PPIE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPIE_HUMAN
• UniProt AC: Q9UNP9
• Protein Name: Peptidyl-prolyl cis-trans isomerase E
• Gene Name: PPIE
• Organism: Homo sapiens (Human).
• Sequence Length: 301
• Subcellular Localization: Nucleus .
• Protein Description: Involved in pre-mRNA splicing as component of the spliceosome. [PubMed: 11991638]
• Protein Sequence: MATTKRVLYVGGLAEEVDDKVLHAAFIPFGDITDIQIPLDYETEKHRGFAFVEFELAEDAAAAIDNMNESELFGRTIRVNLAKPMRIKEGSSRPVWSDDDWLKKFSGKTLEENKEEEGSEPPKAETQEGEPIAKKARSNPQVYMDIKIGNKPAGRIQMLLRSDVVPMTAENFRCLCTHEKGFGFKGSSFHRIIPQFMCQGGDFTNHNGTGGKSIYGKKFDDENFILKHTGPGLLSMANSGPNTNGSQFFLTCDKTDWLDGKHVVFGEVTEGLDVLRQIEAQGSKDGKPKQKVIIADCGEYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	DIQIPLDYETEKHRG EEECCCCCCCCCCCC	32.22	25159151
83	Ubiquitination	TIRVNLAKPMRIKEG EEEEEECCCEECCCC	42.38	21890473
83	Ubiquitination	TIRVNLAKPMRIKEG EEEEEECCCEECCCC	42.38	21890473
83	Ubiquitination	TIRVNLAKPMRIKEG EEEEEECCCEECCCC	42.38	21890473
83	Acetylation	TIRVNLAKPMRIKEG EEEEEECCCEECCCC	42.38	25953088
83 (in isoform 1)	Ubiquitination	-	42.38	21890473
83 (in isoform 2)	Ubiquitination	-	42.38	21890473
88	Sumoylation	LAKPMRIKEGSSRPV ECCCEECCCCCCCCC	45.73	-
88	Sumoylation	LAKPMRIKEGSSRPV ECCCEECCCCCCCCC	45.73	-
91	Phosphorylation	PMRIKEGSSRPVWSD CEECCCCCCCCCCCC	25.02	25159151
92	Phosphorylation	MRIKEGSSRPVWSDD EECCCCCCCCCCCCH	52.00	25159151
97	Phosphorylation	GSSRPVWSDDDWLKK CCCCCCCCCHHHHHH	31.25	25159151
103	Ubiquitination	WSDDDWLKKFSGKTL CCCHHHHHHHCCCCH	47.74	-
108	Acetylation	WLKKFSGKTLEENKE HHHHHCCCCHHHCCC	49.06	26051181
108	Sumoylation	WLKKFSGKTLEENKE HHHHHCCCCHHHCCC	49.06	-
108	Ubiquitination	WLKKFSGKTLEENKE HHHHHCCCCHHHCCC	49.06	-
114	Acetylation	GKTLEENKEEEGSEP CCCHHHCCCCCCCCC	70.54	26051181
119	Phosphorylation	ENKEEEGSEPPKAET HCCCCCCCCCCCCCC	50.65	9747881
126	Phosphorylation	SEPPKAETQEGEPIA CCCCCCCCCCCCCCH	36.46	21815630
134	Acetylation	QEGEPIAKKARSNPQ CCCCCCHHHHHCCCE	47.92	26051181
143	Phosphorylation	ARSNPQVYMDIKIGN HHCCCEEEEEEEECC	5.48	-
167	Sulfoxidation	LRSDVVPMTAENFRC ECCCCCCCCCCCEEE	3.61	21406390
180	Acetylation	RCLCTHEKGFGFKGS EEEEECCCCCCCCCC	52.51	26051181
185	Methylation	HEKGFGFKGSSFHRI CCCCCCCCCCCCHHH	59.26	115975515
212	Ubiquitination	NHNGTGGKSIYGKKF CCCCCCCCCCCCEEC	34.72	-
212	Acetylation	NHNGTGGKSIYGKKF CCCCCCCCCCCCEEC	34.72	23236377
218 (in isoform 1)	Ubiquitination	-	50.06	21890473
218	Ubiquitination	GKSIYGKKFDDENFI CCCCCCEECCCCCEE	50.06	21890473
218 (in isoform 2)	Ubiquitination	-	50.06	21890473
218	Ubiquitination	GKSIYGKKFDDENFI CCCCCCEECCCCCEE	50.06	21890473
