dbPTM

FYV1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FYV1_HUMAN
UniProt AC	Q9Y2I7
Protein Name	1-phosphatidylinositol 3-phosphate 5-kinase
Gene Name	PIKFYVE
Organism	Homo sapiens (Human).
Sequence Length	2098
Subcellular Localization	Endosome membrane . Mainly associated with membranes of the late endocytic pathway.
Protein Description	The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes..
Protein Sequence	MATDDKTSPTLDSANDLPRSPTSPSHLTHFKPLTPDQDEPPFKSAYSSFVNLFRFNKERAEGGQGEQQPLSGSWTSPQLPSRTQSVRSPTPYKKQLNEELQRRSSALDTRRKAEPTFGGHDPRTAVQLRSLSTVLKRLKEIMEGKSQDSDLKQYWMPDSQCKECYDCSEKFTTFRRRHHCRLCGQIFCSRCCNQEIPGKFMGYTGDLRACTYCRKIALSYAHSTDSNSIGEDLNALSDSACSVSVLDPSEPRTPVGSRKASRNIFLEDDLAWQSLIHPDSSNTPLSTRLVSVQEDAGKSPARNRSASITNLSLDRSGSPMVPSYETSVSPQANRTYVRTETTEDERKILLDSVQLKDLWKKICHHSSGMEFQDHRYWLRTHPNCIVGKELVNWLIRNGHIATRAQAIAIGQAMVDGRWLDCVSHHDQLFRDEYALYRPLQSTEFSETPSPDSDSVNSVEGHSEPSWFKDIKFDDSDTEQIAEEGDDNLANSASPSKRTSVSSFQSTVDSDSAASISLNVELDNVNFHIKKPSKYPHVPPHPADQKEYLISDTGGQQLSISDAFIKESLFNRRVEEKSKELPFTPLGWHHNNLELLREENGEKQAMERLLSANHNHMMALLQQLLHSDSLSSSWRDIIVSLVCQVVQTVRPDVKNQDDDMDIRQFVHIKKIPGGKKFDSVVVNGFVCTKNIAHKKMSSCIKNPKILLLKCSIEYLYREETKFTCIDPIVLQEREFLKNYVQRIVDVRPTLVLVEKTVSRIAQDMLLEHGITLVINVKSQVLERISRMTQGDLVMSMDQLLTKPHLGTCHKFYMQIFQLPNEQTKTLMFFEGCPQHLGCTIKLRGGSDYELARVKEILIFMICVAYHSQLEISFLMDEFAMPPTLMQNPSFHSLIEGRGHEGAVQEQYGGGSIPWDPDIPPESLPCDDSSLLELRIVFEKGEQENKNLPQAVASVKHQEHSTTACPAGLPCAFFAPVPESLLPLPVDDQQDALGSEQPETLQQTVVLQDPKSQIRAFRDPLQDDTGLYVTEEVTSSEDKRKTYSLAFKQELKDVILCISPVITFREPFLLTEKGMRCSTRDYFAEQVYWSPLLNKEFKEMENRRKKQLLRDLSGLQGMNGSIQAKSIQVLPSHELVSTRIAEHLGDSQSLGRMLADYRARGGRIQPKNSDPFAHSKDASSTSSGQSGSKNEGDEERGLILSDAVWSTKVDCLNPINHQRLCVLFSSSSAQSSNAPSACVSPWIVTMEFYGKNDLTLGIFLERYCFRPSYQCPSMFCDTPMVHHIRRFVHGQGCVQIILKELDSPVPGYQHTILTYSWCRICKQVTPVVALSNESWSMSFAKYLELRFYGHQYTRRANAEPCGHSIHHDYHQYFSYNQMVASFSYSPIRLLEVCVPLPKIFIKRQAPLKVSLLQDLKDFFQKVSQVYVAIDERLASLKTDTFSKTREEKMEDIFAQKEMEEGEFKNWIEKMQARLMSSSVDTPQQLQSVFESLIAKKQSLCEVLQAWNNRLQDLFQQEKGRKRPSVPPSPGRLRQGEESKISAMDASPRNISPGLQNGEKEDRFLTTLSSQSSTSSTHLQLPTPPEVMSEQSVGGPPELDTASSSEDVFDGHLLGSTDSQVKEKSTMKAIFANLLPGNSYNPIPFPFDPDKHYLMYEHERVPIAVCEKEPSSIIAFALSCKEYRNALEELSKATQWNSAEEGLPTNSTSDSRPKSSSPIRLPEMSGGQTNRTTETEPQPTKKASGMLSFFRGTAGKSPDLSSQKRETLRGADSAYYQVGQTGKEGTENQGVEPQDEVDGGDTQKKQLINPHVELQFSDANAKFYCRLYYAGEFHKMREVILDSSEEDFIRSLSHSSPWQARGGKSGAAFYATEDDRFILKQMPRLEVQSFLDFAPHYFNYITNAVQQKRPTALAKILGVYRIGYKNSQNNTEKKLDLLVMENLFYGRKMAQVFDLKGSLRNRNVKTDTGKESCDVVLLDENLLKMVRDNPLYIRSHSKAVLRTSIHSDSHFLSSHLIIDYSLLVGRDDTSNELVVGIIDYIRTFTWDKKLEMVVKSTGILGGQGKMPTVVSPELYRTRFCEAMDKYFLMVPDHWTGLGLNC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATDDKTSP ------CCCCCCCCC	30.92	19369195
