NT5D2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NT5D2_HUMAN
• UniProt AC: Q9H857
• Protein Name: 5'-nucleotidase domain-containing protein 2
• Gene Name: NT5DC2
• Organism: Homo sapiens (Human).
• Sequence Length: 520
• Protein Sequence: MRVESGSAQERGILLESLSTLLEKTTASHEGRAPGNRELTDLLPPEVCSLLNPAAIYANNEISLRDVEVYGFDYDYTLAQYADALHPEIFSTARDILIEHYKYPEGIRKYDYNPSFAIRGLHYDIQKSLLMKIDAFHYVQLGTAYRGLQPVPDEEVIELYGGTQHIPLYQMSGFYGKGPSIKQFMDIFSLPEMALLSCVVDYFLGHSLEFDQAHLYKDVTDAIRDVHVKGLMYQWIEQDMEKYILRGDETFAVLSRLVAHGKQLFLITNSPFSFVDKGMRHMVGPDWRQLFDVVIVQADKPSFFTDRRKPFRKLDEKGSLQWDRITRLEKGKIYRQGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRIINTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLNYRVDFTFYPRRTPLQHEAPLWMDQLCTGCMKTPFLGDMAHIR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	LLPPEVCSLLNPAAI CCCHHHHHHHCHHHH	40.86	-
57	Phosphorylation	LLNPAAIYANNEISL HHCHHHHHCCCCEEC	9.88	-
63	Phosphorylation	IYANNEISLRDVEVY HHCCCCEECCCEEEE	15.92	-
68 (in isoform 2)	Ubiquitination	-	34.02	21890473
81	Phosphorylation	YDYTLAQYADALHPE CCCHHHHHHHHHCHH	10.80	22817900
86 (in isoform 2)	Phosphorylation	-	21.48	-
94 (in isoform 2)	Phosphorylation	-	31.43	-
100 (in isoform 2)	Phosphorylation	-	19.86	-
102	Ubiquitination	DILIEHYKYPEGIRK HHHHHHCCCCCCCCC	57.12	21890473
102	Malonylation	DILIEHYKYPEGIRK HHHHHHCCCCCCCCC	57.12	26320211
102	Acetylation	DILIEHYKYPEGIRK HHHHHHCCCCCCCCC	57.12	25953088
102 (in isoform 1)	Ubiquitination	-	57.12	21890473
109	Acetylation	KYPEGIRKYDYNPSF CCCCCCCCCCCCHHH	40.32	23236377
109	Ubiquitination	KYPEGIRKYDYNPSF CCCCCCCCCCCCHHH	40.32	-
109	Malonylation	KYPEGIRKYDYNPSF CCCCCCCCCCCCHHH	40.32	26320211
139 (in isoform 2)	Ubiquitination	-	2.58	21890473
139	Ubiquitination	KIDAFHYVQLGTAYR HHCCEEEEECCCCCC	2.58	-
139	Ubiquitination	KIDAFHYVQLGTAYR HHCCEEEEECCCCCC	2.58	21890473
146	Acetylation	VQLGTAYRGLQPVPD EECCCCCCCCCCCCC	36.56	-
146	Ubiquitination	VQLGTAYRGLQPVPD EECCCCCCCCCCCCC	36.56	-
233	Phosphorylation	VHVKGLMYQWIEQDM HHHHHHHHHHHHHHH	13.02	29759185
317	Ubiquitination	PFRKLDEKGSLQWDR CCCCCCCCCCCCHHH	54.16	29967540
324	Methylation	KGSLQWDRITRLEKG CCCCCHHHHHHHHCC	29.26	115485681
329	Ubiquitination	WDRITRLEKGKIYRQ HHHHHHHHCCCEEEC	57.37	-
354	Ubiquitination	EWRGPRVLYFGDHLY CCCCCEEEEECHHHH	2.86	-
354	Ubiquitination	EWRGPRVLYFGDHLY CCCCCEEEEECHHHH	2.86	29967540
456	Phosphorylation	FRTFHNPTYFSRRLV HHHCCCCHHHHHHHH	42.38	28152594
457	Phosphorylation	RTFHNPTYFSRRLVR HHCCCCHHHHHHHHH	10.79	25884760
459	Phosphorylation	FHNPTYFSRRLVRFS CCCCHHHHHHHHHHH	13.18	28152594
484	Phosphorylation	LNYRVDFTFYPRRTP HCCCCCEEEECCCCC	20.14	28331001
486	Phosphorylation	YRVDFTFYPRRTPLQ CCCCEEEECCCCCCC	7.86	28152594
510	Phosphorylation	LCTGCMKTPFLGDMA HCHHHCCCCCCCCCC	7.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NT5D2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NT5D2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NT5D2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NT5D2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.