218	Ubiquitination	GKSIYGKKFDDENFI CCCCCCEECCCCCEE	50.06	21890473
235	Phosphorylation	HTGPGLLSMANSGPN ECCCCHHHCCCCCCC	22.38	-
243	O-linked_Glycosylation	MANSGPNTNGSQFFL CCCCCCCCCCCCEEE	44.05	28510447
251	O-linked_Glycosylation	NGSQFFLTCDKTDWL CCCCEEEECCCCCCC	17.32	28510447
251	Phosphorylation	NGSQFFLTCDKTDWL CCCCEEEECCCCCCC	17.32	-
254	Methylation	QFFLTCDKTDWLDGK CEEEECCCCCCCCCE	51.00	23644510
261	Ubiquitination	KTDWLDGKHVVFGEV CCCCCCCEEEEEEEE	32.66	-
291	Ubiquitination	KDGKPKQKVIIADCG CCCCCCCEEEEECCC	41.34	-
291	Acetylation	KDGKPKQKVIIADCG CCCCCCCEEEEECCC	41.34	26051181
306 (in isoform 3)	Phosphorylation	-		20068231
308	Sumoylation	V-------------- C--------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPIE_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPIE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPIE_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYF1_HUMAN	XAB2	physical	16189514
KMT2A_HUMAN	KMT2A	physical	11313484
SF3A2_HUMAN	SF3A2	physical	22939629
SYF1_HUMAN	XAB2	physical	22365833
SYF1_HUMAN	XAB2	physical	25416956
GCP60_HUMAN	ACBD3	physical	26186194
ISY1_HUMAN	ISY1	physical	26186194
SYF1_HUMAN	XAB2	physical	26186194
ZN830_HUMAN	ZNF830	physical	26186194
BUD31_HUMAN	BUD31	physical	26186194
RBM22_HUMAN	RBM22	physical	26186194
AQR_HUMAN	AQR	physical	26186194
TR61B_HUMAN	TRMT61B	physical	26186194
CDC5L_HUMAN	CDC5L	physical	26186194
CCD12_HUMAN	CCDC12	physical	26186194
SNW1_HUMAN	SNW1	physical	26186194
CRNL1_HUMAN	CRNKL1	physical	26186194
GPTC1_HUMAN	GPATCH1	physical	26186194
SYF2_HUMAN	SYF2	physical	26186194
CTF8_HUMAN	CHTF8	physical	26186194
C19L2_HUMAN	CWF19L2	physical	26186194
WDR83_HUMAN	WDR83	physical	26186194
SPF27_HUMAN	BCAS2	physical	26186194
AQR_HUMAN	AQR	physical	26344197
ISY1_HUMAN	ISY1	physical	26344197
U2AF2_HUMAN	U2AF2	physical	26344197
SYF1_HUMAN	XAB2	physical	26344197
ZN830_HUMAN	ZNF830	physical	28514442
ISY1_HUMAN	ISY1	physical	28514442
AQR_HUMAN	AQR	physical	28514442
SYF1_HUMAN	XAB2	physical	28514442
TR61B_HUMAN	TRMT61B	physical	28514442
WDR83_HUMAN	WDR83	physical	28514442
CTF8_HUMAN	CHTF8	physical	28514442
PRP19_HUMAN	PRPF19	physical	28514442
GPTC1_HUMAN	GPATCH1	physical	28514442
CRNL1_HUMAN	CRNKL1	physical	28514442
CCD12_HUMAN	CCDC12	physical	28514442
RBM22_HUMAN	RBM22	physical	28514442
BUD31_HUMAN	BUD31	physical	28514442
PLRG1_HUMAN	PLRG1	physical	28514442
C19L2_HUMAN	CWF19L2	physical	28514442
SNR40_HUMAN	SNRNP40	physical	28514442
SPF27_HUMAN	BCAS2	physical	28514442
SNW1_HUMAN	SNW1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.