3	Phosphorylation	-----MATDDKTSPT -----CCCCCCCCCC	57.50	25850435
6	Ubiquitination	--MATDDKTSPTLDS --CCCCCCCCCCCCC	54.43	24816145
7	Phosphorylation	-MATDDKTSPTLDSA -CCCCCCCCCCCCCC	47.11	17192257
8	Phosphorylation	MATDDKTSPTLDSAN CCCCCCCCCCCCCCC	22.94	21815630
10	Phosphorylation	TDDKTSPTLDSANDL CCCCCCCCCCCCCCC	42.86	30576142
13	Phosphorylation	KTSPTLDSANDLPRS CCCCCCCCCCCCCCC	31.89	30576142
20	Phosphorylation	SANDLPRSPTSPSHL CCCCCCCCCCCCHHH	30.50	23927012
22	Phosphorylation	NDLPRSPTSPSHLTH CCCCCCCCCCHHHCC	55.29	23401153
23	Phosphorylation	DLPRSPTSPSHLTHF CCCCCCCCCHHHCCC	27.99	25159151
25	Phosphorylation	PRSPTSPSHLTHFKP CCCCCCCHHHCCCCC	30.78	23927012
28	Phosphorylation	PTSPSHLTHFKPLTP CCCCHHHCCCCCCCC	21.60	23927012
34	Phosphorylation	LTHFKPLTPDQDEPP HCCCCCCCCCCCCCC	33.09	25159151
43	Methylation	DQDEPPFKSAYSSFV CCCCCCCHHHHHHHH	39.69	115975009
44	Phosphorylation	QDEPPFKSAYSSFVN CCCCCCHHHHHHHHH	32.58	26434776
46	Phosphorylation	EPPFKSAYSSFVNLF CCCCHHHHHHHHHHH	16.37	14729942
47	Phosphorylation	PPFKSAYSSFVNLFR CCCHHHHHHHHHHHH	19.60	26434776
48	Phosphorylation	PFKSAYSSFVNLFRF CCHHHHHHHHHHHHH	22.12	28857561
71	Phosphorylation	QGEQQPLSGSWTSPQ CCCCCCCCCCCCCCC	37.15	23403867
73	Phosphorylation	EQQPLSGSWTSPQLP CCCCCCCCCCCCCCC	24.65	30175587
75	Phosphorylation	QPLSGSWTSPQLPSR CCCCCCCCCCCCCCC	32.02	22115753
76	Phosphorylation	PLSGSWTSPQLPSRT CCCCCCCCCCCCCCC	12.37	25159151
81	Phosphorylation	WTSPQLPSRTQSVRS CCCCCCCCCCCCCCC	57.46	23403867
83	Phosphorylation	SPQLPSRTQSVRSPT CCCCCCCCCCCCCCC	29.54	23403867
85	Phosphorylation	QLPSRTQSVRSPTPY CCCCCCCCCCCCCHH	20.91	23403867
88	Phosphorylation	SRTQSVRSPTPYKKQ CCCCCCCCCCHHHHH	30.85	23401153
90	O-linked_Glycosylation	TQSVRSPTPYKKQLN CCCCCCCCHHHHHHH	40.26	29351928
90	Phosphorylation	TQSVRSPTPYKKQLN CCCCCCCCHHHHHHH	40.26	23403867
92	Phosphorylation	SVRSPTPYKKQLNEE CCCCCCHHHHHHHHH	33.04	23403867
94	Ubiquitination	RSPTPYKKQLNEELQ CCCCHHHHHHHHHHH	54.92	29967540
104	Phosphorylation	NEELQRRSSALDTRR HHHHHHHHHHHHHHH	23.35	26699800
104 (in isoform 2)	Phosphorylation	-	23.35	24719451
105	Phosphorylation	EELQRRSSALDTRRK HHHHHHHHHHHHHHH	30.92	26699800
105 (in isoform 2)	Phosphorylation	-	30.92	28348404
109	Phosphorylation	RRSSALDTRRKAEPT HHHHHHHHHHHCCCC	32.97	21406692
