RCC1L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RCC1L_HUMAN
• UniProt AC: Q96I51
• Protein Name: RCC1-like G exchanging factor-like protein
• Gene Name: RCC1L {ECO:0000312|HGNC:HGNC:14948}
• Organism: Homo sapiens (Human).
• Sequence Length: 464
• Subcellular Localization: Mitochondrion membrane . Mitochondrion inner membrane .
• Protein Description: Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion. [PubMed: 28746876 Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system]
• Protein Sequence: MALVALVAGARLGRRLSGPGLGRGHWTAARRSRSRREAAEAEAEVPVVQYVGERAARADRVFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTLAKSFI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	ARLGRRLSGPGLGRG CCCCCCCCCCCCCCC		28122231
140	Phosphorylation	GMGLNKDSQLGFHRS ECCCCCCCCCCCCCC		21406692
147	Phosphorylation	SQLGFHRSRKDKTRG CCCCCCCCCCCCCCC		21406692
186	Phosphorylation	VSCGRAHSLVLTDRE EECCCCCEEEEECCC		-
190	Phosphorylation	RAHSLVLTDREGVFS CCCEEEEECCCCEEE		-
197	Phosphorylation	TDREGVFSMGNNSYG ECCCCEEECCCCCCC		21406692
202	Phosphorylation	VFSMGNNSYGQCGRK EEECCCCCCCCCCCC		21406692
203	Phosphorylation	FSMGNNSYGQCGRKV EECCCCCCCCCCCCH		21406692
209	Ubiquitination	SYGQCGRKVVENEIY CCCCCCCCHHHCCCC		21906983
209	Malonylation	SYGQCGRKVVENEIY CCCCCCCCHHHCCCC		26320211
209	Ubiquitination	SYGQCGRKVVENEIY CCCCCCCCHHHCCCC		22817900
216	Phosphorylation	KVVENEIYSESHRVH CHHHCCCCCCCCCEE		25159151
217	Phosphorylation	VVENEIYSESHRVHR HHHCCCCCCCCCEEE		-
262	Phosphorylation	GWGADGQTGLGHYNI ECCCCCCCCCCCCCC		28787133
270	Phosphorylation	GLGHYNITSSPTKLG CCCCCCCCCCCCCCC		25627689
271	Phosphorylation	LGHYNITSSPTKLGG CCCCCCCCCCCCCCC		25627689
272	Phosphorylation	GHYNITSSPTKLGGD CCCCCCCCCCCCCCC		25627689
274	Phosphorylation	YNITSSPTKLGGDLA CCCCCCCCCCCCCCC		28787133

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RCC1L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RCC1L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RCC1L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RCC1L_HUMAN	WBSCR16	physical	27499296
TRUB2_HUMAN	TRUB2	physical	27499296
CF203_HUMAN	C6orf203	physical	27499296
NDK6_HUMAN	NME6	physical	27499296
NRDC_HUMAN	NRD1	physical	27499296
DHRS4_HUMAN	DHRS4	physical	27499296
MPPB_HUMAN	PMPCB	physical	27499296
MPPA_HUMAN	PMPCA	physical	27499296
STAR7_HUMAN	STARD7	physical	27499296
NUD19_HUMAN	NUDT19	physical	27499296
CLPB_HUMAN	CLPB	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
NGRN_HUMAN	NGRN	physical	27667664
NDK6_HUMAN	NME6	physical	27667664
TRUB2_HUMAN	TRUB2	physical	27667664
FAKD2_HUMAN	FASTKD2	physical	27667664
RUSD3_HUMAN	RPUSD3	physical	27667664
TEFM_HUMAN	TEFM	physical	27667664
GTPBA_HUMAN	GTPBP10	physical	27667664
TBRG4_HUMAN	TBRG4	physical	27667664
RUSD4_HUMAN	RPUSD4	physical	27667664
RM20_HUMAN	MRPL20	physical	27667664

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.