EIF1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EIF1A_HUMAN
• UniProt AC: Q8N9N8
• Protein Name: Probable RNA-binding protein EIF1AD
• Gene Name: EIF1AD
• Organism: Homo sapiens (Human).
• Sequence Length: 165
• Subcellular Localization: Nucleus .
• Protein Description: Plays a role into cellular response to oxidative stress. Decreases cell proliferation..
• Protein Sequence: MSQATKRKHVVKEVLGEHIVPSDQQQIVRVLRTPGNNLHEVETAQGQRFLVSMPSKYRKNIWIKRGDFLIVDPIEEGEKVKAEISFVLCKDHVRSLQKEGFWPEAFSEVAEKHNNRNRQTQPELPAEPQLSGEESSSEDDSDLFVNTNRRQYHESEEESEEEEAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Ubiquitination	TKRKHVVKEVLGEHI HHHHHHHHHHHCCCC	40.80	-
33	Phosphorylation	QIVRVLRTPGNNLHE HHHHEEECCCCCCEE	31.24	25159151
52	Phosphorylation	QGQRFLVSMPSKYRK CCCEEEECCCHHHCC	27.42	21406692
55	Phosphorylation	RFLVSMPSKYRKNIW EEEECCCHHHCCCEE	33.41	21406692
56	Ubiquitination	FLVSMPSKYRKNIWI EEECCCHHHCCCEEE	43.11	21890473
79	Ubiquitination	DPIEEGEKVKAEISF CCCCCCCEEEEEEEE	60.95	-
98	Ubiquitination	DHVRSLQKEGFWPEA HHHHHHHHCCCCHHH	66.16	21890473
112	Ubiquitination	AFSEVAEKHNNRNRQ HHHHHHHHHCCCCCC	41.73	21890473
120	Phosphorylation	HNNRNRQTQPELPAE HCCCCCCCCCCCCCC	42.74	21406692
131	Phosphorylation	LPAEPQLSGEESSSE CCCCCCCCCCCCCCC	38.62	20363803
135	Phosphorylation	PQLSGEESSSEDDSD CCCCCCCCCCCCCCC	34.56	20363803
136	Phosphorylation	QLSGEESSSEDDSDL CCCCCCCCCCCCCCC	40.81	20363803
137	Phosphorylation	LSGEESSSEDDSDLF CCCCCCCCCCCCCCE	55.08	20363803
141	Phosphorylation	ESSSEDDSDLFVNTN CCCCCCCCCCEEECC	48.84	21406692
147	Phosphorylation	DSDLFVNTNRRQYHE CCCCEEECCHHHCCC	25.46	21406692
152	Phosphorylation	VNTNRRQYHESEEES EECCHHHCCCCHHHH	13.02	22167270
155	Phosphorylation	NRRQYHESEEESEEE CHHHCCCCHHHHHHH	36.68	26503892
159	Phosphorylation	YHESEEESEEEEAA- CCCCHHHHHHHHHC-	54.29	26503892

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EIF1A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EIF1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EIF1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GLYR1_HUMAN	GLYR1	physical	25416956
BEND7_HUMAN	BEND7	physical	25416956
ZBT8A_HUMAN	ZBTB8A	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-155 AND SER-159, ANDMASS SPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-155 AND SER-159, ANDMASS SPECTROMETRY.
PubMed: 18669648

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131; SER-135; SER-136AND SER-137, AND MASS SPECTROMETRY.
PubMed: 17081983