	physical	11823428
NOT4_YEAST	MOT2	physical	11823428
UBC_HUMAN	UBC	physical	22902369
UBC_HUMAN	UBC	physical	22496338
CUL3_HUMAN	CUL3	physical	19256485
UBQL1_HUMAN	UBQLN1	physical	22939629
UB2L3_HUMAN	UBE2L3	physical	22939629
UBC12_HUMAN	UBE2M	physical	22939629
UBXN7_HUMAN	UBXN7	physical	22939629
ZPR1_HUMAN	ZPR1	physical	22939629
UB2V1_HUMAN	UBE2V1	physical	22939629
USP9X_HUMAN	USP9X	physical	22939629
XIAP_HUMAN	XIAP	physical	23259674
DOA10_YEAST	SSM4	physical	11641273
UBI4P_YEAST	UBI4	physical	23936628
RNF25_HUMAN	RNF25	physical	24901938
UB2D2_HUMAN	UBE2D2	physical	20061386
RNF26_HUMAN	RNF26	physical	19549727
APC11_HUMAN	ANAPC11	physical	11739784
CCNB1_HUMAN	CCNB1	physical	11739784
TRI25_HUMAN	TRIM25	physical	22350887
MDM2_HUMAN	MDM2	physical	15280377
UBR5_HUMAN	UBR5	physical	23027739
UBB_HUMAN	UBB	physical	26186194
RNF25_HUMAN	RNF25	physical	26186194
ACOX1_HUMAN	ACOX1	physical	26186194
RNF10_HUMAN	RNF10	physical	26186194
OTUB1_HUMAN	OTUB1	physical	26186194
RN114_HUMAN	RNF114	physical	26186194
ADPPT_HUMAN	AASDHPPT	physical	26344197
CCD58_HUMAN	CCDC58	physical	26344197
UBE2F_HUMAN	UBE2F	physical	26344197
RNF25_HUMAN	RNF25	physical	26475854
FA12_HUMAN	F12	physical	18838541
CHIP_HUMAN	STUB1	physical	28134249
RNF25_HUMAN	RNF25	physical	28514442
OTUB1_HUMAN	OTUB1	physical	28514442
RNF10_HUMAN	RNF10	physical	28514442
UBB_HUMAN	UBB	physical	28514442
ACOX1_HUMAN	ACOX1	physical	28514442
RN114_HUMAN	RNF114	physical	28514442
PLEC_HUMAN	PLEC	physical	27173435
SC24B_HUMAN	SEC24B	physical	27173435
DVL3_HUMAN	DVL3	physical	27173435
VIP2_HUMAN	PPIP5K2	physical	27173435
QSER1_HUMAN	QSER1	physical	27173435
LUZP1_HUMAN	LUZP1	physical	27173435
TF_HUMAN	F3	physical	27599717
RN111_HUMAN	RNF111	physical	28647409
RN114_HUMAN	RNF114	physical	28625874
SQSTM_HUMAN	SQSTM1	physical	28322253
ANPRA_HUMAN	NPR1	physical	28322253

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UB2D2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-8, AND MASS SPECTROMETRY.	19608861 [Abstract]