SBP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SBP1_HUMAN
• UniProt AC: Q13228
• Protein Name: Methanethiol oxidase {ECO:0000303|PubMed:29255262}
• Gene Name: SELENBP1
• Organism: Homo sapiens (Human).
• Sequence Length: 472
• Subcellular Localization: Nucleus . Cytoplasm, cytosol . Membrane ; Peripheral membrane protein . May associate with Golgi membrane (By similarity). May associate with the membrane of autophagosomes (By similarity).
• Protein Description: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. [PubMed: 29255262 Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity]
• Protein Sequence: MATKCGNCGPGYSTPLEAMKGPREEIVYLPCIYRNTGTEAPDYLATVDVDPKSPQYCQVIHRLPMPNLKDELHHSGWNTCSSCFGDSTKSRTKLVLPSLISSRIYVVDVGSEPRAPKLHKVIEPKDIHAKCELAFLHTSHCLASGEVMISSLGDVKGNGKGGFVLLDGETFEVKGTWERPGGAAPLGYDFWYQPRHNVMISTEWAAPNVLRDGFNPADVEAGLYGSHLYVWDWQRHEIVQTLSLKDGLIPLEIRFLHNPDAAQGFVGCALSSTIQRFYKNEGGTWSVEKVIQVPPKKVKGWLLPEMPGLITDILLSLDDRFLYFSNWLHGDLRQYDISDPQRPRLTGQLFLGGSIVKGGPVQVLEDEELKSQPEPLVVKGKRVAGGPQMIQLSLDGKRLYITTSLYSAWDKQFYPDLIREGSVMLQVDVDTVKGGLKLNPNFLVDFGKEPLGPALAHELRYPGGDCSSDIWI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATKCGNCG ------CCCCCCCCC	18.77	22814378
31	S-nitrosylation	EEIVYLPCIYRNTGT HHEEEEEEEECCCCC	3.84	25040305
42 (in isoform 4)	Phosphorylation	-	59.11	20068231
43 (in isoform 4)	Phosphorylation	-	9.36	20068231
45 (in isoform 4)	Phosphorylation	-	10.19	20068231
52	Ubiquitination	ATVDVDPKSPQYCQV EEEECCCCCCCEEEE	71.01	-
53	Phosphorylation	TVDVDPKSPQYCQVI EEECCCCCCCEEEEE	23.71	26657352
57	S-nitrosylation	DPKSPQYCQVIHRLP CCCCCCEEEEEECCC	1.88	25040305
89	Ubiquitination	SCFGDSTKSRTKLVL HHHCCCCCCCCEEHH	41.72	-
95	Phosphorylation	TKSRTKLVLPSLISS CCCCCEEHHHHHCCC	8.66	27251275
98	Phosphorylation	RTKLVLPSLISSRIY CCEEHHHHHCCCCEE	33.89	20068231
102	Phosphorylation	VLPSLISSRIYVVDV HHHHHCCCCEEEEEC	18.72	20068231
111	Phosphorylation	IYVVDVGSEPRAPKL EEEEECCCCCCCCCC	44.25	28857561
120	Ubiquitination	PRAPKLHKVIEPKDI CCCCCCCCCCCHHHH	56.17	-
125	Ubiquitination	LHKVIEPKDIHAKCE CCCCCCHHHHHHHHE	57.43	-
153	Phosphorylation	EVMISSLGDVKGNGK CEEEEECCCCCCCCC	39.34	27251275
201	Phosphorylation	PRHNVMISTEWAAPN CCCCEEEEECCCCCC	11.37	20068231
202	Phosphorylation	RHNVMISTEWAAPNV CCCEEEEECCCCCCH	25.31	20068231
241	Phosphorylation	QRHEIVQTLSLKDGL CCCCCEEEEECCCCC	13.86	23312004
243	Phosphorylation	HEIVQTLSLKDGLIP CCCEEEEECCCCCEE	36.44	23911959
268	S-nitrosylation	AAQGFVGCALSSTIQ HHHCCHHHHHHHHHH	2.64	25040305
278	Phosphorylation	SSTIQRFYKNEGGTW HHHHHHHHHCCCCCE	18.32	-
279	Ubiquitination	STIQRFYKNEGGTWS HHHHHHHHCCCCCEE	45.90	-
284	Phosphorylation	FYKNEGGTWSVEKVI HHHCCCCCEEEEEEE	25.98	22673903
285	Phosphorylation	YKNEGGTWSVEKVIQ HHCCCCCEEEEEEEE	12.03	27251275
286	Phosphorylation	KNEGGTWSVEKVIQV HCCCCCEEEEEEEEC	21.89	26437602
338	Phosphorylation	DLRQYDISDPQRPRL CHHHCCCCCCCCCCC	40.10	24719451
346	Phosphorylation	DPQRPRLTGQLFLGG CCCCCCCEEEEEECC	24.94	-
370	Ubiquitination	VLEDEELKSQPEPLV EECCHHHHCCCCCEE	50.77	-
371	Phosphorylation	LEDEELKSQPEPLVV ECCHHHHCCCCCEEE	64.69	26657352
379	Ubiquitination	QPEPLVVKGKRVAGG CCCCEEECCEECCCC	51.76	-
397	Acetylation	IQLSLDGKRLYITTS EEEEECCCEEEEEEE	38.61	7692205
413	Phosphorylation	YSAWDKQFYPDLIRE HHHHHHHHHHHHHHC	13.57	27251275
422	Phosphorylation	PDLIREGSVMLQVDV HHHHHCCEEEEEEEC	10.29	20068231
431	Phosphorylation	MLQVDVDTVKGGLKL EEEEECCCCCCCEEE	24.78	20068231
467	Phosphorylation	RYPGGDCSSDIWI-- CCCCCCCCCCCCC--	35.47	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SBP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SBP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SBP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCH2_HUMAN	TRIP13	physical	16189514
ANDR_HUMAN	AR	physical	1540595
PDIP2_HUMAN	POLDIP2	physical	16169070
RFA1_HUMAN	RPA1	physical	16169070
MED31_HUMAN	MED31	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
UBP33_HUMAN	USP33	physical	19118533
GORS2_HUMAN	GORASP2	physical	21900206
TRA2A_HUMAN	TRA2A	physical	21900206
EED_HUMAN	EED	physical	21900206
MED31_HUMAN	MED31	physical	21900206
UCRI_HUMAN	UQCRFS1	physical	22939629
SUCA_HUMAN	SUCLG1	physical	22939629
UPAR_HUMAN	PLAUR	physical	22939629
SUMO2_HUMAN	SUMO2	physical	22939629
TMED9_HUMAN	TMED9	physical	22939629
VMA21_HUMAN	VMA21	physical	22939629
SFR15_HUMAN	SCAF4	physical	22939629
WDHD1_HUMAN	WDHD1	physical	22939629
DUT_HUMAN	DUT	physical	26344197
FA49B_HUMAN	FAM49B	physical	26344197
MEMO1_HUMAN	MEMO1	physical	26344197
MMAC_HUMAN	MMACHC	physical	28514442
CMKMT_HUMAN	CAMKMT	physical	28514442
HOOK1_HUMAN	HOOK1	physical	28514442
FA60A_HUMAN	FAM60A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.