PDIP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDIP2_HUMAN
• UniProt AC: Q9Y2S7
• Protein Name: Polymerase delta-interacting protein 2
• Gene Name: POLDIP2
• Organism: Homo sapiens (Human).
• Sequence Length: 368
• Subcellular Localization: Nucleus .
• Protein Sequence: MAACTARRALAVGSRWWSRSLTGARWPRPLCAAAGAGAFSPASTTTTRRHLSSRNRPEGKVLETVGVFEVPKQNGKYETGQLFLHSIFGYRGVVLFPWQARLYDRDVASAAPEKAENPAGHGSKEVKGKTHTYYQVLIDARDCPHISQRSQTEAVTFLANHDDSRALYAIPGLDYVSHEDILPYTSTDQVPIQHELFERFLLYDQTKAPPFVARETLRAWQEKNHPWLELSDVHRETTENIRVTVIPFYMGMREAQNSHVYWWRYCIRLENLDSDVVQLRERHWRIFSLSGTLETVRGRGVVGREPVLSKEQPAFQYSSHVSLQASSGHMWGTFRFERPDGSHFDVRIPPFSLESNKDEKTPPSGLHW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	RRALAVGSRWWSRSL HHHHHCCCCHHHCCC	20.37	29514088
18	Phosphorylation	AVGSRWWSRSLTGAR HCCCCHHHCCCCCCC	12.67	29514088
44	Phosphorylation	GAFSPASTTTTRRHL CCCCCCCCHHHHHHH	30.21	29116813
103	Phosphorylation	FPWQARLYDRDVASA EEEHHHCCCHHHHHC	11.90	-
123	Phosphorylation	ENPAGHGSKEVKGKT CCCCCCCCCCCCCCE	21.70	-
129	Malonylation	GSKEVKGKTHTYYQV CCCCCCCCEEEEEEE	31.26	26320211
132	Phosphorylation	EVKGKTHTYYQVLID CCCCCEEEEEEEEEE	29.20	29496907
133	Phosphorylation	VKGKTHTYYQVLIDA CCCCEEEEEEEEEEC	5.58	29496907
143	S-nitrosylation	VLIDARDCPHISQRS EEEECCCCCCCCCCC	1.89	19483679
143	S-nitrosocysteine	VLIDARDCPHISQRS EEEECCCCCCCCCCC	1.89	-
218	Methylation	FVARETLRAWQEKNH CHHHHHHHHHHHHCC	41.00	115488063
223	Ubiquitination	TLRAWQEKNHPWLEL HHHHHHHHCCCCEEH	45.51	21890473
288	Phosphorylation	ERHWRIFSLSGTLET HHCEEEEEEECEEEE	21.18	30266825
290	Phosphorylation	HWRIFSLSGTLETVR CEEEEEEECEEEEEC	28.65	30266825
292	Phosphorylation	RIFSLSGTLETVRGR EEEEEECEEEEECCC	20.32	19664994
295	Phosphorylation	SLSGTLETVRGRGVV EEECEEEEECCCCCC	20.72	27794612
364	Phosphorylation	KDEKTPPSGLHW--- CCCCCCCCCCCC---	56.01	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDIP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDIP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDIP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCNA_HUMAN	PCNA	physical	12522211
A4_HUMAN	APP	physical	21832049
CLPX_HUMAN	CLPX	physical	28561026
NT5D2_HUMAN	NT5DC2	physical	28561026
PDIP2_HUMAN	POLDIP2	physical	28561026

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-292, AND MASSSPECTROMETRY.
PubMed: 19690332