dbPTM

DVL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DVL3_HUMAN
UniProt AC	Q92997
Protein Name	Segment polarity protein dishevelled homolog DVL-3
Gene Name	DVL3
Organism	Homo sapiens (Human).
Sequence Length	716
Subcellular Localization	Cytoplasm .
Protein Description	Involved in the signal transduction pathway mediated by multiple Wnt genes..
Protein Sequence	MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPDPAPFCADNPSELPPPMERTGGIGDSRPPSFHPHAGGGSQENLDNDTETDSLVSAQRERPRRRDGPEHATRLNGTAKGERRREPGGYDSSSTLMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTITSTSSSITSSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYGGGSASSQHSEGSRSSGSNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSERSGPAASEHSHRSHHSLASSLRSHHTHPSYGPPGVPPLYGPPMLMMPPPPAAMGPPGAPPGRDLASVPPELTASRQSFRMAMGNPSEFFVDVM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MGETKIIYHLD ----CCCEEEEEECC	23.09	26074081
8	Phosphorylation	MGETKIIYHLDGQET CCCEEEEEECCCCCC	10.37	27642862
15	Phosphorylation	YHLDGQETPYLVKLP EECCCCCCCEEEECC	14.89	25159151
17	Phosphorylation	LDGQETPYLVKLPLP CCCCCCCEEEECCCC	31.39	26074081
27	Methylation	KLPLPAERVTLADFK ECCCCHHHEEHHHHC	28.91	22612246
34	Ubiquitination	RVTLADFKGVLQRPS HEEHHHHCHHHCCCC	48.97	-
34	Ubiquitination	RVTLADFKGVLQRPS HEEHHHHCHHHCCCC	48.97	-
41	Phosphorylation	KGVLQRPSYKFFFKS CHHHCCCCEEEEEEE	43.05	27251275
48	Phosphorylation	SYKFFFKSMDDDFGV CEEEEEEECCCCCCE	23.45	28355574
61	Phosphorylation	GVVKEEISDDNAKLP CEEEEEECCCCCCCC	42.04	-
106	Phosphorylation	LPPPMERTGGIGDSR CCCCCCCCCCCCCCC	26.84	23401153
112	Phosphorylation	RTGGIGDSRPPSFHP CCCCCCCCCCCCCCC	41.28	23927012
116	Phosphorylation	IGDSRPPSFHPHAGG CCCCCCCCCCCCCCC	38.58	23927012
125	Phosphorylation	HPHAGGGSQENLDND CCCCCCCCCCCCCCC	37.28	23401153
133	Phosphorylation	QENLDNDTETDSLVS CCCCCCCCHHHHHHH	47.22	23927012
135	Phosphorylation	NLDNDTETDSLVSAQ CCCCCCHHHHHHHHH	32.74	23663014
137	Phosphorylation	DNDTETDSLVSAQRE CCCCHHHHHHHHHHH	37.78	30576142
140	Phosphorylation	TETDSLVSAQRERPR CHHHHHHHHHHHCCC	24.79	23927012
175	Phosphorylation	REPGGYDSSSTLMSS CCCCCCCCHHHHCCC	20.08	-
178	Phosphorylation	GGYDSSSTLMSSELE CCCCCHHHHCCCCCE	28.55	28985074
186	Phosphorylation	LMSSELETTSFFDSD HCCCCCEECCCCCCC	40.12	29449344
187	Phosphorylation	MSSELETTSFFDSDE CCCCCEECCCCCCCC	17.73	30576142
188	Phosphorylation	SSELETTSFFDSDED CCCCEECCCCCCCCC	31.19	30576142
192	Phosphorylation	ETTSFFDSDEDDSTS EECCCCCCCCCCCCC	37.43	28985074
197	Phosphorylation	FDSDEDDSTSRFSSS CCCCCCCCCCCCCCC	40.37	29523821
198	Phosphorylation	DSDEDDSTSRFSSST CCCCCCCCCCCCCCC	30.80	25841592
199	Phosphorylation	SDEDDSTSRFSSSTE CCCCCCCCCCCCCCC	34.97	25841592
202	Phosphorylation	DDSTSRFSSSTEQSS CCCCCCCCCCCCHHH	23.44	29255136