112	Ubiquitination	SALDTRRKAEPTFGG HHHHHHHHCCCCCCC	54.53	29967540
132	Phosphorylation	AVQLRSLSTVLKRLK HHHHHHHHHHHHHHH	20.09	28555341
133	Phosphorylation	VQLRSLSTVLKRLKE HHHHHHHHHHHHHHH	34.84	-
136	Ubiquitination	RSLSTVLKRLKEIME HHHHHHHHHHHHHHC	51.88	29967540
139	Ubiquitination	STVLKRLKEIMEGKS HHHHHHHHHHHCCCC	49.59	29967540
152	Ubiquitination	KSQDSDLKQYWMPDS CCCCCCHHHHCCCHH	46.46	29967540
154	Phosphorylation	QDSDLKQYWMPDSQC CCCCHHHHCCCHHHC	11.33	22817900
173	Phosphorylation	DCSEKFTTFRRRHHC CCCHHHHHHHHHHHH	20.48	-
189	Phosphorylation	LCGQIFCSRCCNQEI CCCCEEEHHHCCCCC	20.01	28555341
201	Ubiquitination	QEIPGKFMGYTGDLR CCCCCCCCCCCCCHH	4.58	29967540
210	Phosphorylation	YTGDLRACTYCRKIA CCCCHHHHHHHHHHH	1.94	32645325
219	Phosphorylation	YCRKIALSYAHSTDS HHHHHHHHHCCCCCC	15.97	27251789
220	Phosphorylation	CRKIALSYAHSTDSN HHHHHHHHCCCCCCC	14.80	27732954
223	Phosphorylation	IALSYAHSTDSNSIG HHHHHCCCCCCCCHH	26.24	27732954
224	Phosphorylation	ALSYAHSTDSNSIGE HHHHCCCCCCCCHHH	33.31	27732954
226	Phosphorylation	SYAHSTDSNSIGEDL HHCCCCCCCCHHHCH	32.34	27732954
228	Phosphorylation	AHSTDSNSIGEDLNA CCCCCCCCHHHCHHH	35.60	27732954
242	Phosphorylation	ALSDSACSVSVLDPS HHCCCCCEEEECCCC	19.69	27251789
244	Phosphorylation	SDSACSVSVLDPSEP CCCCCEEEECCCCCC	10.73	28348404
250	Ubiquitination	VSVLDPSEPRTPVGS EEECCCCCCCCCCCC	44.16	29967540
253	Phosphorylation	LDPSEPRTPVGSRKA CCCCCCCCCCCCCCC	32.80	25159151
259	Ubiquitination	RTPVGSRKASRNIFL CCCCCCCCCCCCEEC	53.03	29967540
261	Phosphorylation	PVGSRKASRNIFLED CCCCCCCCCCEECCC	28.97	24247654
264	Ubiquitination	SRKASRNIFLEDDLA CCCCCCCEECCCCCC	3.97	29967540
274	Phosphorylation	EDDLAWQSLIHPDSS CCCCCHHHHCCCCCC	20.70	-
280	Phosphorylation	QSLIHPDSSNTPLST HHHCCCCCCCCCCCE	29.91	28122231
281	Phosphorylation	SLIHPDSSNTPLSTR HHCCCCCCCCCCCEE	52.70	28122231
283	Phosphorylation	IHPDSSNTPLSTRLV CCCCCCCCCCCEEEE	27.79	28122231
286	Phosphorylation	DSSNTPLSTRLVSVQ CCCCCCCCEEEEEEE	16.82	28122231
287	Phosphorylation	SSNTPLSTRLVSVQE CCCCCCCEEEEEEEC	35.39	28122231
291	Phosphorylation	PLSTRLVSVQEDAGK CCCEEEEEEECCCCC	23.75	25159151
298	Ubiquitination	SVQEDAGKSPARNRS EEECCCCCCCCCCCC	55.79	29967540
299	Phosphorylation	VQEDAGKSPARNRSA EECCCCCCCCCCCCC	23.91	23401153
305	Phosphorylation	KSPARNRSASITNLS CCCCCCCCCCCEEEE	29.89	30266825
307	Phosphorylation	PARNRSASITNLSLD CCCCCCCCCEEEEEC	31.06	19664994
309	Phosphorylation	RNRSASITNLSLDRS CCCCCCCEEEEECCC	27.84	30266825
