WDR83_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR83_HUMAN
• UniProt AC: Q9BRX9
• Protein Name: WD repeat domain-containing protein 83
• Gene Name: WDR83
• Organism: Homo sapiens (Human).
• Sequence Length: 315
• Subcellular Localization: Cytoplasm. Nucleus. Predominantly cytoplasmic. Partially nuclear..
• Protein Description: Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing..
• Protein Sequence: MAFPEPKPRPPELPQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTAMGGSVQCWREEAYEAEDGAG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Ubiquitination	RPPELPQKRLKTLDC CCCCCCHHHCCEECC	58.73	29967540
19	Ubiquitination	ELPQKRLKTLDCGQG CCCHHHCCEECCCCC	51.58	22505724
39	Phosphorylation	RFNVDGNYCLTCGSD EEEECCCEEEEECCC	8.38	27642862
47	Ubiquitination	CLTCGSDKTLKLWNP EEEECCCCEEECCCC	58.41	29967540
50	Ubiquitination	CGSDKTLKLWNPLRG ECCCCEEECCCCCCC	57.60	29967540
160	Ubiquitination	RDGVSSVKVSDHEIL CCCCCEEEECCCEEE	37.66	-
206	Phosphorylation	FSRDGQCTLVSSLDS ECCCCEEEEEECHHH	23.47	26074081
209	Phosphorylation	DGQCTLVSSLDSTLR CCEEEEEECHHHHEE	28.44	26074081
210	Phosphorylation	GQCTLVSSLDSTLRL CEEEEEECHHHHEEE	28.81	26074081
213	Phosphorylation	TLVSSLDSTLRLLDK EEEECHHHHEEEECC	34.33	26074081
214	Phosphorylation	LVSSLDSTLRLLDKD EEECHHHHEEEECCC	18.63	26074081
220	Ubiquitination	STLRLLDKDTGELLG HHEEEECCCHHHHCC	58.10	29967540
222	Phosphorylation	LRLLDKDTGELLGEY EEEECCCHHHHCCCC	37.99	26074081
230	Ubiquitination	GELLGEYKGHKNQEY HHHCCCCCCCCCCEE	50.68	29967540
233	Ubiquitination	LGEYKGHKNQEYKLD CCCCCCCCCCEEEEE	69.83	-
238	Ubiquitination	GHKNQEYKLDCCLSE CCCCCEEEEEEECCC	36.78	29967540
244	Phosphorylation	YKLDCCLSERDTHVV EEEEEECCCCCCEEE	19.37	30631047

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR83_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR83_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR83_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LTOR3_HUMAN	LAMTOR3	physical	15118098
RU1C_HUMAN	SNRPC	physical	22365833
SF3B4_HUMAN	SF3B4	physical	22365833
SF01_HUMAN	SF1	physical	22365833
PRP8_HUMAN	PRPF8	physical	22365833
LSM3_HUMAN	LSM3	physical	22365833
PPIL1_HUMAN	PPIL1	physical	22365833
AQR_HUMAN	AQR	physical	22365833
HSPB1_HUMAN	HSPB1	physical	22365833
UBL5_HUMAN	UBL5	physical	22365833
S30BP_HUMAN	SAP30BP	physical	22365833
HNRH2_HUMAN	HNRNPH2	physical	22365833
PCBP2_HUMAN	PCBP2	physical	22365833
BAG2_HUMAN	BAG2	physical	22365833
TOE1_HUMAN	TOE1	physical	22365833
GPKOW_HUMAN	GPKOW	physical	22365833
RACK1_HUMAN	GNB2L1	physical	22365833
KDM1A_HUMAN	KDM1A	physical	23455924
PAR6B_HUMAN	PARD6B	physical	23439680
CRUM3_HUMAN	CRB3	physical	23439680
TCPH_HUMAN	CCT7	physical	26186194
UBB_HUMAN	UBB	physical	26186194
K1671_HUMAN	KIAA1671	physical	26186194
NUMA1_HUMAN	NUMA1	physical	26186194
TCPG_HUMAN	CCT3	physical	26186194
RB15B_HUMAN	RBM15B	physical	26186194
C19L2_HUMAN	CWF19L2	physical	26186194
TCPW_HUMAN	CCT6B	physical	26186194
TCPZ_HUMAN	CCT6A	physical	26186194
TCPB_HUMAN	CCT2	physical	26186194
TCPQ_HUMAN	CCT8	physical	26186194
SYF1_HUMAN	XAB2	physical	26186194
GPTC1_HUMAN	GPATCH1	physical	26186194
TCPD_HUMAN	CCT4	physical	26186194
DHX35_HUMAN	DHX35	physical	26186194
CRNL1_HUMAN	CRNKL1	physical	26186194
CUX1_HUMAN	CUX1	physical	26186194
CASP_HUMAN	CUX1	physical	26186194
NEK1_HUMAN	NEK1	physical	26186194
CDC5L_HUMAN	CDC5L	physical	26186194
TCPA_HUMAN	TCP1	physical	26186194
