SPA5L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPA5L_HUMAN
• UniProt AC: Q9BVQ7
• Protein Name: Spermatogenesis-associated protein 5-like protein 1
• Gene Name: SPATA5L1
• Organism: Homo sapiens (Human).
• Sequence Length: 753
• Subcellular Localization: Cytoplasm .
• Protein Sequence: MAPDSDPFPEGPLLKLLPLDARDRGTQRCRLGPAALHALGARLGSAVKISLPDGGSCLCTAWPRRDGADGFVQLDPLCASPGAAVGASRSRRSLSLNRLLLVPCPPLRRVAVWPVLRERAGAPGARNTAAVLEAAQELLRNRPISLGHVVVAPPGAPGLVAALHIVGGTPSPDPAGLVTPRTRVSLGGEPPSEAQPQPEVPLGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAELLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGSRAPESRVVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEILQVITSKMPISSHVDLGLLAEMTVGYVGADLTALCREAAMHALLHSEKNQDNPVIDEIDFLEAFKNIQPSSFRSVIGLMDIKPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTGCDVQERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLCTEAALLALQENGLDATTVKQEHFLKSLKTVKPSLSCKDLALYENLFKKEGFSNVEGI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MAPDSDPF -------CCCCCCCC	12.62	22814378
5	Phosphorylation	---MAPDSDPFPEGP ---CCCCCCCCCCCC	46.23	-
15	Ubiquitination	FPEGPLLKLLPLDAR CCCCCCCEECCCCHH	56.51	-
48	Ubiquitination	ARLGSAVKISLPDGG HCCCCCEEEECCCCC	26.71	-
80	Phosphorylation	QLDPLCASPGAAVGA EECHHHCCCCCCCCC	23.91	21712546
93	Phosphorylation	GASRSRRSLSLNRLL CCCCCCCCCCCCEEE	22.62	24719451
179	Phosphorylation	PDPAGLVTPRTRVSL CCCCCCCCCCCEEEC	16.46	24719451
182	Phosphorylation	AGLVTPRTRVSLGGE CCCCCCCCEEECCCC	36.30	28555341
185	Phosphorylation	VTPRTRVSLGGEPPS CCCCCEEECCCCCCC	20.29	27050516
247	Ubiquitination	AGPPGVGKTQLVRAV CCCCCCCHHHHHHHH	30.59	23000965
309	Glutathionylation	LDEMDALCPQRGSRA EHHHHHHCCCCCCCC	2.64	22555962
368	Phosphorylation	DREVVIGTPTLKQRK CCEEEECCCCHHHHH	11.28	23403867
370	Phosphorylation	EVVIGTPTLKQRKEI EEEECCCCHHHHHHH	46.56	23403867
372 (in isoform 2)	Ubiquitination	-	51.00	21906983
372 (in isoform 1)	Ubiquitination	-	51.00	21906983
372	Acetylation	VIGTPTLKQRKEILQ EECCCCHHHHHHHHH	51.00	30592581
372	Ubiquitination	VIGTPTLKQRKEILQ EECCCCHHHHHHHHH	51.00	21906983
375	Acetylation	TPTLKQRKEILQVIT CCCHHHHHHHHHHHH	46.76	30592587
375	Ubiquitination	TPTLKQRKEILQVIT CCCHHHHHHHHHHHH	46.76	22817900
425	Ubiquitination	HALLHSEKNQDNPVI HHHHHCCCCCCCCCC	64.02	21963094
442	Ubiquitination	IDFLEAFKNIQPSSF HHHHHHHHCCCCCCC	61.25	21987572
451	Phosphorylation	IQPSSFRSVIGLMDI CCCCCCHHHEECCCC	18.97	22210691
459 (in isoform 1)	Ubiquitination	-	34.42	21906983
459	Ubiquitination	VIGLMDIKPVDWEEI HEECCCCCCCCHHHC	34.42	21906983
459 (in isoform 2)	Ubiquitination	-	34.42	21906983