312	Phosphorylation	SASITNLSLDRSGSP CCCCEEEEECCCCCC	30.23	30266825
316	Phosphorylation	TNLSLDRSGSPMVPS EEEEECCCCCCCCCC	43.20	21945579
318	Phosphorylation	LSLDRSGSPMVPSYE EEECCCCCCCCCCCC	15.86	21945579
323	Phosphorylation	SGSPMVPSYETSVSP CCCCCCCCCCCCCCC	24.96	21945579
324	Phosphorylation	GSPMVPSYETSVSPQ CCCCCCCCCCCCCCC	19.70	21945579
326	Phosphorylation	PMVPSYETSVSPQAN CCCCCCCCCCCCCCC	26.62	21945579
327	Phosphorylation	MVPSYETSVSPQANR CCCCCCCCCCCCCCC	14.52	21945579
329	Phosphorylation	PSYETSVSPQANRTY CCCCCCCCCCCCCEE	15.86	23401153
335	Phosphorylation	VSPQANRTYVRTETT CCCCCCCEEEEECCC	26.61	26074081
336	Phosphorylation	SPQANRTYVRTETTE CCCCCCEEEEECCCH	5.68	26074081
339	Phosphorylation	ANRTYVRTETTEDER CCCEEEEECCCHHHH	27.86	-
341	Phosphorylation	RTYVRTETTEDERKI CEEEEECCCHHHHHH	34.57	22817900
342	Phosphorylation	TYVRTETTEDERKIL EEEEECCCHHHHHHH	34.90	-
347	Ubiquitination	ETTEDERKILLDSVQ CCCHHHHHHHHHHHH	35.34	29967540
352	Phosphorylation	ERKILLDSVQLKDLW HHHHHHHHHHHHHHH	16.25	17192257
356	Ubiquitination	LLDSVQLKDLWKKIC HHHHHHHHHHHHHHC	33.41	29967540
361	Ubiquitination	QLKDLWKKICHHSSG HHHHHHHHHCCCCCC	38.70	29967540
366	Phosphorylation	WKKICHHSSGMEFQD HHHHCCCCCCCCCCC	12.62	-
367	Phosphorylation	KKICHHSSGMEFQDH HHHCCCCCCCCCCCC	37.49	-
380	Phosphorylation	DHRYWLRTHPNCIVG CCHHHHHHCCCCCCC	39.24	18691976
445	Phosphorylation	PLQSTEFSETPSPDS CCCCCCCCCCCCCCC	34.04	30576142
449	Phosphorylation	TEFSETPSPDSDSVN CCCCCCCCCCCCCCC	49.08	22817900
452	Phosphorylation	SETPSPDSDSVNSVE CCCCCCCCCCCCCCC	34.86	30576142
454	Phosphorylation	TPSPDSDSVNSVEGH CCCCCCCCCCCCCCC	27.44	30576142
457	Phosphorylation	PDSDSVNSVEGHSEP CCCCCCCCCCCCCCC	21.27	22817900
475	Phosphorylation	KDIKFDDSDTEQIAE CCCCCCCCCHHHHHH	48.56	30266825
477	Phosphorylation	IKFDDSDTEQIAEEG CCCCCCCHHHHHHHC	33.47	30266825
491	Phosphorylation	GDDNLANSASPSKRT CCCCCCCCCCCCCCC	25.23	30266825
493	Phosphorylation	DNLANSASPSKRTSV CCCCCCCCCCCCCCH	29.53	30266825
495	Phosphorylation	LANSASPSKRTSVSS CCCCCCCCCCCCHHH	32.07	30266825
498	Phosphorylation	SASPSKRTSVSSFQS CCCCCCCCCHHHCEE	36.90	26074081
499	Phosphorylation	ASPSKRTSVSSFQST CCCCCCCCHHHCEEC	24.84	26074081
501	Phosphorylation	PSKRTSVSSFQSTVD CCCCCCHHHCEECCC	25.79	26074081
502	Phosphorylation	SKRTSVSSFQSTVDS CCCCCHHHCEECCCC	25.75	26074081
505	Phosphorylation	TSVSSFQSTVDSDSA CCHHHCEECCCCCCC	28.52	26074081
506	Phosphorylation	SVSSFQSTVDSDSAA CHHHCEECCCCCCCC	19.97	26074081
