SGO2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SGO2_HUMAN
• UniProt AC: Q562F6
• Protein Name: Shugoshin 2 {ECO:0000312|HGNC:HGNC:30812}
• Gene Name: SGO2 {ECO:0000312|HGNC:HGNC:30812}
• Organism: Homo sapiens (Human).
• Sequence Length: 1265
• Subcellular Localization: Nucleus . Chromosome, centromere . Chromosome, centromere, kinetochore . During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres (By similarity)
• Protein Description: Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase..
• Protein Sequence: MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLITAIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLRDKMRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MECPVMETGSLFTSG CCCCCCCCCCCCHHH		28634298
10	Phosphorylation	CPVMETGSLFTSGIK CCCCCCCCCCHHHHH		28634298
13	Phosphorylation	METGSLFTSGIKRHL CCCCCCCHHHHHHHH		28634298
14	Phosphorylation	ETGSLFTSGIKRHLK CCCCCCHHHHHHHHC		28634298
34	Phosphorylation	KTTKLNVSLASKIKT CCCCCCHHHHHHHCE		25159151
47	Phosphorylation	KTKILNNSSIFKISL CEEECCCCCCEEEEC		25159151
48	Phosphorylation	TKILNNSSIFKISLK EEECCCCCCEEEECC		24719451
72	Phosphorylation	LSREKENSRRITTEK HHHHHHHHHCCCHHH		29978859
76	Phosphorylation	KENSRRITTEKMLLQ HHHHHCCCHHHHHHH		29978859
77	Phosphorylation	ENSRRITTEKMLLQK HHHHCCCHHHHHHHH		29978859
99	Ubiquitination	ENTFLRLKLNNLNKK CCHHHHHHHHHHCHH		-
138	Phosphorylation	HQSSFLLSASKKKRI HHHHHHHCHHHHHHH		23312004
162	Phosphorylation	PFARVPLTSNDDEDE CCCCCCCCCCCCCCH		28555341
250	Phosphorylation	SSKTSLMSEMRNAQS CCHHHHHHHHHHHHH		28555341
266	Phosphorylation	GRRWEKPSPSNVTER HCCCCCCCCCCCCCH		25159151
268	Phosphorylation	RWEKPSPSNVTERKK CCCCCCCCCCCCHHH		19691289
271	Phosphorylation	KPSPSNVTERKKRGS CCCCCCCCCHHHCCC		19691289
278	Phosphorylation	TERKKRGSSWESNNL CCHHHCCCCCCCCCC		25159151
279	Phosphorylation	ERKKRGSSWESNNLS CHHHCCCCCCCCCCC		25159151
282	Phosphorylation	KRGSSWESNNLSADT HCCCCCCCCCCCCCC		26074081
286	Phosphorylation	SWESNNLSADTPCAT CCCCCCCCCCCCCEE		26074081
289	Phosphorylation	SNNLSADTPCATVLD CCCCCCCCCCEEEEC		26074081
293	Phosphorylation	SADTPCATVLDKQHI CCCCCCEEEECCCCC		26074081
301	Phosphorylation	VLDKQHISSPELNCN EECCCCCCCCCCCCC		26074081
302	Phosphorylation	LDKQHISSPELNCNN ECCCCCCCCCCCCCC		26074081
333	Phosphorylation	KQDLPGLSSESAREP CCCCCCCCHHHCCCC		28674419
373	Phosphorylation	DLTASEVSKIVTVST CCCHHHHHHEEEECC		19664995