203	Phosphorylation	DSTSRFSSSTEQSSA CCCCCCCCCCCHHHH	38.27	29255136
204	Phosphorylation	STSRFSSSTEQSSAS CCCCCCCCCCHHHHH	34.46	29255136
205	Phosphorylation	TSRFSSSTEQSSASR CCCCCCCCCHHHHHH	39.74	29255136
208	Phosphorylation	FSSSTEQSSASRLMR CCCCCCHHHHHHHHH	22.95	29255136
209	Phosphorylation	SSSTEQSSASRLMRR CCCCCHHHHHHHHHH	29.92	29255136
211	Phosphorylation	STEQSSASRLMRRHK CCCHHHHHHHHHHHH	28.09	29255136
212	Methylation	TEQSSASRLMRRHKR CCHHHHHHHHHHHHH	32.02	22612246
232	Phosphorylation	KVSRIERSSSFSSIT HHHHHHHCCCCCCCC	19.97	27251275
233	Phosphorylation	VSRIERSSSFSSITD HHHHHHCCCCCCCCC	41.44	28348404
234	Phosphorylation	SRIERSSSFSSITDS HHHHHCCCCCCCCCC	30.32	27251275
236	Phosphorylation	IERSSSFSSITDSTM HHHCCCCCCCCCCCC	23.84	28348404
237	Phosphorylation	ERSSSFSSITDSTMS HHCCCCCCCCCCCCC	27.74	27251275
239	Phosphorylation	SSSFSSITDSTMSLN CCCCCCCCCCCCCEE	26.33	30576142
241	Phosphorylation	SFSSITDSTMSLNII CCCCCCCCCCCEEEE	19.84	30576142
244	Phosphorylation	SITDSTMSLNIITVT CCCCCCCCEEEEEEE	20.53	23532336
249	Phosphorylation	TMSLNIITVTLNMEK CCCEEEEEEEECCHH	12.02	23532336
257	Phosphorylation	VTLNMEKYNFLGISI EEECCHHCCEEEEEE	9.61	19920076
263	Phosphorylation	KYNFLGISIVGQSNE HCCEEEEEEEECCCC	14.93	19690332
268	Phosphorylation	GISIVGQSNERGDGG EEEEEECCCCCCCCC	34.43	-
271	Asymmetric dimethylarginine	IVGQSNERGDGGIYI EEECCCCCCCCCEEE	53.40	-
271	Methylation	IVGQSNERGDGGIYI EEECCCCCCCCCEEE	53.40	23150776
277	Phosphorylation	ERGDGGIYIGSIMKG CCCCCCEEEECEEEC	11.51	19920076
280	Phosphorylation	DGGIYIGSIMKGGAV CCCEEEECEEECCEE	15.22	-
283	Ubiquitination	IYIGSIMKGGAVAAD EEEECEEECCEEEEC	53.15	21906983
283	Ubiquitination	IYIGSIMKGGAVAAD EEEECEEECCEEEEC	53.15	2190698
311	Phosphorylation	EINFENMSNDDAVRV EECCCCCCCHHHHHH	49.00	-
325	Ubiquitination	VLREIVHKPGPITLT HHHHHHCCCCCEEEE	40.55	-
325	Ubiquitination	VLREIVHKPGPITLT HHHHHHCCCCCEEEE	40.55	-
340	Phosphorylation	VAKCWDPSPRGCFTL EEECCCCCCCCCEEC	25.42	28985074
342	Symmetric dimethylarginine	KCWDPSPRGCFTLPR ECCCCCCCCCEECCC	59.87	-
342	Methylation	KCWDPSPRGCFTLPR ECCCCCCCCCEECCC	59.87	23150776
346	Phosphorylation	PSPRGCFTLPRSEPI CCCCCCEECCCCCCC	39.67	30576142
350	Phosphorylation	GCFTLPRSEPIRPID CCEECCCCCCCCCCC	45.87	-
421	Phosphorylation	AIVKAMASPESGLEV HHHHHHHCCCCCCCC	19.00	21815630
449	Ubiquitination	FIGSDVVDWLYHNVE CCCHHHHHHHHHCCC	29.52	-
456	Ubiquitination	DWLYHNVEGFTDRRE HHHHHCCCCCCCHHH	54.64	-
466	Ubiquitination	TDRREARKYASNLLK CCHHHHHHHHHHHHH	52.82	-
473	Ubiquitination	KYASNLLKAGFIRHT HHHHHHHHHHHHHHH	50.02	-
512	Phosphorylation	SLHDHDGSSGASDQD CCCCCCCCCCCCCCC	31.49	-
516	Phosphorylation	HDGSSGASDQDTLAP CCCCCCCCCCCCCCC	39.05	-
564	Phosphorylation	GYSYGGGSASSQHSE CCCCCCCCCCCCCCC	28.40	-
566	Phosphorylation	SYGGGSASSQHSEGS CCCCCCCCCCCCCCC	32.03	-