565	Ubiquitination	SISDAFIKESLFNRR ECCHHHHHHHHHCHH	34.49	29967540
578	Ubiquitination	RRVEEKSKELPFTPL HHHHHHHCCCCCCCC	74.47	29967540
583	Phosphorylation	KSKELPFTPLGWHHN HHCCCCCCCCCCCCC	18.70	-
669	Acetylation	RQFVHIKKIPGGKKF HHHEEEEECCCCCCC	54.23	18584519
675	Acetylation	KKIPGGKKFDSVVVN EECCCCCCCCEEEEE	58.65	18584531
720	Ubiquitination	YLYREETKFTCIDPI HHHCCCCCCEEECHH	41.79	29967540
736	Ubiquitination	LQEREFLKNYVQRIV HHCHHHHHHHHHHHH	52.10	-
754	Ubiquitination	PTLVLVEKTVSRIAQ CCEEEEEHHHHHHHH	46.90	-
755	Phosphorylation	TLVLVEKTVSRIAQD CEEEEEHHHHHHHHH	15.37	21945579
757	Phosphorylation	VLVEKTVSRIAQDML EEEEHHHHHHHHHHH	24.17	21945579
770	Phosphorylation	MLLEHGITLVINVKS HHHHCCCEEEEECHH	21.40	21945579
822	Phosphorylation	FQLPNEQTKTLMFFE HCCCCCCCCEEEEEC	21.59	18491316
845	Phosphorylation	TIKLRGGSDYELARV EEEECCCCHHHHHHH	39.58	-
888	Phosphorylation	PTLMQNPSFHSLIEG CCHHCCCCHHHHHCC	43.04	-
938	Ubiquitination	ELRIVFEKGEQENKN EEEEEEECCHHHCCC	57.17	-
944	Ubiquitination	EKGEQENKNLPQAVA ECCHHHCCCCCHHHH	60.14	29967540
1026	Phosphorylation	LQDDTGLYVTEEVTS CCCCCCEEEEEEECC	13.48	27642862
1040	Phosphorylation	SSEDKRKTYSLAFKQ CCCHHHHHHHHHHHH	23.52	25627689
1041	Phosphorylation	SEDKRKTYSLAFKQE CCHHHHHHHHHHHHH	12.53	28152594
1042	Phosphorylation	EDKRKTYSLAFKQEL CHHHHHHHHHHHHHH	20.60	25627689
1046	Ubiquitination	KTYSLAFKQELKDVI HHHHHHHHHHHHHHE	36.94	29967540
1111	Phosphorylation	KQLLRDLSGLQGMNG HHHHHHHHHCCCCCC	41.57	28555341
1119	Phosphorylation	GLQGMNGSIQAKSIQ HCCCCCCCCEEEEEE	13.41	28555341
1122	Ubiquitination	GMNGSIQAKSIQVLP CCCCCCEEEEEEECC	13.09	24816145
1124	Phosphorylation	NGSIQAKSIQVLPSH CCCCEEEEEEECCCC	22.67	28555341
1155	Phosphorylation	LGRMLADYRARGGRI HHHHHHHHHHCCCCC	10.68	22817900
1165	Ubiquitination	RGGRIQPKNSDPFAH CCCCCCCCCCCCCCC	53.35	29967540
1167	Phosphorylation	GRIQPKNSDPFAHSK CCCCCCCCCCCCCCC	53.43	-
1177	Phosphorylation	FAHSKDASSTSSGQS CCCCCCCCCCCCCCC	44.26	-
1206	Ubiquitination	SDAVWSTKVDCLNPI HHHHHCCCCCCCCCC	30.47	-
1225	Phosphorylation	LCVLFSSSSAQSSNA EEEEECCCCCCCCCC	28.61	18691976
1230	Phosphorylation	SSSSAQSSNAPSACV CCCCCCCCCCCCCCC	25.57	18691976
1238	Ubiquitination	NAPSACVSPWIVTME CCCCCCCCCEEEEEE	17.88	24816145
1288	Ubiquitination	HIRRFVHGQGCVQII HHHHHHCCCCHHHHH	21.92	24816145
1294	Ubiquitination	HGQGCVQIILKELDS CCCCHHHHHHHCCCC	1.66	24816145
1301	Phosphorylation	IILKELDSPVPGYQH HHHHCCCCCCCCCHH	40.18	-
1312	Phosphorylation	GYQHTILTYSWCRIC CCHHEHHHHHHHHHC	16.20	-
1344	Ubiquitination	FAKYLELRFYGHQYT HHHHHHHHHCCCHHC	17.23	24816145