379	Phosphorylation	VSKIVTVSTGIKKKS HHHEEEECCCCCCCC		25159151
385	Acetylation	VSTGIKKKSNKKTNE ECCCCCCCCCCCCCH		20167786
390	Phosphorylation	KKKSNKKTNEHGMKT CCCCCCCCCHHHHHH		23403867
420	Phosphorylation	SKRQFKNSSDVDIGE HHHHHCCCCCCCHHH		28555341
421	Phosphorylation	KRQFKNSSDVDIGEK HHHHCCCCCCCHHHH		20860994
433	Phosphorylation	GEKIENRTERSDVLD HHHHCCCCCCCCCCC		19691289
436	Phosphorylation	IENRTERSDVLDGKR HCCCCCCCCCCCCCC		19691289
442	Acetylation	RSDVLDGKRGAEDPG CCCCCCCCCCCCCCC		19807387
471	Acetylation	LAQVNELKKMTLQTG HHHHHHHHHHHHHHC		19807397
471	Ubiquitination	LAQVNELKKMTLQTG HHHHHHHHHHHHHHC		-
497	Phosphorylation	NKKEKRITNEQEETY CHHHCCCCCCHHHHH		19691289
503	Phosphorylation	ITNEQEETYSLSQSS CCCCHHHHHCCHHCC		29978859
504	Phosphorylation	TNEQEETYSLSQSSG CCCHHHHHCCHHCCC		29978859
505	Phosphorylation	NEQEETYSLSQSSGK CCHHHHHCCHHCCCC		29978859
507	Phosphorylation	QEETYSLSQSSGKFH HHHHHCCHHCCCCCC		17525332
509	Phosphorylation	ETYSLSQSSGKFHQE HHHCCHHCCCCCCCC		25159151
512	Acetylation	SLSQSSGKFHQESKF CCHHCCCCCCCCCCC		26051181
518	Ubiquitination	GKFHQESKFDKGQNS CCCCCCCCCCCCCCC		-
521	Ubiquitination	HQESKFDKGQNSLTC CCCCCCCCCCCCCCC		-
534	Phosphorylation	TCNKSKASRQTFVIH CCCCCHHHCCEEEEE		20860994
537	Phosphorylation	KSKASRQTFVIHKLE CCHHHCCEEEEEEHH		28122231
559	Phosphorylation	QKDKVTIYENLDVTN CCCCEEEEECCCCCC		27642862
593	Ubiquitination	THNILDLKKYVTDIQ CCCHHHHHHHHHCCC		-
594	Ubiquitination	HNILDLKKYVTDIQP CCHHHHHHHHHCCCC		-
611	Ubiquitination	QNESNINKLRKKVNR CCHHHHHHHHHHHHH		-
620	Phosphorylation	RKKVNRKTEIISGMN HHHHHHHHHHHHCCC		28555341
624	Phosphorylation	NRKTEIISGMNHMYE HHHHHHHHCCCHHCC		28555341
658	Phosphorylation	QEDKEPISENIEVSK CCCCCCCCCCEEECC		28270605
664	Phosphorylation	ISENIEVSKELQIPA CCCCEEECCCCCCCC		28270605
673	Phosphorylation	ELQIPALSTRDNENQ CCCCCCCCCCCCCCC		28270605
674	Phosphorylation	LQIPALSTRDNENQC CCCCCCCCCCCCCCC		28270605
683	Phosphorylation	DNENQCDYRTQNVLG CCCCCCCHHHHHHHH		29759185
693	Ubiquitination	QNVLGLQKQITNMYP HHHHHHHHHHHHCCC		-
720	Phosphorylation	RQKVNRKTEIISEVN HHHHHHHHHHHHHHC		25850435
724	Phosphorylation	NRKTEIISEVNHLDN HHHHHHHHHHCCCCC		27794612
734	Phosphorylation	NHLDNDKSIEYTVKS CCCCCCCCEEEEEHH		29214152
743	Phosphorylation	EYTVKSHSLFLTQKD EEEEHHCEEEEECCC		25159151
751	Ubiquitination	LFLTQKDKEIIPGNL EEEECCCCCCCCCCC		-
774	Phosphorylation	PALSTKDSGNLYDSE CCCCCCCCCCCCHHH		25159151