473	Ubiquitination	IGGLEDVKLKLKQSI CCCHHHHEEEEHHCC	52.83	21963094
475	Ubiquitination	GLEDVKLKLKQSIEW CHHHHEEEEHHCCCC	48.17	22817900
477	Ubiquitination	EDVKLKLKQSIEWPL HHHEEEEHHCCCCCC	40.17	22817900
485	Ubiquitination	QSIEWPLKFPWEFVR HCCCCCCCCCHHHHC	45.35	21987572
499	Ubiquitination	RMGLTQPKGVLLYGP CCCCCCCCEEEEECC	52.40	21963094
504	Phosphorylation	QPKGVLLYGPPGCAK CCCEEEEECCCCHHH	24.35	29496907
511	Ubiquitination	YGPPGCAKTTLVRAL ECCCCHHHHHHHHHH	46.23	27667366
547	Phosphorylation	GDSEKVLSQIFRQAR CCHHHHHHHHHHHHH	24.98	28857561
577	Ubiquitination	LGARSASKTGCDVQE HCHHHHHHCCCCHHH	48.96	-
600 (in isoform 2)	Ubiquitination	-	41.34	21906983
600	Ubiquitination	ELDGVGLKTIERRGS HCCCCCHHHHHHCCC	41.34	21906983
600 (in isoform 1)	Ubiquitination	-	41.34	21906983
607	Phosphorylation	KTIERRGSKSSQQEF HHHHHCCCCCHHHHH	27.79	28464451
608	Ubiquitination	TIERRGSKSSQQEFQ HHHHCCCCCHHHHHH	57.88	33845483
609	Phosphorylation	IERRGSKSSQQEFQE HHHCCCCCHHHHHHH	34.77	28450419
610	Phosphorylation	ERRGSKSSQQEFQEV HHCCCCCHHHHHHHH	39.35	28464451
656	Ubiquitination	YIPPPDHKGRLSILK EECCCCCCCCEEEEH	53.78	29967540
660	Phosphorylation	PDHKGRLSILKVCTK CCCCCCEEEEHHHCC	25.23	24719451
663	Ubiquitination	KGRLSILKVCTKTMP CCCEEEEHHHCCCCC	33.33	21963094
667	Ubiquitination	SILKVCTKTMPIGPD EEEHHHCCCCCCCCC	37.39	21963094
715	Ubiquitination	GLDATTVKQEHFLKS CCCCCHHCHHHHHHH	48.12	21963094
721	Ubiquitination	VKQEHFLKSLKTVKP HCHHHHHHHCCCCCC	53.45	29967540
724	Ubiquitination	EHFLKSLKTVKPSLS HHHHHHCCCCCCCCC	59.36	29967540
724	Acetylation	EHFLKSLKTVKPSLS HHHHHHCCCCCCCCC	59.36	21339330
727	Ubiquitination	LKSLKTVKPSLSCKD HHHCCCCCCCCCHHH	33.83	29967540
731	Phosphorylation	KTVKPSLSCKDLALY CCCCCCCCHHHHHHH	24.37	-
733	Ubiquitination	VKPSLSCKDLALYEN CCCCCCHHHHHHHHH	53.02	29967540
738	Phosphorylation	SCKDLALYENLFKKE CHHHHHHHHHHHHHC	9.36	25159151
743	Ubiquitination	ALYENLFKKEGFSNV HHHHHHHHHCCCCCC	53.75	22817900
743	Sumoylation	ALYENLFKKEGFSNV HHHHHHHHHCCCCCC	53.75	-
743	Sumoylation	ALYENLFKKEGFSNV HHHHHHHHHCCCCCC	53.75	-
744	Ubiquitination	LYENLFKKEGFSNVE HHHHHHHHCCCCCCC	56.59	22817900
744 (in isoform 1)	Ubiquitination	-	56.59	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPA5L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPA5L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPA5L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CA109_HUMAN	C1orf109	physical	28514442
FMN2_HUMAN	FMN2	physical	28514442
SPAT5_HUMAN	SPATA5	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
METH_HUMAN	MTR	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.