FYV1_HUMAN	PIKFYVE	physical	26186194
DPYL2_HUMAN	DPYSL2	physical	26186194
IF4E2_HUMAN	EIF4E2	physical	26186194
IASPP_HUMAN	PPP1R13L	physical	26186194
SGO2_HUMAN	SGOL2	physical	26186194
SNW1_HUMAN	SNW1	physical	26186194
GGYF2_HUMAN	GIGYF2	physical	26186194
ZHX1_HUMAN	ZHX1	physical	26186194
DCA13_HUMAN	DCAF13	physical	26186194
SLIRP_HUMAN	SLIRP	physical	26186194
PSMG2_HUMAN	PSMG2	physical	26186194
ARHG2_HUMAN	ARHGEF2	physical	26186194
AAKG2_HUMAN	PRKAG2	physical	26186194
EXO1_HUMAN	EXO1	physical	26186194
ISY1_HUMAN	ISY1	physical	26186194
PRP17_HUMAN	CDC40	physical	26186194
AQR_HUMAN	AQR	physical	26186194
KCTD3_HUMAN	KCTD3	physical	26186194
SHKB1_HUMAN	SHKBP1	physical	26186194
RN187_HUMAN	RNF187	physical	26186194
SYF2_HUMAN	SYF2	physical	26186194
SI1L1_HUMAN	SIPA1L1	physical	26186194
RIMS4_HUMAN	RIMS4	physical	26186194
SI1L3_HUMAN	SIPA1L3	physical	26186194
FRM4A_HUMAN	FRMD4A	physical	26186194
F122B_HUMAN	FAM122B	physical	26186194
ZN140_HUMAN	ZNF140	physical	26186194
MPRIP_HUMAN	MPRIP	physical	26186194
SH2B2_HUMAN	SH2B2	physical	26186194
CCD12_HUMAN	CCDC12	physical	26186194
GPSM1_HUMAN	GPSM1	physical	26186194
ARHGH_HUMAN	ARHGEF17	physical	26186194
CYH3_HUMAN	CYTH3	physical	26186194
BUD31_HUMAN	BUD31	physical	26186194
ARHG8_HUMAN	NET1	physical	26186194
ZHX1_HUMAN	ZHX1	physical	28514442
SI1L3_HUMAN	SIPA1L3	physical	28514442
DCA13_HUMAN	DCAF13	physical	28514442
K1671_HUMAN	KIAA1671	physical	28514442
GPTC1_HUMAN	GPATCH1	physical	28514442
SH2B2_HUMAN	SH2B2	physical	28514442
GPSM1_HUMAN	GPSM1	physical	28514442
SGO2_HUMAN	SGOL2	physical	28514442
RB15B_HUMAN	RBM15B	physical	28514442
DHX35_HUMAN	DHX35	physical	28514442
KCTD3_HUMAN	KCTD3	physical	28514442
RN187_HUMAN	RNF187	physical	28514442
IASPP_HUMAN	PPP1R13L	physical	28514442
PRP19_HUMAN	PRPF19	physical	28514442
F122B_HUMAN	FAM122B	physical	28514442
RIMS4_HUMAN	RIMS4	physical	28514442
SHKB1_HUMAN	SHKBP1	physical	28514442
ZN140_HUMAN	ZNF140	physical	28514442
ARHG2_HUMAN	ARHGEF2	physical	28514442
FYV1_HUMAN	PIKFYVE	physical	28514442
C19L2_HUMAN	CWF19L2	physical	28514442
NEK1_HUMAN	NEK1	physical	28514442
AAKG2_HUMAN	PRKAG2	physical	28514442
SI1L1_HUMAN	SIPA1L1	physical	28514442
GGYF1_HUMAN	GIGYF1	physical	28514442
NUMA1_HUMAN	NUMA1	physical	28514442
SYF1_HUMAN	XAB2	physical	28514442
FRM4A_HUMAN	FRMD4A	physical	28514442
EXO1_HUMAN	EXO1	physical	28514442
PRP17_HUMAN	CDC40	physical	28514442
ISY1_HUMAN	ISY1	physical	28514442
AQR_HUMAN	AQR	physical	28514442
DPYL2_HUMAN	DPYSL2	physical	28514442
IF4E2_HUMAN	EIF4E2	physical	28514442
ARHG8_HUMAN	NET1	physical	28514442
MPRIP_HUMAN	MPRIP	physical	28514442
CRNL1_HUMAN	CRNKL1	physical	28514442
TCPD_HUMAN	CCT4	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442
TCPH_HUMAN	CCT7	physical	28514442
BUD31_HUMAN	BUD31	physical	28514442
PSMG2_HUMAN	PSMG2	physical	28514442
CCD12_HUMAN	CCDC12	physical	28514442
TCPZ_HUMAN	CCT6A	physical	28514442
TCPW_HUMAN	CCT6B	physical	28514442
DACH1_HUMAN	DACH1	physical	28514442
CUX1_HUMAN	CUX1	physical	28514442
CASP_HUMAN	CUX1	physical	28514442
TCPA_HUMAN	TCP1	physical	28514442
SNW1_HUMAN	SNW1	physical	28514442
TCPG_HUMAN	CCT3	physical	28514442
CDC5L_HUMAN	CDC5L	physical	28514442
UBB_HUMAN	UBB	physical	28514442
ARHGH_HUMAN	ARHGEF17	physical	28514442
GGYF2_HUMAN	GIGYF2	physical	28514442
TCPE_HUMAN	CCT5	physical	28514442
XRP2_HUMAN	RP2	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.