CMKMT_HUMAN - dbPTM
CMKMT_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CMKMT_HUMAN
UniProt AC Q7Z624
Protein Name Calmodulin-lysine N-methyltransferase
Gene Name CAMKMT
Organism Homo sapiens (Human).
Sequence Length 323
Subcellular Localization Isoform 1: Cytoplasm . Nucleus .
Isoform 2: Golgi apparatus .
Protein Description Catalyzes the trimethylation of 'Lys-116' in calmodulin..
Protein Sequence MESRVADAGTGETARAAGGSPAVGCTTRGPVVSAPLGAARWKLLRQVLKQKHLDDCLRHVSVRRFESFNLFSVTEGKERETEEEVGAWVQYTSIFCPEYSISLRHNSGSLNVEDVLTSFDNTGNVCIWPSEEVLAYYCLKHNNIFRALAVCELGGGMTCLAGLMVAISADVKEVLLTDGNEKAIRNVQDIITRNQKAGVFKTQKISSCVLRWDNETDVSQLEGHFDIVMCADCLFLDQYRASLVDAIKRLLQPRGKAMVFAPRRGNTLNQFCNLAEKAGFCIQRHENYDEHISNFHSKLKKENPDIYEENLHYPLLLILTKHG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13PhosphorylationADAGTGETARAAGGS
CCCCCCHHHHHCCCC		23.84-
13O-linked_GlycosylationADAGTGETARAAGGS
CCCCCCHHHHHCCCC		23.8429351928
20PhosphorylationTARAAGGSPAVGCTT
HHHHCCCCCCCCCCC		14.5721815630
49MethylationKLLRQVLKQKHLDDC
HHHHHHHHHCCHHHH		59.45-
51MethylationLRQVLKQKHLDDCLR
HHHHHHHCCHHHHHH		44.54-
100PhosphorylationSIFCPEYSISLRHNS
EEECCCCEEEECCCC		12.2129496963
102PhosphorylationFCPEYSISLRHNSGS
ECCCCEEEECCCCCC		17.2629496963
182UbiquitinationLLTDGNEKAIRNVQD
EECCCCHHHHHHHHH		53.78-
196UbiquitinationDIITRNQKAGVFKTQ
HHHHHCCCCCCEECE		51.13-
201UbiquitinationNQKAGVFKTQKISSC
CCCCCCEECEEEEEE		47.87-
256UbiquitinationRLLQPRGKAMVFAPR
HHHCCCCCEEEEECC		34.29-
298UbiquitinationHISNFHSKLKKENPD
HHHHHHHHHHHHCCC		56.61-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CMKMT_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CMKMT_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CMKMT_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
TCPB_HUMANCCT2physical
23349634
TCPG_HUMANCCT3physical
23349634
TCPZ_HUMANCCT6Aphysical
23349634
TCPQ_HUMANCCT8physical
23349634
HS90A_HUMANHSP90AA1physical
23349634
HS90B_HUMANHSP90AB1physical
23349634
GRP78_HUMANHSPA5physical
23349634
HSP7C_HUMANHSPA8physical
23349634
PSA_HUMANNPEPPSphysical
23349634
TBB3_HUMANTUBB3physical
23349634
TBB4A_HUMANTUBB4Aphysical
23349634
TBB6_HUMANTUBB6physical
23349634
RIC8B_HUMANRIC8Bphysical
26186194
CO1A1_HUMANCOL1A1physical
26186194
HECD1_HUMANHECTD1physical
26186194
SNX6_HUMANSNX6physical
26186194
IREB2_HUMANIREB2physical
26186194
SPA5L_HUMANSPATA5L1physical
26186194
FEM1B_HUMANFEM1Bphysical
26186194
CO1A2_HUMANCOL1A2physical
26186194
AMRA1_HUMANAMBRA1physical
26186194
CO1A2_HUMANCOL1A2physical
28514442
CO1A1_HUMANCOL1A1physical
28514442
SNX6_HUMANSNX6physical
28514442
HECD1_HUMANHECTD1physical
28514442
FEM1B_HUMANFEM1Bphysical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CMKMT_HUMAN

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Related Literatures of Post-Translational Modification

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