778	Phosphorylation	TKDSGNLYDSEIQNV CCCCCCCCHHHHHHH		18669648
780	Phosphorylation	DSGNLYDSEIQNVLG CCCCCCHHHHHHHHC		21712546
816	Phosphorylation	RLNVCQKSEIIPETN CCCCCCCCCCCCCCC		28555341
831	Ubiquitination	QIYENDNKGVHDLEK CCCCCCCCCCCCCCC		-
838	Ubiquitination	KGVHDLEKDNFFSLT CCCCCCCCCCCCCCC		-
843	Phosphorylation	LEKDNFFSLTPKDKE CCCCCCCCCCCCCHH		25159151
845	Phosphorylation	KDNFFSLTPKDKETI CCCCCCCCCCCHHHH		30266825
851	Phosphorylation	LTPKDKETISENLQV CCCCCHHHHHHHCCC		26074081
887	Ubiquitination	TQNILELKKYVTDRK HHHHHHHHHHHHCHH		-
914	Phosphorylation	RNKVNWKTEIISEMN HHHHHHHHHHHHHHH		29978859
918	Phosphorylation	NWKTEIISEMNQIYE HHHHHHHHHHHHHHH		29978859
924	Phosphorylation	ISEMNQIYEDNDKDA HHHHHHHHHCCCCCH		29978859
936	Phosphorylation	KDAHVQESYTKDLDF CCHHHHHHHHHHCCC		29978859
937	Phosphorylation	DAHVQESYTKDLDFK CHHHHHHHHHHCCCC		29978859
938	Phosphorylation	AHVQESYTKDLDFKV HHHHHHHHHHCCCCC		29978859
939	Ubiquitination	HVQESYTKDLDFKVN HHHHHHHHHCCCCCC		-
960	Ubiquitination	ECQDIINKHYMEVNS CHHHHHHHHHHHCCC		-
1027	Phosphorylation	ESDLKHITSEADSDP HHHHHHHHHCCCCCC		28450419
1028	Phosphorylation	SDLKHITSEADSDPG HHHHHHHHCCCCCCC		28450419
1032	Phosphorylation	HITSEADSDPGNPVE HHHHCCCCCCCCHHH		25159151
1047	Phosphorylation	LCKTQKQSTTTLNKK HHCCCCCCCCCCCHH		24043423
1048	Phosphorylation	CKTQKQSTTTLNKKD HCCCCCCCCCCCHHH		24043423
1049	Phosphorylation	KTQKQSTTTLNKKDL CCCCCCCCCCCHHHC		24043423
1050	Phosphorylation	TQKQSTTTLNKKDLP CCCCCCCCCCHHHCC		24043423
1070	Trimethylation	KEGECQVKKVNKMTS HCCCCEEECHHHCCC		-
1070	Methylation	KEGECQVKKVNKMTS HCCCCEEECHHHCCC		-
1074	Acetylation	CQVKKVNKMTSKSKK CEEECHHHCCCCCCC		7683721
1084	Phosphorylation	SKSKKRKTSIDPSPE CCCCCCCCCCCCCHH		29255136
1085	Phosphorylation	KSKKRKTSIDPSPES CCCCCCCCCCCCHHH		23401153
1089	Phosphorylation	RKTSIDPSPESHEVM CCCCCCCCHHHHHHH		23927012
1092	Phosphorylation	SIDPSPESHEVMERI CCCCCHHHHHHHHHH		23927012
1102	Phosphorylation	VMERILDSVQGKSTV HHHHHHHHHCCCCCH		20860994
1106	Ubiquitination	ILDSVQGKSTVSEQA HHHHHCCCCCHHHHH		-
1138	Phosphorylation	FYTKAFRSLSEIHSP HHHHHHHHHHHHCCC		30266825
1140	Phosphorylation	TKAFRSLSEIHSPNI HHHHHHHHHHCCCCC		23401153
1144	Phosphorylation	RSLSEIHSPNIQDSS HHHHHHCCCCCCCCC		30266825
1150	Phosphorylation	HSPNIQDSSFDSVRE CCCCCCCCCCCCHHC		25159151
1151	Phosphorylation	SPNIQDSSFDSVREG CCCCCCCCCCCHHCC		25159151