567	Phosphorylation	YGGGSASSQHSEGSR CCCCCCCCCCCCCCC	31.46	-
570	Phosphorylation	GSASSQHSEGSRSSG CCCCCCCCCCCCCCC	35.70	-
573	Phosphorylation	SSQHSEGSRSSGSNR CCCCCCCCCCCCCCC	25.57	-
575	Phosphorylation	QHSEGSRSSGSNRSG CCCCCCCCCCCCCCC	40.52	-
576	Phosphorylation	HSEGSRSSGSNRSGS CCCCCCCCCCCCCCC	45.17	-
578	Phosphorylation	EGSRSSGSNRSGSDR CCCCCCCCCCCCCCC	30.90	-
596	Phosphorylation	KDPKAGDSKSGGSGS CCCCCCCCCCCCCCC	28.01	22817900
598	Phosphorylation	PKAGDSKSGGSGSES CCCCCCCCCCCCCCC	52.95	27732954
601	Phosphorylation	GDSKSGGSGSESDHT CCCCCCCCCCCCCCC	42.54	26699800
603	Phosphorylation	SKSGGSGSESDHTTR CCCCCCCCCCCCCCH	35.31	30242111
605	Phosphorylation	SGGSGSESDHTTRSS CCCCCCCCCCCCHHH	36.07	30242111
608	Phosphorylation	SGSESDHTTRSSLRG CCCCCCCCCHHHCCC	28.97	22817900
609	Phosphorylation	GSESDHTTRSSLRGP CCCCCCCCHHHCCCC	25.74	22817900
611	Phosphorylation	ESDHTTRSSLRGPRE CCCCCCHHHCCCCCC	31.47	29214152
612	Phosphorylation	SDHTTRSSLRGPRER CCCCCHHHCCCCCCC	20.85	27794612
614	Symmetric dimethylarginine	HTTRSSLRGPRERAP CCCHHHCCCCCCCCC	55.83	-
614	Methylation	HTTRSSLRGPRERAP CCCHHHCCCCCCCCC	55.83	23150776
622	Phosphorylation	GPRERAPSERSGPAA CCCCCCCCCCCCCCC	44.66	-
625	Phosphorylation	ERAPSERSGPAASEH CCCCCCCCCCCCCCC	45.11	26471730
633	Phosphorylation	GPAASEHSHRSHHSL CCCCCCCCHHCHHHH	19.28	-
636	O-linked_Glycosylation	ASEHSHRSHHSLASS CCCCCHHCHHHHHHH	21.81	30379171
636	Phosphorylation	ASEHSHRSHHSLASS CCCCCHHCHHHHHHH	21.81	20873877
639	O-linked_Glycosylation	HSHRSHHSLASSLRS CCHHCHHHHHHHHHH	21.87	30379171
639	Phosphorylation	HSHRSHHSLASSLRS CCHHCHHHHHHHHHH	21.87	20873877
642	Phosphorylation	RSHHSLASSLRSHHT HCHHHHHHHHHHCCC	34.89	23401153
643	Phosphorylation	SHHSLASSLRSHHTH CHHHHHHHHHHCCCC	23.38	23401153
646	Phosphorylation	SLASSLRSHHTHPSY HHHHHHHHCCCCCCC	25.55	27642862
662	Phosphorylation	PPGVPPLYGPPMLMM CCCCCCCCCCCCCCC	33.10	27642862
689	Phosphorylation	PPGRDLASVPPELTA CCCCCCCCCCHHHHH	42.31	30266825
695	Phosphorylation	ASVPPELTASRQSFR CCCCHHHHHCHHHHH	22.41	30266825
697	Phosphorylation	VPPELTASRQSFRMA CCHHHHHCHHHHHHH	26.14	30266825
698	Dimethylation	PPELTASRQSFRMAM CHHHHHCHHHHHHHC	33.43	-
698	Methylation	PPELTASRQSFRMAM CHHHHHCHHHHHHHC	33.43	22612246
700	Phosphorylation	ELTASRQSFRMAMGN HHHHCHHHHHHHCCC	17.45	23150776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
15	T	Phosphorylation	Kinase	NEK2	P51955	PSP
280	S	Phosphorylation	Kinase	CK1E	P49674	PSP
280	S	Phosphorylation	Kinase	NEK2	P51955	PSP
311	S	Phosphorylation	Kinase	CK1E	P49674	PSP
611	S	Phosphorylation	Kinase	CK1E	P49674	PSP
612	S	Phosphorylation	Kinase	CK1E	P49674	PSP
633	S	Phosphorylation	Kinase	CK1E	P49674	PSP
636	S	Phosphorylation	Kinase	CK1E	P49674	PSP