1350	Phosphorylation	LRFYGHQYTRRANAE HHHCCCHHCCCCCCC	9.13	-
1355	Ubiquitination	HQYTRRANAEPCGHS CHHCCCCCCCCCCCC	42.92	24816145
1356	Ubiquitination	QYTRRANAEPCGHSI HHCCCCCCCCCCCCC	22.56	24816145
1379	Ubiquitination	SYNQMVASFSYSPIR CHHHHEEEEECCCHH	11.87	24816145
1391	Ubiquitination	PIRLLEVCVPLPKIF CHHHHHHEEECCCEE	1.58	24816145
1396	Ubiquitination	EVCVPLPKIFIKRQA HHEEECCCEEEECCC	58.91	24816145
1397	Ubiquitination	VCVPLPKIFIKRQAP HEEECCCEEEECCCC	3.99	24816145
1414	Ubiquitination	VSLLQDLKDFFQKVS CHHHHHHHHHHHHHH	61.86	-
1433	O-linked_Glycosylation	AIDERLASLKTDTFS HHHHHHHHCCCCCCC	34.68	29351928
1435	Ubiquitination	DERLASLKTDTFSKT HHHHHHCCCCCCCCH	41.69	24816145
1436	O-linked_Glycosylation	ERLASLKTDTFSKTR HHHHHCCCCCCCCHH	45.63	29351928
1436	Phosphorylation	ERLASLKTDTFSKTR HHHHHCCCCCCCCHH	45.63	-
1438	O-linked_Glycosylation	LASLKTDTFSKTREE HHHCCCCCCCCHHHH	34.73	29351928
1440	Phosphorylation	SLKTDTFSKTREEKM HCCCCCCCCHHHHHH	34.90	-
1441	Ubiquitination	LKTDTFSKTREEKME CCCCCCCCHHHHHHH	47.62	24816145
1446	Ubiquitination	FSKTREEKMEDIFAQ CCCHHHHHHHHHHHH	42.72	29967540
1447	Ubiquitination	SKTREEKMEDIFAQK CCHHHHHHHHHHHHH	6.73	24816145
1452	Ubiquitination	EKMEDIFAQKEMEEG HHHHHHHHHHHHHCC	21.62	24816145
1453	Ubiquitination	KMEDIFAQKEMEEGE HHHHHHHHHHHHCCH	31.34	24816145
1474	Phosphorylation	KMQARLMSSSVDTPQ HHHHHHHCCCCCCHH	24.85	-
1475	Phosphorylation	MQARLMSSSVDTPQQ HHHHHHCCCCCCHHH	22.03	-
1479	Phosphorylation	LMSSSVDTPQQLQSV HHCCCCCCHHHHHHH	22.35	-
1489	Phosphorylation	QLQSVFESLIAKKQS HHHHHHHHHHHHHHH	17.38	-
1493	Ubiquitination	VFESLIAKKQSLCEV HHHHHHHHHHHHHHH	44.33	-
1494	Ubiquitination	FESLIAKKQSLCEVL HHHHHHHHHHHHHHH	35.78	-
1496	Phosphorylation	SLIAKKQSLCEVLQA HHHHHHHHHHHHHHH	43.81	-
1516	Ubiquitination	QDLFQQEKGRKRPSV HHHHHHHCCCCCCCC	60.73	-
1522	Phosphorylation	EKGRKRPSVPPSPGR HCCCCCCCCCCCCCC	51.82	23403867
1526	Phosphorylation	KRPSVPPSPGRLRQG CCCCCCCCCCCCCCC	33.64	23403867
1539	Phosphorylation	QGEESKISAMDASPR CCCCCCCCCCCCCCC	22.68	29396449
1541	Sulfoxidation	EESKISAMDASPRNI CCCCCCCCCCCCCCC	3.36	21406390
1544	Phosphorylation	KISAMDASPRNISPG CCCCCCCCCCCCCCC	21.81	29255136
1549	Phosphorylation	DASPRNISPGLQNGE CCCCCCCCCCCCCCC	19.23	29255136
1689	Ubiquitination	NALEELSKATQWNSA HHHHHHHHHHHCCCC	68.99	29967540
1702	Phosphorylation	SAEEGLPTNSTSDSR CCCCCCCCCCCCCCC	47.01	26074081
1704	Phosphorylation	EEGLPTNSTSDSRPK CCCCCCCCCCCCCCC	31.59	26074081
