SPAT5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPAT5_HUMAN
• UniProt AC: Q8NB90
• Protein Name: Spermatogenesis-associated protein 5
• Gene Name: SPATA5
• Organism: Homo sapiens (Human).
• Sequence Length: 893
• Subcellular Localization: Cytoplasm . Mitochondrion .
• Protein Description: May be involved in morphological and functional mitochondrial transformations during spermatogenesis..
• Protein Sequence: MSSKKNRKRLNQSAENGSSLPSAASSCAEARAPSAGSDFAATSGTLTVTNLLEKVDDKIPKTFQNSLIHLGLNTMKSANICIGRPVLLTSLNGKQEVYTAWPMAGFPGGKVGLSEMAQKNVGVRPGDAIQVQPLVGAVLQAEEMDVALSDKDMEINEEELTGCILRKLDGKIVLPGNFLYCTFYGRPYKLQVLRVKGADGMILGGPQSDSDTDAQRMAFEQSSMETSSLELSLQLSQLDLEDTQIPTSRSTPYKPIDDRITNKASDVLLDVTQSPGDGSGLMLEEVTGLKCNFESAREGNEQLTEEERLLKFSIGAKCNTDTFYFISSTTRVNFTEIDKNSKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQPNLPDVKVAGLVKITLKDFLQAMNDIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVCREAALLALEEDIQANLIMKRHFTQALSTVTPRIPESLRRFYEDYQEKSGLHTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
189	Ubiquitination	TFYGRPYKLQVLRVK EECCCEEEEEEEEEE	34.82	21890473
189 (in isoform 1)	Ubiquitination	-	34.82	21890473
189 (in isoform 3)	Ubiquitination	-	34.82	21890473
189 (in isoform 2)	Ubiquitination	-	34.82	21890473
263 (in isoform 1)	Ubiquitination	-	40.39	21890473
263 (in isoform 3)	Ubiquitination	-	40.39	21890473
263 (in isoform 2)	Ubiquitination	-	40.39	21890473
311	Ubiquitination	TEEERLLKFSIGAKC CHHHHHHHHHHCCCC	41.48	21890473
311 (in isoform 1)	Ubiquitination	-	41.48	21890473
311 (in isoform 3)	Ubiquitination	-	41.48	21890473
311 (in isoform 2)	Ubiquitination	-	41.48	21890473
636 (in isoform 3)	Ubiquitination	-	49.18	21890473
636 (in isoform 1)	Ubiquitination	-	49.18	21890473
636 (in isoform 2)	Ubiquitination	-	49.18	21890473
638 (in isoform 3)	Ubiquitination	-	45.00	21890473
638 (in isoform 2)	Ubiquitination	-	45.00	21890473
638 (in isoform 1)	Ubiquitination	-	45.00	21890473
693 (in isoform 1)	Ubiquitination	-	63.91	21890473
700 (in isoform 1)	Ubiquitination	-	27.61	21890473
700	Acetylation	KGPELMNKYVGESER ECHHHHHHHCCHHHH	27.61	25953088
859	Sumoylation	IQANLIMKRHFTQAL HHHHHHHHHHHHHHH	35.41	28112733

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPAT5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPAT5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPAT5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPAT5_HUMAN	SPATA5	physical	26472760
SPA5L_HUMAN	SPATA5L1	physical	26472760
CINP_HUMAN	CINP	physical	26472760
CA109_HUMAN	C1orf109	physical	26472760
RCC1L_HUMAN	WBSCR16	physical	26472760
PFD5_HUMAN	PFDN5	physical	26472760
ATD3A_HUMAN	ATAD3A	physical	26472760
RCN2_HUMAN	RCN2	physical	26472760
AIFM1_HUMAN	AIFM1	physical	26472760
PFD2_HUMAN	PFDN2	physical	26472760

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.