639	S	Phosphorylation	Kinase	CK1E	P49674	PSP
642	S	Phosphorylation	Kinase	CK1E	P49674	PSP
643	S	Phosphorylation	Kinase	CK1E	P49674	PSP
643	S	Phosphorylation	Kinase	NEK2	P51955	PSP
697	S	Phosphorylation	Kinase	NEK2	P51955	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	KLHL12	Q53G59	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DVL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DVL3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCNK_HUMAN	CCNK	physical	16189514
KLH12_HUMAN	KLHL12	physical	16189514
KAT7_HUMAN	KAT7	physical	16189514
BAHD1_HUMAN	BAHD1	physical	16189514
ZN408_HUMAN	ZNF408	physical	16189514
SNX22_HUMAN	SNX22	physical	16189514
DPPA2_HUMAN	DPPA2	physical	16189514
LNX1_HUMAN	LNX1	physical	16189514
TZAP_HUMAN	ZBTB48	physical	16189514
PITX1_HUMAN	PITX1	physical	16189514
TP8L1_HUMAN	TNFAIP8L1	physical	16189514
PRPF3_HUMAN	PRPF3	physical	16189514
DIDO1_HUMAN	DIDO1	physical	16189514
DAB2_HUMAN	DAB2	physical	12805222
CSK21_HUMAN	CSNK2A1	physical	10806215
CTNB1_HUMAN	CTNNB1	physical	10806215
DVL1_HUMAN	DVL1	physical	10330181
PRIC1_HUMAN	PRICKLE1	physical	17030191
KLH12_HUMAN	KLHL12	physical	16547521
CYLD_HUMAN	CYLD	physical	20227366
ITCH_HUMAN	ITCH	physical	22826439
LRRK2_HUMAN	LRRK2	physical	19625296
CE164_HUMAN	CEP164	physical	22863007
MATN2_HUMAN	MATN2	physical	21988832
PPLA_HUMAN	PLN	physical	21988832
HUWE1_HUMAN	HUWE1	physical	24643799
DVL3_HUMAN	DVL3	physical	24643799
STOM_HUMAN	STOM	physical	25416956
ZN264_HUMAN	ZNF264	physical	25416956
RWD2B_HUMAN	RWDD2B	physical	25416956
NXF1_HUMAN	NXF1	physical	25416956
ADAP1_HUMAN	ADAP1	physical	25416956
KLF3_HUMAN	KLF3	physical	25416956
SAS10_HUMAN	UTP3	physical	25416956
NOL12_HUMAN	NOL12	physical	25416956
ZN697_HUMAN	ZNF697	physical	25416956
YTDC1_HUMAN	YTHDC1	physical	25416956
SYT6_HUMAN	SYT6	physical	25416956
FA13C_HUMAN	FAM13C	physical	25416956
WWTR1_HUMAN	WWTR1	physical	20412773
DVL2_HUMAN	DVL2	physical	28514442
FOXK2_HUMAN	FOXK2	physical	28514442
FOXK1_HUMAN	FOXK1	physical	28514442
VANG2_HUMAN	VANGL2	physical	28514442
CRNL1_HUMAN	CRNKL1	physical	28514442
NXN_HUMAN	NXN	physical	28514442
VANG1_HUMAN	VANGL1	physical	28514442
SYF2_HUMAN	SYF2	physical	28514442
AQR_HUMAN	AQR	physical	28514442
SYF1_HUMAN	XAB2	physical	28514442
CCD12_HUMAN	CCDC12	physical	28514442
ISY1_HUMAN	ISY1	physical	28514442
WDR83_HUMAN	WDR83	physical	28514442
PPIE_HUMAN	PPIE	physical	28514442
CSK21_HUMAN	CSNK2A1	physical	28514442
PCBP3_HUMAN	PCBP3	physical	28514442
OBSL1_HUMAN	OBSL1	physical	28514442
SNW1_HUMAN	SNW1	physical	28514442
CDC5L_HUMAN	CDC5L	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DVL3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-346, AND MASSSPECTROMETRY.	19690332 [Abstract]