1705	Phosphorylation	EGLPTNSTSDSRPKS CCCCCCCCCCCCCCC	38.33	26074081
1706	Phosphorylation	GLPTNSTSDSRPKSS CCCCCCCCCCCCCCC	33.15	26074081
1708	Phosphorylation	PTNSTSDSRPKSSSP CCCCCCCCCCCCCCC	50.69	26074081
1712	Phosphorylation	TSDSRPKSSSPIRLP CCCCCCCCCCCCCCC	38.44	21712546
1713	Phosphorylation	SDSRPKSSSPIRLPE CCCCCCCCCCCCCCC	46.38	21712546
1714	Phosphorylation	DSRPKSSSPIRLPEM CCCCCCCCCCCCCCC	31.28	23401153
1722	Phosphorylation	PIRLPEMSGGQTNRT CCCCCCCCCCCCCCC	37.80	26074081
1726	Phosphorylation	PEMSGGQTNRTTETE CCCCCCCCCCCCCCC	29.91	26074081
1729	Phosphorylation	SGGQTNRTTETEPQP CCCCCCCCCCCCCCC	30.93	26074081
1730	Phosphorylation	GGQTNRTTETEPQPT CCCCCCCCCCCCCCC	37.36	26074081
1732	Phosphorylation	QTNRTTETEPQPTKK CCCCCCCCCCCCCCC	51.37	26074081
1737	Phosphorylation	TETEPQPTKKASGML CCCCCCCCCCCCCCH	39.67	26074081
1741	Phosphorylation	PQPTKKASGMLSFFR CCCCCCCCCCHHHHC	33.35	29759185
1745	Phosphorylation	KKASGMLSFFRGTAG CCCCCCHHHHCCCCC	17.28	24719451
1750	Phosphorylation	MLSFFRGTAGKSPDL CHHHHCCCCCCCCCC	28.16	23403867
1754	Phosphorylation	FRGTAGKSPDLSSQK HCCCCCCCCCCCHHH	23.80	29255136
1758	Phosphorylation	AGKSPDLSSQKRETL CCCCCCCCHHHHHHH	37.80	23403867
1759	Phosphorylation	GKSPDLSSQKRETLR CCCCCCCHHHHHHHC	47.20	23403867
1761	Ubiquitination	SPDLSSQKRETLRGA CCCCCHHHHHHHCCC	54.90	29967540
1764	Phosphorylation	LSSQKRETLRGADSA CCHHHHHHHCCCCCC	26.28	21945579
1770	Phosphorylation	ETLRGADSAYYQVGQ HHHCCCCCCCEECCC	20.03	21945579
1772	Phosphorylation	LRGADSAYYQVGQTG HCCCCCCCEECCCCC	9.81	21945579
1773	Phosphorylation	RGADSAYYQVGQTGK CCCCCCCEECCCCCC	9.09	21945579
1778	Phosphorylation	AYYQVGQTGKEGTEN CCEECCCCCCCCCCC	44.27	21945579
1801	Ubiquitination	VDGGDTQKKQLINPH CCCCCCCCHHCCCCC	44.58	-
1832	Ubiquitination	YYAGEFHKMREVILD EECCCHHHEEEEECC	45.00	-
1861	Ubiquitination	PWQARGGKSGAAFYA CCCCCCCCCCCEEEE	48.84	-
1953	Ubiquitination	MAQVFDLKGSLRNRN HHHHHCCCHHHHCCC	48.58	-
1962	Ubiquitination	SLRNRNVKTDTGKES HHHCCCCCCCCCCCC	44.20	-
1967	Ubiquitination	NVKTDTGKESCDVVL CCCCCCCCCCCCEEE	48.85	29967540
1992	Phosphorylation	DNPLYIRSHSKAVLR CCCEEEEECCCEEHH	23.66	30576142
2001	Phosphorylation	SKAVLRTSIHSDSHF CCEEHHHCCCCCCHH	16.33	30576142
2004	Phosphorylation	VLRTSIHSDSHFLSS EHHHCCCCCCHHHHC	38.86	30576142
2026	Phosphorylation	LLVGRDDTSNELVVG EEECCCCCCCCEEEH	37.43	-
2037	Phosphorylation	LVVGIIDYIRTFTWD EEEHHHHHHHHCCCC	5.06	-
2052	Ubiquitination	KKLEMVVKSTGILGG HHHHEEEECCCCCCC	30.78	29967540