1154	Phosphorylation	IQDSSFDSVREGLVP CCCCCCCCHHCCCEE		24732914
1163	Phosphorylation	REGLVPLSVSSGKNV HCCCEEEEECCCCCE		30266825
1165	Phosphorylation	GLVPLSVSSGKNVII CCEEEEECCCCCEEE		30266825
1166	Phosphorylation	LVPLSVSSGKNVIIK CEEEEECCCCCEEEE		30266825
1181	Phosphorylation	ENFALECSPAFQVSD CCCEEEECCCEECCC		30266825
1187	Phosphorylation	CSPAFQVSDDEHEKM ECCCEECCCCHHHHH		30266825
1208	Phosphorylation	VNRRTQKSGIGDRPL ECCCCCCCCCCCCCC		25159151
1221	Phosphorylation	PLQDLSNTSFVSNNT CCHHHCCCCCCCCCC		25850435
1222	Phosphorylation	LQDLSNTSFVSNNTA CHHHCCCCCCCCCCC		30576142
1225	Phosphorylation	LSNTSFVSNNTAESE HCCCCCCCCCCCCCC		27690223
1239	Phosphorylation	ENKSEDLSSERTSRR CCCCCCCCCHHHHHH		20860994
1250	Phosphorylation	TSRRRRCTPFYFKEP HHHHHCCCCCCCCCH		28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SGO2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SGO2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SGO2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BOREA_HUMAN	CDCA8	physical	20739936
GBB2_HUMAN	GNB2	physical	26186194
HPHL1_HUMAN	HEPHL1	physical	26186194
H2B1J_HUMAN	HIST1H2BJ	physical	26186194
2AAB_HUMAN	PPP2R1B	physical	26186194
PKP1_HUMAN	PKP1	physical	26186194
IF1AX_HUMAN	EIF1AX	physical	26186194
LYPA2_HUMAN	LYPLA2	physical	26186194
SPB5_HUMAN	SERPINB5	physical	26186194
ARL8B_HUMAN	ARL8B	physical	26186194
PP2AA_HUMAN	PPP2CA	physical	26186194
PPCE_HUMAN	PREP	physical	26186194
SBP1_HUMAN	SELENBP1	physical	26186194
LYG2_HUMAN	LYG2	physical	26186194
PADI3_HUMAN	PADI3	physical	26186194
KC1E_HUMAN	CSNK1E	physical	26186194
DUS14_HUMAN	DUSP14	physical	26186194
PKP3_HUMAN	PKP3	physical	26186194
LRC15_HUMAN	LRRC15	physical	26186194
SPB13_HUMAN	SERPINB13	physical	26186194
DSG4_HUMAN	DSG4	physical	26186194
PLP2_HUMAN	PLP2	physical	26186194
HPHL1_HUMAN	HEPHL1	physical	28514442
LYPA2_HUMAN	LYPLA2	physical	28514442
SBP1_HUMAN	SELENBP1	physical	28514442
DUS14_HUMAN	DUSP14	physical	28514442
LYG2_HUMAN	LYG2	physical	28514442
PP2AA_HUMAN	PPP2CA	physical	28514442
PKP3_HUMAN	PKP3	physical	28514442
PADI3_HUMAN	PADI3	physical	28514442
PPCE_HUMAN	PREP	physical	28514442
DSG4_HUMAN	DSG4	physical	28514442
RGN_HUMAN	RGN	physical	28514442
ARL8B_HUMAN	ARL8B	physical	28514442
LRC15_HUMAN	LRRC15	physical	28514442
FA26D_HUMAN	FAM26D	physical	28514442
2AAB_HUMAN	PPP2R1B	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.