NXN_HUMAN - dbPTM
NXN_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NXN_HUMAN
UniProt AC Q6DKJ4
Protein Name Nucleoredoxin
Gene Name NXN
Organism Homo sapiens (Human).
Sequence Length 435
Subcellular Localization Cytoplasm, cytosol . Nucleus .
Protein Description Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity)..
Protein Sequence MSGFLEELLGEKLVTGGGEEVDVHSLGARGISLLGLYFGCSLSAPCAQLSASLAAFYGRLRGDAAAGPGPGAGAGAAAEPEPRRRLEIVFVSSDQDQRQWQDFVRDMPWLALPYKEKHRKLKLWNKYRISNIPSLIFLDATTGKVVCRNGLLVIRDDPEGLEFPWGPKPFREVIAGPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEIIFVSADRSEESFKQYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVLELSDSNAAQLNEGPCLVLFVDSEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEEITPAIVEAFVNDFLAEKLKPEPI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSGFLEELL
------CCCHHHHHH		37.9519413330
2Acetylation------MSGFLEELL
------CCCHHHHHH		37.9519413330
130PhosphorylationLWNKYRISNIPSLIF
HHHHHCCCCCCEEEE		21.5122210691
134PhosphorylationYRISNIPSLIFLDAT
HCCCCCCEEEEEECC		30.2422210691
141PhosphorylationSLIFLDATTGKVVCR
EEEEEECCCCCEEEE		35.4322210691
142PhosphorylationLIFLDATTGKVVCRN
EEEEECCCCCEEEEC		36.4022210691
218PhosphorylationLTRVLVESYRKIKEA
HHHHHHHHHHHHHHH		23.8221406692
219PhosphorylationTRVLVESYRKIKEAG
HHHHHHHHHHHHHHC		11.4721406692
241UbiquitinationVSADRSEESFKQYFS
EECCCCHHHHHHHHH		63.8221890473
245UbiquitinationRSEESFKQYFSEMPW
CCHHHHHHHHHCCCC		42.3623000965
246UbiquitinationSEESFKQYFSEMPWL
CHHHHHHHHHCCCCE		15.0621890473
247UbiquitinationEESFKQYFSEMPWLA
HHHHHHHHHCCCCEE		4.6423000965
250UbiquitinationFKQYFSEMPWLAVPY
HHHHHHCCCCEECCC		2.5323000965
252UbiquitinationQYFSEMPWLAVPYTD
HHHHCCCCEECCCCH		8.8123000965
289PhosphorylationDPQGEVITRQGRVEV
CCCCCEEEECCCEEE		23.3221406692
294UbiquitinationVITRQGRVEVLNDED
EEEECCCEEECCCCH		8.3621890473
298UbiquitinationQGRVEVLNDEDCREF
CCCEEECCCCHHCCC		56.6623000965
300UbiquitinationRVEVLNDEDCREFPW
CEEECCCCHHCCCCC		58.9223000965
318PhosphorylationPVLELSDSNAAQLNE
CEEECCCCCHHHCCC		25.6228102081
335PhosphorylationCLVLFVDSEDDGESE
EEEEEEECCCCCCCH		37.3128102081
341PhosphorylationDSEDDGESEAAKQLI
ECCCCCCCHHHHHHH		37.7628102081
345UbiquitinationDGESEAAKQLIQPIA
CCCCHHHHHHHHHHH		53.3221906983
354UbiquitinationLIQPIAEKIIAKYKA
HHHHHHHHHHHHHHC		30.3221890473
354UbiquitinationLIQPIAEKIIAKYKA
HHHHHHHHHHHHHHC		30.3221890473
354 (in isoform 1)Ubiquitination-30.3221890473
354UbiquitinationLIQPIAEKIIAKYKA
HHHHHHHHHHHHHHC		30.3221890473
358UbiquitinationIAEKIIAKYKAKEEE
HHHHHHHHHHCCHHC		36.5523000965
360UbiquitinationEKIIAKYKAKEEEAP
HHHHHHHHCCHHCCC		52.8823000965
378SulfoxidationFVAGEDDMTDSLRDY
EEECCCCCCHHHHHH		7.4930846556
385PhosphorylationMTDSLRDYTNLPEAA
CCHHHHHHCCCCHHH		7.3520068231
386PhosphorylationTDSLRDYTNLPEAAP
CHHHHHHCCCCHHHH		34.2720068231
396PhosphorylationPEAAPLLTILDMSAR
CHHHHHHHHHCHHHC		27.4620068231
401PhosphorylationLLTILDMSARAKYVM
HHHHHCHHHCCCEEC		17.8020068231
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NXN_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NXN_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NXN_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NXN_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NXN_HUMAN

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Related Literatures of Post-Translational Modification

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