2062	Ubiquitination	GILGGQGKMPTVVSP CCCCCCCCCCCCCCH	33.54	29967540
2065	Phosphorylation	GGQGKMPTVVSPELY CCCCCCCCCCCHHHH	30.00	23403867
2068	Phosphorylation	GKMPTVVSPELYRTR CCCCCCCCHHHHHHH	14.34	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
307	S	Phosphorylation	Kinase	AKT1	P31749	PSP
307	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
307	S	Phosphorylation	Kinase	PKB_GROUP	-	PhosphoELM
318	S	Phosphorylation	Kinase	AKT1	P31749	Uniprot
318	S	Phosphorylation	Kinase	AKT2	P31751	Uniprot
318	S	Phosphorylation	Kinase	SGK1	O00141	PSP
318	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
318	S	Phosphorylation		20513353
Phosphorylated in response to insulin at Ser-318 in a protein kinase B (PKB)-dependent manner.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FYV1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RABEK_HUMAN	RABEPK	physical	14530284
VAC14_HUMAN	VAC14	physical	19037259
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Disease
H00957	Fleck corneal dystrophy (FCD); Francois-Neetens speckled corneal dystrophy
OMIM Disease
121850	Corneal dystrophy, fleck (CFD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FYV1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT THR-34, AND MASS SPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307 AND SER-329, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8; SER-20; SER-73;SER-76; SER-88; SER-219; SER-223; SER-299; SER-307; SER-323; SER-329;SER-449; SER-452; SER-454; SER-457; SER-475; THR-477; SER-491;SER-493; SER-1526; SER-1544; SER-1549; SER-1714; SER-1754 ANDTYR-1772, AND MASS SPECTROMETRY.	19369195 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-318 AND SER-329, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-7; SER-76; SER-299;SER-307; SER-352; SER-1544; SER-1549 AND SER-1754, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT THR-34, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1155, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1772, AND MASSSPECTROMETRY.	15592455 [Abstract]
"Robust phosphoproteomic profiling of tyrosine phosphorylation sitesfrom human T cells using immobilized metal affinity chromatography andtandem mass spectrometry."; Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,Peters E.C.; Anal. Chem. 76:2763-2772(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-46, AND MASSSPECTROMETRY.	15144186 [Abstract]

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