DPPA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DPPA2_HUMAN
• UniProt AC: Q7Z7J5
• Protein Name: Developmental pluripotency-associated protein 2
• Gene Name: DPPA2
• Organism: Homo sapiens (Human).
• Sequence Length: 298
• Subcellular Localization: Nucleus .
• Protein Description: Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes..
• Protein Sequence: MSDANLDSSKKNFLEGEVDDEESVILTLVPVKDDANMEQMEPSVSSTSDVKLEKPKKYNPGHLLQTNEQFTAPQKARCKIPALPLPTILPPINKVCRDTLRDWCQQLGLSTNGKKIEVYLRLHRHAYPEQRQDMPEMSQETRLQRCSRKRKAVTKRARLQRSYEMNERAEETNTVEVITSAPGAMLASWARIAARAVQPKALNSCSIPVSVEAFLMQASGVRWCVVHGRLLSADTKGWVRLQFHAGQAWVPTTHRRMISLFLLPACIFPSPGIEDNMLCPDCAKRNKKMMKRLMTVEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Sumoylation	VKLEKPKKYNPGHLL CCCCCCCCCCCCCCC	59.80	-
57	Sumoylation	VKLEKPKKYNPGHLL CCCCCCCCCCCCCCC	59.80	-
124	Dimethylation	EVYLRLHRHAYPEQR EEEHHHHHCCCHHHH	22.26	-
127	Phosphorylation	LRLHRHAYPEQRQDM HHHHHCCCHHHHCCC	10.94	-
138	Phosphorylation	RQDMPEMSQETRLQR HCCCHHHCHHHHHHH	24.17	24043423
141	Phosphorylation	MPEMSQETRLQRCSR CHHHCHHHHHHHHHH	29.10	24043423
148	Dimethylation	TRLQRCSRKRKAVTK HHHHHHHHHHHHHHH	46.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DPPA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DPPA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DPPA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DPPA2_HUMAN	DPPA2	physical	16189514
FGF12_HUMAN	FGF12	physical	21516116
EIF1A_HUMAN	EIF1AD	physical	21516116

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.